Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	203100
Gene name	HtrA serine peptidase 4
Gene symbol	HTRA4
Synonyms (NCBI Gene)	-
Chromosome	8
Chromosome location	8p11.22
Summary	This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies o

108

Show/Hide all (108)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017453	hsa-miR-335-5p	Microarray	18185580
MIRT021941	hsa-miR-128-3p	Microarray	17612493
MIRT025641	hsa-miR-7-5p	Microarray	17612493
MIRT1057381	hsa-miR-1185	CLIP-seq
MIRT1057382	hsa-miR-135a	CLIP-seq
MIRT1057383	hsa-miR-135b	CLIP-seq
MIRT1057384	hsa-miR-140-3p	CLIP-seq
MIRT1057385	hsa-miR-153	CLIP-seq
MIRT1057386	hsa-miR-2117	CLIP-seq
MIRT1057387	hsa-miR-3156-3p	CLIP-seq
MIRT738586	hsa-miR-3180-5p	CLIP-seq
MIRT1057388	hsa-miR-3605-5p	CLIP-seq
MIRT1057389	hsa-miR-3679-5p	CLIP-seq
MIRT738585	hsa-miR-4267	CLIP-seq
MIRT1057390	hsa-miR-4273	CLIP-seq
MIRT1057391	hsa-miR-4289	CLIP-seq
MIRT1057392	hsa-miR-4301	CLIP-seq
MIRT1057393	hsa-miR-4663	CLIP-seq
MIRT1057394	hsa-miR-532-3p	CLIP-seq
MIRT1057395	hsa-miR-604	CLIP-seq
MIRT1057396	hsa-miR-628-5p	CLIP-seq
MIRT1057397	hsa-miR-647	CLIP-seq
MIRT738586	hsa-miR-3180-5p	CLIP-seq
MIRT738585	hsa-miR-4267	CLIP-seq
MIRT738584	hsa-miR-4716-5p	CLIP-seq
MIRT1057381	hsa-miR-1185	CLIP-seq
MIRT2013106	hsa-miR-1271	CLIP-seq
MIRT2013107	hsa-miR-146a	CLIP-seq
MIRT2013108	hsa-miR-146b-5p	CLIP-seq
MIRT2013109	hsa-miR-182	CLIP-seq
MIRT2013110	hsa-miR-3130-3p	CLIP-seq
MIRT1057387	hsa-miR-3156-3p	CLIP-seq
MIRT738586	hsa-miR-3180-5p	CLIP-seq
MIRT1057388	hsa-miR-3605-5p	CLIP-seq
MIRT1057389	hsa-miR-3679-5p	CLIP-seq
MIRT2013111	hsa-miR-3945	CLIP-seq
MIRT2013112	hsa-miR-4253	CLIP-seq
MIRT738585	hsa-miR-4267	CLIP-seq
MIRT1057392	hsa-miR-4301	CLIP-seq
MIRT1057393	hsa-miR-4663	CLIP-seq
MIRT2013113	hsa-miR-4705	CLIP-seq
MIRT738584	hsa-miR-4716-5p	CLIP-seq
MIRT1057394	hsa-miR-532-3p	CLIP-seq
MIRT2013114	hsa-miR-589	CLIP-seq
MIRT2013115	hsa-miR-616	CLIP-seq
MIRT2013116	hsa-miR-622	CLIP-seq
MIRT1057396	hsa-miR-628-5p	CLIP-seq
MIRT2013117	hsa-miR-659	CLIP-seq
MIRT2013118	hsa-miR-96	CLIP-seq
MIRT1057381	hsa-miR-1185	CLIP-seq
MIRT1057382	hsa-miR-135a	CLIP-seq
MIRT1057383	hsa-miR-135b	CLIP-seq
MIRT2013107	hsa-miR-146a	CLIP-seq
MIRT2013108	hsa-miR-146b-5p	CLIP-seq
MIRT1057385	hsa-miR-153	CLIP-seq
MIRT2245400	hsa-miR-1539	CLIP-seq
MIRT2245401	hsa-miR-199a-5p	CLIP-seq
MIRT2245402	hsa-miR-199b-5p	CLIP-seq
MIRT2245403	hsa-miR-3074-5p	CLIP-seq
MIRT2245404	hsa-miR-3140-3p	CLIP-seq
MIRT1057387	hsa-miR-3156-3p	CLIP-seq
MIRT2245405	hsa-miR-3161	CLIP-seq
MIRT2245406	hsa-miR-3193	CLIP-seq
MIRT2245407	hsa-miR-338-3p	CLIP-seq
MIRT1057388	hsa-miR-3605-5p	CLIP-seq
MIRT1057389	hsa-miR-3679-5p	CLIP-seq
MIRT2245408	hsa-miR-3940-5p	CLIP-seq
MIRT2013111	hsa-miR-3945	CLIP-seq
MIRT2013112	hsa-miR-4253	CLIP-seq
MIRT1057391	hsa-miR-4289	CLIP-seq
MIRT1057392	hsa-miR-4301	CLIP-seq
MIRT2245409	hsa-miR-4302	CLIP-seq
MIRT2245410	hsa-miR-4326	CLIP-seq
MIRT2245411	hsa-miR-4455	CLIP-seq
MIRT2245412	hsa-miR-4507	CLIP-seq
MIRT2245413	hsa-miR-4652-3p	CLIP-seq
MIRT1057393	hsa-miR-4663	CLIP-seq
MIRT2245414	hsa-miR-4694-5p	CLIP-seq
MIRT2245415	hsa-miR-4755-3p	CLIP-seq
MIRT1057394	hsa-miR-532-3p	CLIP-seq
MIRT2245416	hsa-miR-586	CLIP-seq
MIRT2013114	hsa-miR-589	CLIP-seq
MIRT1057395	hsa-miR-604	CLIP-seq
MIRT2245417	hsa-miR-609	CLIP-seq
