Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	201176
Gene name	Rho GTPase activating protein 27
Gene symbol	ARHGAP27
Synonyms (NCBI Gene)	CAMGAP1PP905SH3D20SH3P20
Chromosome	17
Chromosome location	17q21.31
Summary	This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding mult

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Show/Hide all (145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT720657	hsa-miR-1908-3p	HITS-CLIP	19536157
MIRT720656	hsa-miR-4632-3p	HITS-CLIP	19536157
MIRT720655	hsa-miR-1199-3p	HITS-CLIP	19536157
MIRT526006	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT526005	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT526004	hsa-miR-500b-3p	PAR-CLIP	22012620
MIRT526003	hsa-miR-589-3p	PAR-CLIP	22012620
MIRT526002	hsa-miR-1324	PAR-CLIP	22012620
MIRT526001	hsa-miR-4726-3p	PAR-CLIP	22012620
MIRT526000	hsa-miR-198	PAR-CLIP	22012620
MIRT720657	hsa-miR-1908-3p	HITS-CLIP	19536157
MIRT720656	hsa-miR-4632-3p	HITS-CLIP	19536157
MIRT720655	hsa-miR-1199-3p	HITS-CLIP	19536157
MIRT526006	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT526005	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT526004	hsa-miR-500b-3p	PAR-CLIP	22012620
MIRT526003	hsa-miR-589-3p	PAR-CLIP	22012620
MIRT526002	hsa-miR-1324	PAR-CLIP	22012620
MIRT526001	hsa-miR-4726-3p	PAR-CLIP	22012620
MIRT526000	hsa-miR-198	PAR-CLIP	22012620
MIRT794316	hsa-miR-1285	CLIP-seq
MIRT794317	hsa-miR-2115	CLIP-seq
MIRT794318	hsa-miR-3187-5p	CLIP-seq
MIRT794319	hsa-miR-326	CLIP-seq
MIRT794320	hsa-miR-330-5p	CLIP-seq
MIRT794321	hsa-miR-378g	CLIP-seq
MIRT794322	hsa-miR-4270	CLIP-seq
MIRT794323	hsa-miR-4300	CLIP-seq
MIRT794324	hsa-miR-4441	CLIP-seq
MIRT794325	hsa-miR-4486	CLIP-seq
MIRT794326	hsa-miR-4685-5p	CLIP-seq
MIRT794327	hsa-miR-4715-3p	CLIP-seq
MIRT794328	hsa-miR-612	CLIP-seq
MIRT794329	hsa-miR-920	CLIP-seq
MIRT794330	hsa-miR-1228	CLIP-seq
MIRT794331	hsa-miR-1234	CLIP-seq
MIRT794332	hsa-miR-125a-5p	CLIP-seq
MIRT794333	hsa-miR-125b	CLIP-seq
MIRT794334	hsa-miR-224	CLIP-seq
MIRT794335	hsa-miR-24	CLIP-seq
MIRT794336	hsa-miR-2467-5p	CLIP-seq
MIRT794337	hsa-miR-298	CLIP-seq
MIRT794338	hsa-miR-3133	CLIP-seq
MIRT794339	hsa-miR-3150a-3p	CLIP-seq
MIRT794340	hsa-miR-3162-3p	CLIP-seq
MIRT794341	hsa-miR-3175	CLIP-seq
MIRT794342	hsa-miR-3179	CLIP-seq
MIRT794343	hsa-miR-3202	CLIP-seq
MIRT794344	hsa-miR-3679-3p	CLIP-seq
MIRT794345	hsa-miR-4259	CLIP-seq
MIRT794346	hsa-miR-4269	CLIP-seq
MIRT794347	hsa-miR-4290	CLIP-seq
MIRT794348	hsa-miR-4319	CLIP-seq
MIRT794349	hsa-miR-4425	CLIP-seq
MIRT794350	hsa-miR-4446-5p	CLIP-seq
MIRT794351	hsa-miR-4459	CLIP-seq
MIRT794352	hsa-miR-4511	CLIP-seq
MIRT794353	hsa-miR-4514	CLIP-seq
MIRT794354	hsa-miR-4525	CLIP-seq
MIRT794355	hsa-miR-4687-5p	CLIP-seq
MIRT794356	hsa-miR-4692	CLIP-seq
MIRT794357	hsa-miR-4722-5p	CLIP-seq
MIRT794358	hsa-miR-4732-3p	CLIP-seq
MIRT794359	hsa-miR-4742-5p	CLIP-seq
MIRT794360	hsa-miR-4747-5p	CLIP-seq
MIRT794361	hsa-miR-4766-5p	CLIP-seq
MIRT794362	hsa-miR-571	CLIP-seq
MIRT794363	hsa-miR-670	CLIP-seq
MIRT794364	hsa-miR-671-5p	CLIP-seq
