NLRC3 (NLR family CARD domain containing 3)

Gene

• Entrez ID: 197358
• Gene name: NLR family CARD domain containing 3
• Gene symbol: NLRC3
• Synonyms (NCBI Gene): CLR16.2, NOD3
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption o

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT701391	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT701390	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT701389	hsa-miR-4293	HITS-CLIP	23313552
MIRT701388	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT701387	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT661797	hsa-miR-3929	HITS-CLIP	23824327
MIRT661796	hsa-miR-4419b	HITS-CLIP	23824327
MIRT661795	hsa-miR-4478	HITS-CLIP	23824327
MIRT661794	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT661793	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT661792	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT661791	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT661790	hsa-miR-8089	HITS-CLIP	23824327
MIRT661789	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT661788	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT661787	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT661786	hsa-miR-3175	HITS-CLIP	23824327
MIRT661785	hsa-miR-1343-5p	HITS-CLIP	23824327
MIRT661784	hsa-miR-939-5p	HITS-CLIP	23824327
MIRT661783	hsa-miR-6825-5p	HITS-CLIP	23824327
MIRT661782	hsa-miR-3150a-3p	HITS-CLIP	23824327
MIRT661781	hsa-miR-6763-5p	HITS-CLIP	23824327
MIRT661780	hsa-miR-665	HITS-CLIP	23824327
MIRT701387	hsa-miR-4684-5p	PAR-CLIP	27292025
MIRT701390	hsa-miR-6771-3p	PAR-CLIP	27292025
MIRT701391	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT701390	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT701389	hsa-miR-4293	HITS-CLIP	23313552
MIRT701388	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT701387	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT661797	hsa-miR-3929	HITS-CLIP	23824327
MIRT661796	hsa-miR-4419b	HITS-CLIP	23824327
MIRT661795	hsa-miR-4478	HITS-CLIP	23824327
MIRT661794	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT661793	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT661792	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT661791	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT661790	hsa-miR-8089	HITS-CLIP	23824327
MIRT661789	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT661788	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT661787	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT661786	hsa-miR-3175	HITS-CLIP	23824327
MIRT661785	hsa-miR-1343-5p	HITS-CLIP	23824327
MIRT661784	hsa-miR-939-5p	HITS-CLIP	23824327
MIRT661783	hsa-miR-6825-5p	HITS-CLIP	23824327
MIRT661782	hsa-miR-3150a-3p	HITS-CLIP	23824327
