Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	2086
Gene name	Endogenous retrovirus group 3 member 1, envelope
Gene symbol	ERV3-1
Synonyms (NCBI Gene)	ERV-RERV3ERVRHERV-RHERVRenvR
Chromosome	7
Chromosome location	7q11.21
Summary	This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This

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miRTarBase ID	miRNA	Experiments
MIRT970049	hsa-miR-1207-5p	CLIP-seq
MIRT970050	hsa-miR-1225-3p	CLIP-seq
MIRT970051	hsa-miR-1233	CLIP-seq
MIRT970052	hsa-miR-1296	CLIP-seq
MIRT970053	hsa-miR-146a	CLIP-seq
MIRT970054	hsa-miR-146b-5p	CLIP-seq
MIRT970055	hsa-miR-1909	CLIP-seq
MIRT970056	hsa-miR-193a-3p	CLIP-seq
MIRT970057	hsa-miR-193b	CLIP-seq
MIRT970058	hsa-miR-200b	CLIP-seq
MIRT970059	hsa-miR-200c	CLIP-seq
MIRT970060	hsa-miR-2909	CLIP-seq
MIRT970061	hsa-miR-3125	CLIP-seq
MIRT970062	hsa-miR-3136-3p	CLIP-seq
MIRT970063	hsa-miR-3143	CLIP-seq
MIRT970064	hsa-miR-3158-3p	CLIP-seq
MIRT970065	hsa-miR-3161	CLIP-seq
MIRT970066	hsa-miR-3173-3p	CLIP-seq
MIRT970067	hsa-miR-335	CLIP-seq
MIRT970068	hsa-miR-3682-5p	CLIP-seq
MIRT970069	hsa-miR-374c	CLIP-seq
MIRT970070	hsa-miR-3916	CLIP-seq
MIRT970071	hsa-miR-3929	CLIP-seq
MIRT970072	hsa-miR-4252	CLIP-seq
MIRT970073	hsa-miR-429	CLIP-seq
MIRT970074	hsa-miR-4419b	CLIP-seq
MIRT970075	hsa-miR-4428	CLIP-seq
MIRT970076	hsa-miR-4478	CLIP-seq
MIRT970077	hsa-miR-4512	CLIP-seq
MIRT970078	hsa-miR-4536	CLIP-seq
MIRT970079	hsa-miR-4663	CLIP-seq
MIRT970080	hsa-miR-4699-3p	CLIP-seq
MIRT970081	hsa-miR-4729	CLIP-seq
MIRT970082	hsa-miR-4736	CLIP-seq
MIRT970083	hsa-miR-4763-3p	CLIP-seq
MIRT970084	hsa-miR-562	CLIP-seq
MIRT970085	hsa-miR-655	CLIP-seq
MIRT2221916	hsa-miR-103b	CLIP-seq
MIRT970050	hsa-miR-1225-3p	CLIP-seq
MIRT970051	hsa-miR-1233	CLIP-seq
MIRT2221917	hsa-miR-1254	CLIP-seq
MIRT2221918	hsa-miR-1286	CLIP-seq
MIRT2221919	hsa-miR-214	CLIP-seq
MIRT2221920	hsa-miR-298	CLIP-seq
MIRT2221921	hsa-miR-3116	CLIP-seq
MIRT970063	hsa-miR-3143	CLIP-seq
MIRT2221922	hsa-miR-3176	CLIP-seq
MIRT2221923	hsa-miR-338-3p	CLIP-seq
MIRT2221924	hsa-miR-3619-5p	CLIP-seq
MIRT2221925	hsa-miR-3678-3p	CLIP-seq
MIRT2221926	hsa-miR-3922-3p	CLIP-seq
MIRT970071	hsa-miR-3929	CLIP-seq
MIRT970074	hsa-miR-4419b	CLIP-seq
MIRT2221927	hsa-miR-4422	CLIP-seq
MIRT970076	hsa-miR-4478	CLIP-seq
MIRT2221928	hsa-miR-4530	CLIP-seq
MIRT970079	hsa-miR-4663	CLIP-seq
MIRT2221929	hsa-miR-487a	CLIP-seq
MIRT2221930	hsa-miR-499a-5p	CLIP-seq
MIRT2221931	hsa-miR-661	CLIP-seq
MIRT2221932	hsa-miR-761	CLIP-seq
MIRT2221933	hsa-miR-766	CLIP-seq
MIRT2387538	hsa-miR-186	CLIP-seq
MIRT2387539	hsa-miR-2278	CLIP-seq
MIRT2387540	hsa-miR-4468	CLIP-seq
MIRT970050	hsa-miR-1225-3p	CLIP-seq
MIRT970051	hsa-miR-1233	CLIP-seq
MIRT2525585	hsa-miR-1298	CLIP-seq
MIRT970053	hsa-miR-146a	CLIP-seq
MIRT970054	hsa-miR-146b-5p	CLIP-seq
MIRT2525586	hsa-miR-204	CLIP-seq
MIRT2525587	hsa-miR-211	CLIP-seq
