EPS15 (epidermal growth factor receptor pathway substrate 15)

Gene

• Entrez ID: 2060
• Gene name: Epidermal growth factor receptor pathway substrate 15
• Gene symbol: EPS15
• Synonyms (NCBI Gene): AF-1P, AF1P, MLLT5
• Chromosome: 1
• Chromosome location: 1p32.3
• Summary: This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440715	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT727757	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT727755	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT727756	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT727754	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT727753	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT727752	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440715	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT967228	hsa-miR-1207-5p	CLIP-seq
MIRT967229	hsa-miR-1236	CLIP-seq
MIRT967230	hsa-miR-1258	CLIP-seq
MIRT967231	hsa-miR-128	CLIP-seq
MIRT967232	hsa-miR-130a	CLIP-seq
MIRT967233	hsa-miR-130b	CLIP-seq
MIRT967234	hsa-miR-140-5p	CLIP-seq
MIRT967235	hsa-miR-142-5p	CLIP-seq
MIRT967236	hsa-miR-148a	CLIP-seq
MIRT967237	hsa-miR-148b	CLIP-seq
MIRT967238	hsa-miR-150	CLIP-seq
MIRT967239	hsa-miR-152	CLIP-seq
MIRT967240	hsa-miR-2467-5p	CLIP-seq
MIRT967241	hsa-miR-27a	CLIP-seq
MIRT967242	hsa-miR-27b	CLIP-seq
MIRT967243	hsa-miR-301a	CLIP-seq
MIRT967244	hsa-miR-301b	CLIP-seq
MIRT967245	hsa-miR-3119	CLIP-seq
MIRT967246	hsa-miR-3128	CLIP-seq
MIRT967247	hsa-miR-3188	CLIP-seq
MIRT967248	hsa-miR-3200-5p	CLIP-seq
MIRT967249	hsa-miR-340	CLIP-seq
MIRT967250	hsa-miR-3545-5p	CLIP-seq
MIRT967251	hsa-miR-3607-3p	CLIP-seq
MIRT967252	hsa-miR-3647-3p	CLIP-seq
MIRT967253	hsa-miR-3658	CLIP-seq
MIRT967254	hsa-miR-3666	CLIP-seq
MIRT967255	hsa-miR-3675-3p	CLIP-seq
MIRT967256	hsa-miR-3686	CLIP-seq
MIRT967257	hsa-miR-377	CLIP-seq
MIRT967258	hsa-miR-3921	CLIP-seq
MIRT967259	hsa-miR-3975	CLIP-seq
MIRT967260	hsa-miR-4274	CLIP-seq
MIRT967261	hsa-miR-4282	CLIP-seq
MIRT967262	hsa-miR-4295	CLIP-seq
MIRT967263	hsa-miR-4460	CLIP-seq
MIRT967264	hsa-miR-4496	CLIP-seq
MIRT967265	hsa-miR-4514	CLIP-seq
MIRT967266	hsa-miR-4519	CLIP-seq
MIRT967267	hsa-miR-4524	CLIP-seq
MIRT967268	hsa-miR-454	CLIP-seq
MIRT967269	hsa-miR-4643	CLIP-seq
MIRT967270	hsa-miR-4649-3p	CLIP-seq
MIRT967271	hsa-miR-4653-5p	CLIP-seq
MIRT967272	hsa-miR-4662a-3p	CLIP-seq
MIRT967273	hsa-miR-4684-5p	CLIP-seq
MIRT967274	hsa-miR-4692	CLIP-seq
MIRT967275	hsa-miR-4696	CLIP-seq
MIRT967276	hsa-miR-4713-5p	CLIP-seq
MIRT967277	hsa-miR-4714-3p	CLIP-seq
MIRT967278	hsa-miR-4720-5p	CLIP-seq
MIRT967279	hsa-miR-4736	CLIP-seq
MIRT967280	hsa-miR-4738-3p	CLIP-seq
MIRT967281	hsa-miR-4742-5p	CLIP-seq
MIRT967282	hsa-miR-4763-3p	CLIP-seq
MIRT967283	hsa-miR-4766-5p	CLIP-seq
MIRT967284	hsa-miR-4768-5p	CLIP-seq
MIRT967285	hsa-miR-4799-3p	CLIP-seq
MIRT967286	hsa-miR-4799-5p	CLIP-seq
