Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	192669
Gene name	Argonaute RISC catalytic component 3
Gene symbol	AGO3
Synonyms (NCBI Gene)	EIF2C3
Chromosome	1
Chromosome location	1p34.3
Summary	This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001954	hsa-miR-129-5p	Luciferase reporter assay	18189265
MIRT005037	hsa-let-7b-5p	Microarray	17699775
MIRT633179	hsa-miR-4686	HITS-CLIP	23824327
MIRT633178	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT633177	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT633176	hsa-miR-764	HITS-CLIP	23824327
MIRT633174	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT676852	hsa-miR-4635	HITS-CLIP	23824327
MIRT633173	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT638989	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT633172	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT633171	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT633170	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT673076	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT673075	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT673074	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT673073	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT673072	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT673071	hsa-miR-4284	HITS-CLIP	23824327
MIRT673070	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673069	hsa-miR-4466	HITS-CLIP	23824327
MIRT673068	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT673067	hsa-miR-1295a	HITS-CLIP	23824327
MIRT673066	hsa-miR-7977	HITS-CLIP	23824327
MIRT673065	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT673064	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT673063	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT673062	hsa-miR-1248	HITS-CLIP	23824327
MIRT673061	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673060	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT673059	hsa-miR-6817-5p	HITS-CLIP	23824327
MIRT673058	hsa-miR-4294	HITS-CLIP	23824327
MIRT673057	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT673056	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT673055	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT673054	hsa-miR-3672	HITS-CLIP	23824327
MIRT673052	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT673053	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT673051	hsa-miR-8055	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT669610	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT669609	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT669608	hsa-miR-1976	HITS-CLIP	23824327
MIRT669607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT669606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT660826	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT660825	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT669605	hsa-miR-4279	HITS-CLIP	23824327
MIRT669604	hsa-miR-1245a	HITS-CLIP	23824327
MIRT669603	hsa-miR-8079	HITS-CLIP	23824327
MIRT669602	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT638993	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT669601	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT638992	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT638991	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT669600	hsa-miR-6131	HITS-CLIP	23824327
MIRT638990	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT669599	hsa-miR-640	HITS-CLIP	23824327
MIRT669598	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT669597	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT524962	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT660841	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT660840	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT660839	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT660838	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT660837	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT660836	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT660835	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT660834	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT660832	hsa-miR-3666	HITS-CLIP	23824327
MIRT660833	hsa-miR-4295	HITS-CLIP	23824327
MIRT660831	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT660830	hsa-miR-652-3p	HITS-CLIP	23824327
MIRT660829	hsa-miR-4634	HITS-CLIP	23824327
MIRT660828	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT660827	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT660826	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT660825	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT660824	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT660823	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT660822	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT660821	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT660820	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT629132	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT633179	hsa-miR-4686	HITS-CLIP	23824327
MIRT633178	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT633177	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT633176	hsa-miR-764	HITS-CLIP	23824327
MIRT633175	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT638993	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633174	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT638992	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT638991	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT638990	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT638989	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT633170	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT633179	hsa-miR-4686	HITS-CLIP	23824327
MIRT633178	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT633177	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT633176	hsa-miR-764	HITS-CLIP	23824327