MIRT661781	hsa-miR-6763-5p	HITS-CLIP	23824327
MIRT661780	hsa-miR-665	HITS-CLIP	23824327
MIRT1187145	hsa-miR-1227	CLIP-seq
MIRT1187146	hsa-miR-1228	CLIP-seq
MIRT1187147	hsa-miR-1273	CLIP-seq
MIRT1187148	hsa-miR-1273c	CLIP-seq
MIRT1187149	hsa-miR-1293	CLIP-seq
MIRT1187150	hsa-miR-186	CLIP-seq
MIRT1187151	hsa-miR-24	CLIP-seq
MIRT1187152	hsa-miR-3120-5p	CLIP-seq
MIRT1187153	hsa-miR-3122	CLIP-seq
MIRT1187154	hsa-miR-3133	CLIP-seq
MIRT1187155	hsa-miR-3165	CLIP-seq
MIRT1187156	hsa-miR-3180-5p	CLIP-seq
MIRT1187157	hsa-miR-3202	CLIP-seq
MIRT1187158	hsa-miR-323-5p	CLIP-seq
MIRT1187159	hsa-miR-335	CLIP-seq
MIRT1187160	hsa-miR-342-3p	CLIP-seq
MIRT1187161	hsa-miR-3613-3p	CLIP-seq
MIRT1187162	hsa-miR-3614-5p	CLIP-seq
MIRT1187163	hsa-miR-3689a-3p	CLIP-seq
MIRT1187164	hsa-miR-3689c	CLIP-seq
MIRT1187165	hsa-miR-371-5p	CLIP-seq
MIRT1187166	hsa-miR-371b-5p	CLIP-seq
MIRT1187167	hsa-miR-3913-5p	CLIP-seq
MIRT1187168	hsa-miR-4252	CLIP-seq
MIRT1187169	hsa-miR-4284	CLIP-seq
MIRT1187170	hsa-miR-4300	CLIP-seq
MIRT1187171	hsa-miR-4424	CLIP-seq
MIRT1187172	hsa-miR-4433	CLIP-seq
MIRT1187173	hsa-miR-4455	CLIP-seq
MIRT1187174	hsa-miR-4459	CLIP-seq
MIRT1187175	hsa-miR-4466	CLIP-seq
MIRT1187176	hsa-miR-4483	CLIP-seq
MIRT1187177	hsa-miR-4486	CLIP-seq
MIRT1187178	hsa-miR-4509	CLIP-seq
MIRT1187179	hsa-miR-4533	CLIP-seq
MIRT1187180	hsa-miR-4633-3p	CLIP-seq
MIRT1187181	hsa-miR-4649-5p	CLIP-seq
MIRT1187182	hsa-miR-4653-3p	CLIP-seq
MIRT1187183	hsa-miR-4728-5p	CLIP-seq
MIRT1187184	hsa-miR-4768-3p	CLIP-seq
MIRT1187185	hsa-miR-4778-5p	CLIP-seq
MIRT1187186	hsa-miR-4793-3p	CLIP-seq
MIRT1187187	hsa-miR-508-5p	CLIP-seq
MIRT1187188	hsa-miR-520a-5p	CLIP-seq
MIRT1187189	hsa-miR-525-5p	CLIP-seq
MIRT1187190	hsa-miR-548a-3p	CLIP-seq
MIRT1187191	hsa-miR-548e	CLIP-seq
MIRT1187192	hsa-miR-548f	CLIP-seq
MIRT1187193	hsa-miR-548m	CLIP-seq
MIRT1187194	hsa-miR-548u	CLIP-seq
MIRT1187195	hsa-miR-609	CLIP-seq
MIRT1187196	hsa-miR-610	CLIP-seq
MIRT1187197	hsa-miR-661	CLIP-seq
MIRT1187198	hsa-miR-675	CLIP-seq
MIRT1187199	hsa-miR-764	CLIP-seq
MIRT1187200	hsa-miR-766	CLIP-seq
MIRT1187201	hsa-miR-876-3p	CLIP-seq
MIRT1187202	hsa-miR-920	CLIP-seq
MIRT1187145	hsa-miR-1227	CLIP-seq
MIRT2054203	hsa-miR-1254	CLIP-seq
MIRT1187149	hsa-miR-1293	CLIP-seq
MIRT1187150	hsa-miR-186	CLIP-seq
MIRT2054204	hsa-miR-199a-5p	CLIP-seq
MIRT2054205	hsa-miR-199b-5p	CLIP-seq
MIRT2054206	hsa-miR-3116	CLIP-seq
MIRT1187153	hsa-miR-3122	CLIP-seq
MIRT1187154	hsa-miR-3133	CLIP-seq
MIRT1187155	hsa-miR-3165	CLIP-seq
MIRT1187162	hsa-miR-3614-5p	CLIP-seq
MIRT2054207	hsa-miR-3619-3p	CLIP-seq
MIRT1187163	hsa-miR-3689a-3p	CLIP-seq
MIRT1187164	hsa-miR-3689c	CLIP-seq
MIRT2054208	hsa-miR-3690	CLIP-seq
MIRT1187167	hsa-miR-3913-5p	CLIP-seq
MIRT2054209	hsa-miR-3938	CLIP-seq