MIRT2525588	hsa-miR-3074-5p	CLIP-seq
MIRT970062	hsa-miR-3136-3p	CLIP-seq
MIRT2525589	hsa-miR-3140-3p	CLIP-seq
MIRT970063	hsa-miR-3143	CLIP-seq
MIRT970064	hsa-miR-3158-3p	CLIP-seq
MIRT970065	hsa-miR-3161	CLIP-seq
MIRT970066	hsa-miR-3173-3p	CLIP-seq
MIRT2221925	hsa-miR-3678-3p	CLIP-seq
MIRT2525590	hsa-miR-3679-3p	CLIP-seq
MIRT2525591	hsa-miR-3690	CLIP-seq
MIRT2525592	hsa-miR-370	CLIP-seq
MIRT970071	hsa-miR-3929	CLIP-seq
MIRT2525593	hsa-miR-3977	CLIP-seq
MIRT2525594	hsa-miR-4254	CLIP-seq
MIRT2525595	hsa-miR-4268	CLIP-seq
MIRT970074	hsa-miR-4419b	CLIP-seq
MIRT970075	hsa-miR-4428	CLIP-seq
MIRT2525596	hsa-miR-4446-5p	CLIP-seq
MIRT2525597	hsa-miR-4448	CLIP-seq
MIRT2525598	hsa-miR-4463	CLIP-seq
MIRT970076	hsa-miR-4478	CLIP-seq
MIRT2525599	hsa-miR-4494	CLIP-seq
MIRT970079	hsa-miR-4663	CLIP-seq
MIRT2525600	hsa-miR-4711-5p	CLIP-seq
MIRT2525601	hsa-miR-4755-5p	CLIP-seq
MIRT2525602	hsa-miR-4789-5p	CLIP-seq
MIRT2525603	hsa-miR-483-3p	CLIP-seq
MIRT2221930	hsa-miR-499a-5p	CLIP-seq
MIRT2525604	hsa-miR-623	CLIP-seq
MIRT2525605	hsa-miR-873	CLIP-seq
MIRT970049	hsa-miR-1207-5p	CLIP-seq
MIRT970050	hsa-miR-1225-3p	CLIP-seq
MIRT970051	hsa-miR-1233	CLIP-seq
MIRT2525585	hsa-miR-1298	CLIP-seq
MIRT970053	hsa-miR-146a	CLIP-seq
MIRT970054	hsa-miR-146b-5p	CLIP-seq
MIRT970055	hsa-miR-1909	CLIP-seq
MIRT2525586	hsa-miR-204	CLIP-seq
MIRT2525587	hsa-miR-211	CLIP-seq
MIRT2221920	hsa-miR-298	CLIP-seq
MIRT2525588	hsa-miR-3074-5p	CLIP-seq
MIRT970062	hsa-miR-3136-3p	CLIP-seq
MIRT2525589	hsa-miR-3140-3p	CLIP-seq
MIRT970063	hsa-miR-3143	CLIP-seq
MIRT970064	hsa-miR-3158-3p	CLIP-seq
MIRT970065	hsa-miR-3161	CLIP-seq
MIRT970066	hsa-miR-3173-3p	CLIP-seq
MIRT2221925	hsa-miR-3678-3p	CLIP-seq
MIRT2525590	hsa-miR-3679-3p	CLIP-seq
MIRT2525591	hsa-miR-3690	CLIP-seq
MIRT2525592	hsa-miR-370	CLIP-seq
MIRT970071	hsa-miR-3929	CLIP-seq
MIRT2525593	hsa-miR-3977	CLIP-seq
MIRT2525594	hsa-miR-4254	CLIP-seq
MIRT2525595	hsa-miR-4268	CLIP-seq
MIRT2680296	hsa-miR-4269	CLIP-seq
MIRT970074	hsa-miR-4419b	CLIP-seq
MIRT970075	hsa-miR-4428	CLIP-seq
MIRT2525596	hsa-miR-4446-5p	CLIP-seq
MIRT2525597	hsa-miR-4448	CLIP-seq
MIRT2525598	hsa-miR-4463	CLIP-seq
MIRT970076	hsa-miR-4478	CLIP-seq
MIRT2525599	hsa-miR-4494	CLIP-seq
MIRT2680297	hsa-miR-4514	CLIP-seq
MIRT970079	hsa-miR-4663	CLIP-seq
MIRT2680298	hsa-miR-4688	CLIP-seq
MIRT2680299	hsa-miR-4692	CLIP-seq
MIRT2525600	hsa-miR-4711-5p	CLIP-seq
MIRT2680300	hsa-miR-4737	CLIP-seq
MIRT2680301	hsa-miR-4742-5p	CLIP-seq
MIRT2525601	hsa-miR-4755-5p	CLIP-seq
MIRT970083	hsa-miR-4763-3p	CLIP-seq
MIRT2525602	hsa-miR-4789-5p	CLIP-seq
MIRT2221930	hsa-miR-499a-5p	CLIP-seq
MIRT2680302	hsa-miR-520d-5p	CLIP-seq
MIRT2680303	hsa-miR-524-5p	CLIP-seq
MIRT2680304	hsa-miR-561	CLIP-seq
MIRT2525604	hsa-miR-623	CLIP-seq
MIRT2525605	hsa-miR-873	CLIP-seq
MIRT2680305	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0008150	Process	Biological_process	ND

