PLD6 (phospholipase D family member 6)

Gene

• Entrez ID: 201164
• Gene name: Phospholipase D family member 6
• Gene symbol: PLD6
• Synonyms (NCBI Gene): ZUC
• Chromosome: 17
• Chromosome location: 17p11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042096	hsa-miR-484	CLASH	23622248
MIRT637597	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT637596	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT637595	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT637594	hsa-miR-4795-5p	HITS-CLIP	23824327
MIRT637593	hsa-miR-6087	HITS-CLIP	23824327
MIRT637592	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT637591	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT637590	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT637589	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT637588	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT637587	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT637586	hsa-miR-7977	HITS-CLIP	23824327
MIRT637585	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT637584	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT637583	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT637582	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT637581	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT637580	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT637579	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT637578	hsa-miR-3689c	HITS-CLIP	23824327
MIRT637577	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT637576	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT637575	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT637574	hsa-miR-3122	HITS-CLIP	23824327
MIRT637573	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT637572	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT637571	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT489564	hsa-miR-589-3p	PAR-CLIP	23592263
MIRT489563	hsa-miR-1470	PAR-CLIP	23592263
MIRT489562	hsa-miR-4667-3p	PAR-CLIP	23592263
MIRT489561	hsa-miR-4469	PAR-CLIP	23592263
MIRT489560	hsa-miR-7113-3p	PAR-CLIP	23592263
MIRT489559	hsa-miR-4287	PAR-CLIP	23592263
MIRT489558	hsa-miR-4685-3p	PAR-CLIP	23592263
MIRT489557	hsa-miR-6867-3p	PAR-CLIP	23592263
MIRT637597	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT637596	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT637595	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT637594	hsa-miR-4795-5p	HITS-CLIP	23824327
MIRT637593	hsa-miR-6087	HITS-CLIP	23824327
MIRT637592	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT637591	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT637590	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT637589	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT637588	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT637587	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT637586	hsa-miR-7977	HITS-CLIP	23824327
