Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	203447
Gene name	Nik related kinase
Gene symbol	NRK
Synonyms (NCBI Gene)	NESK
Chromosome	X
Chromosome location	Xq22.3
Summary	The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]

106

Show/Hide all (106)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018046	hsa-miR-335-5p	Microarray	18185580
MIRT1194186	hsa-miR-1183	CLIP-seq
MIRT1194187	hsa-miR-1285	CLIP-seq
MIRT1194188	hsa-miR-130a	CLIP-seq
MIRT1194189	hsa-miR-130b	CLIP-seq
MIRT1194190	hsa-miR-1911	CLIP-seq
MIRT1194191	hsa-miR-219-1-3p	CLIP-seq
MIRT1194192	hsa-miR-301a	CLIP-seq
MIRT1194193	hsa-miR-301b	CLIP-seq
MIRT1194194	hsa-miR-30a	CLIP-seq
MIRT1194195	hsa-miR-30b	CLIP-seq
MIRT1194196	hsa-miR-30c	CLIP-seq
MIRT1194197	hsa-miR-30d	CLIP-seq
MIRT1194198	hsa-miR-30e	CLIP-seq
MIRT1194199	hsa-miR-3187-5p	CLIP-seq
MIRT1194200	hsa-miR-3198	CLIP-seq
MIRT1194201	hsa-miR-326	CLIP-seq
MIRT1194202	hsa-miR-330-5p	CLIP-seq
MIRT1194203	hsa-miR-3616-5p	CLIP-seq
MIRT1194204	hsa-miR-3617	CLIP-seq
MIRT1194205	hsa-miR-3647-5p	CLIP-seq
MIRT1194206	hsa-miR-3665	CLIP-seq
MIRT1194207	hsa-miR-3666	CLIP-seq
MIRT1194208	hsa-miR-378g	CLIP-seq
MIRT1194209	hsa-miR-3945	CLIP-seq
MIRT1194210	hsa-miR-4253	CLIP-seq
MIRT1194211	hsa-miR-4295	CLIP-seq
MIRT1194212	hsa-miR-4309	CLIP-seq
MIRT1194213	hsa-miR-4457	CLIP-seq
MIRT1194214	hsa-miR-4486	CLIP-seq
MIRT1194215	hsa-miR-454	CLIP-seq
MIRT1194216	hsa-miR-4642	CLIP-seq
MIRT1194217	hsa-miR-4643	CLIP-seq
MIRT1194218	hsa-miR-466	CLIP-seq
MIRT1194219	hsa-miR-4709-3p	CLIP-seq
MIRT1194220	hsa-miR-4768-5p	CLIP-seq
MIRT1194221	hsa-miR-4789-3p	CLIP-seq
MIRT1194222	hsa-miR-554	CLIP-seq
MIRT1194223	hsa-miR-556-5p	CLIP-seq
MIRT1194224	hsa-miR-563	CLIP-seq
MIRT1194225	hsa-miR-571	CLIP-seq
MIRT1194226	hsa-miR-573	CLIP-seq
MIRT1194227	hsa-miR-612	CLIP-seq
MIRT1194228	hsa-miR-617	CLIP-seq
MIRT1194229	hsa-miR-641	CLIP-seq
MIRT1194230	hsa-miR-657	CLIP-seq
MIRT2056358	hsa-miR-1207-3p	CLIP-seq
MIRT2056359	hsa-miR-1246	CLIP-seq
MIRT2056360	hsa-miR-3124-3p	CLIP-seq
MIRT2056361	hsa-miR-3134	CLIP-seq
MIRT2056362	hsa-miR-3155	CLIP-seq
MIRT2056363	hsa-miR-3155b	CLIP-seq
MIRT2056364	hsa-miR-3671	CLIP-seq
MIRT2056365	hsa-miR-3685	CLIP-seq
MIRT2056366	hsa-miR-384	CLIP-seq
MIRT2056367	hsa-miR-3915	CLIP-seq
MIRT2056368	hsa-miR-4461	CLIP-seq
MIRT2056369	hsa-miR-4729	CLIP-seq
MIRT2056370	hsa-miR-4766-5p	CLIP-seq
MIRT2056371	hsa-miR-484	CLIP-seq
MIRT2056372	hsa-miR-607	CLIP-seq
MIRT2284890	hsa-miR-1245b-3p	CLIP-seq
MIRT2284891	hsa-miR-2115	CLIP-seq
MIRT2284892	hsa-miR-221	CLIP-seq
MIRT2284893	hsa-miR-222	CLIP-seq
MIRT2284894	hsa-miR-224	CLIP-seq
MIRT2284895	hsa-miR-3182	CLIP-seq
MIRT2284896	hsa-miR-3942-3p	CLIP-seq
MIRT2284897	hsa-miR-4274	CLIP-seq
MIRT2284898	hsa-miR-4283	CLIP-seq
MIRT2284899	hsa-miR-4421	CLIP-seq
MIRT2284900	hsa-miR-4489	CLIP-seq
MIRT2284901	hsa-miR-4492	CLIP-seq
MIRT2284902	hsa-miR-4498	CLIP-seq
MIRT2284903	hsa-miR-4505	CLIP-seq
MIRT2284904	hsa-miR-4519	CLIP-seq
MIRT2284905	hsa-miR-4524	CLIP-seq
MIRT2284906	hsa-miR-4677-3p	CLIP-seq
MIRT2284907	hsa-miR-4679	CLIP-seq
MIRT2284908	hsa-miR-4731-5p	CLIP-seq
MIRT1194221	hsa-miR-4789-3p	CLIP-seq
MIRT2284909	hsa-miR-4796-5p	CLIP-seq
MIRT2284910	hsa-miR-4803	CLIP-seq
MIRT2284911	hsa-miR-494	CLIP-seq
MIRT2284912	hsa-miR-495	CLIP-seq
MIRT2284913	hsa-miR-548ag	CLIP-seq
MIRT2284914	hsa-miR-548ai	CLIP-seq
MIRT2284915	hsa-miR-548v	CLIP-seq
MIRT1194223	hsa-miR-556-5p	CLIP-seq
MIRT2284916	hsa-miR-561	CLIP-seq
MIRT2284917	hsa-miR-624	CLIP-seq
MIRT2284918	hsa-miR-652	CLIP-seq
MIRT2284919	hsa-miR-664	CLIP-seq
MIRT2284920	hsa-miR-762	CLIP-seq
MIRT2455466	hsa-miR-4251	CLIP-seq
MIRT2455467	hsa-miR-4303	CLIP-seq
MIRT2455468	hsa-miR-4329	CLIP-seq
MIRT2455469	hsa-miR-539	CLIP-seq
MIRT2455470	hsa-miR-548aa	CLIP-seq
MIRT2455471	hsa-miR-548ac	CLIP-seq
MIRT2455472	hsa-miR-548d-3p	CLIP-seq
MIRT2455473	hsa-miR-548z	CLIP-seq
MIRT2455471	hsa-miR-548ac	CLIP-seq
MIRT2455472	hsa-miR-548d-3p	CLIP-seq
MIRT2455473	hsa-miR-548z	CLIP-seq
MIRT2686581	hsa-miR-653	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IBA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
300791	25391	ENSG00000123572

