EIF4A1 (eukaryotic translation initiation factor 4A1)

Gene

• Entrez ID: 1973
• Gene name: Eukaryotic translation initiation factor 4A1
• Gene symbol: EIF4A1
• Synonyms (NCBI Gene): DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I
• Chromosome: 17
• Chromosome location: 17p13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004526	hsa-miR-15b-5p	Luciferase reporter assay	16609010
MIRT020524	hsa-miR-155-5p	Proteomics	18668040
MIRT028833	hsa-miR-26b-5p	Microarray	19088304
MIRT032222	hsa-let-7b-5p	Proteomics	18668040
MIRT051467	hsa-let-7e-5p	CLASH	23622248
MIRT046374	hsa-miR-23b-3p	CLASH	23622248
MIRT044105	hsa-miR-361-5p	CLASH	23622248
MIRT044001	hsa-miR-378a-5p	CLASH	23622248
MIRT041969	hsa-miR-484	CLASH	23622248
MIRT041969	hsa-miR-484	CLASH	23622248
MIRT041969	hsa-miR-484	CLASH	23622248
MIRT040186	hsa-miR-615-3p	CLASH	23622248
MIRT039364	hsa-miR-421	CLASH	23622248
MIRT039072	hsa-miR-769-3p	CLASH	23622248
MIRT038829	hsa-miR-93-3p	CLASH	23622248
MIRT038829	hsa-miR-93-3p	CLASH	23622248
MIRT037664	hsa-miR-744-5p	CLASH	23622248
MIRT036660	hsa-miR-935	CLASH	23622248
MIRT053110	hcmv-miR-US25-2-3p	Luciferase reporter assay, Western blot	23747307
MIRT345927	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT345929	hsa-miR-3154	PAR-CLIP	20371350
MIRT345935	hsa-miR-4802-5p	PAR-CLIP	20371350
MIRT345933	hsa-miR-3689d	PAR-CLIP	20371350
MIRT345938	hsa-miR-6851-5p	PAR-CLIP	20371350
MIRT574807	hsa-miR-3613-5p	PAR-CLIP	20371350
MIRT574806	hsa-miR-670-3p	PAR-CLIP	20371350
MIRT574805	hsa-miR-1238-3p	PAR-CLIP	20371350
MIRT345931	hsa-miR-3674	PAR-CLIP	20371350
MIRT198187	hsa-miR-1284	Luciferase reporter assay, qRT-PCR, Western blot	26936591
MIRT198187	hsa-miR-1284	Luciferase reporter assay, qRT-PCR, Western blot	26936591
MIRT345927	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT345929	hsa-miR-3154	PAR-CLIP	20371350
MIRT345935	hsa-miR-4802-5p	PAR-CLIP	20371350
MIRT345933	hsa-miR-3689d	PAR-CLIP	20371350
MIRT345938	hsa-miR-6851-5p	PAR-CLIP	20371350
MIRT574807	hsa-miR-3613-5p	PAR-CLIP	20371350
MIRT574806	hsa-miR-670-3p	PAR-CLIP	20371350
MIRT574805	hsa-miR-1238-3p	PAR-CLIP	20371350
MIRT345931	hsa-miR-3674	PAR-CLIP	20371350
MIRT957720	hsa-miR-1237	CLIP-seq
MIRT957721	hsa-miR-1246	CLIP-seq
MIRT957722	hsa-miR-1248	CLIP-seq
MIRT957723	hsa-miR-154	CLIP-seq
MIRT957724	hsa-miR-3162-5p	CLIP-seq
MIRT957725	hsa-miR-3192	CLIP-seq
MIRT957726	hsa-miR-326	CLIP-seq
MIRT957727	hsa-miR-330-5p	CLIP-seq
MIRT957728	hsa-miR-3591-5p	CLIP-seq
MIRT957729	hsa-miR-3662	CLIP-seq
MIRT957730	hsa-miR-4255	CLIP-seq
MIRT957731	hsa-miR-4314	CLIP-seq
MIRT957732	hsa-miR-450b-3p	CLIP-seq
MIRT957733	hsa-miR-4646-5p	CLIP-seq
MIRT957734	hsa-miR-4694-3p	CLIP-seq
MIRT957735	hsa-miR-4713-3p	CLIP-seq
MIRT957736	hsa-miR-516b	CLIP-seq
MIRT957737	hsa-miR-638	CLIP-seq
MIRT957738	hsa-miR-1207-3p	CLIP-seq
MIRT957739	hsa-miR-1225-3p	CLIP-seq
MIRT957740	hsa-miR-1233	CLIP-seq
MIRT957720	hsa-miR-1237	CLIP-seq
MIRT957721	hsa-miR-1246	CLIP-seq
MIRT957722	hsa-miR-1248	CLIP-seq
MIRT957741	hsa-miR-1253	CLIP-seq
MIRT957742	hsa-miR-129-5p	CLIP-seq
MIRT957743	hsa-miR-133a	CLIP-seq
MIRT957744	hsa-miR-133b	CLIP-seq
MIRT957745	hsa-miR-1470	CLIP-seq
MIRT957723	hsa-miR-154	CLIP-seq
MIRT957746	hsa-miR-188-5p	CLIP-seq
MIRT957747	hsa-miR-1976	CLIP-seq
MIRT957748	hsa-miR-2113	CLIP-seq
MIRT957749	hsa-miR-2114	CLIP-seq
MIRT957750	hsa-miR-2467-5p	CLIP-seq
MIRT957751	hsa-miR-28-5p	CLIP-seq
MIRT957752	hsa-miR-2964a-5p	CLIP-seq
MIRT957753	hsa-miR-3064-5p	CLIP-seq
MIRT957754	hsa-miR-3122	CLIP-seq
MIRT957755	hsa-miR-3139	CLIP-seq
MIRT957756	hsa-miR-3150b-3p	CLIP-seq
MIRT957757	hsa-miR-3152-5p	CLIP-seq
MIRT957724	hsa-miR-3162-5p	CLIP-seq
MIRT957758	hsa-miR-3188	CLIP-seq
MIRT957725	hsa-miR-3192	CLIP-seq
MIRT957726	hsa-miR-326	CLIP-seq
MIRT957727	hsa-miR-330-5p	CLIP-seq
MIRT957759	hsa-miR-338-3p	CLIP-seq
MIRT957760	hsa-miR-34b	CLIP-seq
MIRT957728	hsa-miR-3591-5p	CLIP-seq
MIRT957761	hsa-miR-3609	CLIP-seq
MIRT957762	hsa-miR-3613-3p	CLIP-seq
MIRT957763	hsa-miR-361-3p	CLIP-seq
MIRT957764	hsa-miR-3652	CLIP-seq
MIRT957729	hsa-miR-3662	CLIP-seq
MIRT957765	hsa-miR-3670	CLIP-seq
MIRT957766	hsa-miR-3689a-3p	CLIP-seq
MIRT957767	hsa-miR-3689c	CLIP-seq
MIRT957768	hsa-miR-3691-3p	CLIP-seq
MIRT957769	hsa-miR-370	CLIP-seq
MIRT957770	hsa-miR-371b-5p	CLIP-seq
MIRT957771	hsa-miR-3913-5p	CLIP-seq
MIRT957772	hsa-miR-3929	CLIP-seq
MIRT957773	hsa-miR-3943	CLIP-seq
MIRT957774	hsa-miR-3975	CLIP-seq
MIRT957730	hsa-miR-4255	CLIP-seq
MIRT957775	hsa-miR-4268	CLIP-seq
MIRT957776	hsa-miR-4272	CLIP-seq
MIRT957777	hsa-miR-4287	CLIP-seq
MIRT957731	hsa-miR-4314	CLIP-seq
MIRT957778	hsa-miR-4419b	CLIP-seq
MIRT957779	hsa-miR-4430	CLIP-seq
MIRT957780	hsa-miR-4434	CLIP-seq
MIRT957781	hsa-miR-4448	CLIP-seq
MIRT957782	hsa-miR-4478	CLIP-seq
MIRT957783	hsa-miR-4505	CLIP-seq
MIRT957732	hsa-miR-450b-3p	CLIP-seq
MIRT957784	hsa-miR-4516	CLIP-seq
MIRT957785	hsa-miR-4530	CLIP-seq
MIRT957733	hsa-miR-4646-5p	CLIP-seq
MIRT957786	hsa-miR-4667-3p	CLIP-seq
MIRT957787	hsa-miR-4685-3p	CLIP-seq
MIRT957788	hsa-miR-4689	CLIP-seq
MIRT957789	hsa-miR-4690-3p	CLIP-seq
MIRT957734	hsa-miR-4694-3p	CLIP-seq
MIRT957790	hsa-miR-4710	CLIP-seq
MIRT957735	hsa-miR-4713-3p	CLIP-seq
MIRT957791	hsa-miR-4729	CLIP-seq
MIRT957792	hsa-miR-4756-3p	CLIP-seq
MIRT957793	hsa-miR-4765	CLIP-seq
MIRT957794	hsa-miR-4774-3p	CLIP-seq
MIRT957795	hsa-miR-4780	CLIP-seq
MIRT957796	hsa-miR-4784	CLIP-seq
MIRT957797	hsa-miR-485-5p	CLIP-seq
MIRT957736	hsa-miR-516b	CLIP-seq
MIRT957798	hsa-miR-545	CLIP-seq
MIRT957799	hsa-miR-548ah	CLIP-seq
MIRT957800	hsa-miR-548t	CLIP-seq
