Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	199953
Gene name	Transmembrane protein 201
Gene symbol	TMEM201
Synonyms (NCBI Gene)	Ima1NET5SAMP1
Chromosome	1
Chromosome location	1p36.22

152

Show/Hide all (152)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032231	hsa-let-7b-5p	Proteomics	18668040
MIRT032231	hsa-let-7b-5p	CLASH	23622248
MIRT710533	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT710532	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT710531	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT710530	hsa-miR-1976	HITS-CLIP	19536157
MIRT710533	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT710532	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT710531	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT710530	hsa-miR-1976	HITS-CLIP	19536157
MIRT710533	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT710532	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT710531	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT710530	hsa-miR-1976	HITS-CLIP	19536157
MIRT710533	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT710532	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT710531	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT710530	hsa-miR-1976	HITS-CLIP	19536157
MIRT1434979	hsa-miR-1200	CLIP-seq
MIRT1434980	hsa-miR-1207-5p	CLIP-seq
MIRT1434981	hsa-miR-1273f	CLIP-seq
MIRT1434982	hsa-miR-1285	CLIP-seq
MIRT1434983	hsa-miR-1286	CLIP-seq
MIRT1434984	hsa-miR-1343	CLIP-seq
MIRT1434985	hsa-miR-143	CLIP-seq
MIRT1434986	hsa-miR-1827	CLIP-seq
MIRT1434987	hsa-miR-197	CLIP-seq
MIRT1434988	hsa-miR-214	CLIP-seq
MIRT1434989	hsa-miR-2467-3p	CLIP-seq
MIRT1434990	hsa-miR-2682	CLIP-seq
MIRT1434991	hsa-miR-296-5p	CLIP-seq
MIRT1434992	hsa-miR-3126-5p	CLIP-seq
MIRT1434993	hsa-miR-3136-3p	CLIP-seq
MIRT1434994	hsa-miR-3137	CLIP-seq
MIRT1434995	hsa-miR-3154	CLIP-seq
MIRT1434996	hsa-miR-3187-5p	CLIP-seq
MIRT1434997	hsa-miR-3199	CLIP-seq
MIRT1434998	hsa-miR-34a	CLIP-seq
MIRT1434999	hsa-miR-34c-5p	CLIP-seq
MIRT1435000	hsa-miR-3607-5p	CLIP-seq
MIRT1435001	hsa-miR-3616-3p	CLIP-seq
MIRT1435002	hsa-miR-3619-5p	CLIP-seq
MIRT1435003	hsa-miR-3661	CLIP-seq
MIRT1435004	hsa-miR-3667-3p	CLIP-seq
MIRT1435005	hsa-miR-3687	CLIP-seq
MIRT1435006	hsa-miR-409-5p	CLIP-seq
MIRT1435007	hsa-miR-4252	CLIP-seq
MIRT1435008	hsa-miR-4283	CLIP-seq
MIRT1435009	hsa-miR-4324	CLIP-seq
MIRT1435010	hsa-miR-4326	CLIP-seq
MIRT1435011	hsa-miR-4419a	CLIP-seq
MIRT1435012	hsa-miR-4436b-3p	CLIP-seq
MIRT1435013	hsa-miR-4442	CLIP-seq
MIRT1435014	hsa-miR-4446-3p	CLIP-seq
MIRT1435015	hsa-miR-4447	CLIP-seq
MIRT1435016	hsa-miR-4472	CLIP-seq
MIRT1435017	hsa-miR-4481	CLIP-seq
MIRT1435018	hsa-miR-4489	CLIP-seq
MIRT1435019	hsa-miR-4493	CLIP-seq
MIRT1435020	hsa-miR-449a	CLIP-seq
MIRT1435021	hsa-miR-449b	CLIP-seq
MIRT1435022	hsa-miR-449c	CLIP-seq
MIRT1435023	hsa-miR-4505	CLIP-seq
MIRT1435024	hsa-miR-4510	CLIP-seq
MIRT1435025	hsa-miR-4511	CLIP-seq
MIRT1435026	hsa-miR-4515	CLIP-seq
MIRT1435027	hsa-miR-4522	CLIP-seq
MIRT1435028	hsa-miR-4634	CLIP-seq
MIRT1435029	hsa-miR-4639-3p	CLIP-seq
MIRT1435030	hsa-miR-4656	CLIP-seq
MIRT1435031	hsa-miR-4663	CLIP-seq
MIRT1435032	hsa-miR-4675	CLIP-seq
MIRT1435033	hsa-miR-4707-5p	CLIP-seq
MIRT1435034	hsa-miR-4708-5p	CLIP-seq
MIRT1435035	hsa-miR-4712-3p	CLIP-seq
MIRT1435036	hsa-miR-4741	CLIP-seq
MIRT1435037	hsa-miR-4745-5p	CLIP-seq
MIRT1435038	hsa-miR-4753-5p	CLIP-seq
MIRT1435039	hsa-miR-4755-3p	CLIP-seq
MIRT1435040	hsa-miR-4763-3p	CLIP-seq
MIRT1435041	hsa-miR-4770	CLIP-seq
MIRT1435042	hsa-miR-4793-3p	CLIP-seq
MIRT1435043	hsa-miR-492	CLIP-seq
MIRT1435044	hsa-miR-544b	CLIP-seq
MIRT1435045	hsa-miR-582-5p	CLIP-seq
