Gene Gene information from NCBI Gene database.
Entrez ID 196740
Gene name V-set and transmembrane domain containing 4
Gene symbol VSTM4
Synonyms (NCBI Gene)
C10orf72
Chromosome 10
Chromosome location 10q11.23
miRNA miRNA information provided by mirtarbase database.
360
miRTarBase ID miRNA Experiments Reference
MIRT665482 hsa-miR-6890-3p HITS-CLIP 23824327
MIRT665481 hsa-miR-1247-3p HITS-CLIP 23824327
MIRT665480 hsa-miR-4532 HITS-CLIP 23824327
MIRT665479 hsa-miR-4485-5p HITS-CLIP 23824327
MIRT665478 hsa-miR-1281 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11
GO ID Ontology Definition Evidence Reference
GO:0001935 Process Endothelial cell proliferation IEA
GO:0002040 Process Sprouting angiogenesis IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IW00
Protein name V-set and transmembrane domain-containing protein 4 [Cleaved into: Peptide Lv]
Protein function Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 29 149 Immunoglobulin V-set domain Domain
Sequence
MRLLALAAAALLARAPAPEVCAALNVTVSPGPVVDYLEGENATLLCHVSQKRRKDSLLAV
RWFFAHSFDSQEALMVKMTKLRVVQYYGNFSRSAKRRRLRLLEEQRGALYRLSVLTLQPS
DQGHYVCRVQEISRHRNKWTAWSNGSSAT
EMRVISLKASEESSFEKTKETWAFFEDLYVY
AVLVCCVGILSILLFMLVIVWQSVFNKRKSRVRHYLVKCPQNSSGETVTSVTSLAPLQPK
KGKRQKEKPDIPPAVPAKAPIAPTFHKPKLLKPQRKVTLPKIAEENLTYAELELIKPHRA
AKGAPTSTVYAQILFEENKL
Sequence length 320
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CATARACT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MIGRAINE WITH AURA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Colorectal Carcinoma Colorectal Cancer UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Migraine Disorders Migraine GWASCAT_DG 23793025
★☆☆☆☆
Found in Text Mining only
Migraine with Aura Migraine with Aura GWASDB_DG 23793025
★★☆☆☆
Found in Text Mining + Unknown/Other Associations