MIRT967287	hsa-miR-485-5p	CLIP-seq
MIRT967288	hsa-miR-532-3p	CLIP-seq
MIRT967289	hsa-miR-548c-3p	CLIP-seq
MIRT967290	hsa-miR-562	CLIP-seq
MIRT967291	hsa-miR-577	CLIP-seq
MIRT967292	hsa-miR-605	CLIP-seq
MIRT967293	hsa-miR-889	CLIP-seq
MIRT967294	hsa-miR-940	CLIP-seq
MIRT967295	hsa-miR-942	CLIP-seq
MIRT967296	hsa-miR-1178	CLIP-seq
MIRT967232	hsa-miR-130a	CLIP-seq
MIRT967233	hsa-miR-130b	CLIP-seq
MIRT967236	hsa-miR-148a	CLIP-seq
MIRT967237	hsa-miR-148b	CLIP-seq
MIRT967239	hsa-miR-152	CLIP-seq
MIRT967297	hsa-miR-196a	CLIP-seq
MIRT967298	hsa-miR-196b	CLIP-seq
MIRT967299	hsa-miR-2052	CLIP-seq
MIRT967300	hsa-miR-298	CLIP-seq
MIRT967301	hsa-miR-29a	CLIP-seq
MIRT967302	hsa-miR-29b	CLIP-seq
MIRT967303	hsa-miR-29c	CLIP-seq
MIRT967243	hsa-miR-301a	CLIP-seq
MIRT967244	hsa-miR-301b	CLIP-seq
MIRT967304	hsa-miR-3121-3p	CLIP-seq
MIRT967305	hsa-miR-3149	CLIP-seq
MIRT967254	hsa-miR-3666	CLIP-seq
MIRT967306	hsa-miR-3927	CLIP-seq
MIRT967307	hsa-miR-3938	CLIP-seq
MIRT967260	hsa-miR-4274	CLIP-seq
MIRT967262	hsa-miR-4295	CLIP-seq
MIRT967266	hsa-miR-4519	CLIP-seq
MIRT967267	hsa-miR-4524	CLIP-seq
MIRT967268	hsa-miR-454	CLIP-seq
MIRT967269	hsa-miR-4643	CLIP-seq
MIRT967308	hsa-miR-4650-3p	CLIP-seq
MIRT967309	hsa-miR-466	CLIP-seq
MIRT967272	hsa-miR-4662a-3p	CLIP-seq
MIRT967275	hsa-miR-4696	CLIP-seq
MIRT967310	hsa-miR-4699-3p	CLIP-seq
MIRT967311	hsa-miR-4789-3p	CLIP-seq
MIRT967312	hsa-miR-491-3p	CLIP-seq
MIRT967313	hsa-miR-498	CLIP-seq
MIRT967314	hsa-miR-513a-5p	CLIP-seq
MIRT967315	hsa-miR-520d-5p	CLIP-seq
MIRT967316	hsa-miR-524-5p	CLIP-seq
MIRT967317	hsa-miR-548m	CLIP-seq
MIRT967318	hsa-miR-630	CLIP-seq
MIRT967319	hsa-miR-767-5p	CLIP-seq
MIRT1548392	hsa-miR-4700-3p	CLIP-seq
MIRT1548393	hsa-miR-5095	CLIP-seq
MIRT967284	hsa-miR-4768-5p	CLIP-seq
MIRT967300	hsa-miR-298	CLIP-seq
MIRT1986520	hsa-miR-3678-3p	CLIP-seq
MIRT1986521	hsa-miR-450b-5p	CLIP-seq
MIRT1986522	hsa-miR-4520a-3p	CLIP-seq
MIRT1986523	hsa-miR-4520b-3p	CLIP-seq
MIRT1986524	hsa-miR-507	CLIP-seq
MIRT1986525	hsa-miR-557	CLIP-seq
MIRT967232	hsa-miR-130a	CLIP-seq
MIRT967233	hsa-miR-130b	CLIP-seq
MIRT967236	hsa-miR-148a	CLIP-seq
MIRT967237	hsa-miR-148b	CLIP-seq
MIRT967239	hsa-miR-152	CLIP-seq
MIRT967243	hsa-miR-301a	CLIP-seq
MIRT967244	hsa-miR-301b	CLIP-seq
MIRT967305	hsa-miR-3149	CLIP-seq
MIRT967254	hsa-miR-3666	CLIP-seq
MIRT967262	hsa-miR-4295	CLIP-seq
MIRT967268	hsa-miR-454	CLIP-seq
MIRT1548392	hsa-miR-4700-3p	CLIP-seq
MIRT1986526	hsa-miR-561	CLIP-seq
MIRT967318	hsa-miR-630	CLIP-seq
MIRT967296	hsa-miR-1178	CLIP-seq
MIRT2221068	hsa-miR-1251	CLIP-seq
MIRT2221069	hsa-miR-1262	CLIP-seq
MIRT967231	hsa-miR-128	CLIP-seq
MIRT967297	hsa-miR-196a	CLIP-seq
MIRT967298	hsa-miR-196b	CLIP-seq
MIRT967299	hsa-miR-2052	CLIP-seq
MIRT2221070	hsa-miR-216a	CLIP-seq
MIRT2221071	hsa-miR-223	CLIP-seq
MIRT2221072	hsa-miR-23a	CLIP-seq
MIRT2221073	hsa-miR-23b	CLIP-seq
MIRT2221074	hsa-miR-23c	CLIP-seq