Q7Z2Y5

Protein name

Nik-related protein kinase (EC 2.7.11.1)

Protein function

May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	25 → 313	Protein kinase domain	Domain
PF00780	CNH	1213 → 1549	CNH domain	Family

Sequence

MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK
TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG
QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG
QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV
WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF
RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR
FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQ
ALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMP
LQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQGQAPEQQQ
RHNQVPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRVNAQVFLPLLSQDHHVLL
PLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLSRDLLRAPNSNNSKPLG
PLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPKRFRAKSSWRPEKLELSDL
EARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHSIQAEVQIEPLKPYISNPK
KIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDIRQRSSQNRQNWLAASESS
SEEESPVTGRRSQSSPPYSTIDQKLLVDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIF
RNDWLTPAPVIQPPEEDGDYVELYDASADTDGDDDDESNDTFEDTYDHANGNDDLDNQVD
QANDVCKDHDDDNNKFVDDVNNNYYEAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYG
SHTANRSHGGSAASEDNAAIGDQEEHAANIGSERRGSEGDGGKGVVRTSEESGALGLNGE
ENCSETDGPGLKRPASQDFEYLQEEPGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQ
SDFSANHSSPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPL
IHMYEKEFTSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLN
LLITISGHKNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVL
QHEETTYIAIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQ
AADPVNRFKRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAES
EVMSDVTLPKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDI
PSSIAFECTQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRN
HHSRVYFMTLGKLEELQSNYDV

Sequence length

1582

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISTIC DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (29)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of large intestine	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	BEFREE	2891388		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	32162334	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervical Intraepithelial Neoplasia	Cervical Intraepithelial Neoplasia	BEFREE	30796317		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	29920359, 30716432, 31545926		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	29710508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	29689570		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	30847937		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	30847937		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	30826930		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	30287505, 30899370, 31163124, 31410746		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary gingival fibromatosis	Hereditary Gingival Fibromatosis	BEFREE	29115510		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	28700904, 31135219		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypermobility syndrome	Hypermobility Syndrome	GENOMICS_ENGLAND_DG	21834033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperoxaluria	Hyperoxaluria	BEFREE	31135219, 31489770		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperplasia	Hyperplasia	Pubtator	32162334	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infiltrating duct carcinoma of female breast	Infiltrating Duct Carcinoma Of Female Breast	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Calculi	Kidney stone	BEFREE	29054323		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	31191310		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure, Acute	Kidney Failure	BEFREE	28487950, 30180910, 30716432, 31216555, 31601792		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	2891388		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephrolithiasis	Nephrolithiasis	BEFREE	29054323		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic hyperplasia	Pubtator	38459501	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	29689570		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal fibrosis	Renal fibrosis	BEFREE	17531120, 27874055, 27988328, 28805491, 29530599, 29771425, 31127625, 31410746		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Insufficiency	Renal Insufficiency	BEFREE	30763685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	30680694		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sotos` syndrome	Sotos` Syndrome	GENOMICS_ENGLAND_DG	21834033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	30175120	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

NRK (Nik related kinase)