MIRT794365	hsa-miR-939	CLIP-seq
MIRT794366	hsa-miR-940	CLIP-seq
MIRT1934407	hsa-miR-1207-3p	CLIP-seq
MIRT1934408	hsa-miR-1252	CLIP-seq
MIRT794332	hsa-miR-125a-5p	CLIP-seq
MIRT794333	hsa-miR-125b	CLIP-seq
MIRT1934409	hsa-miR-2110	CLIP-seq
MIRT794334	hsa-miR-224	CLIP-seq
MIRT1934410	hsa-miR-2355-5p	CLIP-seq
MIRT1934411	hsa-miR-23a	CLIP-seq
MIRT1934412	hsa-miR-23b	CLIP-seq
MIRT1934413	hsa-miR-23c	CLIP-seq
MIRT1934414	hsa-miR-3127-5p	CLIP-seq
MIRT1934415	hsa-miR-3136-3p	CLIP-seq
MIRT794339	hsa-miR-3150a-3p	CLIP-seq
MIRT1934416	hsa-miR-3152-5p	CLIP-seq
MIRT794341	hsa-miR-3175	CLIP-seq
MIRT794342	hsa-miR-3179	CLIP-seq
MIRT794343	hsa-miR-3202	CLIP-seq
MIRT794345	hsa-miR-4259	CLIP-seq
MIRT1934417	hsa-miR-4271	CLIP-seq
MIRT1934418	hsa-miR-4297	CLIP-seq
MIRT794348	hsa-miR-4319	CLIP-seq
MIRT794349	hsa-miR-4425	CLIP-seq
MIRT794350	hsa-miR-4446-5p	CLIP-seq
MIRT794351	hsa-miR-4459	CLIP-seq
MIRT1934419	hsa-miR-450b-5p	CLIP-seq
MIRT794353	hsa-miR-4514	CLIP-seq
MIRT794354	hsa-miR-4525	CLIP-seq
MIRT1934420	hsa-miR-4649-3p	CLIP-seq
MIRT794356	hsa-miR-4692	CLIP-seq
MIRT1934421	hsa-miR-4725-3p	CLIP-seq
MIRT794358	hsa-miR-4732-3p	CLIP-seq
MIRT794360	hsa-miR-4747-5p	CLIP-seq
MIRT1934422	hsa-miR-4755-5p	CLIP-seq
MIRT1934423	hsa-miR-4774-3p	CLIP-seq
MIRT1934424	hsa-miR-507	CLIP-seq
MIRT1934425	hsa-miR-518a-5p	CLIP-seq
MIRT1934426	hsa-miR-527	CLIP-seq
MIRT1934427	hsa-miR-544b	CLIP-seq
MIRT1934428	hsa-miR-557	CLIP-seq
MIRT794362	hsa-miR-571	CLIP-seq
MIRT1934429	hsa-miR-642a	CLIP-seq
MIRT794363	hsa-miR-670	CLIP-seq
MIRT794365	hsa-miR-939	CLIP-seq
MIRT2174216	hsa-miR-1193	CLIP-seq
MIRT2174217	hsa-miR-1293	CLIP-seq
MIRT1934409	hsa-miR-2110	CLIP-seq
MIRT1934411	hsa-miR-23a	CLIP-seq
MIRT1934412	hsa-miR-23b	CLIP-seq
MIRT1934413	hsa-miR-23c	CLIP-seq
MIRT2174218	hsa-miR-3065-3p	CLIP-seq
MIRT794338	hsa-miR-3133	CLIP-seq
MIRT2174219	hsa-miR-3650	CLIP-seq
MIRT2174220	hsa-miR-3654	CLIP-seq
MIRT2174221	hsa-miR-3680	CLIP-seq
MIRT1934417	hsa-miR-4271	CLIP-seq
MIRT2174222	hsa-miR-4314	CLIP-seq
MIRT2174223	hsa-miR-4483	CLIP-seq
MIRT1934419	hsa-miR-450b-5p	CLIP-seq
MIRT794352	hsa-miR-4511	CLIP-seq
MIRT2174224	hsa-miR-4535	CLIP-seq
MIRT2174225	hsa-miR-4536	CLIP-seq
MIRT2174226	hsa-miR-4667-5p	CLIP-seq
MIRT2174227	hsa-miR-4700-5p	CLIP-seq
MIRT1934421	hsa-miR-4725-3p	CLIP-seq
MIRT2174228	hsa-miR-4747-3p	CLIP-seq
MIRT794361	hsa-miR-4766-5p	CLIP-seq
MIRT2174229	hsa-miR-492	CLIP-seq
MIRT1934424	hsa-miR-507	CLIP-seq
MIRT1934425	hsa-miR-518a-5p	CLIP-seq
MIRT1934426	hsa-miR-527	CLIP-seq
MIRT2174230	hsa-miR-548q	CLIP-seq
MIRT1934428	hsa-miR-557	CLIP-seq
MIRT2174231	hsa-miR-637	CLIP-seq
MIRT2174232	hsa-miR-668	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	ISS
GO:0005096	Function	GTPase activator activity	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IBA
GO:0007266	Process	Rho protein signal transduction	ISS
GO:0016020	Component	Membrane	IEA
GO:0017124	Function	SH3 domain binding	ISS
GO:0051015	Function	Actin filament binding	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051291	Process	Protein heterooligomerization	IEA

