Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	196403
Gene name	Deltex E3 ubiquitin ligase 3
Gene symbol	DTX3
Synonyms (NCBI Gene)	RNF154deltex3
Chromosome	12
Chromosome location	12q13.3
Summary	DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

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Show/Hide all (213)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044416	hsa-miR-320a	CLASH	23622248
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT947011	hsa-miR-1234	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT947016	hsa-miR-3175	CLIP-seq
MIRT947017	hsa-miR-3184	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT947019	hsa-miR-3656	CLIP-seq
MIRT947020	hsa-miR-3670	CLIP-seq
MIRT947021	hsa-miR-3689d	CLIP-seq
MIRT947022	hsa-miR-423-5p	CLIP-seq
MIRT947023	hsa-miR-4300	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT947025	hsa-miR-432	CLIP-seq
MIRT947026	hsa-miR-4440	CLIP-seq
MIRT947027	hsa-miR-4443	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT947031	hsa-miR-4688	CLIP-seq
MIRT947032	hsa-miR-4690-3p	CLIP-seq
MIRT947033	hsa-miR-4728-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT947036	hsa-miR-4773	CLIP-seq
MIRT947037	hsa-miR-4802-5p	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT947039	hsa-miR-602	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT947042	hsa-miR-920	CLIP-seq
MIRT947043	hsa-miR-939	CLIP-seq
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT947011	hsa-miR-1234	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT1980442	hsa-miR-1909	CLIP-seq
MIRT1980443	hsa-miR-217	CLIP-seq
MIRT1980444	hsa-miR-24	CLIP-seq
MIRT1980445	hsa-miR-3151	CLIP-seq
MIRT1980446	hsa-miR-3154	CLIP-seq
MIRT947016	hsa-miR-3175	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT1980447	hsa-miR-33a	CLIP-seq
MIRT1980448	hsa-miR-33b	CLIP-seq
MIRT1980449	hsa-miR-342-3p	CLIP-seq
MIRT1980450	hsa-miR-3650	CLIP-seq
MIRT947021	hsa-miR-3689d	CLIP-seq
MIRT1980451	hsa-miR-4284	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT947025	hsa-miR-432	CLIP-seq
MIRT947027	hsa-miR-4443	CLIP-seq
MIRT1980452	hsa-miR-4447	CLIP-seq
MIRT1980453	hsa-miR-4472	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT1980454	hsa-miR-4499	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT1980455	hsa-miR-4727-5p	CLIP-seq
MIRT947033	hsa-miR-4728-5p	CLIP-seq
MIRT1980456	hsa-miR-4757-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT1980457	hsa-miR-4769-3p	CLIP-seq
MIRT947036	hsa-miR-4773	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT1980458	hsa-miR-491-5p	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT2215500	hsa-miR-139-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT2215501	hsa-miR-3128	CLIP-seq
MIRT2215502	hsa-miR-3173-3p	CLIP-seq
MIRT2215503	hsa-miR-3180-5p	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT2215504	hsa-miR-4428	CLIP-seq
MIRT1980454	hsa-miR-4499	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT2215505	hsa-miR-4720-5p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT947036	hsa-miR-4773	CLIP-seq
MIRT2215506	hsa-miR-4799-3p	CLIP-seq
MIRT2215507	hsa-miR-520a-5p	CLIP-seq
MIRT2215508	hsa-miR-525-5p	CLIP-seq
MIRT2215509	hsa-miR-548v	CLIP-seq
MIRT2215510	hsa-miR-555	CLIP-seq
MIRT2215511	hsa-miR-622	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT2215512	hsa-miR-885-3p	CLIP-seq
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT2519891	hsa-miR-1275	CLIP-seq
MIRT2519892	hsa-miR-1324	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT1980442	hsa-miR-1909	CLIP-seq
MIRT1980443	hsa-miR-217	CLIP-seq
MIRT2519893	hsa-miR-3150b-3p	CLIP-seq
MIRT1980445	hsa-miR-3151	CLIP-seq
MIRT2519894	hsa-miR-3187-3p	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT2519895	hsa-miR-3202	CLIP-seq
MIRT1980447	hsa-miR-33a	CLIP-seq
MIRT1980448	hsa-miR-33b	CLIP-seq
MIRT2519896	hsa-miR-3614-5p	CLIP-seq
MIRT2519897	hsa-miR-3615	CLIP-seq
MIRT1980450	hsa-miR-3650	CLIP-seq
MIRT947019	hsa-miR-3656	CLIP-seq
MIRT947020	hsa-miR-3670	CLIP-seq
MIRT2519898	hsa-miR-3917	CLIP-seq
MIRT2519899	hsa-miR-3934	CLIP-seq
MIRT2519900	hsa-miR-4271	CLIP-seq
MIRT2519901	hsa-miR-4279	CLIP-seq
MIRT2519902	hsa-miR-4287	CLIP-seq
MIRT947023	hsa-miR-4300	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT2519903	hsa-miR-4313	CLIP-seq
MIRT2519904	hsa-miR-4435	CLIP-seq
MIRT1980452	hsa-miR-4447	CLIP-seq
MIRT2519905	hsa-miR-4469	CLIP-seq
MIRT1980453	hsa-miR-4472	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT2519906	hsa-miR-4525	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT2519907	hsa-miR-4665-5p	CLIP-seq