MIRT1187171	hsa-miR-4424	CLIP-seq
MIRT1187172	hsa-miR-4433	CLIP-seq
MIRT1187174	hsa-miR-4459	CLIP-seq
MIRT1187176	hsa-miR-4483	CLIP-seq
MIRT2054210	hsa-miR-4640-3p	CLIP-seq
MIRT1187182	hsa-miR-4653-3p	CLIP-seq
MIRT1187183	hsa-miR-4728-5p	CLIP-seq
MIRT2054211	hsa-miR-4742-3p	CLIP-seq
MIRT1187184	hsa-miR-4768-3p	CLIP-seq
MIRT2054212	hsa-miR-4776-5p	CLIP-seq
MIRT1187187	hsa-miR-508-5p	CLIP-seq
MIRT2054213	hsa-miR-515-5p	CLIP-seq
MIRT2054214	hsa-miR-550a	CLIP-seq
MIRT2054215	hsa-miR-630	CLIP-seq
MIRT1187197	hsa-miR-661	CLIP-seq
MIRT2054216	hsa-miR-663b	CLIP-seq
MIRT1187145	hsa-miR-1227	CLIP-seq
MIRT1187146	hsa-miR-1228	CLIP-seq
MIRT2283365	hsa-miR-1253	CLIP-seq
MIRT1187147	hsa-miR-1273	CLIP-seq
MIRT1187148	hsa-miR-1273c	CLIP-seq
MIRT1187149	hsa-miR-1293	CLIP-seq
MIRT2283366	hsa-miR-139-5p	CLIP-seq
MIRT2283367	hsa-miR-1827	CLIP-seq
MIRT2283368	hsa-miR-1908	CLIP-seq
MIRT2283369	hsa-miR-1909	CLIP-seq
MIRT1187151	hsa-miR-24	CLIP-seq
MIRT2283370	hsa-miR-28-5p	CLIP-seq
MIRT1187153	hsa-miR-3122	CLIP-seq
MIRT2283371	hsa-miR-3139	CLIP-seq
MIRT2283372	hsa-miR-3160-3p	CLIP-seq
MIRT1187155	hsa-miR-3165	CLIP-seq
MIRT1187158	hsa-miR-323-5p	CLIP-seq
MIRT1187159	hsa-miR-335	CLIP-seq
MIRT1187160	hsa-miR-342-3p	CLIP-seq
MIRT2283373	hsa-miR-34b	CLIP-seq
MIRT1187162	hsa-miR-3614-5p	CLIP-seq
MIRT2283374	hsa-miR-3656	CLIP-seq
MIRT1187163	hsa-miR-3689a-3p	CLIP-seq
MIRT1187164	hsa-miR-3689c	CLIP-seq
MIRT1187167	hsa-miR-3913-5p	CLIP-seq
MIRT1187168	hsa-miR-4252	CLIP-seq
MIRT2283375	hsa-miR-4270	CLIP-seq
MIRT1187169	hsa-miR-4284	CLIP-seq
MIRT1187170	hsa-miR-4300	CLIP-seq
MIRT1187171	hsa-miR-4424	CLIP-seq
MIRT1187172	hsa-miR-4433	CLIP-seq
MIRT2283376	hsa-miR-4441	CLIP-seq
MIRT1187173	hsa-miR-4455	CLIP-seq
MIRT1187174	hsa-miR-4459	CLIP-seq
MIRT1187175	hsa-miR-4466	CLIP-seq
MIRT1187176	hsa-miR-4483	CLIP-seq
MIRT1187177	hsa-miR-4486	CLIP-seq
MIRT2283377	hsa-miR-4487	CLIP-seq
MIRT1187181	hsa-miR-4649-5p	CLIP-seq
MIRT1187182	hsa-miR-4653-3p	CLIP-seq
MIRT2283378	hsa-miR-4659a-3p	CLIP-seq
MIRT2283379	hsa-miR-4659b-3p	CLIP-seq
MIRT2283380	hsa-miR-4712-5p	CLIP-seq
MIRT2283381	hsa-miR-4722-5p	CLIP-seq
MIRT1187183	hsa-miR-4728-5p	CLIP-seq
MIRT1187184	hsa-miR-4768-3p	CLIP-seq
MIRT2283382	hsa-miR-4778-3p	CLIP-seq
MIRT1187185	hsa-miR-4778-5p	CLIP-seq
MIRT1187186	hsa-miR-4793-3p	CLIP-seq
MIRT1187187	hsa-miR-508-5p	CLIP-seq
MIRT2283383	hsa-miR-526b	CLIP-seq
MIRT2283384	hsa-miR-544b	CLIP-seq
MIRT1187194	hsa-miR-548u	CLIP-seq
MIRT2054214	hsa-miR-550a	CLIP-seq
MIRT2283385	hsa-miR-558	CLIP-seq
MIRT2283386	hsa-miR-580	CLIP-seq
MIRT2283387	hsa-miR-603	CLIP-seq
MIRT2283388	hsa-miR-606	CLIP-seq
MIRT1187195	hsa-miR-609	CLIP-seq
MIRT2283389	hsa-miR-658	CLIP-seq
MIRT1187197	hsa-miR-661	CLIP-seq
MIRT2283390	hsa-miR-663	CLIP-seq
