Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2155
Gene name	Coagulation factor VII
Gene symbol	F7
Synonyms (NCBI Gene)	SPCA
Chromosome	13
Chromosome location	13q34
Summary	This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by

Show/Hide all (33)

SNP ID	Visualize variation	Clinical significance	Consequence
rs6046	G>A,C,T	Risk-factor, benign	Coding sequence variant, non coding transcript variant, missense variant
rs36209567	C>T	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs45572939	T>A	Likely-pathogenic	Missense variant, non coding transcript variant, genic upstream transcript variant, intron variant, coding sequence variant
rs121964926	G>A	Other, pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs121964927	G>A,T	Likely-pathogenic, pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs121964931	C>T	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs121964934	T>C,G	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs121964936	T>G	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs200016360	A>G	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant, intron variant
rs267606790	C>G,T	Pathogenic	Stop gained, coding sequence variant, non coding transcript variant, missense variant
rs375134790	G>A	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant, intron variant
rs387906507	T>A,C	Pathogenic	Genic upstream transcript variant, coding sequence variant, non coding transcript variant, missense variant
rs387906508	T>C	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs531225271	C>A,T	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs539578931	A>C,G	Likely-pathogenic	Non coding transcript variant, synonymous variant, 5 prime UTR variant, missense variant, coding sequence variant, genic upstream transcript variant
rs746625213	G>A	Likely-pathogenic	Intron variant
rs750457207	C>-	Likely-pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs750980786	C>G,T	Likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant
rs754785708	GGGT>-	Likely-pathogenic	Coding sequence variant, non coding transcript variant, intron variant, splice donor variant
rs755377592	G>A	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs757743255	CTCAGCGAGCACGAC>-	Likely-pathogenic	Coding sequence variant, non coding transcript variant, inframe deletion
rs769452933	G>T	Likely-pathogenic	Splice donor variant
rs769455161	G>A	Likely-pathogenic	Genic upstream transcript variant, intron variant
rs779589651	C>T	Pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs786205091	GCGGGTGGCGCAGGTCA>-	Pathogenic	Coding sequence variant, frameshift variant, non coding transcript variant
rs1056071555	G>A	Likely-pathogenic	Genic upstream transcript variant, splice donor variant, upstream transcript variant
rs1160146175	C>A	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs1250204261	A>G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1250853566	G>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant
rs1367115848	T>G	Likely-pathogenic	5 prime UTR variant, genic upstream transcript variant, upstream transcript variant
rs1418012389	C>A,T	Likely-pathogenic	Genic upstream transcript variant, upstream transcript variant, 5 prime UTR variant
rs1595080617	C>T	Likely-pathogenic	Non coding transcript variant, stop gained, coding sequence variant
rs1595080725	T>C	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant

Show/Hide all (49)

