Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2203
Gene name	Fructose-bisphosphatase 1
Gene symbol	FBP1
Synonyms (NCBI Gene)	FBP
Chromosome	9
Chromosome location	9q22.32
Summary	Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic

Show/Hide all (27)

SNP ID	Visualize variation	Clinical significance	Consequence
rs111437558	C>G,T	Pathogenic	Splice donor variant
rs121918188	C>T	Pathogenic	Coding sequence variant, missense variant
rs121918189	G>A,T	Pathogenic	Coding sequence variant, missense variant
rs121918190	C>A,T	Pathogenic	Coding sequence variant, missense variant, stop gained, intron variant
rs121918191	A>G	Pathogenic	Coding sequence variant, missense variant
rs121918192	G>C	Pathogenic	Coding sequence variant, missense variant
rs139264724	G>A,T	Likely-pathogenic	Coding sequence variant, synonymous variant, stop gained
rs140222720	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, missense variant
rs200679026	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs201508880	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs566453434	C>A,T	Pathogenic, likely-pathogenic	Missense variant, stop gained, coding sequence variant
rs757653154	->C	Pathogenic	Coding sequence variant, frameshift variant
rs758609113	C>T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs761470205	TTTT>-	Pathogenic, pathogenic-likely-pathogenic	Coding sequence variant, frameshift variant
rs765743651	A>T	Likely-pathogenic	Coding sequence variant, missense variant
rs766005419	G>A	Pathogenic	Coding sequence variant, missense variant
rs774362519	G>-,GG	Pathogenic	Coding sequence variant, frameshift variant
rs780803192	C>T	Pathogenic	Coding sequence variant, missense variant
rs1057517733	T>CC	Pathogenic	Coding sequence variant, frameshift variant
rs1060499726	CCCCATAAGG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1064795826	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1085308003	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554682769	->GTGCAG	Pathogenic	Coding sequence variant, inframe insertion, intron variant
rs1563983184	C>A	Likely-pathogenic	Splice donor variant
rs1563983269	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1563984164	CTTTTCTCCGGTTCCACTATGATGGCGTGTTTATCTTCTTCTGACACGAGAACACACGTGGCAAAGGATGACTTTAACATGTTCATAACCAGGTCGTTGGAGAGGACGTCCAGCTTCTTAACTTGATCACCTGTCACGTTGGTAGAACCAGCAATGCCATAGC>-	Likely-pathogenic	5 prime UTR variant, splice acceptor variant, coding sequence variant, initiator codon variant
rs1563991556	AGGTGCGCGATGCCCGCCTTGCGCACCGCCGAAGAGATGGCTTTGACTGCTGTGCAGAGCGAGTTGAGCAGCTGGGTCAACTCGCCCGTGCCGCGGGCCTTCCTGCCCTCCTCCATGACGAAGCGGGTCAGGGTGTTGACGTCCGTGTCGAAGGGCGCCTGGTCAGCCAT>-	Pathogenic	Frameshift variant, intron variant, initiator codon variant

Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT732692	hsa-miR-18a-5p	ImmunofluorescenceImmunohistochemistry (IHC)Luciferase reporter assayWestern blotting	33557774
MIRT732927	hsa-miR-21-3p	ImmunofluorescenceImmunohistochemistry (IHC)Luciferase reporter assayRNA-seq	34221869
MIRT732927	hsa-miR-21-3p	ImmunofluorescenceImmunohistochemistry (IHC)Luciferase reporter assayRNA-seq	34221869
MIRT990135	hsa-miR-1207-5p	CLIP-seq
MIRT990136	hsa-miR-1256	CLIP-seq
MIRT990137	hsa-miR-1321	CLIP-seq
MIRT990138	hsa-miR-139-5p	CLIP-seq
MIRT990139	hsa-miR-3120-3p	CLIP-seq
MIRT990140	hsa-miR-3140-3p	CLIP-seq
MIRT990141	hsa-miR-3162-5p	CLIP-seq
MIRT990142	hsa-miR-3165	CLIP-seq
MIRT990143	hsa-miR-3591-3p	CLIP-seq
MIRT990144	hsa-miR-3927	CLIP-seq
MIRT990145	hsa-miR-4310	CLIP-seq
MIRT990146	hsa-miR-4436b-3p	CLIP-seq
MIRT990147	hsa-miR-4451	CLIP-seq
MIRT990148	hsa-miR-4514	CLIP-seq
MIRT990149	hsa-miR-4692	CLIP-seq
MIRT990150	hsa-miR-4739	CLIP-seq
MIRT990151	hsa-miR-4756-5p	CLIP-seq
MIRT990152	hsa-miR-4763-3p	CLIP-seq
MIRT990153	hsa-miR-4802-5p	CLIP-seq
MIRT990154	hsa-miR-544	CLIP-seq
MIRT990155	hsa-miR-659	CLIP-seq
MIRT990156	hsa-miR-940	CLIP-seq
MIRT990157	hsa-miR-1179	CLIP-seq
MIRT990136	hsa-miR-1256	CLIP-seq
MIRT990137	hsa-miR-1321	CLIP-seq
MIRT990138	hsa-miR-139-5p	CLIP-seq
MIRT990139	hsa-miR-3120-3p	CLIP-seq
MIRT990141	hsa-miR-3162-5p	CLIP-seq
MIRT990142	hsa-miR-3165	CLIP-seq
MIRT990143	hsa-miR-3591-3p	CLIP-seq
MIRT990158	hsa-miR-371b-5p	CLIP-seq
MIRT990159	hsa-miR-4279	CLIP-seq
MIRT990145	hsa-miR-4310	CLIP-seq
MIRT990160	hsa-miR-4480	CLIP-seq
MIRT990161	hsa-miR-4691-5p	CLIP-seq
MIRT990162	hsa-miR-4698	CLIP-seq
MIRT990150	hsa-miR-4739	CLIP-seq
MIRT990151	hsa-miR-4756-5p	CLIP-seq
MIRT990153	hsa-miR-4802-5p	CLIP-seq
MIRT990155	hsa-miR-659	CLIP-seq
MIRT990163	hsa-miR-888	CLIP-seq
MIRT990136	hsa-miR-1256	CLIP-seq
MIRT990141	hsa-miR-3162-5p	CLIP-seq
MIRT990143	hsa-miR-3591-3p	CLIP-seq
MIRT990158	hsa-miR-371b-5p	CLIP-seq
MIRT990145	hsa-miR-4310	CLIP-seq
MIRT990162	hsa-miR-4698	CLIP-seq
MIRT990153	hsa-miR-4802-5p	CLIP-seq
MIRT990155	hsa-miR-659	CLIP-seq
MIRT990163	hsa-miR-888	CLIP-seq
MIRT990157	hsa-miR-1179	CLIP-seq
MIRT990135	hsa-miR-1207-5p	CLIP-seq
MIRT990138	hsa-miR-139-5p	CLIP-seq
MIRT990139	hsa-miR-3120-3p	CLIP-seq
MIRT990142	hsa-miR-3165	CLIP-seq
MIRT990145	hsa-miR-4310	CLIP-seq
MIRT990146	hsa-miR-4436b-3p	CLIP-seq
MIRT990148	hsa-miR-4514	CLIP-seq
MIRT990149	hsa-miR-4692	CLIP-seq
MIRT990152	hsa-miR-4763-3p	CLIP-seq
MIRT990156	hsa-miR-940	CLIP-seq

Show/Hide all (6)

Transcription factor	Regulation	Reference
NFKB1	Unknown	11023824
RELA	Unknown	11023824
SP1	Unknown	11023824
SP3	Unknown	11023824
USF1	Unknown	11023824
USF2	Unknown	11023824

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	25043030
GO:0003824	Function	Catalytic activity	IEA
GO:0005515	Function	Protein binding	IPI	8387495, 10222032, 16189514, 16275660, 25043030, 25416956, 25910212, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IMP	25043030
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	20096900
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006000	Process	Fructose metabolic process	IBA
GO:0006000	Process	Fructose metabolic process	TAS	7558035
GO:0006002	Process	Fructose 6-phosphate metabolic process	IBA
GO:0006002	Process	Fructose 6-phosphate metabolic process	IDA	8387495, 16442285
GO:0006002	Process	Fructose 6-phosphate metabolic process	IEA
GO:0006094	Process	Gluconeogenesis	IBA
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006094	Process	Gluconeogenesis	IMP	19259699, 20096900
GO:0006094	Process	Gluconeogenesis	ISS
GO:0006111	Process	Regulation of gluconeogenesis	IMP	7558035
GO:0016208	Function	AMP binding	IDA	8387495, 10222032, 18650089
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0030308	Process	Negative regulation of cell growth	IDA	19881551
GO:0030388	Process	Fructose 1,6-bisphosphate metabolic process	IBA
GO:0031667	Process	Response to nutrient levels	IEA
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0042132	Function	Fructose 1,6-bisphosphate 1-phosphatase activity	IBA
GO:0042132	Function	Fructose 1,6-bisphosphate 1-phosphatase activity	IDA	8387495, 16442285, 18650089
GO:0042132	Function	Fructose 1,6-bisphosphate 1-phosphatase activity	IEA
GO:0042132	Function	Fructose 1,6-bisphosphate 1-phosphatase activity	IMP	7558035, 19259699, 20096900
GO:0042578	Function	Phosphoric ester hydrolase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	16169070, 16189514, 16442285, 18650089, 21516116, 25416956, 25502805, 25910212, 31515488, 32296183
GO:0045820	Process	Negative regulation of glycolytic process	IDA	19881551
GO:0045820	Process	Negative regulation of glycolytic process	IMP	25043030
GO:0046580	Process	Negative regulation of Ras protein signal transduction	IDA	19881551
GO:0046872	Function	Metal ion binding	IEA
GO:0046872	Function	Metal ion binding	IMP	8387495
GO:0048029	Function	Monosaccharide binding	IEA
GO:0048029	Function	Monosaccharide binding	ISS
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IMP	25043030
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0071286	Process	Cellular response to magnesium ion	IDA	10222032
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0071466	Process	Cellular response to xenobiotic stimulus	IDA	16442285, 18650089
GO:0071475	Process	Cellular hyperosmotic salinity response	IEA
GO:0071477	Process	Cellular hypotonic salinity response	IEA
GO:0097403	Process	Cellular response to raffinose	IEA
GO:1904628	Process	Cellular response to phorbol 13-acetate 12-myristate	IEA

