LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing)

Gene

• Entrez ID: 220074
• Gene name: Leucine rich transmembrane and O-methyltransferase domain containing
• Gene symbol: LRTOMT
• Synonyms (NCBI Gene): CFAP111, DFNB63, LRRC51, LRRC51-TOMT, TOMT
• Chromosome: 11
• Chromosome location: 11q13.4
• Summary: This locus represents naturally occurring readthrough transcription between the neighboring LRRC51 (leucine-rich repeat containing 51) and TOMT (transmembrane O-methyltransferase) genes on chromosome 11. The readthrough transcript encodes a fusion protein

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT694485	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT694484	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT694483	hsa-miR-3974	HITS-CLIP	23313552
MIRT694482	hsa-miR-6502-3p	HITS-CLIP	23313552
MIRT694481	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT694480	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT694479	hsa-miR-4457	HITS-CLIP	23313552
MIRT694478	hsa-miR-125b-2-3p	HITS-CLIP	23313552
MIRT694477	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694476	hsa-miR-4459	HITS-CLIP	23313552
MIRT694475	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT694474	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT694473	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT694472	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT694471	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT694470	hsa-miR-8073	HITS-CLIP	23313552
MIRT694469	hsa-miR-4794	HITS-CLIP	23313552
MIRT694468	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT694467	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT694466	hsa-miR-1273f	HITS-CLIP	23313552
MIRT694465	hsa-miR-6134	HITS-CLIP	23313552
MIRT694464	hsa-miR-4534	HITS-CLIP	23313552
MIRT694463	hsa-miR-8082	HITS-CLIP	23313552
MIRT694462	hsa-miR-139-3p	HITS-CLIP	23313552
MIRT694461	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT694460	hsa-miR-6745	HITS-CLIP	23313552
MIRT694459	hsa-miR-6756-5p	HITS-CLIP	23313552
MIRT694458	hsa-miR-6766-5p	HITS-CLIP	23313552
MIRT694457	hsa-miR-1293	HITS-CLIP	23313552
MIRT694456	hsa-miR-4483	HITS-CLIP	23313552
MIRT694455	hsa-miR-3165	HITS-CLIP	23313552
MIRT694454	hsa-miR-6769a-5p	HITS-CLIP	23313552
MIRT694453	hsa-miR-6769b-5p	HITS-CLIP	23313552
MIRT694452	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT694451	hsa-miR-513b-5p	HITS-CLIP	23313552
MIRT694450	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT681433	hsa-miR-4537	HITS-CLIP	23706177
MIRT681432	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681431	hsa-miR-4252	HITS-CLIP	23706177
MIRT681430	hsa-miR-25-5p	HITS-CLIP	23706177
MIRT681429	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT681428	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT681433	hsa-miR-4537	HITS-CLIP	23706177
MIRT681432	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681431	hsa-miR-4252	HITS-CLIP	23706177
