Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	201562
Gene name	3-hydroxyacyl-CoA dehydratase 2
Gene symbol	HACD2
Synonyms (NCBI Gene)	PTPLB
Chromosome	3
Chromosome location	3q21.1
Summary	The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. [provided by RefSeq, Jul 2016]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT700532	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT700531	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT700530	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT700529	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT700528	hsa-miR-205-3p	HITS-CLIP	23313552
MIRT700527	hsa-miR-4762-5p	HITS-CLIP	23313552
MIRT700526	hsa-miR-6501-3p	HITS-CLIP	23313552
MIRT700525	hsa-miR-4514	HITS-CLIP	23313552
MIRT700524	hsa-miR-4692	HITS-CLIP	23313552
MIRT700523	hsa-miR-4645-5p	HITS-CLIP	23313552
MIRT700522	hsa-miR-4673	HITS-CLIP	23313552
MIRT700521	hsa-miR-3671	HITS-CLIP	23313552
MIRT700520	hsa-miR-607	HITS-CLIP	23313552
MIRT508907	hsa-miR-2392	PAR-CLIP	23446348
MIRT508905	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508906	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508904	hsa-miR-940	PAR-CLIP	23446348
MIRT521572	hsa-miR-3929	PAR-CLIP	23446348
MIRT521571	hsa-miR-4419b	PAR-CLIP	23446348
MIRT521570	hsa-miR-4478	PAR-CLIP	23446348
MIRT508903	hsa-miR-4459	PAR-CLIP	23446348
MIRT521569	hsa-miR-1247-3p	PAR-CLIP	23446348
MIRT508902	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT508901	hsa-miR-3605-5p	PAR-CLIP	23446348
MIRT508900	hsa-miR-1827	PAR-CLIP	23446348
MIRT521568	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT521567	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT521566	hsa-miR-6134	PAR-CLIP	23446348
MIRT508899	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT521565	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT508898	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT521564	hsa-miR-3689d	PAR-CLIP	23446348
MIRT521563	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT521562	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT521561	hsa-miR-6880-5p	PAR-CLIP	23446348
MIRT521560	hsa-miR-665	PAR-CLIP	23446348
MIRT508907	hsa-miR-2392	PAR-CLIP	23446348
MIRT508905	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508906	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508904	hsa-miR-940	PAR-CLIP	23446348
MIRT508903	hsa-miR-4459	PAR-CLIP	23446348
MIRT508902	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT508901	hsa-miR-3605-5p	PAR-CLIP	23446348
MIRT508900	hsa-miR-1827	PAR-CLIP	23446348
MIRT508899	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT508898	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT470016	hsa-miR-1205	PAR-CLIP	23592263
MIRT470015	hsa-miR-6132	PAR-CLIP	23592263
MIRT470014	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT470013	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT470012	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT470011	hsa-miR-3148	PAR-CLIP	23592263
MIRT470010	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT470009	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT470008	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT470007	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT470006	hsa-miR-5698	PAR-CLIP	23592263
MIRT470005	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT470004	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT470003	hsa-miR-4525	PAR-CLIP	23592263
MIRT470002	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT470001	hsa-miR-1275	PAR-CLIP	23592263
MIRT470000	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT740767	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT740768	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT740769	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT740770	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT740771	hsa-miR-205-3p	HITS-CLIP	23313552
MIRT740772	hsa-miR-4762-5p	HITS-CLIP	23313552
MIRT740773	hsa-miR-6501-3p	HITS-CLIP	23313552
MIRT740774	hsa-miR-4514	HITS-CLIP	23313552
MIRT740775	hsa-miR-4692	HITS-CLIP	23313552
MIRT740776	hsa-miR-4645-5p	HITS-CLIP	23313552
MIRT740777	hsa-miR-4673	HITS-CLIP	23313552
MIRT740778	hsa-miR-3671	HITS-CLIP	23313552
MIRT740779	hsa-miR-607	HITS-CLIP	23313552
MIRT754605	hsa-miR-2392	PAR-CLIP	23446348
MIRT754606	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT754607	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT754608	hsa-miR-940	PAR-CLIP	23446348
MIRT754609	hsa-miR-3929	PAR-CLIP	23446348
MIRT754610	hsa-miR-4419b	PAR-CLIP	23446348
MIRT754611	hsa-miR-4478	PAR-CLIP	23446348
MIRT754612	hsa-miR-4459	PAR-CLIP	23446348
MIRT754613	hsa-miR-1247-3p	PAR-CLIP	23446348
MIRT754614	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT754615	hsa-miR-3605-5p	PAR-CLIP	23446348
MIRT754616	hsa-miR-1827	PAR-CLIP	23446348
MIRT754617	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT754618	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT754619	hsa-miR-6134	PAR-CLIP	23446348
MIRT754620	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT754621	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT754622	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT754623	hsa-miR-3689d	PAR-CLIP	23446348
MIRT754624	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT754625	hsa-miR-6799-5p	PAR-CLIP	23446348
MIRT754626	hsa-miR-6880-5p	PAR-CLIP	23446348
MIRT754627	hsa-miR-665	PAR-CLIP	23446348
MIRT754605	hsa-miR-2392	PAR-CLIP	23446348
MIRT754606	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT754607	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT754608	hsa-miR-940	PAR-CLIP	23446348
MIRT754612	hsa-miR-4459	PAR-CLIP	23446348
MIRT754614	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT754615	hsa-miR-3605-5p	PAR-CLIP	23446348
MIRT754616	hsa-miR-1827	PAR-CLIP	23446348
MIRT754620	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT754622	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT755110	hsa-miR-1205	PAR-CLIP	23592263
MIRT755111	hsa-miR-6132	PAR-CLIP	23592263
MIRT755112	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT755113	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT755114	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT755115	hsa-miR-3148	PAR-CLIP	23592263
MIRT755116	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT755117	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT755118	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT755119	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT755120	hsa-miR-5698	PAR-CLIP	23592263
MIRT755121	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT755122	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT755123	hsa-miR-4525	PAR-CLIP	23592263
MIRT755124	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT755125	hsa-miR-1275	PAR-CLIP	23592263
MIRT755126	hsa-miR-4665-5p	PAR-CLIP	23592263