MIRT633175	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT633174	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT633173	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT633172	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT633171	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT633170	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT630535	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT630534	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT630533	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT630532	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT630531	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT630530	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT629132	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616322	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616322	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT482265	hsa-miR-302f	PAR-CLIP	20371350
MIRT482260	hsa-miR-4768-3p	PAR-CLIP	20371350
MIRT482258	hsa-miR-4740-3p	PAR-CLIP	20371350
MIRT568581	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT482257	hsa-miR-6087	PAR-CLIP	20371350
MIRT482256	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT482255	hsa-miR-1273e	PAR-CLIP	20371350
MIRT559689	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT559688	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT559687	hsa-miR-148a-3p	PAR-CLIP	21572407
MIRT559686	hsa-miR-148b-3p	PAR-CLIP	21572407
MIRT559685	hsa-miR-152-3p	PAR-CLIP	21572407
MIRT559684	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT559683	hsa-miR-551b-5p	PAR-CLIP	21572407
MIRT559681	hsa-miR-8063	PAR-CLIP	21572407
MIRT559682	hsa-miR-4698	PAR-CLIP	21572407
MIRT559680	hsa-miR-1825	PAR-CLIP	21572407
MIRT559679	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT559678	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT559677	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT559676	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT559675	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT559674	hsa-miR-548aw	PAR-CLIP	21572407
MIRT559673	hsa-miR-300	PAR-CLIP	21572407
MIRT559672	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT559671	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT026974	hsa-miR-107	PAR-CLIP	21572407
MIRT559670	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT559669	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT559668	hsa-miR-382-3p	PAR-CLIP	21572407
MIRT559667	hsa-miR-126-5p	PAR-CLIP	21572407
MIRT559666	hsa-miR-4528	PAR-CLIP	21572407
MIRT559664	hsa-miR-5689	PAR-CLIP	21572407
MIRT559665	hsa-miR-4795-3p	PAR-CLIP	21572407
MIRT482258	hsa-miR-4740-3p	PAR-CLIP	22012620
MIRT524961	hsa-miR-619-5p	PAR-CLIP	22012620
MIRT524960	hsa-miR-6506-5p	PAR-CLIP	22012620
MIRT524958	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT539342	hsa-miR-877-5p	PAR-CLIP	22012620
MIRT539341	hsa-miR-6866-5p	PAR-CLIP	22012620
MIRT524947	hsa-miR-5089-5p	PAR-CLIP	22012620
MIRT524986	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT524985	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT524984	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT524983	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT524982	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT524981	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT524980	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT524979	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT524978	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT524977	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT524976	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT524975	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT524974	hsa-miR-302e	PAR-CLIP	23446348
MIRT524973	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT524972	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT524971	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT524970	hsa-miR-520b	PAR-CLIP	23446348
MIRT524969	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT524968	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT524967	hsa-miR-520e	PAR-CLIP	23446348
MIRT524966	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT524965	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT524964	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT524963	hsa-miR-212-5p	PAR-CLIP	23446348
MIRT524962	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT524961	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT524960	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT524959	hsa-miR-4252	PAR-CLIP	23446348
MIRT524958	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT524957	hsa-miR-4312	PAR-CLIP	23446348
MIRT524956	hsa-miR-7106-3p	PAR-CLIP	23446348
MIRT524955	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT524954	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT524953	hsa-miR-4757-5p	PAR-CLIP	23446348
MIRT524952	hsa-miR-6744-3p	PAR-CLIP	23446348
MIRT524951	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT524950	hsa-miR-6511b-5p	PAR-CLIP	23446348
MIRT524949	hsa-miR-6811-5p	PAR-CLIP	23446348
MIRT524948	hsa-miR-6878-3p	PAR-CLIP	23446348
MIRT524947	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT482265	hsa-miR-302f	PAR-CLIP	23592263
MIRT482263	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT482262	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT482261	hsa-miR-940	PAR-CLIP	23592263
MIRT482260	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT482258	hsa-miR-4740-3p	PAR-CLIP	23592263
MIRT482259	hsa-miR-1827	PAR-CLIP	23592263
MIRT482257	hsa-miR-6087	PAR-CLIP	23592263
MIRT482256	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT482255	hsa-miR-1273e	PAR-CLIP	23592263
MIRT660828	hsa-miR-106a-3p	PAR-CLIP	27292025
MIRT660837	hsa-miR-130a-3p	PAR-CLIP	27292025
MIRT660836	hsa-miR-130b-3p	PAR-CLIP	27292025