MIRT637585	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT637584	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT637583	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT637582	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT637581	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT637580	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT637579	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT637578	hsa-miR-3689c	HITS-CLIP	23824327
MIRT637577	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT637576	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT637575	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT637574	hsa-miR-3122	HITS-CLIP	23824327
MIRT637573	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT637572	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT637571	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT489564	hsa-miR-589-3p	PAR-CLIP	23592263
MIRT489563	hsa-miR-1470	PAR-CLIP	23592263
MIRT489562	hsa-miR-4667-3p	PAR-CLIP	23592263
MIRT489561	hsa-miR-4469	PAR-CLIP	23592263
MIRT489560	hsa-miR-7113-3p	PAR-CLIP	23592263
MIRT489559	hsa-miR-4287	PAR-CLIP	23592263
MIRT489558	hsa-miR-4685-3p	PAR-CLIP	23592263
MIRT489557	hsa-miR-6867-3p	PAR-CLIP	23592263
MIRT1240329	hsa-miR-10a	CLIP-seq
MIRT1240330	hsa-miR-10b	CLIP-seq
MIRT1240331	hsa-miR-1207-5p	CLIP-seq
MIRT1240332	hsa-miR-1227	CLIP-seq
MIRT1240333	hsa-miR-1248	CLIP-seq
MIRT1240334	hsa-miR-1271	CLIP-seq
MIRT1240335	hsa-miR-1286	CLIP-seq
MIRT1240336	hsa-miR-141	CLIP-seq
MIRT1240337	hsa-miR-182	CLIP-seq
MIRT1240338	hsa-miR-1827	CLIP-seq
MIRT1240339	hsa-miR-1910	CLIP-seq
MIRT1240340	hsa-miR-194	CLIP-seq
MIRT1240341	hsa-miR-200a	CLIP-seq
MIRT1240342	hsa-miR-204	CLIP-seq
MIRT1240343	hsa-miR-211	CLIP-seq
MIRT1240344	hsa-miR-3124-3p	CLIP-seq
MIRT1240345	hsa-miR-3148	CLIP-seq
MIRT1240346	hsa-miR-3157-5p	CLIP-seq
MIRT1240347	hsa-miR-3187-3p	CLIP-seq
MIRT1240348	hsa-miR-339-5p	CLIP-seq
MIRT1240349	hsa-miR-3613-3p	CLIP-seq
MIRT1240350	hsa-miR-3685	CLIP-seq
MIRT1240351	hsa-miR-3688-5p	CLIP-seq
MIRT1240352	hsa-miR-384	CLIP-seq
MIRT1240353	hsa-miR-3929	CLIP-seq
MIRT1240354	hsa-miR-3934	CLIP-seq
MIRT1240355	hsa-miR-425	CLIP-seq
MIRT1240356	hsa-miR-4252	CLIP-seq
MIRT1240357	hsa-miR-4419b	CLIP-seq
MIRT1240358	hsa-miR-4421	CLIP-seq
MIRT1240359	hsa-miR-4436a	CLIP-seq
MIRT1240360	hsa-miR-4446-5p	CLIP-seq
MIRT1240361	hsa-miR-4470	CLIP-seq
MIRT1240362	hsa-miR-4474-3p	CLIP-seq
MIRT1240363	hsa-miR-4478	CLIP-seq
MIRT1240364	hsa-miR-451b	CLIP-seq
MIRT1240365	hsa-miR-4529-5p	CLIP-seq
MIRT1240366	hsa-miR-4537	CLIP-seq
MIRT1240367	hsa-miR-455-3p	CLIP-seq
MIRT1240368	hsa-miR-4633-3p	CLIP-seq
MIRT1240369	hsa-miR-4640-5p	CLIP-seq
MIRT1240370	hsa-miR-4649-3p	CLIP-seq
MIRT1240371	hsa-miR-4670-3p	CLIP-seq
MIRT1240372	hsa-miR-4677-3p	CLIP-seq
MIRT1240373	hsa-miR-4684-5p	CLIP-seq
MIRT1240374	hsa-miR-4691-3p	CLIP-seq
MIRT1240375	hsa-miR-4726-5p	CLIP-seq
MIRT1240376	hsa-miR-4736	CLIP-seq
MIRT1240377	hsa-miR-4742-3p	CLIP-seq
MIRT1240378	hsa-miR-4755-5p	CLIP-seq
MIRT1240379	hsa-miR-4763-3p	CLIP-seq
MIRT1240380	hsa-miR-4793-3p	CLIP-seq
MIRT1240381	hsa-miR-4797-5p	CLIP-seq
MIRT1240382	hsa-miR-485-5p	CLIP-seq
MIRT1240383	hsa-miR-508-5p	CLIP-seq
MIRT1240384	hsa-miR-513a-3p	CLIP-seq
MIRT1240385	hsa-miR-548a-5p	CLIP-seq
MIRT1240386	hsa-miR-548ab	CLIP-seq
MIRT1240387	hsa-miR-548ak	CLIP-seq