miRTarBase ID	miRNA	Experiments	Reference
MIRT735390	hsa-miR-409-3p	qRT-PCR	32246041
MIRT974637	hsa-miR-1208	CLIP-seq
MIRT974638	hsa-miR-3647-3p	CLIP-seq
MIRT974639	hsa-miR-4276	CLIP-seq
MIRT974640	hsa-miR-4447	CLIP-seq
MIRT974641	hsa-miR-4472	CLIP-seq
MIRT974642	hsa-miR-4481	CLIP-seq
MIRT974643	hsa-miR-4488	CLIP-seq
MIRT974644	hsa-miR-452	CLIP-seq
MIRT974645	hsa-miR-4676-3p	CLIP-seq
MIRT974646	hsa-miR-4677-3p	CLIP-seq
MIRT974647	hsa-miR-4682	CLIP-seq
MIRT974648	hsa-miR-4697-5p	CLIP-seq
MIRT974649	hsa-miR-4745-5p	CLIP-seq
MIRT974650	hsa-miR-4755-3p	CLIP-seq
MIRT974651	hsa-miR-4758-5p	CLIP-seq
MIRT974652	hsa-miR-579	CLIP-seq
MIRT974653	hsa-miR-653	CLIP-seq
MIRT974654	hsa-miR-1224-3p	CLIP-seq
MIRT974655	hsa-miR-1322	CLIP-seq
MIRT974656	hsa-miR-3120-5p	CLIP-seq
MIRT974657	hsa-miR-3200-3p	CLIP-seq
MIRT974658	hsa-miR-371b-3p	CLIP-seq
MIRT974639	hsa-miR-4276	CLIP-seq
MIRT974659	hsa-miR-4313	CLIP-seq
MIRT974646	hsa-miR-4677-3p	CLIP-seq
MIRT974652	hsa-miR-579	CLIP-seq
MIRT974660	hsa-miR-593	CLIP-seq
MIRT974653	hsa-miR-653	CLIP-seq
MIRT1988786	hsa-miR-324-5p	CLIP-seq
MIRT2223169	hsa-miR-1343	CLIP-seq
MIRT2223170	hsa-miR-3192	CLIP-seq
MIRT2223171	hsa-miR-371-5p	CLIP-seq
MIRT2223172	hsa-miR-4300	CLIP-seq
MIRT2223173	hsa-miR-4469	CLIP-seq
MIRT2223174	hsa-miR-4530	CLIP-seq
MIRT2223175	hsa-miR-4633-3p	CLIP-seq
MIRT2223176	hsa-miR-548v	CLIP-seq
MIRT2223177	hsa-miR-920	CLIP-seq
MIRT2223178	hsa-miR-922	CLIP-seq
MIRT974654	hsa-miR-1224-3p	CLIP-seq
MIRT2449053	hsa-miR-1470	CLIP-seq
MIRT974656	hsa-miR-3120-5p	CLIP-seq
MIRT2449054	hsa-miR-4286	CLIP-seq
MIRT2449055	hsa-miR-4287	CLIP-seq
MIRT2223173	hsa-miR-4469	CLIP-seq
MIRT2449056	hsa-miR-4667-3p	CLIP-seq
MIRT2449057	hsa-miR-4685-3p	CLIP-seq
MIRT974660	hsa-miR-593	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
ATF4	Unknown	22848420
SP1	Unknown	9716591

Show/Hide all (59)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEA
GO:0002690	Process	Positive regulation of leukocyte chemotaxis	IDA	17991872
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	IDA	24998411
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	TAS	3037537
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	3455766, 8598903, 8940045, 9414278, 15522303, 15664864, 25241761
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS	3037537
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005796	Component	Golgi lumen	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006950	Process	Response to stress	IEA
GO:0007596	Process	Blood coagulation	IBA
GO:0007596	Process	Blood coagulation	IDA	8632006, 24998411
GO:0007596	Process	Blood coagulation	IEA
GO:0007596	Process	Blood coagulation	IEA
GO:0007596	Process	Blood coagulation	TAS	3037537
GO:0007599	Process	Hemostasis	IEA
GO:0007623	Process	Circadian rhythm	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	TAS	3037537
GO:0009725	Process	Response to hormone	IEA
GO:0010037	Process	Response to carbon dioxide	IEA
GO:0010641	Process	Positive regulation of platelet-derived growth factor receptor signaling pathway	IDA	17991872
GO:0016485	Process	Protein processing	IBA
GO:0016485	Process	Protein processing	IDA	24998411
GO:0016787	Function	Hydrolase activity	IEA
GO:0030194	Process	Positive regulation of blood coagulation	IEA
GO:0030335	Process	Positive regulation of cell migration	TAS	18612547
GO:0031012	Component	Extracellular matrix	HDA	25037231
GO:0031100	Process	Animal organ regeneration	IEA
GO:0031667	Process	Response to nutrient levels	IEA
GO:0031982	Component	Vesicle	IEA
GO:0032008	Process	Positive regulation of TOR signaling	IDA	18612547
GO:0032008	Process	Positive regulation of TOR signaling	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032571	Process	Response to vitamin K	IEA
GO:0033595	Process	Response to genistein	IEA
GO:0043627	Process	Response to estrogen	IEA
GO:0050878	Process	Regulation of body fluid levels	IEA
GO:0050927	Process	Positive regulation of positive chemotaxis	IDA	17991872
GO:0060416	Process	Response to growth hormone	IEA
GO:0070723	Process	Response to cholesterol	IEA
GO:0097066	Process	Response to thyroid hormone	IEA
GO:0097068	Process	Response to thyroxine	IEA
GO:1904400	Process	Response to Thyroid stimulating hormone	IEA
GO:1904612	Process	Response to 2,3,7,8-tetrachlorodibenzodioxine	IEA
GO:1905217	Process	Response to astaxanthin	IEA
GO:1905225	Process	Response to thyrotropin-releasing hormone	IEA
GO:1905286	Component	Serine-type peptidase complex	IPI	24998411