MIRT1187198	hsa-miR-675	CLIP-seq
MIRT2283391	hsa-miR-708	CLIP-seq
MIRT1187200	hsa-miR-766	CLIP-seq
MIRT2283392	hsa-miR-770-5p	CLIP-seq
MIRT1187201	hsa-miR-876-3p	CLIP-seq
MIRT2283393	hsa-miR-890	CLIP-seq
MIRT1187202	hsa-miR-920	CLIP-seq
MIRT2283394	hsa-miR-940	CLIP-seq
MIRT2439011	hsa-miR-149	CLIP-seq
MIRT2439012	hsa-miR-3650	CLIP-seq
MIRT2439013	hsa-miR-4299	CLIP-seq
MIRT2439014	hsa-miR-4456	CLIP-seq
MIRT2439015	hsa-miR-548q	CLIP-seq
MIRT2054214	hsa-miR-550a	CLIP-seq
MIRT2439016	hsa-miR-760	CLIP-seq
MIRT2455247	hsa-miR-103a	CLIP-seq
MIRT2455248	hsa-miR-107	CLIP-seq
MIRT2455249	hsa-miR-1184	CLIP-seq
MIRT1187146	hsa-miR-1228	CLIP-seq
MIRT2455250	hsa-miR-1283	CLIP-seq
MIRT1187149	hsa-miR-1293	CLIP-seq
MIRT2283368	hsa-miR-1908	CLIP-seq
MIRT2455251	hsa-miR-1976	CLIP-seq
MIRT2283370	hsa-miR-28-5p	CLIP-seq
MIRT2455252	hsa-miR-298	CLIP-seq
MIRT1187153	hsa-miR-3122	CLIP-seq
MIRT2283371	hsa-miR-3139	CLIP-seq
MIRT1187155	hsa-miR-3165	CLIP-seq
MIRT1187158	hsa-miR-323-5p	CLIP-seq
MIRT1187161	hsa-miR-3613-3p	CLIP-seq
MIRT1187162	hsa-miR-3614-5p	CLIP-seq
MIRT2455253	hsa-miR-3622b-5p	CLIP-seq
MIRT2283374	hsa-miR-3656	CLIP-seq
MIRT2455254	hsa-miR-3670	CLIP-seq
MIRT1187163	hsa-miR-3689a-3p	CLIP-seq
MIRT1187164	hsa-miR-3689c	CLIP-seq
MIRT1187165	hsa-miR-371-5p	CLIP-seq
MIRT1187166	hsa-miR-371b-5p	CLIP-seq
MIRT1187167	hsa-miR-3913-5p	CLIP-seq
MIRT2455255	hsa-miR-4253	CLIP-seq
MIRT1187172	hsa-miR-4433	CLIP-seq
MIRT1187173	hsa-miR-4455	CLIP-seq
MIRT1187174	hsa-miR-4459	CLIP-seq
MIRT1187175	hsa-miR-4466	CLIP-seq
MIRT1187176	hsa-miR-4483	CLIP-seq
MIRT1187182	hsa-miR-4653-3p	CLIP-seq
MIRT1187183	hsa-miR-4728-5p	CLIP-seq
MIRT1187184	hsa-miR-4768-3p	CLIP-seq
MIRT2455256	hsa-miR-483-3p	CLIP-seq
MIRT2455257	hsa-miR-495	CLIP-seq
MIRT1187190	hsa-miR-548a-3p	CLIP-seq
MIRT1187191	hsa-miR-548e	CLIP-seq
MIRT1187192	hsa-miR-548f	CLIP-seq
MIRT1187195	hsa-miR-609	CLIP-seq
MIRT2283390	hsa-miR-663	CLIP-seq
MIRT1187198	hsa-miR-675	CLIP-seq
MIRT2283391	hsa-miR-708	CLIP-seq
MIRT1187201	hsa-miR-876-3p	CLIP-seq
MIRT2455258	hsa-miR-922	CLIP-seq
MIRT1187146	hsa-miR-1228	CLIP-seq
MIRT1187149	hsa-miR-1293	CLIP-seq
MIRT1187153	hsa-miR-3122	CLIP-seq
MIRT1187155	hsa-miR-3165	CLIP-seq
MIRT1187162	hsa-miR-3614-5p	CLIP-seq
MIRT1187163	hsa-miR-3689a-3p	CLIP-seq
MIRT1187164	hsa-miR-3689c	CLIP-seq
MIRT1187167	hsa-miR-3913-5p	CLIP-seq
MIRT1187173	hsa-miR-4455	CLIP-seq
MIRT1187176	hsa-miR-4483	CLIP-seq
MIRT1187183	hsa-miR-4728-5p	CLIP-seq
MIRT1187195	hsa-miR-609	CLIP-seq
MIRT1187146	hsa-miR-1228	CLIP-seq
MIRT1187147	hsa-miR-1273	CLIP-seq
MIRT1187148	hsa-miR-1273c	CLIP-seq
MIRT2455250	hsa-miR-1283	CLIP-seq
MIRT1187149	hsa-miR-1293	CLIP-seq
MIRT2439011	hsa-miR-149	CLIP-seq
MIRT1187150	hsa-miR-186	CLIP-seq