MIRT957801	hsa-miR-607	CLIP-seq
MIRT957802	hsa-miR-623	CLIP-seq
MIRT957737	hsa-miR-638	CLIP-seq
MIRT957803	hsa-miR-642a	CLIP-seq
MIRT957804	hsa-miR-708	CLIP-seq
MIRT1983717	hsa-miR-1200	CLIP-seq
MIRT957738	hsa-miR-1207-3p	CLIP-seq
MIRT957721	hsa-miR-1246	CLIP-seq
MIRT957745	hsa-miR-1470	CLIP-seq
MIRT957723	hsa-miR-154	CLIP-seq
MIRT957748	hsa-miR-2113	CLIP-seq
MIRT957749	hsa-miR-2114	CLIP-seq
MIRT957751	hsa-miR-28-5p	CLIP-seq
MIRT1983718	hsa-miR-3074-5p	CLIP-seq
MIRT957755	hsa-miR-3139	CLIP-seq
MIRT1983719	hsa-miR-3140-5p	CLIP-seq
MIRT957756	hsa-miR-3150b-3p	CLIP-seq
MIRT957724	hsa-miR-3162-5p	CLIP-seq
MIRT957725	hsa-miR-3192	CLIP-seq
MIRT957726	hsa-miR-326	CLIP-seq
MIRT957727	hsa-miR-330-5p	CLIP-seq
MIRT957760	hsa-miR-34b	CLIP-seq
MIRT957728	hsa-miR-3591-5p	CLIP-seq
MIRT957765	hsa-miR-3670	CLIP-seq
MIRT957768	hsa-miR-3691-3p	CLIP-seq
MIRT957730	hsa-miR-4255	CLIP-seq
MIRT957777	hsa-miR-4287	CLIP-seq
MIRT957731	hsa-miR-4314	CLIP-seq
MIRT957732	hsa-miR-450b-3p	CLIP-seq
MIRT957733	hsa-miR-4646-5p	CLIP-seq
MIRT957786	hsa-miR-4667-3p	CLIP-seq
MIRT957787	hsa-miR-4685-3p	CLIP-seq
MIRT957788	hsa-miR-4689	CLIP-seq
MIRT957734	hsa-miR-4694-3p	CLIP-seq
MIRT957790	hsa-miR-4710	CLIP-seq
MIRT957735	hsa-miR-4713-3p	CLIP-seq
MIRT957793	hsa-miR-4765	CLIP-seq
MIRT957795	hsa-miR-4780	CLIP-seq
MIRT957796	hsa-miR-4784	CLIP-seq
MIRT957736	hsa-miR-516b	CLIP-seq
MIRT1983720	hsa-miR-599	CLIP-seq
MIRT957801	hsa-miR-607	CLIP-seq
MIRT957802	hsa-miR-623	CLIP-seq
MIRT957737	hsa-miR-638	CLIP-seq
MIRT957803	hsa-miR-642a	CLIP-seq
MIRT957804	hsa-miR-708	CLIP-seq
MIRT957738	hsa-miR-1207-3p	CLIP-seq
MIRT957743	hsa-miR-133a	CLIP-seq
MIRT957744	hsa-miR-133b	CLIP-seq
MIRT957745	hsa-miR-1470	CLIP-seq
MIRT957723	hsa-miR-154	CLIP-seq
MIRT957746	hsa-miR-188-5p	CLIP-seq
MIRT957747	hsa-miR-1976	CLIP-seq
MIRT957750	hsa-miR-2467-5p	CLIP-seq
MIRT957751	hsa-miR-28-5p	CLIP-seq
MIRT957752	hsa-miR-2964a-5p	CLIP-seq
MIRT957755	hsa-miR-3139	CLIP-seq
MIRT957756	hsa-miR-3150b-3p	CLIP-seq
MIRT957758	hsa-miR-3188	CLIP-seq
MIRT957725	hsa-miR-3192	CLIP-seq
MIRT957726	hsa-miR-326	CLIP-seq
MIRT957727	hsa-miR-330-5p	CLIP-seq
MIRT957759	hsa-miR-338-3p	CLIP-seq
MIRT957760	hsa-miR-34b	CLIP-seq
MIRT957763	hsa-miR-361-3p	CLIP-seq
MIRT957765	hsa-miR-3670	CLIP-seq
MIRT957768	hsa-miR-3691-3p	CLIP-seq
MIRT957769	hsa-miR-370	CLIP-seq
MIRT957772	hsa-miR-3929	CLIP-seq
MIRT957773	hsa-miR-3943	CLIP-seq
MIRT957774	hsa-miR-3975	CLIP-seq
MIRT957775	hsa-miR-4268	CLIP-seq
MIRT957777	hsa-miR-4287	CLIP-seq
MIRT957731	hsa-miR-4314	CLIP-seq
MIRT957778	hsa-miR-4419b	CLIP-seq
MIRT957781	hsa-miR-4448	CLIP-seq
MIRT957782	hsa-miR-4478	CLIP-seq
MIRT957732	hsa-miR-450b-3p	CLIP-seq
MIRT957785	hsa-miR-4530	CLIP-seq
MIRT957733	hsa-miR-4646-5p	CLIP-seq
MIRT957786	hsa-miR-4667-3p	CLIP-seq
MIRT957787	hsa-miR-4685-3p	CLIP-seq