MIRT2519908	hsa-miR-4685-3p	CLIP-seq
MIRT947032	hsa-miR-4690-3p	CLIP-seq
MIRT2519909	hsa-miR-4701-5p	CLIP-seq
MIRT2519910	hsa-miR-4707-5p	CLIP-seq
MIRT2519911	hsa-miR-4723-5p	CLIP-seq
MIRT2519912	hsa-miR-4725-3p	CLIP-seq
MIRT2519913	hsa-miR-4747-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT2519914	hsa-miR-4784	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT1980458	hsa-miR-491-5p	CLIP-seq
MIRT2519915	hsa-miR-494	CLIP-seq
MIRT2519916	hsa-miR-548s	CLIP-seq
MIRT2519917	hsa-miR-552	CLIP-seq
MIRT2519918	hsa-miR-583	CLIP-seq
MIRT2519919	hsa-miR-588	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT2519920	hsa-miR-625	CLIP-seq
MIRT2519921	hsa-miR-642a	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT947042	hsa-miR-920	CLIP-seq
MIRT947043	hsa-miR-939	CLIP-seq
MIRT947010	hsa-miR-1207-5p	CLIP-seq
MIRT2519891	hsa-miR-1275	CLIP-seq
MIRT2519892	hsa-miR-1324	CLIP-seq
MIRT947012	hsa-miR-146a	CLIP-seq
MIRT947013	hsa-miR-146b-5p	CLIP-seq
MIRT947014	hsa-miR-185	CLIP-seq
MIRT947015	hsa-miR-1908	CLIP-seq
MIRT1980442	hsa-miR-1909	CLIP-seq
MIRT1980443	hsa-miR-217	CLIP-seq
MIRT1980445	hsa-miR-3151	CLIP-seq
MIRT2519894	hsa-miR-3187-3p	CLIP-seq
MIRT947018	hsa-miR-3200-5p	CLIP-seq
MIRT2519895	hsa-miR-3202	CLIP-seq
MIRT1980447	hsa-miR-33a	CLIP-seq
MIRT1980448	hsa-miR-33b	CLIP-seq
MIRT2519896	hsa-miR-3614-5p	CLIP-seq
MIRT2519897	hsa-miR-3615	CLIP-seq
MIRT1980450	hsa-miR-3650	CLIP-seq
MIRT947019	hsa-miR-3656	CLIP-seq
MIRT947020	hsa-miR-3670	CLIP-seq
MIRT2519898	hsa-miR-3917	CLIP-seq
MIRT2519899	hsa-miR-3934	CLIP-seq
MIRT2519900	hsa-miR-4271	CLIP-seq
MIRT2519901	hsa-miR-4279	CLIP-seq
MIRT2519902	hsa-miR-4287	CLIP-seq
MIRT947023	hsa-miR-4300	CLIP-seq
MIRT947024	hsa-miR-4306	CLIP-seq
MIRT2519903	hsa-miR-4313	CLIP-seq
MIRT2519904	hsa-miR-4435	CLIP-seq
MIRT1980452	hsa-miR-4447	CLIP-seq
MIRT2519905	hsa-miR-4469	CLIP-seq
MIRT1980453	hsa-miR-4472	CLIP-seq
MIRT947028	hsa-miR-4475	CLIP-seq
MIRT947029	hsa-miR-4502	CLIP-seq
MIRT2519906	hsa-miR-4525	CLIP-seq
MIRT947030	hsa-miR-4644	CLIP-seq
MIRT2519907	hsa-miR-4665-5p	CLIP-seq
MIRT2519908	hsa-miR-4685-3p	CLIP-seq
MIRT947032	hsa-miR-4690-3p	CLIP-seq
MIRT2519909	hsa-miR-4701-5p	CLIP-seq
MIRT2519910	hsa-miR-4707-5p	CLIP-seq
MIRT2519911	hsa-miR-4723-5p	CLIP-seq
MIRT2519912	hsa-miR-4725-3p	CLIP-seq
MIRT2519913	hsa-miR-4747-5p	CLIP-seq
MIRT947034	hsa-miR-4763-3p	CLIP-seq
MIRT947035	hsa-miR-4768-3p	CLIP-seq
MIRT947038	hsa-miR-486-3p	CLIP-seq
MIRT1980458	hsa-miR-491-5p	CLIP-seq
MIRT2519915	hsa-miR-494	CLIP-seq
MIRT2519916	hsa-miR-548s	CLIP-seq
MIRT2519917	hsa-miR-552	CLIP-seq
MIRT2519919	hsa-miR-588	CLIP-seq
MIRT947040	hsa-miR-624	CLIP-seq
MIRT2519920	hsa-miR-625	CLIP-seq
MIRT2519921	hsa-miR-642a	CLIP-seq
MIRT947041	hsa-miR-663	CLIP-seq
MIRT947042	hsa-miR-920	CLIP-seq
MIRT947043	hsa-miR-939	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19549727, 22493164, 25416956, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0007219	Process	Notch signaling pathway	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
613142	24457	ENSG00000178498

Q8N9I9

Protein name

Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)

Protein function

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13923	zf-C3HC4_2	163 → 202		Domain
PF18102	DTC	210 → 344	Deltex C-terminal domain	Domain

Sequence

MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL
QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA
GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC
RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI
QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT
GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD

Sequence length

347

Interactions

View interactions

	KEGG
	Notch signaling pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	25151356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25151356, 33616774	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35098394	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	25151356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	25151356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	25151356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	25151356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31772627		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	33300431	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DTX3 (deltex E3 ubiquitin ligase 3)