TMEM26 (transmembrane protein 26)

Gene

• Entrez ID: 219623
• Gene name: Transmembrane protein 26
• Gene symbol: TMEM26
• Synonyms (NCBI Gene): -
• Chromosome: 10
• Chromosome location: 10q21.2
• Summary: This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1436189	hsa-let-7a	CLIP-seq
MIRT1436190	hsa-let-7b	CLIP-seq
MIRT1436191	hsa-let-7c	CLIP-seq
MIRT1436192	hsa-let-7d	CLIP-seq
MIRT1436193	hsa-let-7e	CLIP-seq
MIRT1436194	hsa-let-7f	CLIP-seq
MIRT1436195	hsa-let-7g	CLIP-seq
MIRT1436196	hsa-let-7i	CLIP-seq
MIRT1436197	hsa-miR-1275	CLIP-seq
MIRT1436198	hsa-miR-128	CLIP-seq
MIRT1436199	hsa-miR-1293	CLIP-seq
MIRT1436200	hsa-miR-1294	CLIP-seq
MIRT1436201	hsa-miR-202	CLIP-seq
MIRT1436202	hsa-miR-299-5p	CLIP-seq
MIRT1436203	hsa-miR-29a	CLIP-seq
MIRT1436204	hsa-miR-29b	CLIP-seq
MIRT1436205	hsa-miR-29c	CLIP-seq
MIRT1436206	hsa-miR-3065-3p	CLIP-seq
MIRT1436207	hsa-miR-3147	CLIP-seq
MIRT1436208	hsa-miR-3156-5p	CLIP-seq
MIRT1436209	hsa-miR-3160-3p	CLIP-seq
MIRT1436210	hsa-miR-3187-3p	CLIP-seq
MIRT1436211	hsa-miR-3658	CLIP-seq
MIRT1436212	hsa-miR-3671	CLIP-seq
MIRT1436213	hsa-miR-3909	CLIP-seq
MIRT1436214	hsa-miR-3921	CLIP-seq
MIRT1436215	hsa-miR-4251	CLIP-seq
MIRT1436216	hsa-miR-4275	CLIP-seq
MIRT1436217	hsa-miR-4329	CLIP-seq
MIRT1436218	hsa-miR-4424	CLIP-seq
MIRT1436219	hsa-miR-4425	CLIP-seq
MIRT1436220	hsa-miR-4435	CLIP-seq
MIRT1436221	hsa-miR-4446-3p	CLIP-seq
MIRT1436222	hsa-miR-4458	CLIP-seq
MIRT1436223	hsa-miR-4483	CLIP-seq
MIRT1436224	hsa-miR-4500	CLIP-seq
MIRT1436225	hsa-miR-4529-5p	CLIP-seq
MIRT1436226	hsa-miR-4633-3p	CLIP-seq
MIRT1436227	hsa-miR-4653-5p	CLIP-seq
MIRT1436228	hsa-miR-4659a-3p	CLIP-seq
MIRT1436229	hsa-miR-4659b-3p	CLIP-seq
MIRT1436230	hsa-miR-4665-5p	CLIP-seq
MIRT1436231	hsa-miR-4675	CLIP-seq
MIRT1436232	hsa-miR-4687-3p	CLIP-seq
MIRT1436233	hsa-miR-4690-3p	CLIP-seq
MIRT1436234	hsa-miR-4693-3p	CLIP-seq
MIRT1436235	hsa-miR-4701-5p	CLIP-seq
MIRT1436236	hsa-miR-4705	CLIP-seq
MIRT1436237	hsa-miR-4723-5p	CLIP-seq
MIRT1436238	hsa-miR-4728-5p	CLIP-seq
MIRT1436239	hsa-miR-4741	CLIP-seq
MIRT1436240	hsa-miR-4775	CLIP-seq
MIRT1436241	hsa-miR-4781-3p	CLIP-seq
MIRT1436242	hsa-miR-548s	CLIP-seq
MIRT1436243	hsa-miR-588	CLIP-seq
MIRT1436244	hsa-miR-590-3p	CLIP-seq
MIRT1436245	hsa-miR-892a	CLIP-seq
MIRT1436246	hsa-miR-98	CLIP-seq
MIRT2130724	hsa-miR-1264	CLIP-seq
MIRT2130725	hsa-miR-1343	CLIP-seq
MIRT2130726	hsa-miR-155	CLIP-seq
MIRT2130727	hsa-miR-3074-5p	CLIP-seq
MIRT2130728	hsa-miR-330-3p	CLIP-seq
MIRT2130729	hsa-miR-3646	CLIP-seq
MIRT2130730	hsa-miR-4426	CLIP-seq
MIRT2130731	hsa-miR-4493	CLIP-seq
MIRT2130732	hsa-miR-4646-5p	CLIP-seq
MIRT2130733	hsa-miR-4647	CLIP-seq
MIRT2130734	hsa-miR-4662b	CLIP-seq
MIRT2130735	hsa-miR-4716-5p	CLIP-seq
MIRT2130736	hsa-miR-4747-5p	CLIP-seq
MIRT2130737	hsa-miR-4766-5p	CLIP-seq
MIRT2130738	hsa-miR-592	CLIP-seq
MIRT2130739	hsa-miR-597	CLIP-seq
MIRT2130740	hsa-miR-616	CLIP-seq
MIRT2130741	hsa-miR-661	CLIP-seq
MIRT2130725	hsa-miR-1343	CLIP-seq
MIRT2352064	hsa-miR-182	CLIP-seq
MIRT2130727	hsa-miR-3074-5p	CLIP-seq
MIRT1436212	hsa-miR-3671	CLIP-seq
MIRT2352065	hsa-miR-4272	CLIP-seq
MIRT2352066	hsa-miR-4420	CLIP-seq
MIRT1436203	hsa-miR-29a	CLIP-seq
MIRT1436204	hsa-miR-29b	CLIP-seq
MIRT1436205	hsa-miR-29c	CLIP-seq
MIRT1436206	hsa-miR-3065-3p	CLIP-seq
MIRT1436212	hsa-miR-3671	CLIP-seq
MIRT1436212	hsa-miR-3671	CLIP-seq
MIRT1436228	hsa-miR-4659a-3p	CLIP-seq
MIRT1436229	hsa-miR-4659b-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 617803
• HGNC: 28550
• e!Ensembl: ENSG00000196932