MIRT967241	hsa-miR-27a	CLIP-seq
MIRT967242	hsa-miR-27b	CLIP-seq
MIRT967300	hsa-miR-298	CLIP-seq
MIRT967305	hsa-miR-3149	CLIP-seq
MIRT2221075	hsa-miR-3180-5p	CLIP-seq
MIRT2221076	hsa-miR-3671	CLIP-seq
MIRT2221077	hsa-miR-3682-5p	CLIP-seq
MIRT2221078	hsa-miR-3714	CLIP-seq
MIRT2221079	hsa-miR-371-5p	CLIP-seq
MIRT2221080	hsa-miR-371b-5p	CLIP-seq
MIRT2221081	hsa-miR-3907	CLIP-seq
MIRT967307	hsa-miR-3938	CLIP-seq
MIRT2221082	hsa-miR-4328	CLIP-seq
MIRT2221083	hsa-miR-4438	CLIP-seq
MIRT2221084	hsa-miR-4453	CLIP-seq
MIRT2221085	hsa-miR-4538	CLIP-seq
MIRT967269	hsa-miR-4643	CLIP-seq
MIRT967309	hsa-miR-466	CLIP-seq
MIRT1548392	hsa-miR-4700-3p	CLIP-seq
MIRT2221086	hsa-miR-4701-3p	CLIP-seq
MIRT2221087	hsa-miR-4731-3p	CLIP-seq
MIRT967311	hsa-miR-4789-3p	CLIP-seq
MIRT2221088	hsa-miR-4801	CLIP-seq
MIRT1548393	hsa-miR-5095	CLIP-seq
MIRT967314	hsa-miR-513a-5p	CLIP-seq
MIRT2221089	hsa-miR-520a-5p	CLIP-seq
MIRT2221090	hsa-miR-525-5p	CLIP-seq
MIRT2221091	hsa-miR-607	CLIP-seq
MIRT967318	hsa-miR-630	CLIP-seq
MIRT967293	hsa-miR-889	CLIP-seq
MIRT2387495	hsa-miR-208a	CLIP-seq
MIRT2387496	hsa-miR-208b	CLIP-seq
MIRT2387497	hsa-miR-3175	CLIP-seq
MIRT2387498	hsa-miR-4432	CLIP-seq
MIRT2387499	hsa-miR-499-5p	CLIP-seq
MIRT2221068	hsa-miR-1251	CLIP-seq
MIRT967231	hsa-miR-128	CLIP-seq
MIRT967241	hsa-miR-27a	CLIP-seq
MIRT967242	hsa-miR-27b	CLIP-seq
MIRT967253	hsa-miR-3658	CLIP-seq
MIRT967265	hsa-miR-4514	CLIP-seq
MIRT967274	hsa-miR-4692	CLIP-seq
MIRT967281	hsa-miR-4742-5p	CLIP-seq
MIRT967294	hsa-miR-940	CLIP-seq
MIRT967228	hsa-miR-1207-5p	CLIP-seq
MIRT967229	hsa-miR-1236	CLIP-seq
MIRT2221068	hsa-miR-1251	CLIP-seq
MIRT2221069	hsa-miR-1262	CLIP-seq
MIRT2524770	hsa-miR-1273f	CLIP-seq
MIRT967231	hsa-miR-128	CLIP-seq
MIRT2524771	hsa-miR-1285	CLIP-seq
MIRT2524772	hsa-miR-1305	CLIP-seq
MIRT2524773	hsa-miR-1912	CLIP-seq
MIRT2221071	hsa-miR-223	CLIP-seq
MIRT2524774	hsa-miR-224	CLIP-seq
MIRT967241	hsa-miR-27a	CLIP-seq
MIRT967242	hsa-miR-27b	CLIP-seq
MIRT967300	hsa-miR-298	CLIP-seq
MIRT2524775	hsa-miR-3123	CLIP-seq
MIRT2524776	hsa-miR-3126-3p	CLIP-seq
MIRT967246	hsa-miR-3128	CLIP-seq
MIRT2524777	hsa-miR-3143	CLIP-seq
MIRT2221075	hsa-miR-3180-5p	CLIP-seq
MIRT2524778	hsa-miR-3187-5p	CLIP-seq
MIRT2524779	hsa-miR-326	CLIP-seq
MIRT2524780	hsa-miR-330-5p	CLIP-seq
MIRT2524781	hsa-miR-3662	CLIP-seq
MIRT2221076	hsa-miR-3671	CLIP-seq
MIRT2221077	hsa-miR-3682-5p	CLIP-seq
MIRT2221078	hsa-miR-3714	CLIP-seq
MIRT2524782	hsa-miR-374c	CLIP-seq
MIRT2524783	hsa-miR-378g	CLIP-seq
MIRT2221081	hsa-miR-3907	CLIP-seq
MIRT2524784	hsa-miR-3918	CLIP-seq
MIRT2524785	hsa-miR-3919	CLIP-seq
MIRT2524786	hsa-miR-4252	CLIP-seq
MIRT2221082	hsa-miR-4328	CLIP-seq
MIRT2524787	hsa-miR-4436a	CLIP-seq
MIRT2221084	hsa-miR-4453	CLIP-seq
MIRT2524788	hsa-miR-4486	CLIP-seq
MIRT2524789	hsa-miR-451	CLIP-seq
MIRT967265	hsa-miR-4514	CLIP-seq
MIRT2221085	hsa-miR-4538	CLIP-seq