MIRT1187152	hsa-miR-3120-5p	CLIP-seq
MIRT1187153	hsa-miR-3122	CLIP-seq
MIRT1187154	hsa-miR-3133	CLIP-seq
MIRT1187155	hsa-miR-3165	CLIP-seq
MIRT1187158	hsa-miR-323-5p	CLIP-seq
MIRT1187159	hsa-miR-335	CLIP-seq
MIRT1187161	hsa-miR-3613-3p	CLIP-seq
MIRT1187162	hsa-miR-3614-5p	CLIP-seq
MIRT2439012	hsa-miR-3650	CLIP-seq
MIRT1187163	hsa-miR-3689a-3p	CLIP-seq
MIRT1187164	hsa-miR-3689c	CLIP-seq
MIRT1187165	hsa-miR-371-5p	CLIP-seq
MIRT1187166	hsa-miR-371b-5p	CLIP-seq
MIRT1187167	hsa-miR-3913-5p	CLIP-seq
MIRT1187168	hsa-miR-4252	CLIP-seq
MIRT2439013	hsa-miR-4299	CLIP-seq
MIRT1187171	hsa-miR-4424	CLIP-seq
MIRT1187172	hsa-miR-4433	CLIP-seq
MIRT1187173	hsa-miR-4455	CLIP-seq
MIRT2439014	hsa-miR-4456	CLIP-seq
MIRT1187174	hsa-miR-4459	CLIP-seq
MIRT1187175	hsa-miR-4466	CLIP-seq
MIRT1187176	hsa-miR-4483	CLIP-seq
MIRT1187177	hsa-miR-4486	CLIP-seq
MIRT1187181	hsa-miR-4649-5p	CLIP-seq
MIRT1187182	hsa-miR-4653-3p	CLIP-seq
MIRT2283380	hsa-miR-4712-5p	CLIP-seq
MIRT1187183	hsa-miR-4728-5p	CLIP-seq
MIRT1187184	hsa-miR-4768-3p	CLIP-seq
MIRT1187185	hsa-miR-4778-5p	CLIP-seq
MIRT1187186	hsa-miR-4793-3p	CLIP-seq
MIRT2455257	hsa-miR-495	CLIP-seq
MIRT1187187	hsa-miR-508-5p	CLIP-seq
MIRT1187190	hsa-miR-548a-3p	CLIP-seq
MIRT1187191	hsa-miR-548e	CLIP-seq
MIRT1187192	hsa-miR-548f	CLIP-seq
MIRT2439015	hsa-miR-548q	CLIP-seq
MIRT2054214	hsa-miR-550a	CLIP-seq
MIRT1187195	hsa-miR-609	CLIP-seq
MIRT1187197	hsa-miR-661	CLIP-seq
MIRT1187198	hsa-miR-675	CLIP-seq
MIRT2439016	hsa-miR-760	CLIP-seq
MIRT1187200	hsa-miR-766	CLIP-seq
MIRT2283392	hsa-miR-770-5p	CLIP-seq
MIRT1187201	hsa-miR-876-3p	CLIP-seq
MIRT1187146	hsa-miR-1228	CLIP-seq
MIRT1187147	hsa-miR-1273	CLIP-seq
MIRT1187148	hsa-miR-1273c	CLIP-seq
MIRT2455250	hsa-miR-1283	CLIP-seq
MIRT1187149	hsa-miR-1293	CLIP-seq
MIRT1187150	hsa-miR-186	CLIP-seq
MIRT1187152	hsa-miR-3120-5p	CLIP-seq
MIRT1187153	hsa-miR-3122	CLIP-seq
MIRT1187154	hsa-miR-3133	CLIP-seq
MIRT1187155	hsa-miR-3165	CLIP-seq
MIRT1187158	hsa-miR-323-5p	CLIP-seq
MIRT1187159	hsa-miR-335	CLIP-seq
MIRT1187161	hsa-miR-3613-3p	CLIP-seq
MIRT1187162	hsa-miR-3614-5p	CLIP-seq
MIRT1187163	hsa-miR-3689a-3p	CLIP-seq
MIRT1187164	hsa-miR-3689c	CLIP-seq
MIRT1187165	hsa-miR-371-5p	CLIP-seq
MIRT1187166	hsa-miR-371b-5p	CLIP-seq
MIRT1187167	hsa-miR-3913-5p	CLIP-seq
MIRT1187168	hsa-miR-4252	CLIP-seq
MIRT1187171	hsa-miR-4424	CLIP-seq
MIRT1187172	hsa-miR-4433	CLIP-seq
MIRT1187173	hsa-miR-4455	CLIP-seq
MIRT1187174	hsa-miR-4459	CLIP-seq
MIRT1187175	hsa-miR-4466	CLIP-seq
MIRT1187176	hsa-miR-4483	CLIP-seq
MIRT1187177	hsa-miR-4486	CLIP-seq
MIRT1187181	hsa-miR-4649-5p	CLIP-seq
MIRT1187182	hsa-miR-4653-3p	CLIP-seq
MIRT2283380	hsa-miR-4712-5p	CLIP-seq
MIRT1187183	hsa-miR-4728-5p	CLIP-seq
MIRT1187184	hsa-miR-4768-3p	CLIP-seq