MIRT681430	hsa-miR-25-5p	HITS-CLIP	23706177
MIRT681429	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT681428	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT626332	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT626331	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT626329	hsa-miR-4267	HITS-CLIP	23824327
MIRT626328	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT626327	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT626326	hsa-miR-7155-5p	HITS-CLIP	23824327
MIRT626325	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT626324	hsa-miR-342-5p	HITS-CLIP	23824327
MIRT626323	hsa-miR-4664-5p	HITS-CLIP	23824327
MIRT626322	hsa-miR-4651	HITS-CLIP	23824327
MIRT626321	hsa-miR-608	HITS-CLIP	23824327
MIRT626320	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT626319	hsa-miR-7703	HITS-CLIP	23824327
MIRT626318	hsa-miR-6737-5p	HITS-CLIP	23824327
MIRT626317	hsa-miR-6812-5p	HITS-CLIP	23824327
MIRT626316	hsa-miR-6819-5p	HITS-CLIP	23824327
MIRT694485	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT694484	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT694483	hsa-miR-3974	HITS-CLIP	23313552
MIRT694482	hsa-miR-6502-3p	HITS-CLIP	23313552
MIRT694481	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT694480	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT694479	hsa-miR-4457	HITS-CLIP	23313552
MIRT694478	hsa-miR-125b-2-3p	HITS-CLIP	23313552
MIRT694477	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694476	hsa-miR-4459	HITS-CLIP	23313552
MIRT694475	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT694474	hsa-miR-4793-5p	HITS-CLIP	23313552
MIRT694473	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT694472	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT694471	hsa-miR-221-5p	HITS-CLIP	23313552
MIRT694470	hsa-miR-8073	HITS-CLIP	23313552
MIRT694469	hsa-miR-4794	HITS-CLIP	23313552
MIRT694468	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT694467	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT694466	hsa-miR-1273f	HITS-CLIP	23313552
MIRT694465	hsa-miR-6134	HITS-CLIP	23313552
MIRT694464	hsa-miR-4534	HITS-CLIP	23313552
MIRT694463	hsa-miR-8082	HITS-CLIP	23313552
MIRT694462	hsa-miR-139-3p	HITS-CLIP	23313552
MIRT694461	hsa-miR-363-5p	HITS-CLIP	23313552
MIRT694460	hsa-miR-6745	HITS-CLIP	23313552
MIRT694459	hsa-miR-6756-5p	HITS-CLIP	23313552
MIRT694458	hsa-miR-6766-5p	HITS-CLIP	23313552
MIRT694457	hsa-miR-1293	HITS-CLIP	23313552
MIRT694456	hsa-miR-4483	HITS-CLIP	23313552
MIRT694455	hsa-miR-3165	HITS-CLIP	23313552
MIRT694454	hsa-miR-6769a-5p	HITS-CLIP	23313552
MIRT694453	hsa-miR-6769b-5p	HITS-CLIP	23313552
MIRT694452	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT694451	hsa-miR-513b-5p	HITS-CLIP	23313552
MIRT694450	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT681433	hsa-miR-4537	HITS-CLIP	23706177