MIM	HGNC	e!Ensembl
611570	3606	ENSG00000165140

P09467

Protein name

Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase)

Protein function

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreati

PDB

1FTA , 2FHY , 2FIE , 2FIX , 2JJK , 2VT5 , 2WBB , 2WBD , 2Y5K , 2Y5L , 3A29 , 3KBZ , 3KC0 , 3KC1 , 4MJO , 5LDZ , 5PZQ , 5PZR , 5PZS , 5PZT , 5PZU , 5PZV , 5PZW , 5PZX , 5PZY , 5PZZ , 5Q00 , 5Q01 , 5Q02 , 5Q03 , 5Q04 , 5Q05 , 5Q06 , 5Q07 , 5Q08 , 5Q09 , 5Q0A , 5Q0B , 6LS5 , 6LW2 , 7C9Q , 7CVH , 7CVN , 7CWE , 7EZF , 7EZP , 7EZR , 7WJV , 7WVB , 8XBK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00316	FBPase	12 → 199	Fructose-1-6-bisphosphatase, N-terminal domain	Domain
PF18913	FBPase_C	203 → 333	Fructose-1-6-bisphosphatase, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in pancreatic islets. {ECO:0000269|PubMed:18375435}.

Sequence

MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ

Sequence length

338

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism Metabolic pathways Carbon metabolism AMPK signaling pathway Insulin signaling pathway Glucagon signaling pathway		Gluconeogenesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
FBP1-related disorder	Pathogenic; Likely pathogenic	rs1057517733, rs780803192	RCV003922670 RCV003918122	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Fructose-biphosphatase deficiency	Pathogenic; Likely pathogenic	rs1563983184, rs2131486442, rs2131509216, rs757653154, rs121918188, rs121918189, rs121918190, rs121918191, rs121918192, rs1460544928, rs780528686, rs758609113, rs2538947228, rs762007074, rs2538965763 View all (27 more)	RCV001783266 RCV001783267 RCV001994826 RCV000000915 RCV000000916 View all (40 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (19)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Abnormality of acid-base homeostasis	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLONIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEFICIENCY OF FRUCTOSE-BISPHOSPHATASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Impaired gluconeogenesis	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER FAILURE, ACUTE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
STOMACH NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (117)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acidosis Lactic	Lactic acidosis	Pubtator	26549536, 37507476, 38111981	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	BEFREE	27599538		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	37386009	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia Hemolytic	Hemolytic anemia	Pubtator	14766013	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Hemolytic	Anemia	BEFREE	14766013		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	28720574, 31497353		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthrogryposis	Arthrogryposis multiplex congenita	BEFREE	14766013		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	27599538		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	27780144, 28485159, 28529559, 28653874, 29463261		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28653874, 32626933, 32927665, 34092577	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	22039417, 36232688	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	19881551		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	22039417, 34221105, 35404841	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	25995247, 26901106, 27079415, 29566023, 32323822, 35653238	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	25844935, 29984231, 30033198		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	28720574	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	19087307, 30723389, 32737333, 33564363, 33723286, 33836688, 34596153	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	29113212, 30720119		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	28990097		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervix carcinoma	Cervix carcinoma	BEFREE	28990097		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	30193944, 31383847		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	37285922	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	22039417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	22039417		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colonic Neoplasms	Colonic Neoplasms	CTD_human_DG	22039417		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30171256		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	22039417	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	30193944		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	25043030, 30723389		★★★★★ ★☆☆☆☆ Found in Text Mining only
Deficiency, Hexosediphosphatase	Deficiency Of Hexosediphosphatase	CTD_human_DG	9382095		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	30035378		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	30035378		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	8530070		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	27599538		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ectopia Lentis with Ectopia of Pupil	Ectopia lentis	Pubtator	14766013	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	29113212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	33232284	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty liver	Pubtator	38034016	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Fructose-1,6-bisphosphatase deficiency	Fructose-1,6-Bisphosphatase Deficiency	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Fructose-1,6-Diphosphatase Deficiency	Fructose-1,6-Diphosphatase Deficiency	ORPHANET_DG	12126934, 24007283, 9382095		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fructose-1,6-Diphosphatase Deficiency	Fructose-1,6-Diphosphatase Deficiency	UNIPROT_DG	12126934, 25601412, 9382095		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fructose-1,6-Diphosphatase Deficiency	Fructose-1,6-Diphosphatase Deficiency	BEFREE	19259699, 27101822, 7558035		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fructose-1,6-Diphosphatase Deficiency	Fructose-1,6-Diphosphatase Deficiency	CLINVAR_DG	20096900, 23881342, 25601412, 27101822, 