MIM	HGNC	e!Ensembl
610591	31813	ENSG00000159314

Q6ZUM4

Protein name

Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20)

Protein function

Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000

PDB

3PP2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00397	WW	248 → 278	WW domain	Domain
PF00397	WW	301 → 330	WW domain	Domain
PF00169	PH	497 → 612	PH domain	Domain
PF00620	RhoGAP	711 → 863	RhoGAP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer. {ECO:0000269|PubMed:15492870}.

Sequence

MAADVVGDVYVLVEHPFEYTGKDGRRVAIRPNERYRLLRRSTEHWWHVRREPGGRPFYLP
AQYVRELPALGNPAAAAPPGPHPSPAAPEPLAYDYRFVSAAATAGPDGAPEESGGRASSL
CGPAQRGAATQRSSLAPGLPACLYLRPAAPVRPAQSLNDLACAAVSPPAGLLGSSGSFKA
CSVAGSWVCPRPLARSDSENVYEVIQDLHVPPPEESAEQVDDPPEPVYANIERQPRATSP
GAAAAPLPSPVWETHTDAGTGRPYYYNPDTGVTTWESPFEAAEGAASPATSPASVDSHVS
LETEWGQYWDEESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPE
TDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRL
EDPHGKPYFYNPEDSSVRWELPQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVG
SWEEVSPATAAVRTKTLDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKT
SAAGGLRQPSKFSTPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAII
STWHKAIAQGIQELSAELPPEESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGL
ESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRA
VEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPE
PLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNR
MSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIFPPH

Sequence length

889

Interactions

View interactions

	Reactome
			Rho GTPase cycle

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERICARDITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	39514479	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	GWASCAT_DG	29059683		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	23535648, 30559148	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	23535648		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	23535648		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23832679		★★★★★ ★☆☆☆☆ Found in Text Mining only

ARHGAP27 (Rho GTPase activating protein 27)