MIRT967273	hsa-miR-4684-5p	CLIP-seq
MIRT967274	hsa-miR-4692	CLIP-seq
MIRT1548392	hsa-miR-4700-3p	CLIP-seq
MIRT2221086	hsa-miR-4701-3p	CLIP-seq
MIRT2524790	hsa-miR-4709-3p	CLIP-seq
MIRT967278	hsa-miR-4720-5p	CLIP-seq
MIRT2524791	hsa-miR-4735-5p	CLIP-seq
MIRT967279	hsa-miR-4736	CLIP-seq
MIRT967280	hsa-miR-4738-3p	CLIP-seq
MIRT967281	hsa-miR-4742-5p	CLIP-seq
MIRT2524792	hsa-miR-4760-5p	CLIP-seq
MIRT967282	hsa-miR-4763-3p	CLIP-seq
MIRT2524793	hsa-miR-4768-3p	CLIP-seq
MIRT967284	hsa-miR-4768-5p	CLIP-seq
MIRT2524794	hsa-miR-4773	CLIP-seq
MIRT967285	hsa-miR-4799-3p	CLIP-seq
MIRT967313	hsa-miR-498	CLIP-seq
MIRT2524795	hsa-miR-499-3p	CLIP-seq
MIRT2524796	hsa-miR-499a-3p	CLIP-seq
MIRT1548393	hsa-miR-5095	CLIP-seq
MIRT967314	hsa-miR-513a-5p	CLIP-seq
MIRT2221089	hsa-miR-520a-5p	CLIP-seq
MIRT2221090	hsa-miR-525-5p	CLIP-seq
MIRT2524797	hsa-miR-548al	CLIP-seq
MIRT2524798	hsa-miR-548an	CLIP-seq
MIRT2524799	hsa-miR-576-5p	CLIP-seq
MIRT2221091	hsa-miR-607	CLIP-seq
MIRT2524800	hsa-miR-612	CLIP-seq
MIRT2524801	hsa-miR-653	CLIP-seq
MIRT2524802	hsa-miR-655	CLIP-seq
MIRT967294	hsa-miR-940	CLIP-seq
MIRT967295	hsa-miR-942	CLIP-seq
MIRT967296	hsa-miR-1178	CLIP-seq
MIRT967228	hsa-miR-1207-5p	CLIP-seq
MIRT967229	hsa-miR-1236	CLIP-seq
MIRT2221068	hsa-miR-1251	CLIP-seq
MIRT2221069	hsa-miR-1262	CLIP-seq
MIRT2524770	hsa-miR-1273f	CLIP-seq
MIRT967231	hsa-miR-128	CLIP-seq
MIRT967238	hsa-miR-150	CLIP-seq
MIRT2524773	hsa-miR-1912	CLIP-seq
MIRT2221070	hsa-miR-216a	CLIP-seq
MIRT2221071	hsa-miR-223	CLIP-seq
MIRT2524774	hsa-miR-224	CLIP-seq
MIRT2221072	hsa-miR-23a	CLIP-seq
MIRT2221073	hsa-miR-23b	CLIP-seq
MIRT2221074	hsa-miR-23c	CLIP-seq
MIRT967241	hsa-miR-27a	CLIP-seq
MIRT967242	hsa-miR-27b	CLIP-seq
MIRT967300	hsa-miR-298	CLIP-seq
MIRT2524775	hsa-miR-3123	CLIP-seq
MIRT2524776	hsa-miR-3126-3p	CLIP-seq
MIRT967246	hsa-miR-3128	CLIP-seq
MIRT2524777	hsa-miR-3143	CLIP-seq
MIRT967305	hsa-miR-3149	CLIP-seq
MIRT2221075	hsa-miR-3180-5p	CLIP-seq
MIRT2221076	hsa-miR-3671	CLIP-seq
MIRT2221077	hsa-miR-3682-5p	CLIP-seq
MIRT2221078	hsa-miR-3714	CLIP-seq
MIRT2221079	hsa-miR-371-5p	CLIP-seq
MIRT2221080	hsa-miR-371b-5p	CLIP-seq
MIRT2524782	hsa-miR-374c	CLIP-seq
MIRT2221081	hsa-miR-3907	CLIP-seq
MIRT2524785	hsa-miR-3919	CLIP-seq
MIRT967307	hsa-miR-3938	CLIP-seq
MIRT2221082	hsa-miR-4328	CLIP-seq
MIRT2221084	hsa-miR-4453	CLIP-seq
MIRT2524789	hsa-miR-451	CLIP-seq
MIRT967265	hsa-miR-4514	CLIP-seq
MIRT2221085	hsa-miR-4538	CLIP-seq
MIRT967273	hsa-miR-4684-5p	CLIP-seq
MIRT967274	hsa-miR-4692	CLIP-seq
MIRT1548392	hsa-miR-4700-3p	CLIP-seq
MIRT2221086	hsa-miR-4701-3p	CLIP-seq
MIRT2524790	hsa-miR-4709-3p	CLIP-seq
MIRT967276	hsa-miR-4713-5p	CLIP-seq
MIRT967278	hsa-miR-4720-5p	CLIP-seq
MIRT2524791	hsa-miR-4735-5p	CLIP-seq
MIRT967279	hsa-miR-4736	CLIP-seq
MIRT967280	hsa-miR-4738-3p	CLIP-seq
MIRT967281	hsa-miR-4742-5p	CLIP-seq