MIRT1240388	hsa-miR-548b-5p	CLIP-seq
MIRT1240389	hsa-miR-548c-3p	CLIP-seq
MIRT1240390	hsa-miR-548c-5p	CLIP-seq
MIRT1240391	hsa-miR-548d-5p	CLIP-seq
MIRT1240392	hsa-miR-548h	CLIP-seq
MIRT1240393	hsa-miR-548i	CLIP-seq
MIRT1240394	hsa-miR-548j	CLIP-seq
MIRT1240395	hsa-miR-548n	CLIP-seq
MIRT1240396	hsa-miR-548w	CLIP-seq
MIRT1240397	hsa-miR-548y	CLIP-seq
MIRT1240398	hsa-miR-559	CLIP-seq
MIRT1240399	hsa-miR-593	CLIP-seq
MIRT1240400	hsa-miR-623	CLIP-seq
MIRT1240401	hsa-miR-642b	CLIP-seq
MIRT1240402	hsa-miR-661	CLIP-seq
MIRT1240403	hsa-miR-759	CLIP-seq
MIRT1240404	hsa-miR-766	CLIP-seq
MIRT1240405	hsa-miR-802	CLIP-seq
MIRT1240406	hsa-miR-940	CLIP-seq
MIRT1240407	hsa-miR-96	CLIP-seq
MIRT2070672	hsa-miR-1182	CLIP-seq
MIRT1240331	hsa-miR-1207-5p	CLIP-seq
MIRT2070673	hsa-miR-1228	CLIP-seq
MIRT2070674	hsa-miR-1236	CLIP-seq
MIRT2070675	hsa-miR-1293	CLIP-seq
MIRT2070676	hsa-miR-134	CLIP-seq
MIRT1240336	hsa-miR-141	CLIP-seq
MIRT2070677	hsa-miR-150	CLIP-seq
MIRT1240338	hsa-miR-1827	CLIP-seq
MIRT1240341	hsa-miR-200a	CLIP-seq
MIRT2070678	hsa-miR-2467-3p	CLIP-seq
MIRT2070679	hsa-miR-3118	CLIP-seq
MIRT1240345	hsa-miR-3148	CLIP-seq
MIRT2070680	hsa-miR-3165	CLIP-seq
MIRT2070681	hsa-miR-3179	CLIP-seq
MIRT2070682	hsa-miR-3183	CLIP-seq
MIRT2070683	hsa-miR-326	CLIP-seq
MIRT2070684	hsa-miR-330-5p	CLIP-seq
MIRT2070685	hsa-miR-3605-5p	CLIP-seq
MIRT2070686	hsa-miR-3612	CLIP-seq
MIRT2070687	hsa-miR-3622b-5p	CLIP-seq
MIRT2070688	hsa-miR-365	CLIP-seq
MIRT2070689	hsa-miR-3672	CLIP-seq
MIRT2070690	hsa-miR-3940-3p	CLIP-seq
MIRT1240356	hsa-miR-4252	CLIP-seq
MIRT2070691	hsa-miR-4253	CLIP-seq
MIRT2070692	hsa-miR-4279	CLIP-seq
MIRT2070693	hsa-miR-4284	CLIP-seq
MIRT2070694	hsa-miR-4459	CLIP-seq
MIRT2070695	hsa-miR-4467	CLIP-seq
MIRT2070696	hsa-miR-4483	CLIP-seq
MIRT1240366	hsa-miR-4537	CLIP-seq
MIRT1240372	hsa-miR-4677-3p	CLIP-seq
MIRT2070697	hsa-miR-4695-5p	CLIP-seq
MIRT2070698	hsa-miR-4713-5p	CLIP-seq
MIRT2070699	hsa-miR-4723-3p	CLIP-seq
MIRT1240376	hsa-miR-4736	CLIP-seq
MIRT1240379	hsa-miR-4763-3p	CLIP-seq
MIRT1240380	hsa-miR-4793-3p	CLIP-seq
MIRT1240383	hsa-miR-508-5p	CLIP-seq
MIRT2070700	hsa-miR-532-3p	CLIP-seq
MIRT1240385	hsa-miR-548a-5p	CLIP-seq
MIRT1240386	hsa-miR-548ab	CLIP-seq
MIRT1240387	hsa-miR-548ak	CLIP-seq
MIRT1240388	hsa-miR-548b-5p	CLIP-seq
MIRT1240390	hsa-miR-548c-5p	CLIP-seq
MIRT1240391	hsa-miR-548d-5p	CLIP-seq
MIRT1240392	hsa-miR-548h	CLIP-seq
MIRT1240393	hsa-miR-548i	CLIP-seq
MIRT1240394	hsa-miR-548j	CLIP-seq
MIRT1240395	hsa-miR-548n	CLIP-seq
MIRT1240396	hsa-miR-548w	CLIP-seq
MIRT1240397	hsa-miR-548y	CLIP-seq
MIRT1240398	hsa-miR-559	CLIP-seq
MIRT1240399	hsa-miR-593	CLIP-seq
MIRT2070701	hsa-miR-650	CLIP-seq
MIRT2070702	hsa-miR-665	CLIP-seq
MIRT1240332	hsa-miR-1227	CLIP-seq
MIRT2297833	hsa-miR-1245b-3p	CLIP-seq
MIRT2297834	hsa-miR-128	CLIP-seq
MIRT1240335	hsa-miR-1286	CLIP-seq
MIRT1240338	hsa-miR-1827	CLIP-seq
MIRT1240339	hsa-miR-1910	CLIP-seq
MIRT2297835	hsa-miR-27a	CLIP-seq
MIRT2297836	hsa-miR-27b	CLIP-seq
MIRT2070681	hsa-miR-3179	CLIP-seq
MIRT2297837	hsa-miR-3186-3p	CLIP-seq
MIRT1240347	hsa-miR-3187-3p	CLIP-seq
MIRT2297838	hsa-miR-3660	CLIP-seq
MIRT1240353	hsa-miR-3929	CLIP-seq