MIRT1187185	hsa-miR-4778-5p	CLIP-seq
MIRT1187186	hsa-miR-4793-3p	CLIP-seq
MIRT2455257	hsa-miR-495	CLIP-seq
MIRT1187187	hsa-miR-508-5p	CLIP-seq
MIRT1187190	hsa-miR-548a-3p	CLIP-seq
MIRT1187191	hsa-miR-548e	CLIP-seq
MIRT1187192	hsa-miR-548f	CLIP-seq
MIRT2054214	hsa-miR-550a	CLIP-seq
MIRT1187195	hsa-miR-609	CLIP-seq
MIRT1187197	hsa-miR-661	CLIP-seq
MIRT1187198	hsa-miR-675	CLIP-seq
MIRT1187200	hsa-miR-766	CLIP-seq
MIRT2283392	hsa-miR-770-5p	CLIP-seq
MIRT1187201	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002683	Process	Negative regulation of immune system process	IEA
GO:0005515	Function	Protein binding	IPI	24560620, 25277106
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	15705585, 24560620, 25277106
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0007249	Process	Canonical NF-kappaB signal transduction	IDA	15705585
GO:0007249	Process	Canonical NF-kappaB signal transduction	IEA
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IDA	15705585
GO:0032687	Process	Negative regulation of interferon-alpha production	ISS
GO:0032688	Process	Negative regulation of interferon-beta production	ISS
GO:0032715	Process	Negative regulation of interleukin-6 production	IDA	22863753
GO:0032715	Process	Negative regulation of interleukin-6 production	IEA
GO:0032715	Process	Negative regulation of interleukin-6 production	IMP	22863753
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IDA	22863753
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IEA
GO:0032720	Process	Negative regulation of tumor necrosis factor production	IMP	22863753
GO:0034451	Component	Centriolar satellite	IDA
GO:0036312	Function	Phosphatidylinositol 3-kinase regulatory subunit binding	ISS
GO:0042110	Process	T cell activation	IEP	15705585
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IBA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IEA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IMP	22863753
GO:0045088	Process	Regulation of innate immune response	IEA
GO:0045824	Process	Negative regulation of innate immune response	ISS
GO:0048147	Process	Negative regulation of fibroblast proliferation	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	24560620
GO:0050680	Process	Negative regulation of epithelial cell proliferation	ISS
GO:0050728	Process	Negative regulation of inflammatory response	IDA	25277106
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0080090	Process	Regulation of primary metabolic process	IEA
GO:1900016	Process	Negative regulation of cytokine production involved in inflammatory response	ISS
GO:1900226	Process	Negative regulation of NLRP3 inflammasome complex assembly	IDA	25277106
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IDA	25277106