MIRT957788	hsa-miR-4689	CLIP-seq
MIRT957789	hsa-miR-4690-3p	CLIP-seq
MIRT957790	hsa-miR-4710	CLIP-seq
MIRT957735	hsa-miR-4713-3p	CLIP-seq
MIRT957792	hsa-miR-4756-3p	CLIP-seq
MIRT957793	hsa-miR-4765	CLIP-seq
MIRT957795	hsa-miR-4780	CLIP-seq
MIRT957796	hsa-miR-4784	CLIP-seq
MIRT957797	hsa-miR-485-5p	CLIP-seq
MIRT957736	hsa-miR-516b	CLIP-seq
MIRT957798	hsa-miR-545	CLIP-seq
MIRT957801	hsa-miR-607	CLIP-seq
MIRT957802	hsa-miR-623	CLIP-seq
MIRT957737	hsa-miR-638	CLIP-seq
MIRT957803	hsa-miR-642a	CLIP-seq
MIRT957804	hsa-miR-708	CLIP-seq
MIRT957725	hsa-miR-3192	CLIP-seq
MIRT957728	hsa-miR-3591-5p	CLIP-seq
MIRT957731	hsa-miR-4314	CLIP-seq
MIRT957732	hsa-miR-450b-3p	CLIP-seq
MIRT957733	hsa-miR-4646-5p	CLIP-seq
MIRT957786	hsa-miR-4667-3p	CLIP-seq
MIRT957735	hsa-miR-4713-3p	CLIP-seq
MIRT957736	hsa-miR-516b	CLIP-seq
MIRT957737	hsa-miR-638	CLIP-seq
MIRT957738	hsa-miR-1207-3p	CLIP-seq
MIRT957721	hsa-miR-1246	CLIP-seq
MIRT957742	hsa-miR-129-5p	CLIP-seq
MIRT957745	hsa-miR-1470	CLIP-seq
MIRT957723	hsa-miR-154	CLIP-seq
MIRT957746	hsa-miR-188-5p	CLIP-seq
MIRT957749	hsa-miR-2114	CLIP-seq
MIRT957751	hsa-miR-28-5p	CLIP-seq
MIRT957752	hsa-miR-2964a-5p	CLIP-seq
MIRT2522304	hsa-miR-31	CLIP-seq
MIRT957754	hsa-miR-3122	CLIP-seq
MIRT957755	hsa-miR-3139	CLIP-seq
MIRT957756	hsa-miR-3150b-3p	CLIP-seq
MIRT957724	hsa-miR-3162-5p	CLIP-seq
MIRT957725	hsa-miR-3192	CLIP-seq
MIRT957726	hsa-miR-326	CLIP-seq
MIRT957727	hsa-miR-330-5p	CLIP-seq
MIRT2522305	hsa-miR-335	CLIP-seq
MIRT957760	hsa-miR-34b	CLIP-seq
MIRT957728	hsa-miR-3591-5p	CLIP-seq
MIRT957765	hsa-miR-3670	CLIP-seq
MIRT957766	hsa-miR-3689a-3p	CLIP-seq
MIRT957767	hsa-miR-3689c	CLIP-seq
MIRT957771	hsa-miR-3913-5p	CLIP-seq
MIRT957730	hsa-miR-4255	CLIP-seq
MIRT957777	hsa-miR-4287	CLIP-seq
MIRT957731	hsa-miR-4314	CLIP-seq
MIRT957732	hsa-miR-450b-3p	CLIP-seq
MIRT957733	hsa-miR-4646-5p	CLIP-seq
MIRT957786	hsa-miR-4667-3p	CLIP-seq
MIRT957787	hsa-miR-4685-3p	CLIP-seq
MIRT957788	hsa-miR-4689	CLIP-seq
MIRT957734	hsa-miR-4694-3p	CLIP-seq
MIRT957790	hsa-miR-4710	CLIP-seq
MIRT957735	hsa-miR-4713-3p	CLIP-seq
MIRT957795	hsa-miR-4780	CLIP-seq
MIRT957796	hsa-miR-4784	CLIP-seq
MIRT2522306	hsa-miR-486-3p	CLIP-seq
MIRT957736	hsa-miR-516b	CLIP-seq
MIRT2522307	hsa-miR-566	CLIP-seq
MIRT957801	hsa-miR-607	CLIP-seq
MIRT957802	hsa-miR-623	CLIP-seq
MIRT957737	hsa-miR-638	CLIP-seq
MIRT957803	hsa-miR-642a	CLIP-seq
MIRT2522308	hsa-miR-661	CLIP-seq
MIRT957804	hsa-miR-708	CLIP-seq
MIRT957738	hsa-miR-1207-3p	CLIP-seq
MIRT957721	hsa-miR-1246	CLIP-seq
MIRT957723	hsa-miR-154	CLIP-seq
MIRT957746	hsa-miR-188-5p	CLIP-seq
MIRT957749	hsa-miR-2114	CLIP-seq
MIRT957751	hsa-miR-28-5p	CLIP-seq
MIRT957752	hsa-miR-2964a-5p	CLIP-seq
MIRT2522304	hsa-miR-31	CLIP-seq
MIRT957755	hsa-miR-3139	CLIP-seq
MIRT957756	hsa-miR-3150b-3p	CLIP-seq
