AHCY (adenosylhomocysteinase)

Gene

• Entrez ID: 191
• Gene name: Adenosylhomocysteinase
• Gene symbol: AHCY
• Synonyms (NCBI Gene): SAHH, adoHcyase
• Chromosome: 20
• Chromosome location: 20q11.22
• Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocystei

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs11552695	T>C	Conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant, 5 prime UTR variant
rs121918607	C>T	Pathogenic	Stop gained, coding sequence variant, 5 prime UTR variant
rs121918608	T>C	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs755222515	G>A	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant
rs757357954	G>A	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs757966746	G>A	Pathogenic	Coding sequence variant, missense variant, 5 prime UTR variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT724958	hsa-miR-3914	HITS-CLIP	19536157
MIRT724957	hsa-miR-29b-1-5p	HITS-CLIP	19536157
MIRT724956	hsa-miR-5681a	HITS-CLIP	19536157
MIRT724955	hsa-miR-6730-5p	HITS-CLIP	19536157
MIRT724954	hsa-miR-340-5p	HITS-CLIP	19536157
MIRT724953	hsa-miR-488-3p	HITS-CLIP	19536157
MIRT724952	hsa-miR-487a-5p	HITS-CLIP	19536157
MIRT724951	hsa-miR-487b-5p	HITS-CLIP	19536157
MIRT724950	hsa-miR-3611	HITS-CLIP	19536157
MIRT705850	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT705849	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT705848	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT705847	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT705846	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT705845	hsa-miR-4421	HITS-CLIP	23313552
MIRT705844	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT705843	hsa-miR-1283	HITS-CLIP	23313552
MIRT705842	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT705841	hsa-miR-3926	HITS-CLIP	23313552
MIRT705840	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT705839	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT705838	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT705837	hsa-miR-548s	HITS-CLIP	23313552
MIRT705836	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT660814	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT660812	hsa-miR-3690	HITS-CLIP	23824327
MIRT660811	hsa-miR-4254	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT660814	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT660812	hsa-miR-3690	HITS-CLIP	23824327
MIRT660811	hsa-miR-4254	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT639805	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT639804	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT639805	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT639804	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	23592263
MIRT482238	hsa-miR-4269	PAR-CLIP	23592263
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	23592263
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT482235	hsa-miR-4673	PAR-CLIP	23592263
MIRT482234	hsa-miR-593-5p	PAR-CLIP	23592263
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	23592263
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	23592263
MIRT482238	hsa-miR-4269	PAR-CLIP	26701625
MIRT482238	hsa-miR-4269	PAR-CLIP	26701625
MIRT482238	hsa-miR-4269	PAR-CLIP	26701625
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	26701625
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	26701625
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	26701625
MIRT482235	hsa-miR-4673	PAR-CLIP	26701625
MIRT482235	hsa-miR-4673	PAR-CLIP	26701625