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004725	Function	Protein tyrosine phosphatase activity	IMP	15024066
GO:0005515	Function	Protein binding	IPI	15024066, 25416956, 30021884, 32296183, 38422897
GO:0005783	Component	Endoplasmic reticulum	IDA	15024066, 18554506
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0018812	Function	3-hydroxyacyl-CoA dehydratase activity	EXP	18554506
GO:0018812	Function	3-hydroxyacyl-CoA dehydratase activity	IBA
GO:0019899	Function	Enzyme binding	IDA	18554506
GO:0030148	Process	Sphingolipid biosynthetic process	IBA
GO:0030148	Process	Sphingolipid biosynthetic process	IGI	18554506
GO:0030497	Process	Fatty acid elongation	IBA
GO:0030497	Process	Fatty acid elongation	IDA	18554506
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IBA
GO:0042761	Process	Very long-chain fatty acid biosynthetic process	IDA	18554506
GO:0102158	Function	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	IDA	18554506
GO:0102158	Function	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	IEA

MIM	HGNC	e!Ensembl
615939	9640	ENSG00000206527

Q6Y1H2

Protein name

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 2) (HACD2) (Protein-tyrosine phosphatase-like member B)

Protein function

Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04387	PTPLA	85 → 246	Protein tyrosine phosphatase-like protein, PTPLA	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis, spleen, prostate, colon and heart, followed by moderate expression in thymus, ovary, small intestine, peripheral blood leukocytes, liver, skeletal muscle and pancreas. Weakly detected in kidney, placenta, br

Sequence

MAAVAATAAAKGNGGGGGRAGAGDASGTRKKKGPGPLATAYLVIYNVVMTAGWLVIAVGL
VRAYLAKGSYHSLYYSIEKPLKFFQTGALLEILHCAIGIVPSSVVLTSFQVMSRVFLIWA
VTHSVKEVQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYLIKWARYTLFIVLYPMGV
SGELLTIYAALPFVRQAGLYSISLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHMIHQR
RKILSHTEEHKKFE

Sequence length

254

Interactions

View interactions

	KEGG		Reactome
	Fatty acid elongation Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism		Synthesis of very long-chain fatty acyl-CoAs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37181808	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	24214394	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HACD2 (3-hydroxyacyl-CoA dehydratase 2)