MIRT957724	hsa-miR-3162-5p	CLIP-seq
MIRT957725	hsa-miR-3192	CLIP-seq
MIRT957726	hsa-miR-326	CLIP-seq
MIRT957727	hsa-miR-330-5p	CLIP-seq
MIRT2522305	hsa-miR-335	CLIP-seq
MIRT957760	hsa-miR-34b	CLIP-seq
MIRT957728	hsa-miR-3591-5p	CLIP-seq
MIRT957765	hsa-miR-3670	CLIP-seq
MIRT957730	hsa-miR-4255	CLIP-seq
MIRT957777	hsa-miR-4287	CLIP-seq
MIRT957731	hsa-miR-4314	CLIP-seq
MIRT957732	hsa-miR-450b-3p	CLIP-seq
MIRT957733	hsa-miR-4646-5p	CLIP-seq
MIRT957786	hsa-miR-4667-3p	CLIP-seq
MIRT957787	hsa-miR-4685-3p	CLIP-seq
MIRT957788	hsa-miR-4689	CLIP-seq
MIRT957734	hsa-miR-4694-3p	CLIP-seq
MIRT957790	hsa-miR-4710	CLIP-seq
MIRT957735	hsa-miR-4713-3p	CLIP-seq
MIRT957795	hsa-miR-4780	CLIP-seq
MIRT957796	hsa-miR-4784	CLIP-seq
MIRT2522306	hsa-miR-486-3p	CLIP-seq
MIRT957736	hsa-miR-516b	CLIP-seq
MIRT2522307	hsa-miR-566	CLIP-seq
MIRT957801	hsa-miR-607	CLIP-seq
MIRT957802	hsa-miR-623	CLIP-seq
MIRT957737	hsa-miR-638	CLIP-seq
MIRT2522308	hsa-miR-661	CLIP-seq
MIRT957804	hsa-miR-708	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000339	Function	RNA cap binding	TAS	3215517
GO:0002183	Process	Cytoplasmic translational initiation	IBA
GO:0002183	Process	Cytoplasmic translational initiation	IDA	34731628
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0003729	Function	MRNA binding	TAS	3215517
GO:0003743	Function	Translation initiation factor activity	IBA
GO:0003743	Function	Translation initiation factor activity	IDA	34731628
GO:0003743	Function	Translation initiation factor activity	IEA
GO:0004386	Function	Helicase activity	IEA
GO:0004386	Function	Helicase activity	TAS	3215517
GO:0005515	Function	Protein binding	IPI	9548260, 16166382, 16932749, 17284590, 18296639, 18606994, 19203580, 19204291, 20156963, 22678294, 23023399, 23444369, 23478064, 24413684, 28514442, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	12426392
GO:0005737	Component	Cytoplasm	IDA	12426392
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	20156963
GO:0005886	Component	Plasma membrane	IEA
GO:0006412	Process	Translation	IEA
GO:0006413	Process	Translational initiation	IEA
GO:0006413	Process	Translational initiation	NAS	19239892
GO:0008135	Function	Translation factor activity, RNA binding	TAS	3215517, 10880459
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016281	Component	Eukaryotic translation initiation factor 4F complex	IEA
GO:0016281	Component	Eukaryotic translation initiation factor 4F complex	NAS	19239892
GO:0016281	Component	Eukaryotic translation initiation factor 4F complex	TAS	9168945
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	20156963
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	20156963
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0097165	Component	Nuclear stress granule	IDA	20156963

