Gene Gene information from NCBI Gene database.
Entrez ID 2169
Gene name Fatty acid binding protein 2
Gene symbol FABP2
Synonyms (NCBI Gene)
FABPII-FABP
Chromosome 4
Chromosome location 4q26
Summary The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and p
miRNA miRNA information provided by mirtarbase database.
137
miRTarBase ID miRNA Experiments Reference
MIRT540734 hsa-miR-3667-5p PAR-CLIP 21572407
MIRT540733 hsa-miR-451b PAR-CLIP 21572407
MIRT540732 hsa-miR-3675-3p PAR-CLIP 21572407
MIRT540731 hsa-miR-520f-5p PAR-CLIP 21572407
MIRT540730 hsa-miR-4696 PAR-CLIP 21572407
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
GATA4 Activation 17290010;22539995
HNF4A Activation 17343826
PIAS1 Activation 22539995
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0005324 Function Long-chain fatty acid transmembrane transporter activity IEA
GO:0005504 Function Fatty acid binding IEA
GO:0005504 Function Fatty acid binding TAS 2824476
GO:0005515 Function Protein binding IPI 21044950, 25416956, 25910212
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
134640 3556 ENSG00000145384
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P12104
Protein name Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)
Protein function FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affini
PDB 1KZW , 1KZX , 2MJI , 2MO5 , 3AKM , 3IFB , 6L7K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 4 132 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum. {ECO:0000269|PubMed:14563446}.
Sequence
Sequence length 132
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  PPAR signaling pathway
Fat digestion and absorption
  Triglyceride catabolism
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
12
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CAROTID STENOSIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute pancreatitis Pancreatitis BEFREE 29771764
★☆☆☆☆
Found in Text Mining only
Anemia Anemia BEFREE 30947347
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 27778448
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 11487582, 11707533 Associate
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 11707533, 27778448
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular Diseases BEFREE 10946885, 15527447, 17907115, 24340071
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular Diseases LHGDN 17907115
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular disease Pubtator 17907115 Associate
★☆☆☆☆
Found in Text Mining only
Carotid Atherosclerosis Carotid Atherosclerosis BEFREE 16013194, 17212611
★☆☆☆☆
Found in Text Mining only
Carotid Stenosis Carotid artery stenosis BEFREE 17212611
★★☆☆☆
Found in Text Mining + Unknown/Other Associations