MIRT482235	hsa-miR-4673	PAR-CLIP	26701625
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	26701625
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	26701625
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	26701625
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	26701625
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	26701625
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	26701625
MIRT482234	hsa-miR-593-5p	PAR-CLIP	26701625
MIRT482234	hsa-miR-593-5p	PAR-CLIP	26701625
MIRT482234	hsa-miR-593-5p	PAR-CLIP	26701625
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	26701625
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	26701625
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	26701625
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	26701625
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	26701625
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	26701625
MIRT724958	hsa-miR-3914	HITS-CLIP	19536157
MIRT724957	hsa-miR-29b-1-5p	HITS-CLIP	19536157
MIRT724956	hsa-miR-5681a	HITS-CLIP	19536157
MIRT724955	hsa-miR-6730-5p	HITS-CLIP	19536157
MIRT724954	hsa-miR-340-5p	HITS-CLIP	19536157
MIRT724953	hsa-miR-488-3p	HITS-CLIP	19536157
MIRT724952	hsa-miR-487a-5p	HITS-CLIP	19536157
MIRT724951	hsa-miR-487b-5p	HITS-CLIP	19536157
MIRT724950	hsa-miR-3611	HITS-CLIP	19536157
MIRT705850	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT705849	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT705848	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT705847	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT705846	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT705845	hsa-miR-4421	HITS-CLIP	23313552
MIRT705844	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT705843	hsa-miR-1283	HITS-CLIP	23313552
MIRT705842	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT705841	hsa-miR-3926	HITS-CLIP	23313552
MIRT705840	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT705839	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT705838	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT705837	hsa-miR-548s	HITS-CLIP	23313552
MIRT705836	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT660814	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT660812	hsa-miR-3690	HITS-CLIP	23824327
MIRT660811	hsa-miR-4254	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT660814	hsa-miR-4650-5p	HITS-CLIP	23824327
MIRT660813	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT660812	hsa-miR-3690	HITS-CLIP	23824327
MIRT660811	hsa-miR-4254	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT639805	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT639804	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT639808	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639807	hsa-miR-6072	HITS-CLIP	23824327
MIRT639806	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT639805	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT639804	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT639803	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT639802	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT639801	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT639800	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT639799	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT482239	hsa-miR-4699-3p	PAR-CLIP	23592263
MIRT482238	hsa-miR-4269	PAR-CLIP	23592263
MIRT482237	hsa-miR-6715b-5p	PAR-CLIP	23592263
