FABP4 (fatty acid binding protein 4)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 2167
Gene name Fatty acid binding protein 4
Gene symbol FABP4
Synonyms (NCBI Gene)
A-FABPAFABPALBPHEL-S-104aP2
Chromosome 8
Chromosome location 8q21.13
Summary FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles inc
miRNA miRNA information provided by mirtarbase database.
6
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (6)
miRTarBase ID miRNA Experiments Reference
MIRT005490 hsa-miR-138-5p qRT-PCR 20486779
MIRT005959 hsa-miR-369-5p Luciferase reporter assay 21660946
MIRT019040 hsa-miR-335-5p Microarray 18185580
MIRT005959 hsa-miR-369-5p Reporter assay 21660946
MIRT736118 hsa-miR-455-3p Luciferase reporter assayWestern blottingqRT-PCR 31638263
Transcription factors Transcription factors information provided by TRRUST V2 database.
5
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
ASXL1 Unknown 21047783
FOXO1 Activation 20102700
PPARA Unknown 19717768
PPARG Activation 11574398
PPARG Unknown 17322100;21047783
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005324 Function Long-chain fatty acid transmembrane transporter activity IEA
GO:0005324 Function Long-chain fatty acid transmembrane transporter activity ISS
GO:0005504 Function Fatty acid binding IBA
GO:0005504 Function Fatty acid binding TAS 2481498
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600434 3559 ENSG00000170323
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P15090
Protein name Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)
Protein function Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
PDB 1TOU , 1TOW , 2HNX , 2NNQ , 3FR2 , 3FR4 , 3FR5 , 3P6C , 3P6D , 3P6E , 3P6F , 3P6G , 3P6H , 3Q6L , 3RZY , 4NNS , 4NNT , 5D45 , 5D47 , 5D48 , 5D4A , 5EDB , 5EDC , 5HZ6 , 5HZ8 , 5Y0F , 5Y0G , 5Y0X , 5Y12 , 5Y13 , 6AYL , 6LJS , 6LJT , 6LJU , 6LJV , 6LJW , 6LJX , 7FVU , 7FVV , 7FVW , 7FVX , 7FVY , 7FVZ , 7FW0 , 7FW1 , 7FW2 , 7FW3 , 7FW4 , 7FW5 , 7FW6 , 7FW7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 6 → 132 Lipocalin / cytosolic fatty-acid binding protein family Domain
Sequence
Sequence length 132
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  PPAR signaling pathway
Regulation of lipolysis in adipocytes 		  Triglyceride catabolism
Transcriptional regulation of white adipocyte differentiation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (5)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONTACT DERMATITIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DERMATITIS, CONTACT — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
KIDNEY DISEASES — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (232)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome BEFREE 26069234
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 27885273, 28108519
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 26657874
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 29285217
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 22476608
★★★★★
★☆☆☆☆
Found in Text Mining only
Anaplastic carcinoma Anaplastic Carcinoma CTD_human_DG 16316942
★★★★★
★☆☆☆☆
Found in Text Mining only
Angina Stable Angina pectoris Pubtator 31234795 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 26657874
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm, Abdominal Aortic Aneurysm BEFREE 31821481
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Valve Stenosis Aortic valve stenosis Pubtator 35955575 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only