Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2037
Gene name	Erythrocyte membrane protein band 4.1 like 2
Gene symbol	EPB41L2
Synonyms (NCBI Gene)	4.1-G4.1G
Chromosome	6
Chromosome location	6q23.1-q23.2

137

Show/Hide all (137)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021017	hsa-miR-155-5p	Proteomics	18668040
MIRT024109	hsa-miR-1-3p	Proteomics	18668040
MIRT024109	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT025572	hsa-miR-34a-5p	Proteomics	21566225
MIRT050941	hsa-miR-17-5p	CLASH	23622248
MIRT047645	hsa-miR-10a-5p	CLASH	23622248
MIRT046632	hsa-miR-222-3p	CLASH	23622248
MIRT043551	hsa-miR-331-3p	CLASH	23622248
MIRT036304	hsa-miR-1229-3p	CLASH	23622248
MIRT965625	hsa-miR-140-3p	CLIP-seq
MIRT965626	hsa-miR-3591-3p	CLIP-seq
MIRT965627	hsa-miR-3943	CLIP-seq
MIRT965628	hsa-miR-4313	CLIP-seq
MIRT965629	hsa-miR-1182	CLIP-seq
MIRT965630	hsa-miR-1284	CLIP-seq
MIRT965625	hsa-miR-140-3p	CLIP-seq
MIRT965631	hsa-miR-140-5p	CLIP-seq
MIRT965632	hsa-miR-196a	CLIP-seq
MIRT965633	hsa-miR-196b	CLIP-seq
MIRT965634	hsa-miR-224	CLIP-seq
MIRT965635	hsa-miR-3126-3p	CLIP-seq
MIRT965636	hsa-miR-3128	CLIP-seq
MIRT965637	hsa-miR-3148	CLIP-seq
MIRT965638	hsa-miR-3155	CLIP-seq
MIRT965639	hsa-miR-3155b	CLIP-seq
MIRT965640	hsa-miR-3169	CLIP-seq
MIRT965641	hsa-miR-3545-5p	CLIP-seq
MIRT965626	hsa-miR-3591-3p	CLIP-seq
MIRT965642	hsa-miR-3663-5p	CLIP-seq
MIRT965643	hsa-miR-376c	CLIP-seq
MIRT965627	hsa-miR-3943	CLIP-seq
MIRT965644	hsa-miR-3978	CLIP-seq
MIRT965645	hsa-miR-4289	CLIP-seq
MIRT965628	hsa-miR-4313	CLIP-seq
MIRT965646	hsa-miR-4460	CLIP-seq
MIRT965647	hsa-miR-4515	CLIP-seq
MIRT965648	hsa-miR-4642	CLIP-seq
MIRT965649	hsa-miR-4700-3p	CLIP-seq
MIRT965650	hsa-miR-4703-3p	CLIP-seq
MIRT965651	hsa-miR-4720-5p	CLIP-seq
MIRT965652	hsa-miR-4799-3p	CLIP-seq
MIRT965653	hsa-miR-484	CLIP-seq
MIRT965654	hsa-miR-513a-5p	CLIP-seq
MIRT965655	hsa-miR-548an	CLIP-seq
MIRT965656	hsa-miR-616	CLIP-seq
MIRT965657	hsa-miR-639	CLIP-seq
MIRT965658	hsa-miR-875-3p	CLIP-seq
MIRT965638	hsa-miR-3155	CLIP-seq
MIRT965639	hsa-miR-3155b	CLIP-seq
MIRT965642	hsa-miR-3663-5p	CLIP-seq
MIRT965653	hsa-miR-484	CLIP-seq
MIRT2442134	hsa-miR-1271	CLIP-seq
MIRT2442135	hsa-miR-4318	CLIP-seq
MIRT2442136	hsa-miR-4466	CLIP-seq
MIRT2442137	hsa-miR-675	CLIP-seq
MIRT2442138	hsa-miR-96	CLIP-seq
MIRT965629	hsa-miR-1182	CLIP-seq
MIRT2524314	hsa-miR-1207-5p	CLIP-seq
MIRT2442134	hsa-miR-1271	CLIP-seq
MIRT2524315	hsa-miR-128	CLIP-seq
MIRT965631	hsa-miR-140-5p	CLIP-seq
MIRT2524316	hsa-miR-148a	CLIP-seq
MIRT2524317	hsa-miR-148b	CLIP-seq
MIRT2524318	hsa-miR-152	CLIP-seq
MIRT2524319	hsa-miR-198	CLIP-seq
MIRT965634	hsa-miR-224	CLIP-seq
MIRT2524320	hsa-miR-3163	CLIP-seq
MIRT965640	hsa-miR-3169	CLIP-seq
MIRT2524321	hsa-miR-323b-3p	CLIP-seq
MIRT2524322	hsa-miR-340	CLIP-seq
MIRT2524323	hsa-miR-345	CLIP-seq
MIRT2524324	hsa-miR-3925-3p	CLIP-seq
MIRT965644	hsa-miR-3978	CLIP-seq
MIRT2524325	hsa-miR-4256	CLIP-seq
MIRT2524326	hsa-miR-4276	CLIP-seq
MIRT2442135	hsa-miR-4318	CLIP-seq
MIRT2442136	hsa-miR-4466	CLIP-seq
MIRT965647	hsa-miR-4515	CLIP-seq
MIRT2524327	hsa-miR-4522	CLIP-seq
MIRT2524328	hsa-miR-4528	CLIP-seq
MIRT2524329	hsa-miR-455-3p	CLIP-seq
MIRT2524330	hsa-miR-4684-5p	CLIP-seq
MIRT2524331	hsa-miR-4697-3p	CLIP-seq
MIRT965649	hsa-miR-4700-3p	CLIP-seq
MIRT2524332	hsa-miR-4756-3p	CLIP-seq
MIRT2524333	hsa-miR-4763-3p	CLIP-seq
MIRT2524334	hsa-miR-4778-3p	CLIP-seq
MIRT2524335	hsa-miR-4795-5p	CLIP-seq
MIRT965654	hsa-miR-513a-5p	CLIP-seq
MIRT2524336	hsa-miR-515-5p	CLIP-seq
MIRT2524337	hsa-miR-520a-5p	CLIP-seq
MIRT2524338	hsa-miR-525-5p	CLIP-seq
MIRT2524339	hsa-miR-548n	CLIP-seq
MIRT2524340	hsa-miR-548t	CLIP-seq
MIRT2442137	hsa-miR-675	CLIP-seq
MIRT2524341	hsa-miR-766	CLIP-seq
MIRT965658	hsa-miR-875-3p	CLIP-seq
MIRT2442138	hsa-miR-96	CLIP-seq
MIRT965629	hsa-miR-1182	CLIP-seq
MIRT2524314	hsa-miR-1207-5p	CLIP-seq
MIRT2442134	hsa-miR-1271	CLIP-seq
MIRT2524315	hsa-miR-128	CLIP-seq
MIRT2524316	hsa-miR-148a	CLIP-seq
MIRT2524317	hsa-miR-148b	CLIP-seq
MIRT2524318	hsa-miR-152	CLIP-seq
MIRT2524319	hsa-miR-198	CLIP-seq
MIRT965634	hsa-miR-224	CLIP-seq
MIRT2524320	hsa-miR-3163	CLIP-seq
MIRT965640	hsa-miR-3169	CLIP-seq
MIRT2524321	hsa-miR-323b-3p	CLIP-seq
MIRT2524323	hsa-miR-345	CLIP-seq
MIRT2524324	hsa-miR-3925-3p	CLIP-seq
MIRT965644	hsa-miR-3978	CLIP-seq
MIRT2524325	hsa-miR-4256	CLIP-seq
MIRT2524326	hsa-miR-4276	CLIP-seq
MIRT2442135	hsa-miR-4318	CLIP-seq
MIRT2442136	hsa-miR-4466	CLIP-seq
MIRT965647	hsa-miR-4515	CLIP-seq
MIRT2524327	hsa-miR-4522	CLIP-seq
MIRT2524328	hsa-miR-4528	CLIP-seq
MIRT2524329	hsa-miR-455-3p	CLIP-seq
MIRT2524330	hsa-miR-4684-5p	CLIP-seq
MIRT2524331	hsa-miR-4697-3p	CLIP-seq
MIRT965649	hsa-miR-4700-3p	CLIP-seq
MIRT2524332	hsa-miR-4756-3p	CLIP-seq
MIRT2524333	hsa-miR-4763-3p	CLIP-seq
MIRT2524334	hsa-miR-4778-3p	CLIP-seq
MIRT965654	hsa-miR-513a-5p	CLIP-seq
MIRT2524336	hsa-miR-515-5p	CLIP-seq
MIRT2524337	hsa-miR-520a-5p	CLIP-seq
MIRT2524338	hsa-miR-525-5p	CLIP-seq
MIRT2524339	hsa-miR-548n	CLIP-seq
MIRT2524340	hsa-miR-548t	CLIP-seq
MIRT2442137	hsa-miR-675	CLIP-seq
MIRT2524341	hsa-miR-766	CLIP-seq
MIRT965658	hsa-miR-875-3p	CLIP-seq
MIRT2442138	hsa-miR-96	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	20936779, 22003208, 23870127, 24996901, 28514442, 33961781, 36931259, 39251607
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9598318
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005938	Component	Cell cortex	IDA	23870127
GO:0005938	Component	Cell cortex	IEA
GO:0008091	Component	Spectrin	TAS	9598318
GO:0008092	Function	Cytoskeletal protein binding	IEA
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030507	Function	Spectrin binding	IEA
GO:0030866	Process	Cortical actin cytoskeleton organization	IEA
GO:0031032	Process	Actomyosin structure organization	IBA
GO:0042731	Function	PH domain binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1904778	Process	Positive regulation of protein localization to cell cortex	IMP	23870127