MIRT2013115	hsa-miR-616	CLIP-seq
MIRT1057396	hsa-miR-628-5p	CLIP-seq
MIRT1057397	hsa-miR-647	CLIP-seq
MIRT2013117	hsa-miR-659	CLIP-seq
MIRT738584	hsa-miR-4716-5p	CLIP-seq
MIRT2245401	hsa-miR-199a-5p	CLIP-seq
MIRT2245402	hsa-miR-199b-5p	CLIP-seq
MIRT2245409	hsa-miR-4302	CLIP-seq
MIRT2245415	hsa-miR-4755-3p	CLIP-seq
MIRT2245401	hsa-miR-199a-5p	CLIP-seq
MIRT2245402	hsa-miR-199b-5p	CLIP-seq
MIRT2245409	hsa-miR-4302	CLIP-seq
MIRT2245415	hsa-miR-4755-3p	CLIP-seq
MIRT2245401	hsa-miR-199a-5p	CLIP-seq
MIRT2245402	hsa-miR-199b-5p	CLIP-seq
MIRT2245409	hsa-miR-4302	CLIP-seq
MIRT2245415	hsa-miR-4755-3p	CLIP-seq
MIRT2013107	hsa-miR-146a	CLIP-seq
MIRT2013108	hsa-miR-146b-5p	CLIP-seq
MIRT2245401	hsa-miR-199a-5p	CLIP-seq
MIRT2245402	hsa-miR-199b-5p	CLIP-seq
MIRT2245409	hsa-miR-4302	CLIP-seq
MIRT2245415	hsa-miR-4755-3p	CLIP-seq
MIRT2013114	hsa-miR-589	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IDA	18387192
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	25002585, 31036715, 31470122
GO:0005576	Component	Extracellular region	IEA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IDA	18387192
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0012501	Process	Programmed cell death	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	ISS
GO:0042802	Function	Identical protein binding	IPI	25002585, 31036715, 31470122
GO:0043065	Process	Positive regulation of apoptotic process	IBA

MIM	HGNC	e!Ensembl
610700	26909	ENSG00000169495

P83105

Protein name

Serine protease HTRA4 (EC 3.4.21.-) (High-temperature requirement factor A4)

Protein function

Serine protease.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00219	IGFBP	40 → 94	Insulin-like growth factor binding protein	Domain
PF07648	Kazal_2	103 → 152	Kazal-type serine protease inhibitor domain	Domain
PF13365	Trypsin_2	202 → 340		Domain
PF13180	PDZ_2	379 → 471	PDZ domain	Domain

Sequence

MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTT
PVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDR
RTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPS
VVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVV
KDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQR
GGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQ
FLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTA
AQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN

Sequence length

476

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Brain Neoplasms	Brain Neoplasms	BEFREE	31546993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	31546993	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31546993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31546993	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	31546993	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cutaneous Mastocytosis	Cutaneous mastocytosis	BEFREE	30148508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eclampsia	Eclampsia	BEFREE	22964307		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31546993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31546993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31546993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mastocytosis Cutaneous	Mastocytosis	Pubtator	30148508	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HTRA4 (HtrA serine peptidase 4)