MIRT660835	hsa-miR-301a-3p	PAR-CLIP	27292025
MIRT660834	hsa-miR-301b-3p	PAR-CLIP	27292025
MIRT660832	hsa-miR-3666	PAR-CLIP	27292025
MIRT660833	hsa-miR-4295	PAR-CLIP	27292025
MIRT660831	hsa-miR-454-3p	PAR-CLIP	27292025
MIRT736499	hsa-miR-31-5p	RNA-seqqRT-PCR	33067542
MIRT633179	hsa-miR-4686	HITS-CLIP	23824327
MIRT633178	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT633177	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT633176	hsa-miR-764	HITS-CLIP	23824327
MIRT633174	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT676852	hsa-miR-4635	HITS-CLIP	23824327
MIRT633173	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT638989	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT633172	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT633171	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT633170	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT673076	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT673075	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT673074	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT673073	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT673072	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT673071	hsa-miR-4284	HITS-CLIP	23824327
MIRT673070	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673069	hsa-miR-4466	HITS-CLIP	23824327
MIRT673068	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT673067	hsa-miR-1295a	HITS-CLIP	23824327
MIRT673066	hsa-miR-7977	HITS-CLIP	23824327
MIRT673065	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT673064	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT673063	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT673062	hsa-miR-1248	HITS-CLIP	23824327
MIRT673061	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673060	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT673059	hsa-miR-6817-5p	HITS-CLIP	23824327
MIRT673058	hsa-miR-4294	HITS-CLIP	23824327
MIRT673057	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT673056	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT673055	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT673054	hsa-miR-3672	HITS-CLIP	23824327
MIRT673052	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT673053	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT673051	hsa-miR-8055	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT669610	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT669609	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT669608	hsa-miR-1976	HITS-CLIP	23824327
MIRT669607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT669606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT660826	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT660825	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT669605	hsa-miR-4279	HITS-CLIP	23824327
MIRT669604	hsa-miR-1245a	HITS-CLIP	23824327
MIRT669603	hsa-miR-8079	HITS-CLIP	23824327
MIRT669602	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT638993	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT669601	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT638992	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT638991	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT669600	hsa-miR-6131	HITS-CLIP	23824327
MIRT638990	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT669599	hsa-miR-640	HITS-CLIP	23824327
MIRT669598	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT669597	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT524962	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT660841	hsa-miR-323a-3p	HITS-CLIP	23824327
MIRT660840	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT660839	hsa-miR-485-3p	HITS-CLIP	23824327
MIRT660838	hsa-miR-539-3p	HITS-CLIP	23824327
MIRT660837	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT660836	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT660835	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT660834	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT660832	hsa-miR-3666	HITS-CLIP	23824327
MIRT660833	hsa-miR-4295	HITS-CLIP	23824327
MIRT660831	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT660830	hsa-miR-652-3p	HITS-CLIP	23824327
MIRT660829	hsa-miR-4634	HITS-CLIP	23824327
MIRT660828	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT660827	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT660826	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT660825	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT660824	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT660823	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT660822	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT660821	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT660820	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT629132	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT633179	hsa-miR-4686	HITS-CLIP	23824327
MIRT633178	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT633177	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT633176	hsa-miR-764	HITS-CLIP	23824327
MIRT633175	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT638993	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT633174	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT638992	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT638991	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT638990	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT638989	hsa-miR-6828-3p	HITS-CLIP	23824327
MIRT633170	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT633179	hsa-miR-4686	HITS-CLIP	23824327
MIRT633178	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT633177	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT633176	hsa-miR-764	HITS-CLIP	23824327
MIRT633175	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT633174	hsa-miR-767-3p	HITS-CLIP	23824327
