Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	205717
Gene name	Upstream transcription factor family member 3
Gene symbol	USF3
Synonyms (NCBI Gene)	KIAA2018
Chromosome	3
Chromosome location	3q13.2
Summary	This gene encodes a large protein that contains a helix-loop-helix domain and a polyglutamine region. A deletion in the polyglutamine region was associated with risk for thyroid carcinoma. [provided by RefSeq, May 2017]

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Show/Hide all (245)

miRTarBase ID	miRNA	Experiments	Reference
MIRT611349	hsa-miR-8485	HITS-CLIP	19536157
MIRT611348	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT611347	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT611346	hsa-miR-603	HITS-CLIP	19536157
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	19536157
MIRT611344	hsa-miR-1-5p	HITS-CLIP	19536157
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	19536157
MIRT611342	hsa-miR-3941	HITS-CLIP	19536157
MIRT611341	hsa-miR-4672	HITS-CLIP	19536157
MIRT611340	hsa-miR-466	HITS-CLIP	19536157
MIRT710917	hsa-miR-4797-5p	HITS-CLIP	19536157
MIRT710916	hsa-miR-5007-5p	HITS-CLIP	19536157
MIRT710915	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT710914	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT710913	hsa-miR-6742-3p	HITS-CLIP	19536157
MIRT710912	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT710911	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT710910	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT710909	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT710908	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT710907	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT710906	hsa-miR-6776-5p	HITS-CLIP	19536157
MIRT710905	hsa-miR-661	HITS-CLIP	19536157
MIRT710904	hsa-miR-542-3p	HITS-CLIP	19536157
MIRT710903	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT710902	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT710901	hsa-miR-1262	HITS-CLIP	19536157
MIRT710900	hsa-miR-4701-3p	HITS-CLIP	19536157
MIRT710899	hsa-miR-6736-5p	HITS-CLIP	19536157
MIRT710898	hsa-miR-4668-5p	HITS-CLIP	19536157
MIRT542156	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT502157	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT542155	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT517826	hsa-miR-3609	HITS-CLIP	21572407
MIRT517825	hsa-miR-548ah-5p	HITS-CLIP	21572407
MIRT509759	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509758	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509757	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509756	hsa-miR-3924	HITS-CLIP	21572407
MIRT207900	hsa-miR-6083	HITS-CLIP	21572407
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT611355	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT611354	hsa-miR-1248	HITS-CLIP	23824327
MIRT611353	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT611352	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611351	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT656899	hsa-let-7a-3p	HITS-CLIP	23824327
MIRT656898	hsa-let-7b-3p	HITS-CLIP	23824327
MIRT656897	hsa-let-7f-1-3p	HITS-CLIP	23824327
MIRT656896	hsa-miR-98-3p	HITS-CLIP	23824327
MIRT656895	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT656894	hsa-let-7f-2-3p	HITS-CLIP	23824327
MIRT656893	hsa-miR-1185-1-3p	HITS-CLIP	23824327
MIRT656892	hsa-miR-1185-2-3p	HITS-CLIP	23824327
MIRT636484	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT611350	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611348	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611347	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611348	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611347	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611341	hsa-miR-4672	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT611356	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT611355	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT611354	hsa-miR-1248	HITS-CLIP	23824327
MIRT611353	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT611352	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611351	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT636484	hsa-miR-6516-3p	HITS-CLIP	23824327
MIRT611350	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT636483	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT636482	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611348	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611347	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611341	hsa-miR-4672	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611348	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611347	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611341	hsa-miR-4672	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611348	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611347	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611341	hsa-miR-4672	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611348	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611347	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611341	hsa-miR-4672	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT626415	hsa-miR-548ac	HITS-CLIP	23824327