MIM	HGNC	e!Ensembl
613878	3544	ENSG00000057593

P08709

Protein name

Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]

Protein function

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence

PDB

1BF9 , 1CVW , 1DAN , 1DVA , 1F7E , 1F7M , 1FAK , 1FF7 , 1FFM , 1J9C , 1JBU , 1KLI , 1KLJ , 1O5D , 1QFK , 1W0Y , 1W2K , 1W7X , 1W8B , 1WQV , 1WSS , 1WTG , 1WUN , 1WV7 , 1YGC , 1Z6J , 2A2Q , 2AEI , 2AER , 2B7D , 2B8O , 2BZ6 , 2C4F , 2EC9 , 2F9B , 2FIR , 2FLB , 2FLR , 2PUQ , 2ZP0 , 2ZWL , 2ZZU , 3ELA , 3TH2 , 3TH3 , 3TH4 , 4IBL , 4ISH , 4ISI , 4JYU , 4JYV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00594	Gla	65 → 105	Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain	Domain
PF00008	EGF	110 → 140	EGF-like domain	Domain
PF00089	Trypsin	213 → 447	Trypsin	Domain

Tissue specificity

TISSUE SPECIFICITY: Plasma.

Sequence

MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP

Sequence length

466

Interactions

View interactions

	KEGG		Reactome
	Complement and coagulation cascades		Extrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Abnormal bleeding	Likely pathogenic; Pathogenic	rs36209567, rs1595080725, rs750457207	RCV000851974 RCV000851999 RCV000851695	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Abnormality of coagulation	Likely pathogenic	rs750980786, rs1595080725	RCV000851653 RCV000852000	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Congenital factor VII deficiency	Likely pathogenic; Pathogenic	rs121964929, rs563972504, rs756151764, rs1293477494, rs190485816, rs2142232799, rs2142229154, rs376384665, rs201991361, rs764741909, rs372577568, rs1566906827, rs2142232898, rs2503057230, rs1414353514 View all (21 more)	RCV003479334 RCV002222725 RCV003147659 RCV003147660 RCV001801311 View all (32 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
F7-related disorder	Likely pathogenic; Pathogenic	rs121964929, rs756151764, rs36209567, rs137919286, rs745374448, rs1186901138, rs755377592, rs121964926, rs531225271, rs200016360, rs121964931, rs750457207, rs1460304955	RCV004753349 RCV004753389 RCV004752703 RCV003417106 RCV003896514 View all (8 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII deficiency	Likely pathogenic; Pathogenic	rs2142212748, rs146795869, rs2142229513, rs2142234775, rs121964929, rs121964927, rs121964928, rs121964930, rs121964932, rs1056071555, rs387906507, rs36209567, rs786205091, rs1263426144, rs121964933 View all (21 more)	RCV001420375 RCV001420377 RCV001420379 RCV001420380 RCV001843373 View all (32 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Padua	Likely pathogenic; Pathogenic	rs121964926	RCV001843424	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Myocardial infarction, susceptibility to	Likely pathogenic; Pathogenic	rs201991361, rs764741909, rs372577568, rs1566906827, rs121964927, rs36209567, rs121964934, rs779658565, rs755377592, rs121964926, rs531225271, rs200016360, rs121964931, rs750457207, rs1056071555	RCV005002805 RCV005002807 RCV005002808 RCV005008491 RCV005008224 View all (10 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (26)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CEREBRAL HEMORRHAGE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CEREBRAL INFARCTION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, INSULIN-DEPENDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DISSEMINATED INTRAVASCULAR COAGULATION	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMATOMA, SUBDURAL, ACUTE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMATURIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hemophilia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHAGE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHAGIC DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTRACRANIAL HEMORRHAGE, TRAUMATIC	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTRACRANIAL HEMORRHAGES	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER FAILURE, ACUTE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial infarction, decreased susceptibility to	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thrombocytopenia	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
THROMBOEMBOLISM	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOSIS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (102)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Coronary Syndrome	Coronary Syndrome	BEFREE	10947911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Angina Unstable	Angina pectoris	Pubtator	10583928	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	LHGDN	11776298, 15173027		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	LHGDN	18608122		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	30178850		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood Coagulation Disorders	LHGDN	16596941		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood coagulation disorder	Pubtator	1904059, 19904262, 21902896, 22848420, 24178511, 31185295, 37761907, 7513203, 8204879, 8940045	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood Coagulation Disorders	