MIRT633173	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT633172	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT633171	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT633170	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT630535	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT630534	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT630533	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT630532	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT630531	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT630530	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT629132	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616322	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT628472	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT616327	hsa-miR-8485	HITS-CLIP	23824327
MIRT616326	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616325	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616324	hsa-miR-603	HITS-CLIP	23824327
MIRT616323	hsa-miR-6752-3p	HITS-CLIP	23824327
MIRT616322	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT616321	hsa-miR-3941	HITS-CLIP	23824327
MIRT482265	hsa-miR-302f	PAR-CLIP	20371350
MIRT482260	hsa-miR-4768-3p	PAR-CLIP	20371350
MIRT482258	hsa-miR-4740-3p	PAR-CLIP	20371350
MIRT568581	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT482257	hsa-miR-6087	PAR-CLIP	20371350
MIRT482256	hsa-miR-4722-5p	PAR-CLIP	20371350
MIRT482255	hsa-miR-1273e	PAR-CLIP	20371350
MIRT559689	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT559688	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT559687	hsa-miR-148a-3p	PAR-CLIP	21572407
MIRT559686	hsa-miR-148b-3p	PAR-CLIP	21572407
MIRT559685	hsa-miR-152-3p	PAR-CLIP	21572407
MIRT559684	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT559683	hsa-miR-551b-5p	PAR-CLIP	21572407
MIRT559681	hsa-miR-8063	PAR-CLIP	21572407
MIRT559682	hsa-miR-4698	PAR-CLIP	21572407
MIRT559680	hsa-miR-1825	PAR-CLIP	21572407
MIRT559679	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT559678	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT559677	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT559676	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT559675	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT559674	hsa-miR-548aw	PAR-CLIP	21572407
MIRT559673	hsa-miR-300	PAR-CLIP	21572407
MIRT559672	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT559671	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT026974	hsa-miR-107	PAR-CLIP	21572407
MIRT559670	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT559669	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT559668	hsa-miR-382-3p	PAR-CLIP	21572407
MIRT559667	hsa-miR-126-5p	PAR-CLIP	21572407
MIRT559666	hsa-miR-4528	PAR-CLIP	21572407
MIRT559664	hsa-miR-5689	PAR-CLIP	21572407
MIRT559665	hsa-miR-4795-3p	PAR-CLIP	21572407
MIRT482258	hsa-miR-4740-3p	PAR-CLIP	22012620
MIRT524961	hsa-miR-619-5p	PAR-CLIP	22012620
MIRT524960	hsa-miR-6506-5p	PAR-CLIP	22012620
MIRT524958	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT539342	hsa-miR-877-5p	PAR-CLIP	22012620
MIRT539341	hsa-miR-6866-5p	PAR-CLIP	22012620
MIRT524947	hsa-miR-5089-5p	PAR-CLIP	22012620
MIRT524986	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT524985	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT524984	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT524983	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT524982	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT524981	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT524980	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT524979	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT524978	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT524977	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT524976	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT524975	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT524974	hsa-miR-302e	PAR-CLIP	23446348
MIRT524973	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT524972	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT524971	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT524970	hsa-miR-520b	PAR-CLIP	23446348
MIRT524969	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT524968	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT524967	hsa-miR-520e	PAR-CLIP	23446348
MIRT524966	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT524965	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT524964	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT524963	hsa-miR-212-5p	PAR-CLIP	23446348
MIRT524962	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT524961	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT524960	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT524959	hsa-miR-4252	PAR-CLIP	23446348
MIRT524958	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT524957	hsa-miR-4312	PAR-CLIP	23446348
MIRT524956	hsa-miR-7106-3p	PAR-CLIP	23446348
MIRT524955	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT524954	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT524953	hsa-miR-4757-5p	PAR-CLIP	23446348
MIRT524952	hsa-miR-6744-3p	PAR-CLIP	23446348
MIRT524951	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT524950	hsa-miR-6511b-5p	PAR-CLIP	23446348
MIRT524949	hsa-miR-6811-5p	PAR-CLIP	23446348
MIRT524948	hsa-miR-6878-3p	PAR-CLIP	23446348
MIRT524947	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT482265	hsa-miR-302f	PAR-CLIP	23592263
MIRT482263	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT482262	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT482261	hsa-miR-940	PAR-CLIP	23592263
MIRT482260	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT482258	hsa-miR-4740-3p	PAR-CLIP	23592263
MIRT482259	hsa-miR-1827	PAR-CLIP	23592263
MIRT482257	hsa-miR-6087	PAR-CLIP	23592263
MIRT482256	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT482255	hsa-miR-1273e	PAR-CLIP	23592263