29016355, 29774539, 9382095		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fructose-1,6-Diphosphatase Deficiency	Fructose-1,6-Diphosphatase Deficiency	GENOMICS_ENGLAND_DG	7763253		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fructose-1,6-Diphosphatase Deficiency	Fructose-1,6-Diphosphatase Deficiency	CTD_human_DG	9382095		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31444412		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31444412		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	24347226		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glycogen Storage Disease	Glycogen Storage Disease	GENOMICS_ENGLAND_DG	27604308		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glycosuria Renal	Renal glycosuria	Pubtator	19087307	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis C	Hepatitis c	Pubtator	25995247	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis C Chronic	Hepatitis c	Pubtator	25995247	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	22039417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperbilirubinemia, Neonatal	Hyperbilirubinemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperuricemia	Hyperuricemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	BEFREE	29992913		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	Pubtator	38111981	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	Pubtator	30332478	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	32439898	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	34596153, 34637697, 36316355	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune system disease	Pubtator	37388727	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intermittent lactic acidemia	Intermittent lactic acidemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ketosis	Ketosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	37386009	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Language Development Disorders	Language development disorders	Pubtator	32020156	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	36232688	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	36232688	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	19637194, 22039417, 22318941, 25487856, 25995247, 27079415, 27197151, 27742690, 28262837, 28387640, 28394358, 29113212, 29566023, 30014490, 30429463, 31497345 View all (1 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	22039417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	Pubtator	22039417	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Failure, Acute	Liver failure	BEFREE	28336726		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Liver Neoplasms	Liver neoplasm	Pubtator	26901106	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	29566023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	29984231	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	37388727	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	27599538		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	27780144, 28485159, 28529559, 28653874, 29463261		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	22039417, 23338277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	25844935, 29984231, 30033198		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	30720119		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	29678579, 30201002, 31497353		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31448674		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	19881551, 27978536, 28848200		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	22039417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24347226, 25844935, 28262837, 28394358		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	28990097		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	22039417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	CTD_human_DG	22039417		★★★★★ ★☆☆☆☆ Found in Text Mining only
Maturity onset diabetes mellitus in young	Mason type diabetes	BEFREE	8530070		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	30003933		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neonatal hypoglycemia	Hypoglycemia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19637194, 22039417, 23620736, 25043030, 25487856, 25687883, 25995247, 27197151, 27599538, 27742690, 27780144, 27978536, 28262837, 28387640, 28394358 View all (10 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	19258502, 25844935, 29218237, 29984231		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	31651209		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	36316355	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	30720119		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	29678579, 30201002, 31497353		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	30201002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	34854226, 35477823	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	CTD_human_DG	18353766		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	BEFREE	20823226		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate carcinoma	Prostate cancer	BEFREE	31448674		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	21703393	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pseudohyperkalemia Cardiff	Pseudohyperkalemia Cardiff	BEFREE	25995247		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rett Syndrome	Rett Syndrome	BEFREE	12939425		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	18460190		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Schizophrenia	Schizophrenia	PSYGENET_DG	18460190		★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Squamous cell carcinoma	Carcinoma	BEFREE	28990097		★★★★★ ★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	19881551, 27978536, 28848200		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	22039417		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Neoplasms	Stomach neoplasms	Pubtator	22039417, 27978536, 28848200, 33407483	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	32626933, 36358906, 36880837	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	32073734	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

FBP1 (fructose-bisphosphatase 1)