MIRT2297839	hsa-miR-3942-3p	CLIP-seq
MIRT2297840	hsa-miR-4266	CLIP-seq
MIRT1240357	hsa-miR-4419b	CLIP-seq
MIRT1240359	hsa-miR-4436a	CLIP-seq
MIRT2070694	hsa-miR-4459	CLIP-seq
MIRT1240363	hsa-miR-4478	CLIP-seq
MIRT2297841	hsa-miR-4526	CLIP-seq
MIRT1240365	hsa-miR-4529-5p	CLIP-seq
MIRT1240367	hsa-miR-455-3p	CLIP-seq
MIRT2297842	hsa-miR-455-5p	CLIP-seq
MIRT1240370	hsa-miR-4649-3p	CLIP-seq
MIRT1240372	hsa-miR-4677-3p	CLIP-seq
MIRT2297843	hsa-miR-4685-5p	CLIP-seq
MIRT2297844	hsa-miR-4708-5p	CLIP-seq
MIRT1240382	hsa-miR-485-5p	CLIP-seq
MIRT2297845	hsa-miR-490-3p	CLIP-seq
MIRT2297846	hsa-miR-513a-5p	CLIP-seq
MIRT1240385	hsa-miR-548a-5p	CLIP-seq
MIRT1240386	hsa-miR-548ab	CLIP-seq
MIRT1240387	hsa-miR-548ak	CLIP-seq
MIRT1240388	hsa-miR-548b-5p	CLIP-seq
MIRT1240390	hsa-miR-548c-5p	CLIP-seq
MIRT1240391	hsa-miR-548d-5p	CLIP-seq
MIRT1240392	hsa-miR-548h	CLIP-seq
MIRT1240393	hsa-miR-548i	CLIP-seq
MIRT1240394	hsa-miR-548j	CLIP-seq
MIRT1240395	hsa-miR-548n	CLIP-seq
MIRT1240396	hsa-miR-548w	CLIP-seq
MIRT1240397	hsa-miR-548y	CLIP-seq
MIRT1240398	hsa-miR-559	CLIP-seq
MIRT2297847	hsa-miR-576-3p	CLIP-seq
MIRT2297848	hsa-miR-619	CLIP-seq
MIRT2297849	hsa-miR-649	CLIP-seq
MIRT2297850	hsa-miR-651	CLIP-seq
MIRT1240406	hsa-miR-940	CLIP-seq
MIRT1240332	hsa-miR-1227	CLIP-seq
MIRT1240356	hsa-miR-4252	CLIP-seq
MIRT1240369	hsa-miR-4640-5p	CLIP-seq
MIRT1240375	hsa-miR-4726-5p	CLIP-seq
MIRT1240380	hsa-miR-4793-3p	CLIP-seq
MIRT1240383	hsa-miR-508-5p	CLIP-seq
MIRT1240385	hsa-miR-548a-5p	CLIP-seq
MIRT1240386	hsa-miR-548ab	CLIP-seq
MIRT1240387	hsa-miR-548ak	CLIP-seq
MIRT1240388	hsa-miR-548b-5p	CLIP-seq
MIRT1240390	hsa-miR-548c-5p	CLIP-seq
MIRT1240391	hsa-miR-548d-5p	CLIP-seq
MIRT1240392	hsa-miR-548h	CLIP-seq
MIRT1240393	hsa-miR-548i	CLIP-seq
MIRT1240394	hsa-miR-548j	CLIP-seq
MIRT1240395	hsa-miR-548n	CLIP-seq
MIRT1240396	hsa-miR-548w	CLIP-seq
MIRT1240397	hsa-miR-548y	CLIP-seq
MIRT1240398	hsa-miR-559	CLIP-seq
MIRT1240402	hsa-miR-661	CLIP-seq
MIRT1240404	hsa-miR-766	CLIP-seq
MIRT1240329	hsa-miR-10a	CLIP-seq
MIRT1240330	hsa-miR-10b	CLIP-seq
MIRT1240348	hsa-miR-339-5p	CLIP-seq
MIRT1240349	hsa-miR-3613-3p	CLIP-seq
MIRT1240358	hsa-miR-4421	CLIP-seq
MIRT1240373	hsa-miR-4684-5p	CLIP-seq
MIRT1240389	hsa-miR-548c-3p	CLIP-seq
MIRT1240399	hsa-miR-593	CLIP-seq
MIRT1240329	hsa-miR-10a	CLIP-seq
MIRT1240330	hsa-miR-10b	CLIP-seq
MIRT2070672	hsa-miR-1182	CLIP-seq
MIRT2595348	hsa-miR-1202	CLIP-seq
MIRT2070673	hsa-miR-1228	CLIP-seq
MIRT2070675	hsa-miR-1293	CLIP-seq
MIRT1240336	hsa-miR-141	CLIP-seq
MIRT2595349	hsa-miR-1587	CLIP-seq
MIRT1240341	hsa-miR-200a	CLIP-seq
MIRT1240345	hsa-miR-3148	CLIP-seq
MIRT2070680	hsa-miR-3165	CLIP-seq
MIRT2070681	hsa-miR-3179	CLIP-seq
MIRT2595350	hsa-miR-3194-5p	CLIP-seq
MIRT2070683	hsa-miR-326	CLIP-seq
MIRT2070684	hsa-miR-330-5p	CLIP-seq
MIRT1240348	hsa-miR-339-5p	CLIP-seq
MIRT1240349	hsa-miR-3613-3p	CLIP-seq
MIRT2595351	hsa-miR-3614-5p	CLIP-seq
MIRT2070688	hsa-miR-365	CLIP-seq
MIRT2070689	hsa-miR-3672	CLIP-seq
MIRT2595352	hsa-miR-3972	CLIP-seq
MIRT2595353	hsa-miR-4417	CLIP-seq
MIRT1240358	hsa-miR-4421	CLIP-seq
MIRT2595354	hsa-miR-4433	CLIP-seq
MIRT2070694	hsa-miR-4459	CLIP-seq
