Gene Gene information from NCBI Gene database.
Entrez ID 219771
Gene name Cyclin Y
Gene symbol CCNY
Synonyms (NCBI Gene)
C10orf9CBCP1CCNXCFP1
Chromosome 10
Chromosome location 10p11.21
Summary Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]
miRNA miRNA information provided by mirtarbase database.
400
miRTarBase ID miRNA Experiments Reference
MIRT024653 hsa-miR-215-5p Microarray 19074876
MIRT026358 hsa-miR-192-5p Microarray 19074876
MIRT032307 hsa-let-7b-5p Proteomics 18668040
MIRT041426 hsa-miR-193b-3p CLASH 23622248
MIRT038847 hsa-miR-93-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 20059949
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IEA
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IPI 19524571
GO:0000308 Component Cytoplasmic cyclin-dependent protein kinase holoenzyme complex IBA
GO:0000308 Component Cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA 19524571, 20059949
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612786 23354 ENSG00000108100
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8ND76
Protein name Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X)
Protein function Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6,
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00134 Cyclin_N 143 265 Cyclin, N-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:18060517}.
Sequence
MGNTTSCCVSSSPKLRRNAHSRLESYRPDTDLSREDTGCNLQHISDRENIDDLNMEFNPS
DHPRASTIFLSKSQTDVREKRKSLFINHHPPGQIARKYSSCSTIFLDDSTVSQPNLKYTI
KCVALAIYYHIKNRDPDGRMLLDIFDENLHPLSKSEVPPDYDKHNPEQKQIYRFVRTLFS
AAQLTAECAIVTLVYLERLLTYAEIDICPANWKRIVLGAILLASKVWDDQAVWNVDYCQI
LKDITVEDMNELERQFLELLQFNIN
VPSSVYAKYYFDLRSLAEANNLSFPLEPLSRERAH
KLEAISRLCEDKYKDLRRSARKRSASADNLTLPRWSPAIIS
Sequence length 341
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC LEFT-SIDED ULCERATIVE COLITIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLITIS, ULCERATIVE CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN DISEASE CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 21273179
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Clear Cell Adenocarcinoma BEFREE 29633253
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 20596919, 21273179, 24167380, 30774378
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 29633253 Associate
★☆☆☆☆
Found in Text Mining only
Colitis Ulcerative Ulcerative colitis Pubtator 21830272 Associate
★☆☆☆☆
Found in Text Mining only
Colonic Diseases Colonic disease Pubtator 21830272 Associate
★☆☆☆☆
Found in Text Mining only
Crohn Disease Crohn Disease LHGDN 18438405
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Crohn Disease Crohn Disease CTD_human_DG 18438405
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Crohn Disease Crohn Disease GWASDB_DG 18587394
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Crohn Disease Crohn Disease BEFREE 20176734, 21830272
★★☆☆☆
Found in Text Mining + Unknown/Other Associations