Show/Hide all (57)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000794	Component	Condensed nuclear chromosome	IEA
GO:0000932	Component	P-body	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IDA	19966796
GO:0003725	Function	Double-stranded RNA binding	IEA
GO:0003727	Function	Single-stranded RNA binding	IBA
GO:0003727	Function	Single-stranded RNA binding	IDA	19966796
GO:0003727	Function	Single-stranded RNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004521	Function	RNA endonuclease activity	IBA
GO:0004521	Function	RNA endonuclease activity	IMP	29040713
GO:0005515	Function	Protein binding	IPI	19167051, 19324964, 19383768, 22915799, 23064648, 28330616, 28683311
GO:0005634	Component	Nucleus	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15260970
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006402	Process	MRNA catabolic process	IDA	18771919
GO:0006417	Process	Regulation of translation	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016442	Component	RISC complex	IBA
GO:0016442	Component	RISC complex	IDA	15260970, 19966796
GO:0016442	Component	RISC complex	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0031054	Process	Pre-miRNA processing	IBA
GO:0031054	Process	Pre-miRNA processing	IDA	19966796
GO:0031054	Process	Pre-miRNA processing	IEA
GO:0035194	Process	Regulatory ncRNA-mediated post-transcriptional gene silencing	IBA
GO:0035196	Process	MiRNA processing	IMP	22795694
GO:0035198	Function	MiRNA binding	IBA
GO:0035198	Function	MiRNA binding	IDA	15260970
GO:0035198	Function	MiRNA binding	IEA
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IDA	18771919
GO:0035278	Process	MiRNA-mediated gene silencing by inhibition of translation	IEA
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	15260970
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IEA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IBA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070578	Component	RISC-loading complex	IDA	19966796
GO:0070578	Component	RISC-loading complex	IEA
GO:0070922	Process	RISC complex assembly	IDA	19966796
GO:0070922	Process	RISC complex assembly	IEA
GO:0072091	Process	Regulation of stem cell proliferation	IEA
GO:0072091	Process	Regulation of stem cell proliferation	IMP	23064648
GO:0090624	Function	Endoribonuclease activity, cleaving miRNA-paired mRNA	IMP	29040713
GO:0090625	Process	SiRNA-mediated gene silencing by mRNA destabilization	IDA	15260970
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
607355	18421	ENSG00000126070

Q9H9G7

Protein name

Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)

Protein function

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) deriv

PDB

5VM9 , 8VAJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16486	ArgoN	28 → 167	N-terminal domain of argonaute	Domain
PF08699	ArgoL1	177 → 227	Argonaute linker 1 domain	Domain
PF02170	PAZ	232 → 366	PAZ domain	Domain
PF16488	ArgoL2	375 → 421	Argonaute linker 2 domain	Family
PF16487	ArgoMid	430 → 512	Mid domain of argonaute	Domain
PF02171	Piwi	518 → 819	Piwi domain	Family

Sequence

MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPR
RVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRP
FKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGR
SFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLD
IHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLE
NGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDN
QTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQ
YGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISK
DAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL
LGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVT
HPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRF
KPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCAD
RTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADEL
QLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDP
QALAKAVQIHQDTLRTMYFA

Sequence length

860

Interactions

View interactions

	Reactome
			Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AGO3-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BARRETT'S ESOPHAGUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Barrett Esophagus	Barrett esophagus	GWASCAT_DG	29551738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18787018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	23398123	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	25271087	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	BEFREE	25271087		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18787018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	18787018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	36508664	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	22174824	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

AGO3 (argonaute RISC catalytic component 3)