MIRT2524792	hsa-miR-4760-5p	CLIP-seq
MIRT967282	hsa-miR-4763-3p	CLIP-seq
MIRT2524793	hsa-miR-4768-3p	CLIP-seq
MIRT967284	hsa-miR-4768-5p	CLIP-seq
MIRT2524794	hsa-miR-4773	CLIP-seq
MIRT967285	hsa-miR-4799-3p	CLIP-seq
MIRT2524795	hsa-miR-499-3p	CLIP-seq
MIRT2524796	hsa-miR-499a-3p	CLIP-seq
MIRT1548393	hsa-miR-5095	CLIP-seq
MIRT967314	hsa-miR-513a-5p	CLIP-seq
MIRT2221089	hsa-miR-520a-5p	CLIP-seq
MIRT2221090	hsa-miR-525-5p	CLIP-seq
MIRT967288	hsa-miR-532-3p	CLIP-seq
MIRT2524799	hsa-miR-576-5p	CLIP-seq
MIRT2221091	hsa-miR-607	CLIP-seq
MIRT967318	hsa-miR-630	CLIP-seq
MIRT2524801	hsa-miR-653	CLIP-seq
MIRT2524802	hsa-miR-655	CLIP-seq
MIRT967294	hsa-miR-940	CLIP-seq
MIRT967295	hsa-miR-942	CLIP-seq
MIRT1548392	hsa-miR-4700-3p	CLIP-seq
MIRT1548393	hsa-miR-5095	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001921	Process	Positive regulation of receptor recycling	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	10064583, 10383425, 16159959, 16325581, 17082820, 17474147, 18199683, 18200045, 19380743, 20448150, 21762413, 23211419, 24768539, 25728925, 26496610, 26822536, 32203420, 35044719, 35271311, 37219487
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	15465819
GO:0005886	Component	Plasma membrane	IEA
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0005905	Component	Clathrin-coated pit	TAS	9762922
GO:0006895	Process	Golgi to endosome transport	IMP	24768539
GO:0006897	Process	Endocytosis	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0009925	Component	Basal plasma membrane	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016050	Process	Vesicle organization	TAS	9762922
GO:0016197	Process	Endosomal transport	IBA
GO:0016235	Component	Aggresome	IDA	16159959
GO:0016324	Component	Apical plasma membrane	IEA
GO:0017124	Function	SH3 domain binding	IEA
GO:0019065	Process	Receptor-mediated endocytosis of virus by host cell	IMP	21047970
GO:0030122	Component	AP-2 adaptor complex	IEA
GO:0030132	Component	Clathrin coat of coated pit	IBA
GO:0030132	Component	Clathrin coat of coated pit	IEA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IDA	24768539
GO:0031901	Component	Early endosome membrane	IEA
GO:0032456	Process	Endocytic recycling	IC	12807910
GO:0032456	Process	Endocytic recycling	IEA
GO:0032880	Process	Regulation of protein localization	IEA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0043130	Function	Ubiquitin binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046718	Process	Symbiont entry into host cell	IMP	20202662
GO:0046872	Function	Metal ion binding	IEA
GO:0048268	Process	Clathrin coat assembly	IDA	12807910
GO:0060170	Component	Ciliary membrane	IEA
GO:0070086	Process	Ubiquitin-dependent endocytosis	IEA
GO:0098843	Component	Postsynaptic endocytic zone	IEA
GO:0098884	Process	Postsynaptic neurotransmitter receptor internalization	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: 600051