MIRT1435046	hsa-miR-612	CLIP-seq
MIRT1435047	hsa-miR-631	CLIP-seq
MIRT1435048	hsa-miR-7	CLIP-seq
MIRT1435049	hsa-miR-761	CLIP-seq
MIRT1434979	hsa-miR-1200	CLIP-seq
MIRT1435050	hsa-miR-1224-5p	CLIP-seq
MIRT1435051	hsa-miR-128	CLIP-seq
MIRT1435052	hsa-miR-27a	CLIP-seq
MIRT1435053	hsa-miR-27b	CLIP-seq
MIRT1435054	hsa-miR-3150b-3p	CLIP-seq
MIRT1435055	hsa-miR-3184	CLIP-seq
MIRT1435056	hsa-miR-3665	CLIP-seq
MIRT1435057	hsa-miR-3934	CLIP-seq
MIRT1435058	hsa-miR-423-5p	CLIP-seq
MIRT1435009	hsa-miR-4324	CLIP-seq
MIRT1435059	hsa-miR-455-3p	CLIP-seq
MIRT1435060	hsa-miR-4688	CLIP-seq
MIRT1435061	hsa-miR-4689	CLIP-seq
MIRT1435062	hsa-miR-4704-3p	CLIP-seq
MIRT1435063	hsa-miR-4710	CLIP-seq
MIRT1435064	hsa-miR-4736	CLIP-seq
MIRT1435065	hsa-miR-4751	CLIP-seq
MIRT1435066	hsa-miR-4779	CLIP-seq
MIRT1435067	hsa-miR-4784	CLIP-seq
MIRT1435068	hsa-miR-486-3p	CLIP-seq
MIRT1435044	hsa-miR-544b	CLIP-seq
MIRT2130349	hsa-miR-1207-3p	CLIP-seq
MIRT1434980	hsa-miR-1207-5p	CLIP-seq
MIRT2130350	hsa-miR-3151	CLIP-seq
MIRT2130351	hsa-miR-3675-5p	CLIP-seq
MIRT2130352	hsa-miR-4254	CLIP-seq
MIRT1435040	hsa-miR-4763-3p	CLIP-seq
MIRT1435066	hsa-miR-4779	CLIP-seq
MIRT1435068	hsa-miR-486-3p	CLIP-seq
MIRT2130353	hsa-miR-940	CLIP-seq
MIRT1434979	hsa-miR-1200	CLIP-seq
MIRT1435050	hsa-miR-1224-5p	CLIP-seq
MIRT2351718	hsa-miR-1226	CLIP-seq
MIRT2351719	hsa-miR-1266	CLIP-seq
MIRT1435051	hsa-miR-128	CLIP-seq
MIRT2351720	hsa-miR-1294	CLIP-seq
MIRT2351721	hsa-miR-1324	CLIP-seq
MIRT2351722	hsa-miR-1825	CLIP-seq
MIRT2351723	hsa-miR-199a-5p	CLIP-seq
MIRT2351724	hsa-miR-199b-5p	CLIP-seq
MIRT1435052	hsa-miR-27a	CLIP-seq
MIRT1435053	hsa-miR-27b	CLIP-seq
MIRT1434998	hsa-miR-34a	CLIP-seq
MIRT1434999	hsa-miR-34c-5p	CLIP-seq
MIRT2351725	hsa-miR-3922-5p	CLIP-seq
MIRT1435057	hsa-miR-3934	CLIP-seq
MIRT1435009	hsa-miR-4324	CLIP-seq
MIRT1435020	hsa-miR-449a	CLIP-seq
MIRT1435021	hsa-miR-449b	CLIP-seq
MIRT2351726	hsa-miR-4518	CLIP-seq
MIRT1435059	hsa-miR-455-3p	CLIP-seq
MIRT2351727	hsa-miR-4691-5p	CLIP-seq
MIRT2351728	hsa-miR-4693-3p	CLIP-seq
MIRT1435062	hsa-miR-4704-3p	CLIP-seq
MIRT1435065	hsa-miR-4751	CLIP-seq
MIRT1435044	hsa-miR-544b	CLIP-seq
MIRT2351729	hsa-miR-574-5p	CLIP-seq
MIRT2351730	hsa-miR-634	CLIP-seq
MIRT2130349	hsa-miR-1207-3p	CLIP-seq
MIRT2395994	hsa-miR-520d-5p	CLIP-seq
MIRT2395995	hsa-miR-524-5p	CLIP-seq
MIRT2441334	hsa-miR-4308	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IEA
GO:0001525	Process	Angiogenesis	IEA
GO:0001525	Process	Angiogenesis	IMP	35311970
GO:0005515	Function	Protein binding	IPI	21610090, 32296183, 35311970
GO:0005521	Function	Lamin binding	IBA
GO:0005521	Function	Lamin binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IDA	27541860
GO:0005637	Component	Nuclear inner membrane	IDA	35311970
GO:0005637	Component	Nuclear inner membrane	IEA
GO:0005637	Component	Nuclear inner membrane	IMP	19494128, 21610090
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006998	Process	Nuclear envelope organization	IMP	21610090
GO:0007097	Process	Nuclear migration	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IMP	35311970
GO:0010761	Process	Fibroblast migration	IEA
GO:0016020	Component	Membrane	IEA
GO:0030473	Process	Nuclear migration along microtubule	IBA
GO:0031616	Component	Spindle pole centrosome	IMP	19494128
GO:0031965	Component	Nuclear membrane	IBA
GO:0031965	Component	Nuclear membrane	IEA
GO:0032541	Component	Cortical endoplasmic reticulum	IMP	19494128
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IEA
GO:0051642	Process	Centrosome localization	IMP	19494128
GO:0090435	Process	Protein localization to nuclear envelope	IDA	27541860