Protein

• UniProt ID: Q6ZUK4
• Protein name: Transmembrane protein 26
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09772	Tmem26	3 → 303	Transmembrane protein 26	Family

• Sequence:

  MEGLVFLNALATRLLFLLHSLVGVWRVTEVKKEPRYWLLALLNLLLFLETALTLKFKRGR
  GYKWFSPAIFLYLISIVPSLWLLELHHETQYCSIQAEGTSQNTSRKEDFNQTLTSNEQTS
  RADDLIETAKVFVNNLSTVCEKVWTLGLHQTFLLMLIIGRWLLPIGGGITRDQLSQLLLM
  FVGTAADILEFTSETLEEQNVRNSPALVYAILVIWTWSMLQFPLDLAVQNVVCPVSVTER
  GFPSLFFCQYSADLWNIGISVFIQDGPFLVVRLILMTYFKVINQMLVFFAAKNFLVVVLQ
  LYRLVVLALAVRASLRSQSEGLKGEHGCRAQTSESGPSQRDWQNESKEGLAIPLRGSPVT
  SDDSHHTP

• Sequence length: 368

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HODGKINS LYMPHOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	GWASCAT_DG	25918132		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Carcinoma	Breast Carcinoma	BEFREE	27224909		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	27224909	Associate	★☆☆☆☆ Found in Text Mining only
Endocrine System Diseases	Endocrine system disease	Pubtator	27224909	Inhibit	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	27224909		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27224909		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	29803631		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	22986903	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	22529986	Associate	★☆☆☆☆ Found in Text Mining only