• HGNC: 3419
• e!Ensembl: ENSG00000085832

Protein

• UniProt ID: P42566
• Protein name: Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
• Protein function: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular
• PDB: 1C07, 1EH2, 1F8H, 1FF1, 2IV9, 2JXC, 4RH5, 4RH9, 4RHG, 4S0G, 5AWT, 5AWU, 5JP2
• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed.
• Sequence:

  MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLA
  DTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAEL
  PWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGML
  DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD
  GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPP
  HVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKE
  DTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCA
  EEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQ
  HLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLN
  EHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDP
  FNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFR
  QSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESF
  GGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTR
  PCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADP
  SNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA

• Sequence length: 896

Pathways

KEGG:

Endocytosis

Reactome:

EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARDIOEMBOLIC STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEASONAL ALLERGIC RHINITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	14704037		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26289382, 28215104		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	18032821, 25260758	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	18032821	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	12679910	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37149115	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	12124344, 14704037, 16826222		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	21900057	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	9041173		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	18395097		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	25263444		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26289382, 28215104		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26289382, 29549343		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18032821, 26289382, 28215104		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	25263444, 27531895, 28215104, 31023336		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	30975166		★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	30214560		★☆☆☆☆ Found in Text Mining only
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	14704037		★☆☆☆☆ Found in Text Mining only