MIRT626414	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT626413	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT626412	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT626411	hsa-miR-548z	HITS-CLIP	23824327
MIRT626410	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT626409	hsa-miR-652-5p	HITS-CLIP	23824327
MIRT626408	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT626407	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611348	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611347	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611348	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611347	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611341	hsa-miR-4672	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT611356	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT611355	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT611354	hsa-miR-1248	HITS-CLIP	23824327
MIRT611353	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT611352	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT611351	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT611350	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT611349	hsa-miR-8485	HITS-CLIP	23824327
MIRT611348	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611347	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611346	hsa-miR-603	HITS-CLIP	23824327
MIRT611345	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT611344	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT611343	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT611342	hsa-miR-3941	HITS-CLIP	23824327
MIRT611341	hsa-miR-4672	HITS-CLIP	23824327
MIRT611340	hsa-miR-466	HITS-CLIP	23824327
MIRT542156	hsa-miR-511-3p	HITS-CLIP	24906430
MIRT502156	hsa-miR-4693-3p	HITS-CLIP	24906430
MIRT502157	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT542155	hsa-miR-223-5p	HITS-CLIP	24906430
MIRT502155	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT509759	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT517824	hsa-miR-4293	PAR-CLIP	20371350
MIRT517823	hsa-miR-596	PAR-CLIP	20371350
MIRT517822	hsa-miR-3651	PAR-CLIP	20371350
MIRT509758	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT509757	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509756	hsa-miR-3924	PAR-CLIP	20371350
MIRT207900	hsa-miR-6083	PAR-CLIP	20371350
MIRT542157	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT542156	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT542155	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT502155	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT502157	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT517826	hsa-miR-3609	PAR-CLIP	21572407
MIRT517825	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT509759	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT517824	hsa-miR-4293	PAR-CLIP	21572407
MIRT517823	hsa-miR-596	PAR-CLIP	21572407
MIRT517822	hsa-miR-3651	PAR-CLIP	21572407
MIRT509758	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509757	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT542157	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT542156	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT542155	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT502155	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT502157	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT517826	hsa-miR-3609	PAR-CLIP	23446348
MIRT517825	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT509759	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT517824	hsa-miR-4293	PAR-CLIP	23446348
MIRT517823	hsa-miR-596	PAR-CLIP	23446348
MIRT517822	hsa-miR-3651	PAR-CLIP	23446348
MIRT509758	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509757	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509756	hsa-miR-3924	PAR-CLIP	23446348
MIRT207900	hsa-miR-6083	PAR-CLIP	23446348
MIRT509759	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509758	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509757	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509756	hsa-miR-3924	PAR-CLIP	23446348
MIRT484024	hsa-miR-4691-3p	PAR-CLIP	24398324
MIRT502156	hsa-miR-4693-3p	PAR-CLIP	24398324
MIRT502157	hsa-miR-574-5p	PAR-CLIP	24398324
MIRT484023	hsa-miR-4252	PAR-CLIP	24398324
MIRT484022	hsa-miR-185-5p	PAR-CLIP	24398324
MIRT484021	hsa-miR-4306	PAR-CLIP	24398324
MIRT484020	hsa-miR-4644	PAR-CLIP	24398324
MIRT484018	hsa-miR-5192	PAR-CLIP	24398324
MIRT502155	hsa-miR-6867-5p	PAR-CLIP	24398324
MIRT484024	hsa-miR-4691-3p	PAR-CLIP	23592263
MIRT484023	hsa-miR-4252	PAR-CLIP	23592263
MIRT484022	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT484021	hsa-miR-4306	PAR-CLIP	23592263
MIRT484020	hsa-miR-4644	PAR-CLIP	23592263
MIRT484018	hsa-miR-5192	PAR-CLIP	23592263