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q5SNT2

Protein name

Transmembrane protein 201 (Spindle-associated membrane protein 1)

Protein function

Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoske

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09779	Ima1_N	46 → 171	Ima1 N-terminal domain	Family
PF10476	DUF2448	191 → 389	Protein of unknown function C-terminus (DUF2448)	Family

Sequence

MEGVSALLARCPTAGLAGGLGVTACAAAGVLLYRIARRMKPTHTMVNCWFCNQDTLVPYG
NRNCWDCPHCEQYNGFQENGDYNKPIPAQYLEHLNHVVSSAPSLRDPSQPQQWVSSQVLL
CKRCNHHQTTKIKQLAAFAPREEGRYDEEVEVYRHHLEQMYKLCRPCQAAVEYYIKHQNR
QLRALLLSHQFKRREADQTHAQNFSSAVKSPVQVILLRALAFLACAFLLTTALYGASGHF
APGTTVPLALPPGGNGSATPDNGTTPGAEGWRQLLGLLPEHMAEKLCEAWAFGQSHQTGV
VALGLLTCLLAMLLAGRIRLRRIDAFCTCLWALLLGLHLAEQHLQAASPSWLDTLKFSTT
SLCCLVGFTAAVATRKATGPRRFRPRRFFPGDSAGLFPTSPSLAIPHPSVGGSPASLFIP
SPPSFLPLANQQLFRSPRRTSPSSLPGRLSRALSLGTIPSLTRADSGYLFSGSRPPSQVS
RSGEFPVSDYFSLLSGSCPSSPLPSPAPSVAGSVASSSGSLRHRRPLISPARLNLKGQKL
LLFPSPPGEAPTTPSSSDEHSPHNGSLFTMEPPHVPRKPPLQDVKHALDLRSKLERGSAC
SNRSIKKEDDSSQSSTCVVDTTTRGCSEEAATWRGRFGPSLVRGLLAVSLAANALFTSVF
LYQSLR

Sequence length

666

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Aortic valve disorder	Aortic Valve Disease	BEFREE	29581213		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	Emery-Dreifuss Muscular Dystrophy	BEFREE	30326651		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37373430	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	26676714, 28301579		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	15685547, 28301579, 29545797, 31750921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glucocorticoid-remediable aldosteronism	Hyperaldosteronism	BEFREE	30222592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Histiocytosis haematophagic	Histiocytosis Haematophagic	BEFREE	30819910		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ileitis	Ileitis	BEFREE	15685547, 28301579, 29545797, 31750921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	31750921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphohistiocytosis, Hemophagocytic	Lymphohistiocytosis	BEFREE	30819910		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28301579		★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy, Emery-Dreifuss	Emery-Dreifuss Muscular Dystrophy	BEFREE	29192166, 30326651		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28893537		★★★★★ ★☆☆☆☆ Found in Text Mining only
Premature aging syndrome	Premature aging	BEFREE	30222592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	31903983	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

TMEM201 (transmembrane protein 201)