MIRT482236	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT482235	hsa-miR-4673	PAR-CLIP	23592263
MIRT482234	hsa-miR-593-5p	PAR-CLIP	23592263
MIRT482233	hsa-miR-5591-3p	PAR-CLIP	23592263
MIRT482231	hsa-miR-6875-3p	PAR-CLIP	23592263
MIRT773353	hsa-miR-1207-3p	CLIP-seq
MIRT773354	hsa-miR-132	CLIP-seq
MIRT773355	hsa-miR-1587	CLIP-seq
MIRT773356	hsa-miR-2054	CLIP-seq
MIRT773357	hsa-miR-212	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773359	hsa-miR-30a	CLIP-seq
MIRT773360	hsa-miR-30b	CLIP-seq
MIRT773361	hsa-miR-30c	CLIP-seq
MIRT773362	hsa-miR-30d	CLIP-seq
MIRT773363	hsa-miR-30e	CLIP-seq
MIRT773364	hsa-miR-3135b	CLIP-seq
MIRT773365	hsa-miR-3143	CLIP-seq
MIRT773366	hsa-miR-3160-3p	CLIP-seq
MIRT773367	hsa-miR-3160-5p	CLIP-seq
MIRT773368	hsa-miR-3174	CLIP-seq
MIRT773369	hsa-miR-3185	CLIP-seq
MIRT773370	hsa-miR-3606	CLIP-seq
MIRT773371	hsa-miR-3607-3p	CLIP-seq
MIRT773372	hsa-miR-3649	CLIP-seq
MIRT773373	hsa-miR-3652	CLIP-seq
MIRT773374	hsa-miR-3654	CLIP-seq
MIRT773375	hsa-miR-3658	CLIP-seq
MIRT773376	hsa-miR-3664-5p	CLIP-seq
MIRT773377	hsa-miR-3667-3p	CLIP-seq
MIRT773378	hsa-miR-3670	CLIP-seq
MIRT773379	hsa-miR-370	CLIP-seq
MIRT773380	hsa-miR-4289	CLIP-seq
MIRT773381	hsa-miR-4430	CLIP-seq
MIRT773382	hsa-miR-4474-3p	CLIP-seq
MIRT773383	hsa-miR-4487	CLIP-seq
MIRT773384	hsa-miR-4492	CLIP-seq
MIRT773385	hsa-miR-4498	CLIP-seq
MIRT773386	hsa-miR-4505	CLIP-seq
MIRT773387	hsa-miR-4528	CLIP-seq
MIRT773388	hsa-miR-4535	CLIP-seq
MIRT773389	hsa-miR-4656	CLIP-seq
MIRT773390	hsa-miR-4675	CLIP-seq
MIRT773391	hsa-miR-4714-5p	CLIP-seq
MIRT773392	hsa-miR-4717-5p	CLIP-seq
MIRT773393	hsa-miR-4741	CLIP-seq
MIRT773394	hsa-miR-492	CLIP-seq
MIRT773395	hsa-miR-543	CLIP-seq
MIRT773396	hsa-miR-548b-3p	CLIP-seq
MIRT773397	hsa-miR-558	CLIP-seq
MIRT773398	hsa-miR-646	CLIP-seq
MIRT773399	hsa-miR-670	CLIP-seq
MIRT773400	hsa-miR-762	CLIP-seq
MIRT773401	hsa-miR-921	CLIP-seq
MIRT773354	hsa-miR-132	CLIP-seq
MIRT773402	hsa-miR-2116	CLIP-seq
MIRT773357	hsa-miR-212	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773403	hsa-miR-3169	CLIP-seq
MIRT773368	hsa-miR-3174	CLIP-seq
MIRT773370	hsa-miR-3606	CLIP-seq
MIRT773376	hsa-miR-3664-5p	CLIP-seq
MIRT773404	hsa-miR-4264	CLIP-seq
MIRT773405	hsa-miR-4476	CLIP-seq
MIRT773406	hsa-miR-4513	CLIP-seq
MIRT773407	hsa-miR-4521	CLIP-seq
MIRT773408	hsa-miR-4533	CLIP-seq
MIRT773409	hsa-miR-4677-5p	CLIP-seq
MIRT773391	hsa-miR-4714-5p	CLIP-seq
MIRT773410	hsa-miR-4740-5p	CLIP-seq
MIRT773411	hsa-miR-4749-3p	CLIP-seq
MIRT773412	hsa-miR-4797-3p	CLIP-seq
MIRT773413	hsa-miR-617	CLIP-seq
MIRT773401	hsa-miR-921	CLIP-seq
MIRT773414	hsa-miR-942	CLIP-seq
MIRT1928258	hsa-miR-1266	CLIP-seq
MIRT773356	hsa-miR-2054	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT1928259	hsa-miR-3155	CLIP-seq
MIRT1928260	hsa-miR-3155b	CLIP-seq
MIRT1928261	hsa-miR-3647-3p	CLIP-seq
MIRT773375	hsa-miR-3658	CLIP-seq
MIRT1928262	hsa-miR-3664-3p	CLIP-seq
MIRT773376	hsa-miR-3664-5p	CLIP-seq
MIRT773380	hsa-miR-4289	CLIP-seq
MIRT1928263	hsa-miR-4323	CLIP-seq
MIRT1928264	hsa-miR-4326	CLIP-seq
MIRT1928265	hsa-miR-4518	CLIP-seq
MIRT1928266	hsa-miR-4709-5p	CLIP-seq
MIRT773391	hsa-miR-4714-5p	CLIP-seq
MIRT1928267	hsa-miR-4755-3p	CLIP-seq
MIRT1928268	hsa-miR-484	CLIP-seq
MIRT1928269	hsa-miR-873	CLIP-seq
MIRT2169051	hsa-miR-296-3p	CLIP-seq
MIRT1928263	hsa-miR-4323	CLIP-seq
MIRT2169052	hsa-miR-488	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773376	hsa-miR-3664-5p	CLIP-seq
MIRT773391	hsa-miR-4714-5p	CLIP-seq
MIRT773372	hsa-miR-3649	CLIP-seq
MIRT773373	hsa-miR-3652	CLIP-seq
