Gene Gene information from NCBI Gene database.
Entrez ID 1994
Gene name ELAV like RNA binding protein 1
Gene symbol ELAVL1
Synonyms (NCBI Gene)
ELAV1HURHuaMelG
Chromosome 19
Chromosome location 19p13.2
Summary The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3` untranslated regions of mRNAs. AREs signal degradation of mR
miRNA miRNA information provided by mirtarbase database.
306
miRTarBase ID miRNA Experiments Reference
MIRT003731 hsa-miR-519b-3p qRT-PCRWestern blot 19088191
MIRT003731 hsa-miR-519b-3p qRT-PCRWestern blot 19088191
MIRT003732 hsa-miR-519c-3p qRT-PCRWestern blot 19088191
MIRT003732 hsa-miR-519c-3p qRT-PCRWestern blot 19088191
MIRT003733 hsa-miR-519a-3p qRT-PCRWestern blot 19088191
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
ZFP36 Activation 15158469
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
60
GO ID Ontology Definition Evidence Reference
GO:0000512 Process LncRNA-mediated post-transcriptional gene silencing IEA
GO:0000932 Component P-body IEA
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IDA 19561594, 21613615
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603466 3312 ENSG00000066044
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15717
Protein name ELAV-like protein 1 (Hu-antigen R) (HuR)
Protein function RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methyl
PDB 3HI9 , 4ED5 , 4EGL , 4FXV , 5SZW , 6G2K , 6GC5 , 6GD1 , 6GD2 , 6GD3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 22 92 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 108 176 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 246 316 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Detected in brain, liver, thymus and muscle. {ECO:0000269|PubMed:8626503}.
Sequence
Sequence length 326
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  AMPK signaling pathway
IL-17 signaling pathway
  HuR (ELAVL1) binds and stabilizes mRNA
mRNA Splicing - Major Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BONE REMODELING DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 30551620
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 18056170, 19208339, 25010987
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 19009247
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 19828005
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma LHGDN 18094611
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 19208339
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 11280780
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 31755389 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 25239623
★☆☆☆☆
Found in Text Mining only
Anaplastic thyroid carcinoma Anaplastic thyroid cancer BEFREE 29285201
★☆☆☆☆
Found in Text Mining only