MIRT681432	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681431	hsa-miR-4252	HITS-CLIP	23706177
MIRT681430	hsa-miR-25-5p	HITS-CLIP	23706177
MIRT681429	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT681428	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT681433	hsa-miR-4537	HITS-CLIP	23706177
MIRT681432	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681431	hsa-miR-4252	HITS-CLIP	23706177
MIRT681430	hsa-miR-25-5p	HITS-CLIP	23706177
MIRT681429	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT681428	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT626332	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT626331	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT626330	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT626329	hsa-miR-4267	HITS-CLIP	23824327
MIRT626328	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT626327	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT626326	hsa-miR-7155-5p	HITS-CLIP	23824327
MIRT626325	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT626324	hsa-miR-342-5p	HITS-CLIP	23824327
MIRT626323	hsa-miR-4664-5p	HITS-CLIP	23824327
MIRT626322	hsa-miR-4651	HITS-CLIP	23824327
MIRT626321	hsa-miR-608	HITS-CLIP	23824327
MIRT626320	hsa-miR-6747-5p	HITS-CLIP	23824327
MIRT626319	hsa-miR-7703	HITS-CLIP	23824327
MIRT626318	hsa-miR-6737-5p	HITS-CLIP	23824327
MIRT626317	hsa-miR-6812-5p	HITS-CLIP	23824327
MIRT626316	hsa-miR-6819-5p	HITS-CLIP	23824327
MIRT1121206	hsa-miR-3163	CLIP-seq
MIRT1121207	hsa-miR-1253	CLIP-seq
MIRT1121208	hsa-miR-1587	CLIP-seq
MIRT1121209	hsa-miR-3151	CLIP-seq
MIRT1121210	hsa-miR-3157-3p	CLIP-seq
MIRT1121211	hsa-miR-3661	CLIP-seq
MIRT1121212	hsa-miR-3676	CLIP-seq
MIRT1121213	hsa-miR-3938	CLIP-seq
MIRT1121214	hsa-miR-4437	CLIP-seq
MIRT1121215	hsa-miR-4674	CLIP-seq
MIRT1121216	hsa-miR-4699-5p	CLIP-seq
MIRT1121217	hsa-miR-4732-3p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT1121219	hsa-miR-541	CLIP-seq
MIRT1121220	hsa-miR-631	CLIP-seq
MIRT1121221	hsa-miR-635	CLIP-seq
MIRT1121222	hsa-miR-654-5p	CLIP-seq
MIRT1121223	hsa-miR-890	CLIP-seq
MIRT1121224	hsa-miR-1207-5p	CLIP-seq
MIRT1121225	hsa-miR-1227	CLIP-seq
MIRT1121226	hsa-miR-1827	CLIP-seq
MIRT1121227	hsa-miR-216b	CLIP-seq
MIRT1121228	hsa-miR-3192	CLIP-seq
MIRT1121229	hsa-miR-3202	CLIP-seq
MIRT1121230	hsa-miR-3622a-3p	CLIP-seq
MIRT1121231	hsa-miR-3622b-3p	CLIP-seq
MIRT1121232	hsa-miR-3672	CLIP-seq
MIRT1121233	hsa-miR-3689a-3p	CLIP-seq
MIRT1121234	hsa-miR-3689c	CLIP-seq
MIRT1121235	hsa-miR-3926	CLIP-seq
MIRT1121236	hsa-miR-3929	CLIP-seq
MIRT1121237	hsa-miR-4419b	CLIP-seq
MIRT1121238	hsa-miR-4433	CLIP-seq
MIRT1121239	hsa-miR-4478	CLIP-seq
MIRT1121240	hsa-miR-4504	CLIP-seq
MIRT1121241	hsa-miR-4533	CLIP-seq
MIRT1121242	hsa-miR-4635	CLIP-seq
MIRT1121243	hsa-miR-4649-3p	CLIP-seq
MIRT1121244	hsa-miR-4662a-5p	CLIP-seq
MIRT1121245	hsa-miR-4676-5p	CLIP-seq
MIRT1121246	hsa-miR-4722-5p	CLIP-seq
MIRT1121247	hsa-miR-4728-5p	CLIP-seq
MIRT1121248	hsa-miR-4736	CLIP-seq