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	33058301
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	33058301
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0010719	Process	Negative regulation of epithelial to mesenchymal transition	IBA
GO:0010719	Process	Negative regulation of epithelial to mesenchymal transition	IMP	28011713
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	33058301
GO:0046983	Function	Protein dimerization activity	IEA

MIM	HGNC	e!Ensembl
617568	30494	ENSG00000176542

Q68DE3

Protein name

Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3)

Protein function

Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. {ECO:0000269

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	19 → 70	Helix-loop-helix DNA-binding domain	Domain

Sequence

MPEMTENETPTKKQHRKKNRETHNAVERHRKKKINAGINRIGELIPCSPALKQSKNMILD
QAFKYITELKRQNDELLLNGGNNEQAEEIKKLRKQLEEIQKENGRYIELLKANDICLYDD
PTIHWKGNLKNSKVSVVIPSDQVQKKIIVYSNGNQPGGNSQGTAVQGITFNVSHNLQKQT
ANVVPVQRTCNLVTPVSISGVYPSENKPWHQTTVPALATNQPVPLCLPAAISAQSILELP
TSESESNVLGATSGSLIAVSIESEPHQHHSLHTCLNDQNSSENKNGQENPKVLKKMTPCV
TNIPHSSSATATKVHHGNKSCLSIQDFRGDFQNTFVVSVTTTVCSQPPRTAGDSSPMSIS
KSADLTSTATVVASSAPGVGKATIPISTLSGNPLDNGWTLSCSLPSSSVSTSDLKNINSL
TRISSAGNTQTTWTTLQLAGNTIQPLSQTPSSAVTPVLNESGTSPTTSNHSRYVATDINL
NNSFPADGQPVEQVVVTLPSCPSLPMQPLIAQPQVKSQPPKNILPLNSAMQVIQMAQPVG
SAVNSAPTNQNVIILQPPSTTPCPTVMRAEVSNQTVGQQIVIIQAANQNPLPLLPAPPPG
SVRLPINGANTVIGSNNSVQNVPTPQTFGGKHLVHILPRPSSLSASNSTQTFSVTMSNQQ
PQTISLNGQLFALQPVMSSSGTTNQTPMQIIQPTTSEDPNTNVALNTFGALASLNQSISQ
MAGQSCVQLSISQPANSQTAANSQTTTANCVSLTTTAAPPVTTDSSATLASTYNLVSTSS
MNTVACLPNMKSKRLNKKPGGRKHLAANKSACPLNSVRDVSKLDCPNTEGSAEPPCNDGL
LESFPAVLPSVSVSQANSVSVSASHSLGVLSSESLIPESVSKSKSAEKSSPPSQESVTSE
HFAMAAAKSKDSTPNLQQETSQDKPPSSLALSDAAKPCASANVLIPSPSDPHILVSQVPG
LSSTTSTTSTDCVSEVEIIAEPCRVEQDSSDTMQTTGLLKGQGLTTLLSDLAKKKNPQKS
SLSDQMDHPDFSSENPKIVDSSVNLHPKQELLLMNNDDRDPPQHHSCLPDQEVINGSLIN
GRQADSPMSTSSGSSRSFSVASMLPETTREDVTSNATTNTCDSCTFVEQTDIVALAARAI
FDQENLEKGRVGLQADIREVASKPSEASLLEGDPPFKSQIPKESGTGQAEATPNEFNSQG
SIEATMERPLEKPSCSLGIKTSNASLQDSTSQPPSITSLSVNNLIHQSSISHPLASCAGL
SPTSEQTTVPATVNLTVSSSSYGSQPPGPSLMTEYSQEQLNTMTSTIPNSQIQEPLLKPS
HESRKDSAKRAVQDDLLLSSAKRQKHCQPAPLRLESMSLMSRTPDTISDQTQMMVSQIPP
NSSNSVVPVSNPAHGDGLTRLFPPSNNFVTPALRQTEVQCGSQPSVAEQQQTQASQHLQA
LQQHVPAQGVSHLHSNHLYIKQQQQQQQQQQQQQQQQQAGQLRERHHLYQMQHHVPHAES
SVHSQPHNVHQQRTLQQEVQMQKKRNLVQGTQTSQLSLQPKHHGTDQSRSKTGQPHPHHQ
QMQQQMQQHFGSSQTEKSCENPSTSRNHHNHPQNHLNQDIMHQQQDVGSRQQGSGVSSEH
VSGHNPMQRLLTSRGLEQQMVSQPSIVTRSSDMTCTPHRPERNRVSSYSAEALIGKTSSN
SEQRMGISIQGSRVSDQLEMRSYLDVPRNKSLAIHNMQGRVDHTVASDIRLSDCQTFKPS
GASQQPQSNFEVQSSRNNEIGNPVSSLRSMQSQAFRISQNTGPPPIDRQKRLSYPPVQSI
PTGNGIPSRDSENTCHQSFMQSLLAPHLSDQVIGSQRSLSEHQRNTQCGPSSAIEYNCPP
THENVHIRRESESQNRESCDMSLGAINTRNSTLNIPFSSSSSSGDIQGRNTSPNVSVQKS
NPMRITESHATKGHMNPPVTTNMHGVARPALPHPSVSHGNGDQGPAVRQANSSVPQRSRH
PLQDSSGSKIRQPERNRSGNQRQSTVFDPSLPHLPLSTGGSMILGRQQPATEKRGSIVRF
MPDSPQVPNDNSGPDQHTLSQNFGFSFIPEGGMNPPINANASFIPQVTQPSATRTPALIP
VDPQNTLPSFYPPYSPAHPTLSNDISIPYFPNQMFSNPSTEKVNSGSLNNRFGSILSPPR
PVGFAQPSFPLLPDMPPMHMTNSHLSNFNMTSLFPEIATALPDGSAMSPLLTIANSSASD
SSKQSSNRPAHNISHILGHDCSSAV

Sequence length

2245

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CIC-rearranged sarcoma	not provided	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COWDEN DISEASE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cowden syndrome	Uncertain significance	ClinVar Orphanet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinogenesis	Carcinogenesis	Pubtator	28011713	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cowden syndrome	Cowden Syndrome	Orphanet			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Differentiated Thyroid Gland Carcinoma	Thyroid Carcinoma	BEFREE	28011713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hamartoma Syndrome, Multiple	Hamartoma	BEFREE	28011713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	28011713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28011713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Necrosis	Pubtator	28011713	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28011713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	28011713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sezary Syndrome	Sezary syndrome	Pubtator	28489605	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	28011713	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	28011713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	28011713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	28011713, 37846061	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

USF3 (upstream transcription factor family member 3)