MIRT2070696	hsa-miR-4483	CLIP-seq
MIRT2595355	hsa-miR-4492	CLIP-seq
MIRT2595356	hsa-miR-4498	CLIP-seq
MIRT2595357	hsa-miR-4505	CLIP-seq
MIRT2595358	hsa-miR-4656	CLIP-seq
MIRT2595359	hsa-miR-4675	CLIP-seq
MIRT1240372	hsa-miR-4677-3p	CLIP-seq
MIRT1240373	hsa-miR-4684-5p	CLIP-seq
MIRT2595360	hsa-miR-4731-5p	CLIP-seq
MIRT2595361	hsa-miR-4741	CLIP-seq
MIRT2595362	hsa-miR-4768-3p	CLIP-seq
MIRT2595363	hsa-miR-4786-5p	CLIP-seq
MIRT1240385	hsa-miR-548a-5p	CLIP-seq
MIRT1240386	hsa-miR-548ab	CLIP-seq
MIRT1240387	hsa-miR-548ak	CLIP-seq
MIRT1240388	hsa-miR-548b-5p	CLIP-seq
MIRT1240389	hsa-miR-548c-3p	CLIP-seq
MIRT1240390	hsa-miR-548c-5p	CLIP-seq
MIRT1240391	hsa-miR-548d-5p	CLIP-seq
MIRT1240392	hsa-miR-548h	CLIP-seq
MIRT1240393	hsa-miR-548i	CLIP-seq
MIRT1240394	hsa-miR-548j	CLIP-seq
MIRT1240395	hsa-miR-548n	CLIP-seq
MIRT1240396	hsa-miR-548w	CLIP-seq
MIRT1240397	hsa-miR-548y	CLIP-seq
MIRT1240398	hsa-miR-559	CLIP-seq
MIRT1240399	hsa-miR-593	CLIP-seq
MIRT2595364	hsa-miR-762	CLIP-seq
MIRT2595365	hsa-miR-769-5p	CLIP-seq
MIRT1240329	hsa-miR-10a	CLIP-seq
MIRT1240330	hsa-miR-10b	CLIP-seq
MIRT1240348	hsa-miR-339-5p	CLIP-seq
MIRT1240349	hsa-miR-3613-3p	CLIP-seq
MIRT2070689	hsa-miR-3672	CLIP-seq
MIRT2688054	hsa-miR-371-5p	CLIP-seq
MIRT2688055	hsa-miR-371b-5p	CLIP-seq
MIRT1240356	hsa-miR-4252	CLIP-seq
MIRT1240358	hsa-miR-4421	CLIP-seq
MIRT1240369	hsa-miR-4640-5p	CLIP-seq
MIRT1240373	hsa-miR-4684-5p	CLIP-seq
MIRT1240375	hsa-miR-4726-5p	CLIP-seq
MIRT1240380	hsa-miR-4793-3p	CLIP-seq
MIRT1240381	hsa-miR-4797-5p	CLIP-seq
MIRT1240383	hsa-miR-508-5p	CLIP-seq
MIRT1240389	hsa-miR-548c-3p	CLIP-seq
MIRT2688056	hsa-miR-577	CLIP-seq
MIRT1240399	hsa-miR-593	CLIP-seq
MIRT1240402	hsa-miR-661	CLIP-seq
MIRT1240403	hsa-miR-759	CLIP-seq
MIRT1240404	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004620	Function	Phospholipase activity	IEA
GO:0005515	Function	Protein binding	IPI	26711011, 28852571
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IDA	17028579, 21397848
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007286	Process	Spermatid development	IEA
GO:0007286	Process	Spermatid development	ISS
GO:0008053	Process	Mitochondrial fusion	IDA	17028579
GO:0008053	Process	Mitochondrial fusion	IGI	38843396
GO:0008053	Process	Mitochondrial fusion	IMP	17028579
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008654	Process	Phospholipid biosynthetic process	IDA	17028579
GO:0010636	Process	Positive regulation of mitochondrial fusion	IDA	24599962
GO:0016020	Component	Membrane	IEA
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016891	Function	RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0030719	Process	P granule organization	IEA
GO:0030719	Process	P granule organization	ISS
GO:0034587	Process	PiRNA processing	IBA
GO:0034587	Process	PiRNA processing	IEA
GO:0035755	Function	Cardiolipin hydrolase activity	IDA	17028579, 21397848
GO:0042802	Function	Identical protein binding	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	17028579
GO:0046872	Function	Metal ion binding	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051321	Process	Meiotic cell cycle	ISS