MIRT1121249	hsa-miR-4763-3p	CLIP-seq
MIRT1121250	hsa-miR-4797-5p	CLIP-seq
MIRT1121251	hsa-miR-485-5p	CLIP-seq
MIRT1121252	hsa-miR-490-3p	CLIP-seq
MIRT1121219	hsa-miR-541	CLIP-seq
MIRT1121253	hsa-miR-542-3p	CLIP-seq
MIRT1121254	hsa-miR-544b	CLIP-seq
MIRT1121255	hsa-miR-548s	CLIP-seq
MIRT1121256	hsa-miR-566	CLIP-seq
MIRT1121257	hsa-miR-575	CLIP-seq
MIRT1121258	hsa-miR-593	CLIP-seq
MIRT1121259	hsa-miR-619	CLIP-seq
MIRT1121222	hsa-miR-654-5p	CLIP-seq
MIRT1121260	hsa-miR-759	CLIP-seq
MIRT1121261	hsa-miR-766	CLIP-seq
MIRT1121262	hsa-miR-769-5p	CLIP-seq
MIRT1121263	hsa-miR-940	CLIP-seq
MIRT1550952	hsa-miR-1275	CLIP-seq
MIRT1550953	hsa-miR-3675-3p	CLIP-seq
MIRT1121235	hsa-miR-3926	CLIP-seq
MIRT1550954	hsa-miR-4271	CLIP-seq
MIRT1550955	hsa-miR-4525	CLIP-seq
MIRT1550956	hsa-miR-4665-5p	CLIP-seq
MIRT1550957	hsa-miR-4723-5p	CLIP-seq
MIRT1550958	hsa-miR-4725-3p	CLIP-seq
MIRT1121255	hsa-miR-548s	CLIP-seq
MIRT1550959	hsa-miR-625	CLIP-seq
MIRT1550960	hsa-miR-637	CLIP-seq
MIRT1550961	hsa-miR-671-5p	CLIP-seq
MIRT1121243	hsa-miR-4649-3p	CLIP-seq
MIRT2034282	hsa-miR-4656	CLIP-seq
MIRT2034283	hsa-miR-550a	CLIP-seq
MIRT2264772	hsa-miR-4254	CLIP-seq
MIRT2264773	hsa-miR-4640-5p	CLIP-seq
MIRT2264774	hsa-miR-4726-5p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT2390373	hsa-miR-1825	CLIP-seq
MIRT2390374	hsa-miR-4326	CLIP-seq
MIRT2390375	hsa-miR-515-3p	CLIP-seq
MIRT2390376	hsa-miR-519e	CLIP-seq
MIRT2034283	hsa-miR-550a	CLIP-seq
MIRT2453438	hsa-miR-106a	CLIP-seq
MIRT2453439	hsa-miR-106b	CLIP-seq
MIRT2453440	hsa-miR-1202	CLIP-seq
MIRT2453441	hsa-miR-1343	CLIP-seq
MIRT2453442	hsa-miR-17	CLIP-seq
MIRT2453443	hsa-miR-1915	CLIP-seq
MIRT2453444	hsa-miR-1972	CLIP-seq
MIRT2453445	hsa-miR-203	CLIP-seq
MIRT2453446	hsa-miR-20a	CLIP-seq
MIRT2453447	hsa-miR-20b	CLIP-seq
MIRT2453448	hsa-miR-2355-5p	CLIP-seq
MIRT2453449	hsa-miR-2861	CLIP-seq
MIRT2453450	hsa-miR-3130-3p	CLIP-seq
MIRT2453451	hsa-miR-3145-5p	CLIP-seq
MIRT2453452	hsa-miR-3189-3p	CLIP-seq
MIRT2453453	hsa-miR-328	CLIP-seq
MIRT2453454	hsa-miR-3663-5p	CLIP-seq
MIRT2453455	hsa-miR-3667-3p	CLIP-seq
MIRT2453456	hsa-miR-371b-3p	CLIP-seq
MIRT2453457	hsa-miR-3918	CLIP-seq
MIRT2453458	hsa-miR-3972	CLIP-seq
MIRT2453459	hsa-miR-4325	CLIP-seq
MIRT2453460	hsa-miR-4435	CLIP-seq
MIRT2453461	hsa-miR-4512	CLIP-seq
MIRT2453462	hsa-miR-4529-5p	CLIP-seq
MIRT2453463	hsa-miR-4685-5p	CLIP-seq
MIRT2453464	hsa-miR-4712-5p	CLIP-seq
MIRT2453465	hsa-miR-4726-3p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT2453466	hsa-miR-4753-3p	CLIP-seq
MIRT2453467	hsa-miR-4755-3p	CLIP-seq
MIRT2453468	hsa-miR-4777-3p	CLIP-seq
MIRT2453469	hsa-miR-4780	CLIP-seq
MIRT2453470	hsa-miR-519d	CLIP-seq
MIRT2453471	hsa-miR-548u	CLIP-seq
MIRT2453472	hsa-miR-601	CLIP-seq
MIRT2453473	hsa-miR-605	CLIP-seq
MIRT2453474	hsa-miR-622	CLIP-seq
MIRT1121221	hsa-miR-635	CLIP-seq
MIRT2453475	hsa-miR-770-5p	CLIP-seq
MIRT2453476	hsa-miR-9	CLIP-seq
MIRT2453477	hsa-miR-93	CLIP-seq