Other IDs

• MIM: 615648
• HGNC: 29889
• e!Ensembl: ENSG00000167984

Protein

• UniProt ID: Q7RTR2
• Protein name: NLR family CARD domain-containing protein 3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (NACHT, LRR and CARD domains-containing protein 3) (Nucleotide-binding oligomerization domain protein 3)
• Protein function: Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molec
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05729	NACHT	139 → 305	NACHT domain	Domain
  PF17779	NOD2_WH	395 → 453	NOD2 winged helix domain	Domain
  PF17776	NLRC4_HD2	455 → 582	NLRC4 helical domain HD2	Domain
  PF13516	LRR_6	664 → 687	Leucine Rich repeat	Repeat
  PF13516	LRR_6	692 → 715	Leucine Rich repeat	Repeat
  PF13516	LRR_6	721 → 743	Leucine Rich repeat	Repeat
  PF13516	LRR_6	776 → 799	Leucine Rich repeat	Repeat
  PF13516	LRR_6	804 → 827	Leucine Rich repeat	Repeat
  PF13516	LRR_6	832 → 855	Leucine Rich repeat	Repeat
  PF13516	LRR_6	860 → 883	Leucine Rich repeat	Repeat
  PF13516	LRR_6	888 → 911	Leucine Rich repeat	Repeat
  PF13516	LRR_6	916 → 939	Leucine Rich repeat	Repeat
  PF13516	LRR_6	972 → 995	Leucine Rich repeat	Repeat
  PF13516	LRR_6	1000 → 1023	Leucine Rich repeat	Repeat
  PF13516	LRR_6	1028 → 1051	Leucine Rich repeat	Repeat

• Sequence:

  MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQALDRTPDAPLGPCSND
  SRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLREHDFTQVEATRGGGHPAR
  TVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFR
  DLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPK
  KEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQ
  MFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTL
  CELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDM
  KAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFT
  ESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQ
  AYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAH
  RAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSV
  LSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKI
  NRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSL
  KELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLS
  LRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWN
  FIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGA
  SGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAI
  CIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM

• Sequence length: 1065

Pathways

Reactome:

IRF3-mediated induction of type I IFN

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	35173266	Associate	★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	28731142		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	30566882		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36808166	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32148377	Associate	★☆☆☆☆ Found in Text Mining only
Cartilage Diseases	Cartilage disease	Pubtator	37312878	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26378020, 28598238		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26378020	Inhibit	★☆☆☆☆ Found in Text Mining only
Common Variable Immunodeficiency	Common variable immunodeficiency	Pubtator	32047491	Associate	★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	28240593		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	35173266	Associate	★☆☆☆☆ Found in Text Mining only
Granulomatosis with Polyangiitis	Granulomatosis with polyangiitis	Pubtator	21412229	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	30271661, 30767203		★☆☆☆☆ Found in Text Mining only
Keratitis	Keratitis	BEFREE	28731142		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30081150		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	30081150		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	37312878	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28598238, 30081150, 30767203		★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	25651569		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28598238, 30081150		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	28240593		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	32034058	Associate	★☆☆☆☆ Found in Text Mining only