Gene Gene information from NCBI Gene database.
Entrez ID 221079
Gene name ARF like GTPase 5B
Gene symbol ARL5B
Synonyms (NCBI Gene)
ARL8
Chromosome 10
Chromosome location 10p12.31
Summary ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]
miRNA miRNA information provided by mirtarbase database.
1103
miRTarBase ID miRNA Experiments Reference
MIRT001567 hsa-miR-155-5p pSILAC 18668040
MIRT017382 hsa-miR-335-5p Microarray 18185580
MIRT001567 hsa-miR-155-5p Proteomics;Other 18668040
MIRT044984 hsa-miR-186-5p CLASH 23622248
MIRT669480 hsa-miR-6828-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005525 Function GTP binding IBA
GO:0005525 Function GTP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608909 23052 ENSG00000165997
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96KC2
Protein name ADP-ribosylation factor-like protein 5B (ADP-ribosylation factor-like protein 8)
Protein function Binds and exchanges GTP and GDP.
PDB 1YZG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00025 Arf 1 176 ADP-ribosylation factor family Domain
Sequence
Sequence length 179
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HENOCH-SCHOENLEIN PURPURA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MELANOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 20932310 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 32805088 Associate
★☆☆☆☆
Found in Text Mining only
Major Depressive Disorder Mental Depression GWASCAT_DG 31164008
★☆☆☆☆
Found in Text Mining only
melanoma Melanoma CTD_human_DG 22535842
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Ovarian Neoplasms Ovarian neoplasm Pubtator 33419459 Associate
★☆☆☆☆
Found in Text Mining only
Urolithiasis Urolithiasis BEFREE 30200873
★☆☆☆☆
Found in Text Mining only