BEFREE	28034354, 28350321		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders	Blood coagulation disorder	Pubtator	35271862, 36920782	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Blood Coagulation Disorders Inherited	Blood coagulation disorder	Pubtator	34342048, 36572978	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19996301, 25447311		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25447311, 36920782	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28618103	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Calcinosis	Calcinosis	Pubtator	28618103	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36154076	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	19904262	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	10102465, 15081566, 29112333, 9409226		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	17903294, 26516624, 26694100, 29112333	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carotid Artery Thrombosis	Carotid artery thrombosis	Pubtator	10803689	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Hemorrhage	Cerebral hemorrhage	Pubtator	17488662	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cerebral Infarction	Cerebral Infarction	LHGDN	12859287		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cerebral Infarction	Cerebral Infarction	BEFREE	14733777		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cerebral Infarction	Ischemic stroke	Pubtator	21114618, 30642921	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cerebral Infarction	Ischemic stroke	Pubtator	33834859	Inhibit	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cerebrovascular accident	Stroke	LHGDN	18608122		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	31424491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Disease	Chronic disease	Pubtator	9716591	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	23494077		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	22166631, 23494077, 30462558		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital factor VII deficiency	Congenital Factor VII Deficiency	Orphanet			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	10803689, 10984565, 12091048, 15081566, 15711754, 17581323, 21838885, 22932775		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	BEFREE	10803689, 10984565, 12091048, 15081566, 15711754, 17581323, 21838885, 22932775, 7604805		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	10803689, 10984565, 11079652, 21477332, 30642921	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Disease	Coronary artery disease	Pubtator	14521602, 19336475, 19415820, 20735728	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	10803689, 10984565, 12091048, 15081566, 15711754, 17581323, 21838885, 22932775		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary heart disease	Coronary Heart Disease	LHGDN	16331575		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Crigler Najjar syndrome, type 1	Crigler-Najjar syndrome	BEFREE	19364077		★★★★★ ★☆☆☆☆ Found in Text Mining only
Deep Vein Thrombosis	Thrombosis	CTD_human_DG	14967414		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder	Major depressive disorder	Pubtator	34488523	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	26694100	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Disseminated Intravascular Coagulation	Disseminated Intravascular Coagulation	CTD_human_DG	16159073		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dyslipidemias	Dyslipidemias	Pubtator	35552711	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Factor VII Deficiency	Factor VII Deficiency	GENOMICS_ENGLAND_DG	10862079		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Deficiency	Factor VII Deficiency	UNIPROT_DG	10862079, 11091194, 11129332, 12472587, 14717781, 1634227, 18976247, 19432927, 19751712, 2070047, 21206266, 21372693, 26761581, 7974346, 7981691 View all (11 more)		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Deficiency	Factor VII Deficiency	CLINVAR_DG	10862079, 11931672, 12903033, 12935978, 15142120, 15456489, 15735798, 18282149, 18976247, 20040857, 2070047, 20958793, 21902896, 22180436, 25582404 View all (7 more)		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Deficiency	Factor VII Deficiency	CLINGEN_DG	10959697, 11091194, 11529858, 22628013, 23141848, 26702064, 3286010, 8652821, 9384381		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Deficiency	Factor vii deficiency	Pubtator	11091194, 11110717, 11830508, 15456489, 15667541, 21902896, 26852649, 27513915, 31273093, 31482689, 31577732, 33038747, 33587484, 35973191, 36123027 View all (6 more)	Associate	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Deficiency	Factor VII Deficiency	LHGDN	12903033, 15456489		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Deficiency	Factor vii deficiency	Pubtator	15667541, 27513915, 36123027, 7919338, 7949091, 8204879	Inhibit	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Deficiency	Factor VII Deficiency	CTD_human_DG	20885134		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Deficiency	