MIRT2453478	hsa-miR-938	CLIP-seq
MIRT2453438	hsa-miR-106a	CLIP-seq
MIRT2453439	hsa-miR-106b	CLIP-seq
MIRT2453440	hsa-miR-1202	CLIP-seq
MIRT2453441	hsa-miR-1343	CLIP-seq
MIRT2453442	hsa-miR-17	CLIP-seq
MIRT2453443	hsa-miR-1915	CLIP-seq
MIRT2453444	hsa-miR-1972	CLIP-seq
MIRT2453445	hsa-miR-203	CLIP-seq
MIRT2453446	hsa-miR-20a	CLIP-seq
MIRT2453447	hsa-miR-20b	CLIP-seq
MIRT2453448	hsa-miR-2355-5p	CLIP-seq
MIRT2453450	hsa-miR-3130-3p	CLIP-seq
MIRT2453451	hsa-miR-3145-5p	CLIP-seq
MIRT2453452	hsa-miR-3189-3p	CLIP-seq
MIRT2453453	hsa-miR-328	CLIP-seq
MIRT2453454	hsa-miR-3663-5p	CLIP-seq
MIRT2453455	hsa-miR-3667-3p	CLIP-seq
MIRT2453456	hsa-miR-371b-3p	CLIP-seq
MIRT2453457	hsa-miR-3918	CLIP-seq
MIRT2453458	hsa-miR-3972	CLIP-seq
MIRT2453459	hsa-miR-4325	CLIP-seq
MIRT2453460	hsa-miR-4435	CLIP-seq
MIRT2453462	hsa-miR-4529-5p	CLIP-seq
MIRT2453463	hsa-miR-4685-5p	CLIP-seq
MIRT2453464	hsa-miR-4712-5p	CLIP-seq
MIRT2453465	hsa-miR-4726-3p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT2453466	hsa-miR-4753-3p	CLIP-seq
MIRT2453467	hsa-miR-4755-3p	CLIP-seq
MIRT2453468	hsa-miR-4777-3p	CLIP-seq
MIRT2453469	hsa-miR-4780	CLIP-seq
MIRT2453470	hsa-miR-519d	CLIP-seq
MIRT2453471	hsa-miR-548u	CLIP-seq
MIRT2453472	hsa-miR-601	CLIP-seq
MIRT2453473	hsa-miR-605	CLIP-seq
MIRT2453474	hsa-miR-622	CLIP-seq
MIRT1121221	hsa-miR-635	CLIP-seq
MIRT2453475	hsa-miR-770-5p	CLIP-seq
MIRT2453476	hsa-miR-9	CLIP-seq
MIRT2453477	hsa-miR-93	CLIP-seq
MIRT2453478	hsa-miR-938	CLIP-seq
MIRT2453438	hsa-miR-106a	CLIP-seq
MIRT2453439	hsa-miR-106b	CLIP-seq
MIRT2453440	hsa-miR-1202	CLIP-seq
MIRT2453441	hsa-miR-1343	CLIP-seq
MIRT2453442	hsa-miR-17	CLIP-seq
MIRT2453443	hsa-miR-1915	CLIP-seq
MIRT2453444	hsa-miR-1972	CLIP-seq
MIRT2453445	hsa-miR-203	CLIP-seq
MIRT2453446	hsa-miR-20a	CLIP-seq
MIRT2453447	hsa-miR-20b	CLIP-seq
MIRT2453448	hsa-miR-2355-5p	CLIP-seq
MIRT2453450	hsa-miR-3130-3p	CLIP-seq
MIRT2453451	hsa-miR-3145-5p	CLIP-seq
MIRT2453452	hsa-miR-3189-3p	CLIP-seq
MIRT2453453	hsa-miR-328	CLIP-seq
MIRT2453454	hsa-miR-3663-5p	CLIP-seq
MIRT2453455	hsa-miR-3667-3p	CLIP-seq
MIRT2453456	hsa-miR-371b-3p	CLIP-seq
MIRT2453457	hsa-miR-3918	CLIP-seq
MIRT2453458	hsa-miR-3972	CLIP-seq
MIRT2453459	hsa-miR-4325	CLIP-seq
MIRT2453460	hsa-miR-4435	CLIP-seq
MIRT2453462	hsa-miR-4529-5p	CLIP-seq
MIRT2453463	hsa-miR-4685-5p	CLIP-seq
MIRT2453464	hsa-miR-4712-5p	CLIP-seq
MIRT2453465	hsa-miR-4726-3p	CLIP-seq
MIRT1121218	hsa-miR-4749-3p	CLIP-seq
MIRT2453466	hsa-miR-4753-3p	CLIP-seq
MIRT2453467	hsa-miR-4755-3p	CLIP-seq
MIRT2453468	hsa-miR-4777-3p	CLIP-seq
MIRT2453469	hsa-miR-4780	CLIP-seq
MIRT2453470	hsa-miR-519d	CLIP-seq
MIRT2453471	hsa-miR-548u	CLIP-seq
MIRT2453472	hsa-miR-601	CLIP-seq
MIRT2453473	hsa-miR-605	CLIP-seq
MIRT2453474	hsa-miR-622	CLIP-seq
MIRT1121221	hsa-miR-635	CLIP-seq
MIRT2453475	hsa-miR-770-5p	CLIP-seq
MIRT2453476	hsa-miR-9	CLIP-seq
MIRT2453477	hsa-miR-93	CLIP-seq
MIRT2453478	hsa-miR-938	CLIP-seq