MIM	HGNC	e!Ensembl
131170	3454	ENSG00000213462

Q14264

Protein name

Endogenous retrovirus group 3 member 1 Env polyprotein (ERV-3 envelope protein) (ERV3 envelope protein) (ERV3-1 envelope protein) (Envelope polyprotein) (HERV-R envelope protein) (ERV-R envelope protein) (HERV-R_7q21.2 provirus ancestral Env polyprotein)

Protein function

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has los

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed at higher level in adrenal, sebaceous glands and placenta. Expressed at lower level in bone marrow, brain, breast, colon, heart, kidney, liver, lung, ovary, PBL, prostate, skin, spleen, testis, thymus, thyroid, trachea. {ECO:

Sequence

MLGMNMLLITLFLLLPLSMLKGEPWEGCLHCTHTTWSGNIMTKTLLYHTYYECAGTCLGT
CTHNQTTYSVCDPGRGQPYVCYDPKSSPGTWFEIHVGSKEGDLLNQTKVFPSGKDVVSLY
FDVCQIVSMGSLFPVIFSSMEYYSSCHKNRYAHPACSTDSPVTTCWDCTTWSTNQQSLGP
IMLTKIPLEPDCKTSTCNSVNLTILEPDQPIWTTGLKAPLGARVSGEEIGPGAYVYLYII
KKTRTRSTQQFRVFESFYEHVNQKLPEPPPLASNLFAQLAENIASSLHVASCYVCGGMNM
GDQWPWEARELMPQDNFTLTASSLEPAPSSQSIWFLKTSIIGKFCIARWGKAFTDPVGEL
TCLGQQYYNETLGKTLWRGKSNNSESPHPSPFSRFPSLNHSWYQLEAPNTWQAPSGLYWI
CGPQAYRQLPAKWSGACVLGTIRPSFFLMPLKQGEALGYPIYDETKRKSKRGITIGDWKD
NEWPPERIIQYYGPATWAEDGMWGYRTPVYMLNRIIRLQAVLEIITNETAGALNLLAQQA
TKMRNVIYQNRLALDYLLAQEEGVCGKFNLTNCCLELDDEGKVIKEITAKIQKLAHIPVQ
TWKG

Sequence length

604

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (22)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenoma	Adenoma	BEFREE	9732235	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	9732235	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	7882554	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	11410490	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	17013901	★★★★★ ★☆☆☆☆ Found in Text Mining only
Choriocarcinoma	Choriocarcinoma	BEFREE	10692254, 2115127, 3346101, 3356751, 8592062, 8707424	★★★★★ ★☆☆☆☆ Found in Text Mining only
Complete atrioventricular block	Complete Atrioventricular Block	BEFREE	9099920	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermoid Cyst	Dermoid Cyst	BEFREE	8592062	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	23085571	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gestational trophoblastic disease	Hydatidiform mole	BEFREE	26992684	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gestational Trophoblastic Neoplasms	Gestational Trophoblastic Neoplasms	BEFREE	26992684	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydatidiform Mole	Hydatidiform Mole	BEFREE	26992684	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	9099920	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	11410490	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	17013901	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29379485	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitral Valve Stenosis	Mitral Valve Stenosis	BEFREE	9345457	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	8871766, 9345457	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	3356751, 9419968	★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	17013901	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	BEFREE	9732235	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	7882554	★★★★★ ★☆☆☆☆ Found in Text Mining only

ERV3-1 (endogenous retrovirus group 3 member 1, envelope)