Factor VII Deficiency	BEFREE	28350321, 8244334		★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor VII Deficiency	Factor VII Deficiency	ORPHANET_DG			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Factor XI Deficiency	Factor xi deficiency	Pubtator	23617568	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Frasier Syndrome	Fraser syndrome	Pubtator	37055848	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	20462964	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematoma	Hematoma	Pubtator	34857025	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemophilia A	Hemophilia	BEFREE	28589615, 28921441		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemophilia, NOS	Hemophilia	BEFREE	28589615		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemorrhage	Hemorrhage	Pubtator	11830508, 26852649, 27513915, 34857025, 35973191, 9716591	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hemorrhagic Disorders	Hemorrhagic Disorders	CTD_human_DG	16706976		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hemorrhagic Disorders	Hemorrhagic disease	Pubtator	8978290	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatoblastoma	Hepatoblastoma	BEFREE	10233895		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperlipoproteinemia Type II	Hyperlipoproteinemia	Pubtator	21477332	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	LHGDN	15452029		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertrophy Left Ventricular	Left ventricular disease	Pubtator	25329069	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	39969330	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intracranial Embolism	Intracranial embolism	Pubtator	37055848	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intracranial Hemorrhages	Intracranial hemorrhage	Pubtator	11342420, 26852649	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intracranial Hemorrhages	Intracranial hemorrhage	Pubtator	31577732	Inhibit	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ischemic stroke	Ischemic Stroke	BEFREE	20453637		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30197794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19996301, 25447311		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	23494077		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	18031796, 18612547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	25447311		★★★★★ ★☆☆☆☆ Found in Text Mining only
MASA SYNDROME (disorder)	MASA syndrome	BEFREE	30831127		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	19364077		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	10691850, 10984565, 11079652, 14521602, 15170085, 22964781, 23274712, 27635400, 9222962, 9420338	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	BEFREE	10706929, 10878696, 11578716, 11776135, 12935410, 15081566, 7749878, 9420338		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	LHGDN	11858502, 15170085, 16116695, 17008590		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	CTD_human_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Ischemia	Myocardial ischemia	Pubtator	10583928	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nasal Polyps	Nasal polyp	Pubtator	35271862	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23494077		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	26694100	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ornithine carbamoyltransferase deficiency	Ornithine Carbamoyltransferase Deficiency	BEFREE	19364077		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Cysts	Ovarian Cysts	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	19904262, 22402494	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Vascular Diseases	Vascular Diseases	LHGDN	17938795		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	27434295	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	21624643	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	21114618	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thromboembolism	Thromboembolism	Pubtator	25447311	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thrombophilia	Thrombophilia	Pubtator	37055848	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombosis	Thrombosis	Pubtator	11038326, 11079652, 16305054, 19904262, 27504943, 35264566	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombosis of cerebral veins	Thrombosis	BEFREE	22136731		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	1904059	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular Diseases	BEFREE	9420338		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular disease	Pubtator	9420338	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Venous Thromboembolism	Venous thromboembolism	Pubtator	17663738, 20031567, 30642921, 35552711	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Venous Thrombosis	Venous thrombosis	Pubtator	25891834	Inhibit	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Venous Thrombosis	Venous thrombosis	Pubtator	32160777	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

F7 (coagulation factor VII)