THAP8 (THAP domain containing 8)

Gene

• Entrez ID: 199745
• Gene name: THAP domain containing 8
• Gene symbol: THAP8
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT518365	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT518364	hsa-miR-7845-5p	PAR-CLIP	23446348
MIRT518363	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT518362	hsa-miR-92b-5p	PAR-CLIP	23446348
MIRT518361	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT518360	hsa-miR-4775	PAR-CLIP	23446348
MIRT518359	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT518358	hsa-miR-6788-3p	PAR-CLIP	23446348
MIRT518357	hsa-miR-3149	PAR-CLIP	23446348
MIRT518365	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT518364	hsa-miR-7845-5p	PAR-CLIP	23446348
MIRT518363	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT518362	hsa-miR-92b-5p	PAR-CLIP	23446348
MIRT518361	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT518360	hsa-miR-4775	PAR-CLIP	23446348
MIRT518359	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT518358	hsa-miR-6788-3p	PAR-CLIP	23446348
MIRT518357	hsa-miR-3149	PAR-CLIP	23446348
MIRT1422714	hsa-miR-1207-3p	CLIP-seq
MIRT1422715	hsa-miR-1207-5p	CLIP-seq
MIRT1422716	hsa-miR-1263	CLIP-seq
MIRT1422717	hsa-miR-1275	CLIP-seq
MIRT1422718	hsa-miR-1290	CLIP-seq
MIRT1422719	hsa-miR-1297	CLIP-seq
MIRT1422720	hsa-miR-1912	CLIP-seq
MIRT1422721	hsa-miR-1915	CLIP-seq
MIRT1422722	hsa-miR-26a	CLIP-seq
MIRT1422723	hsa-miR-26b	CLIP-seq
MIRT1422724	hsa-miR-298	CLIP-seq
MIRT1422725	hsa-miR-29a	CLIP-seq
MIRT1422726	hsa-miR-29b	CLIP-seq
MIRT1422727	hsa-miR-29c	CLIP-seq
MIRT1422728	hsa-miR-3130-5p	CLIP-seq
MIRT1422729	hsa-miR-3200-5p	CLIP-seq
MIRT1422730	hsa-miR-3616-3p	CLIP-seq
MIRT1422731	hsa-miR-3663-3p	CLIP-seq
MIRT1422732	hsa-miR-4303	CLIP-seq
MIRT1422733	hsa-miR-4436b-3p	CLIP-seq
MIRT1422734	hsa-miR-4450	CLIP-seq
MIRT1422735	hsa-miR-4465	CLIP-seq
MIRT1422736	hsa-miR-4482	CLIP-seq
MIRT1422737	hsa-miR-4488	CLIP-seq
MIRT1422738	hsa-miR-4502	CLIP-seq
MIRT1422739	hsa-miR-4537	CLIP-seq
MIRT1422740	hsa-miR-4651	CLIP-seq
MIRT1422741	hsa-miR-4656	CLIP-seq
MIRT1422742	hsa-miR-4665-5p	CLIP-seq
MIRT1422743	hsa-miR-4697-5p	CLIP-seq
MIRT1422744	hsa-miR-4712-3p	CLIP-seq
MIRT1422745	hsa-miR-4721	CLIP-seq
MIRT1422746	hsa-miR-4763-3p	CLIP-seq
MIRT1422747	hsa-miR-4787-5p	CLIP-seq
MIRT1422748	hsa-miR-608	CLIP-seq
MIRT1422749	hsa-miR-767-5p	CLIP-seq
MIRT1422750	hsa-miR-888	CLIP-seq
MIRT1422751	hsa-miR-934	CLIP-seq
MIRT2348614	hsa-miR-1238	CLIP-seq
MIRT2348615	hsa-miR-3124-3p	CLIP-seq
MIRT2348616	hsa-miR-4691-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 612536
• HGNC: 23191
• e!Ensembl: ENSG00000161277

Protein

• UniProt ID: Q8NA92
• Protein name: THAP domain-containing protein 8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05485	THAP	5 → 85	THAP domain	Domain

• Sequence:

  MPKYCRAPNCSNTAGRLGADNRPVSFYKFPLKDGPRLQAWLQHMGCEHWVPSCHQHLCSE
  HFTPSCFQWRWGVRYLRPDAVPSIFSRGPPAKSQRRTRSTQKPVSPPPPLQKNTPLPQSP
  AIPVSGPVRLVVLGPTSGSPKTVATMLLTPLAPAPTPERSQPEVPAQQAQTGLGPVLGAL
  QRRVRRLQRCQERHQAQLQALERLAQQLHGESLLARARRGLQRLTTAQTLGPEESQTFTI
  ICGGPDIAMVLAQDPAPATVDAKPELLDTRIPSA

• Sequence length: 274

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations