Gene Gene information from NCBI Gene database.
Entrez ID 2054
Gene name Syntaxin 2
Gene symbol STX2
Synonyms (NCBI Gene)
EPIMEPMSTX2ASTX2BSTX2C
Chromosome 12
Chromosome location 12q24.33
Summary The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal
miRNA miRNA information provided by mirtarbase database.
464
miRTarBase ID miRNA Experiments Reference
MIRT002690 hsa-miR-124-3p Microarray 15685193
MIRT052827 hsa-miR-3200-3p CLASH 23622248
MIRT680922 hsa-miR-1247-3p HITS-CLIP 23706177
MIRT680921 hsa-miR-3160-3p HITS-CLIP 23706177
MIRT680920 hsa-miR-558 HITS-CLIP 23706177
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0000149 Function SNARE binding IBA
GO:0005198 Function Structural molecule activity IDA 22226963
GO:0005484 Function SNAP receptor activity IBA
GO:0005484 Function SNAP receptor activity IEA
GO:0005515 Function Protein binding IPI 12773094, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
132350 3403 ENSG00000111450
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P32856
Protein name Syntaxin-2 (Epimorphin)
Protein function Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00804 Syntaxin 29 226 Syntaxin Domain
PF05739 SNARE 227 279 SNARE domain Family
Sequence
Sequence length 288
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  SNARE interactions in vesicular transport
Synaptic vesicle cycle
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute pancreatitis Pancreatitis BEFREE 29360461
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 28800327 Associate
★☆☆☆☆
Found in Text Mining only
Anxiety Anxiety Disorder BEFREE 29156991, 30297990, 30547285, 30562568, 30878321, 31798427
★☆☆☆☆
Found in Text Mining only
Anxiety Disorders Anxiety Disorder BEFREE 29156991, 30297990, 30547285, 30562568, 30878321, 31798427
★☆☆☆☆
Found in Text Mining only
Azoospermia, Nonobstructive Azoospermia BEFREE 29570232
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder GWASCAT_DG 29064472
★☆☆☆☆
Found in Text Mining only
Blood Coagulation Disorders Blood coagulation disorder Pubtator 12540565 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 33247676 Associate
★☆☆☆☆
Found in Text Mining only
Carotid Artery Thrombosis Carotid artery thrombosis Pubtator 21156930 Associate
★☆☆☆☆
Found in Text Mining only
Colitis Colitis Pubtator 10024592 Stimulate
★☆☆☆☆
Found in Text Mining only