MIM	HGNC	e!Ensembl
603237	3379	ENSG00000079819

O43491

Protein name

Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G)

Protein function

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09379	FERM_N	222 → 285	FERM N-terminal domain	Domain
PF00373	FERM_M	300 → 409	FERM central domain	Domain
PF09380	FERM_C	413 → 503	FERM C-terminal PH-like domain	Domain
PF08736	FA	507 → 550	FERM adjacent (FA)	Family
PF04382	SAB	630 → 676	SAB domain	Domain
PF05902	4_1_CTD	892 → 998	4.1 protein C-terminal domain (CTD)	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed.

Sequence

MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLR
RQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPE
EQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKG
QVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPD
PSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSE
FQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIK
LGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRA
AKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFE
RTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPT
KAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTP
EPRPNEWEKRRITPLSLQTQGSSHETLNIVEEKKRAEVGKDERVITEEMNGKEISPGSGP
GEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEE
PRPAAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGALKQDMGE
EAEEEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTE
TKTITYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVI
TGDGDIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED

Sequence length

1005

Interactions

View interactions

	Reactome
			Neurexins and neuroligins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE WITH AURA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	31063460		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	31063460	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	32852391	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	32329852	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31063460		★★★★★ ★☆☆☆☆ Found in Text Mining only
Urolithiasis	Urolithiasis	GWASCAT_DG	30975718		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

EPB41L2 (erythrocyte membrane protein band 4.1 like 2)