Other IDs

• MIM: 612414
• HGNC: 25033
• e!Ensembl: ENSG00000284922

Protein

• UniProt ID: Q8WZ04
• Protein name: Transmembrane O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) (Protein LRTOMT2)
• Protein function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01596	Methyltransf_3	96 → 252	O-methyltransferase	Domain

• Sequence:

  MGTPWRKRKGIAGPGLPDLSCALVLQPRAQVGTMSPAIALAFLPLVVTLLVRYRHYFRLL
  VRTVLLRSLRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSRCEYLSHMGPVKG
  QILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAG
  FDEHMVELIVGSSEDVIPCLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATV
  LADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG

• Sequence length: 291

Pathways

KEGG:

Steroid hormone biosynthesis
Tyrosine metabolism
Metabolic pathways
Dopaminergic synapse

Reactome:

Enzymatic degradation of dopamine by COMT

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Autosomal recessive nonsyndromic hearing loss 63	Pathogenic; Likely pathogenic	rs137853185, rs137853186, rs137853187, rs137853188, rs1391956558, rs545947177, rs780468292, rs797044907, rs1565331646, rs1298804148	RCV000000573 RCV000000574 RCV000000575 RCV000000576 RCV002283829 RCV000156590 RCV002471368 RCV001449954 RCV000770827 RCV000779080	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Rare genetic deafness	Pathogenic; Likely pathogenic	rs137853185, rs545947177	RCV000603810 RCV000211724	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOSOMAL RECESSIVE ISOLATED SENSORINEURAL DEAFNESS TYPE DFNB	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 63	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hearing impairment	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Hearing loss, autosomal recessive	Uncertain significance; Conflicting classifications of pathogenicity; Likely benign; Benign	ClinVar GWAS catalog	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
LRTOMT-related disorder	Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS OF BILATERAL EARS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autosomal recessive non-syndromic sensorineural deafness type DFNB	Non-Syndromic Sensorineural Deafness	Orphanet			★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	14504192		★☆☆☆☆ Found in Text Mining only
Congenital sensorineural hearing loss	Congenital Sensorineural Hearing Loss	HPO_DG			★☆☆☆☆ Found in Text Mining only
Deafness	Deafness	Pubtator	34514748	Associate	★☆☆☆☆ Found in Text Mining only
Deafness Autosomal Recessive	Deafness	Pubtator	24926664	Associate	★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL RECESSIVE 63	Deafness	CLINGEN_DG	18794526, 18953341, 21739586, 23053991		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 63	Deafness	UNIPROT_DG	18794526, 18953341, 28281779		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 63	Deafness	GENOMICS_ENGLAND_DG	18794526, 18953341		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 63	Deafness	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 63	Deafness	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hearing Loss	Hearing loss	Pubtator	28281779, 36928321	Associate	★☆☆☆☆ Found in Text Mining only
Hearing Loss Sensorineural	Hearing loss	Pubtator	31835641	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	14504192		★☆☆☆☆ Found in Text Mining only
Nonsyndromic Deafness	Nonsyndromic Deafness	BEFREE	17066295, 18794526, 18953341, 23053991		★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	GENOMICS_ENGLAND_DG	18794526		★☆☆☆☆ Found in Text Mining only