Other IDs

• MIM: 614960
• HGNC: 30447
• e!Ensembl: ENSG00000179598

Protein

• UniProt ID: Q8N2A8
• Protein name: Mitochondrial cardiolipin hydrolase (EC 3.1.4.-) (Choline phosphatase 6) (Mitochondrial phospholipase) (MitoPLD) (Phosphatidylcholine-hydrolyzing phospholipase D6) (Phospholipase D6) (PLD6) (Protein zucchini homolog)
• Protein function: Presents phospholipase and nuclease activities, depending on the different physiological conditions (PubMed:17028579, PubMed:21397847, PubMed:28063496). Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating t
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13091	PLDc_2	83 → 206	PLD-like domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in testis and ovary, but not limited to gonads (at protein level) (PubMed:17028579, PubMed:21397847). It is also found in brain, heart, pituitary gland, prostate, pancreas, thyroid, bone marrow, lung and muscle
• Sequence:

  MGRLSWQVAAAAAVGLALTLEALPWVLRWLRSRRRRPRREALFFPSQVTCTEALLRAPGA
  ELAELPEGCPCGLPHGESALSRLLRALLAARASLDLCLFAFSSPQLGRAVQLLHQRGVRV
  RVVTDCDYMALNGSQIGLLRKAGIQVRHDQDPGYMHHKFAIVDKRVLITGSLNWTTQAIQ
  NNRENVLITEDDEYVRLFLEEFERIWEQFNPTKYTFFPPKKSHGSCAPPVSRAGGRLLSW
  HRTCGTSSESQT

• Sequence length: 252

Pathways

Reactome:

Synthesis of PA

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Male infertility	Likely pathogenic	rs2544099502	RCV004573393	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	31128893		★☆☆☆☆ Found in Text Mining only
Asthenozoospermia	Asthenozoospermia	Pubtator	34326815	Inhibit	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	37782162	Associate	★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	21124956	Associate	★☆☆☆☆ Found in Text Mining only