Gene Gene information from NCBI Gene database.
Entrez ID 1979
Gene name Eukaryotic translation initiation factor 4E binding protein 2
Gene symbol EIF4EBP2
Synonyms (NCBI Gene)
4EBP2PHASII
Chromosome 10
Chromosome location 10q22.1
Summary This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via
miRNA miRNA information provided by mirtarbase database.
2156
miRTarBase ID miRNA Experiments Reference
MIRT019719 hsa-miR-375 Microarray 20215506
MIRT025698 hsa-miR-7-5p Microarray 19073608
MIRT030777 hsa-miR-21-5p Microarray 18591254
MIRT051622 hsa-let-7e-5p CLASH 23622248
MIRT050703 hsa-miR-18a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15153109, 16271312, 24207126, 24722188, 24981860, 25416956, 25533957, 28514442, 31515488, 32296183, 33961781
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IEA
GO:0006412 Process Translation TAS 7935836
GO:0006417 Process Regulation of translation IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602224 3289 ENSG00000148730
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13542
Protein name Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)
Protein function Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with E
PDB 2MX4 , 3AM7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05456 eIF_4EBP 1 120 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Family
Sequence
Sequence length 120
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Longevity regulating pathway - multiple species  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Autistic Disorder Autism BEFREE 31427534
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 27779207 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 21088106
★☆☆☆☆
Found in Text Mining only
Diabetes Diabetes BEFREE 20547975
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Diabetes Mellitus BEFREE 20547975
★☆☆☆☆
Found in Text Mining only
Glioma Glioma BEFREE 30066885
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 28881582
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus, Systemic Lupus Erythematosus BEFREE 11120763
★☆☆☆☆
Found in Text Mining only
Malignant Glioma Glioma BEFREE 30066885
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 29453322
★☆☆☆☆
Found in Text Mining only