Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	196743
Gene name	Polyamine oxidase
Gene symbol	PAOX
Synonyms (NCBI Gene)	PAO
Chromosome	10
Chromosome location	10q26.3

176

Show/Hide all (176)

miRTarBase ID	miRNA	Experiments	Reference
MIRT713717	hsa-miR-4695-5p	HITS-CLIP	19536157
MIRT713716	hsa-miR-1470	HITS-CLIP	19536157
MIRT713715	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT713714	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT713713	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT616575	hsa-miR-4469	HITS-CLIP	19536157
MIRT713712	hsa-miR-6087	HITS-CLIP	19536157
MIRT713711	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT713717	hsa-miR-4695-5p	HITS-CLIP	19536157
MIRT713716	hsa-miR-1470	HITS-CLIP	19536157
MIRT713715	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT713714	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT713713	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT616575	hsa-miR-4469	HITS-CLIP	19536157
MIRT713712	hsa-miR-6087	HITS-CLIP	19536157
MIRT713711	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT667068	hsa-miR-1245a	HITS-CLIP	23824327
MIRT667067	hsa-miR-8079	HITS-CLIP	23824327
MIRT667066	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT667065	hsa-miR-4421	HITS-CLIP	23824327
MIRT667063	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT667064	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT667062	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667061	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT667060	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT713717	hsa-miR-4695-5p	HITS-CLIP	19536157
MIRT713716	hsa-miR-1470	HITS-CLIP	19536157
MIRT713715	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT713714	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT713713	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT616575	hsa-miR-4469	HITS-CLIP	19536157
MIRT713712	hsa-miR-6087	HITS-CLIP	19536157
MIRT713711	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT713717	hsa-miR-4695-5p	HITS-CLIP	19536157
MIRT713716	hsa-miR-1470	HITS-CLIP	19536157
MIRT713715	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT713714	hsa-miR-1234-3p	HITS-CLIP	19536157
MIRT713713	hsa-miR-7107-5p	HITS-CLIP	19536157
MIRT616575	hsa-miR-4469	HITS-CLIP	19536157
MIRT713712	hsa-miR-6087	HITS-CLIP	19536157
MIRT713711	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT667068	hsa-miR-1245a	HITS-CLIP	23824327
MIRT667067	hsa-miR-8079	HITS-CLIP	23824327
MIRT667066	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT667065	hsa-miR-4421	HITS-CLIP	23824327
MIRT667063	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT667064	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT667062	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667061	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT667060	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT616575	hsa-miR-4469	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT614014	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT614013	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT614012	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT614011	hsa-miR-4287	HITS-CLIP	23824327
MIRT614010	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT614009	hsa-miR-6792-5p	HITS-CLIP	23824327
MIRT614008	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT614007	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT614006	hsa-miR-4503	HITS-CLIP	23824327
MIRT614005	hsa-miR-629-3p	HITS-CLIP	23824327

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005777	Component	Peroxisome	IEA
GO:0005782	Component	Peroxisomal matrix	IEA
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006598	Process	Polyamine catabolic process	IDA	12477380
GO:0006598	Process	Polyamine catabolic process	IEA
GO:0006598	Process	Polyamine catabolic process	IEA
GO:0008215	Process	Spermine metabolic process	IEA
GO:0009446	Process	Putrescine biosynthetic process	IDA	16354669
GO:0009447	Process	Putrescine catabolic process	IDA	16354669
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0046203	Process	Spermidine catabolic process	IBA
GO:0046203	Process	Spermidine catabolic process	IDA	16354669
GO:0046203	Process	Spermidine catabolic process	IEA
GO:0046208	Process	Spermine catabolic process	IDA	16354669
GO:0046208	Process	Spermine catabolic process	IEA
GO:0046592	Function	Polyamine oxidase activity	IBA
GO:0046592	Function	Polyamine oxidase activity	IDA	12477380, 16354669
GO:0046592	Function	Polyamine oxidase activity	IEA
GO:0052903	Function	N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity	IEA
GO:1901307	Process	Positive regulation of spermidine biosynthetic process	IDA	16354669

MIM	HGNC	e!Ensembl
615853	20837	ENSG00000148832

Q6QHF9

Protein name

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase)

Protein function

Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylsperm

Family and domains

Pfam

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Accession	ID	Position in sequence	Description	Type
PF01593	Amino_oxidase	23 → 168	Flavin containing amine oxidoreductase	Domain
PF01593	Amino_oxidase	168 → 635	Flavin containing amine oxidoreductase	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues. {ECO:0000269|PubMed:12477380}.

Sequence

MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATARAGGRIRSERCF
GGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGA
SVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLKKEIGQHVAGWTEDEETRKLK
LAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLDCTFSKGYQGLTNCMMAALPEDT
VVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPLGFLREHLDTFF
DPPLPAEKAEAIRKIGFGTNNKIFLEFEEPFWEPDCQLIQLVWEDTSPLEDAAPELQDAW
FRKLIGFVVLPAFASVHVLCGFIAGLESEFMETLSDEEVLLCLTQVLRRVTGNPRLPAPK
SVLRSRWHSAPYTRGSYSYVAVGSTGGDLDLLAQPLPADGAGAQLQILFAGEATHRTFYS
TTHGALLSGWREADRLLSLWAPQVQQPRPRL

Sequence length

511

Interactions

View interactions

	KEGG		Reactome
	Peroxisome		PAOs oxidise polyamines to amines Interconversion of polyamines Peroxisomal protein import

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CEREBROVASCULAR ACCIDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OROPHARYNX CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	CTD, GWAS catalog CTD, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Cerebrovascular Accidents	Stroke	CTD_human_DG	16269634		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	19773450		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	31422082		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	31422082		★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	Pubtator	37854191	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	17610126		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	35886868	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral hemorrhage with amyloidosis, hereditary, Dutch type	Cerebral Amyloid Angiopathy	BEFREE	2398939		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	CTD_human_DG	16269634		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cystic Fibrosis	Cystic Fibrosis	BEFREE	2140147		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	28370312		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	31422082		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	31422082		★★★★★ ★☆☆☆☆ Found in Text Mining only
Encephalitis	Encephalitis	BEFREE	29775745		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Angioedema Type III	Hereditary angioedema	Pubtator	35886868	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperlipidemia	Hyperlipidemia	BEFREE	31422082		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	17610126		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	19773450		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	16207710		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	30686964		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31016788		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary Myelofibrosis	Myelofibrosis	BEFREE	26547506		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	19773450		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinal Diseases	Retinal Diseases	BEFREE	30686964		★★★★★ ★☆☆☆☆ Found in Text Mining only

PAOX (polyamine oxidase)