Other IDs

• MIM: 602641
• HGNC: 3282
• e!Ensembl: ENSG00000161960

Protein

• UniProt ID: P60842
• Protein name: Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
• Protein function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures
• PDB: 2G9N, 2ZU6, 3EIQ, 5ZBZ, 5ZC9, 6ZMW, 7PPZ, 7PQ0, 8HUJ, 8OZ0, 8XXN, 9AVR, 9BLN, 9DTS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00270	DEAD	56 → 223	DEAD/DEAH box helicase	Domain
  PF00271	Helicase_C	258 → 367	Helicase conserved C-terminal domain	Family

• Sequence:

  MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
  RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
  MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
  LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
  LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
  AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
  GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI

• Sequence length: 406

Pathways

Reactome:

ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
Deadenylation of mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Autism spectrum disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acoustic Neuroma	Acoustic Neuroma	BEFREE	26951381		★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	31672935		★☆☆☆☆ Found in Text Mining only
Aortic Dissection	Aortic dissection	Pubtator	36818541	Associate	★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	25320244		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22484424, 25611378		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25611378	Associate	★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt lymphoma	Pubtator	34676755	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	26498689		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32871777	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33461173	Associate	★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	29163714		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	29163714		★☆☆☆☆ Found in Text Mining only
Childhood Acute Myeloid Leukemia	Acute Myeloid Leukemia	BEFREE	15715967		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	27913706		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28466778		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28627973, 33237662	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Restenosis	Coronary restenosis	Pubtator	35968900	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	32978410	Associate	★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	25320244		★☆☆☆☆ Found in Text Mining only
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1	Ectrodactyly	BEFREE	22415234		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	22415234	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	40658715	Associate	★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	26274822	Stimulate	★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	27913706		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	25079319, 25392452		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	36482393	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	36482393	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	15142884	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	12521301		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24844222	Stimulate	★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	25320244		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	36058921	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22484424, 25611378, 29844125		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	30744688, 31672935		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	31190893		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25079319, 26614665, 27864075, 28627973, 28757063, 29228324, 29471358, 29786657, 29844125, 29844128, 31395685		★☆☆☆☆ Found in Text Mining only
Malignant Peripheral Nerve Sheath Tumor	Malignant Peripheral Nerve Sheath Tumor	BEFREE	26951381, 31848295		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	29163714		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	25611378		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	12085193, 27879264	Associate	★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	25079330, 27533468		★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	BEFREE	28610844		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	25392452		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25934076, 28466778, 30760284, 31310112, 31723131, 31807078		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	33540613	Stimulate	★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	BEFREE	29228324		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	12970751		★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	25611378		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	30744688, 31672935		★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	31723131		★☆☆☆☆ Found in Text Mining only
Patent ductus arteriosus	Patent ductus arteriosus	BEFREE	31723131		★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	25079319		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35361883	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	31807078		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	31190893		★☆☆☆☆ Found in Text Mining only
Thromboangiitis Obliterans	Thromboangiitis obliterans	Pubtator	38275601	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	35672711, 37983610	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	24844222	Associate	★☆☆☆☆ Found in Text Mining only