MIRT773381	hsa-miR-4430	CLIP-seq
MIRT773382	hsa-miR-4474-3p	CLIP-seq
MIRT773386	hsa-miR-4505	CLIP-seq
MIRT773399	hsa-miR-670	CLIP-seq
MIRT2471605	hsa-miR-103a	CLIP-seq
MIRT2471606	hsa-miR-107	CLIP-seq
MIRT2471607	hsa-miR-1184	CLIP-seq
MIRT773354	hsa-miR-132	CLIP-seq
MIRT2471608	hsa-miR-144	CLIP-seq
MIRT773402	hsa-miR-2116	CLIP-seq
MIRT773357	hsa-miR-212	CLIP-seq
MIRT2471609	hsa-miR-2467-3p	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773366	hsa-miR-3160-3p	CLIP-seq
MIRT773368	hsa-miR-3174	CLIP-seq
MIRT773370	hsa-miR-3606	CLIP-seq
MIRT773372	hsa-miR-3649	CLIP-seq
MIRT773373	hsa-miR-3652	CLIP-seq
MIRT773378	hsa-miR-3670	CLIP-seq
MIRT773404	hsa-miR-4264	CLIP-seq
MIRT773381	hsa-miR-4430	CLIP-seq
MIRT773382	hsa-miR-4474-3p	CLIP-seq
MIRT773383	hsa-miR-4487	CLIP-seq
MIRT773386	hsa-miR-4505	CLIP-seq
MIRT773409	hsa-miR-4677-5p	CLIP-seq
MIRT773411	hsa-miR-4749-3p	CLIP-seq
MIRT2471610	hsa-miR-4757-3p	CLIP-seq
MIRT773412	hsa-miR-4797-3p	CLIP-seq
MIRT773397	hsa-miR-558	CLIP-seq
MIRT2471611	hsa-miR-668	CLIP-seq
MIRT773399	hsa-miR-670	CLIP-seq
MIRT773401	hsa-miR-921	CLIP-seq
MIRT2471612	hsa-miR-922	CLIP-seq
MIRT773414	hsa-miR-942	CLIP-seq
MIRT2471605	hsa-miR-103a	CLIP-seq
MIRT2471606	hsa-miR-107	CLIP-seq
MIRT2471607	hsa-miR-1184	CLIP-seq
MIRT2674759	hsa-miR-1245	CLIP-seq
MIRT773354	hsa-miR-132	CLIP-seq
MIRT2471608	hsa-miR-144	CLIP-seq
MIRT773402	hsa-miR-2116	CLIP-seq
MIRT773357	hsa-miR-212	CLIP-seq
MIRT2471609	hsa-miR-2467-3p	CLIP-seq
MIRT773358	hsa-miR-3064-3p	CLIP-seq
MIRT773366	hsa-miR-3160-3p	CLIP-seq
MIRT773368	hsa-miR-3174	CLIP-seq
MIRT773370	hsa-miR-3606	CLIP-seq
MIRT773373	hsa-miR-3652	CLIP-seq
MIRT773378	hsa-miR-3670	CLIP-seq
MIRT773404	hsa-miR-4264	CLIP-seq
MIRT773381	hsa-miR-4430	CLIP-seq
MIRT773382	hsa-miR-4474-3p	CLIP-seq
MIRT773383	hsa-miR-4487	CLIP-seq
MIRT773386	hsa-miR-4505	CLIP-seq
MIRT773409	hsa-miR-4677-5p	CLIP-seq
MIRT773411	hsa-miR-4749-3p	CLIP-seq
MIRT2471610	hsa-miR-4757-3p	CLIP-seq
MIRT773412	hsa-miR-4797-3p	CLIP-seq
MIRT2674760	hsa-miR-548ae	CLIP-seq
MIRT2674761	hsa-miR-548aj	CLIP-seq
MIRT2674762	hsa-miR-548am	CLIP-seq
MIRT2674763	hsa-miR-548x	CLIP-seq
MIRT773397	hsa-miR-558	CLIP-seq
MIRT2471611	hsa-miR-668	CLIP-seq
MIRT773399	hsa-miR-670	CLIP-seq
MIRT773401	hsa-miR-921	CLIP-seq
MIRT2471612	hsa-miR-922	CLIP-seq
MIRT773414	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004013	Function	Adenosylhomocysteinase activity	IBA
GO:0004013	Function	Adenosylhomocysteinase activity	IDA	10933798
GO:0004013	Function	Adenosylhomocysteinase activity	IEA
GO:0004013	Function	Adenosylhomocysteinase activity	TAS	2596825
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 28514442, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006730	Process	One-carbon metabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0033353	Process	S-adenosylmethionine cycle	IBA
GO:0042470	Component	Melanosome	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145

Other IDs

• MIM: 180960
• HGNC: 343
• e!Ensembl: ENSG00000101444

Protein

• UniProt ID: P23526
• Protein name: Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase)
• Protein function: Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:10933798). Binds copper ions (By similarity).
• PDB: 1A7A, 1LI4, 3NJ4, 4PFJ, 4PGF, 4YVF, 5W49, 5W4B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05221	AdoHcyase	6 → 142	S-adenosyl-L-homocysteine hydrolase	Domain
  PF05221	AdoHcyase	140 → 431	S-adenosyl-L-homocysteine hydrolase	Domain
  PF00670	AdoHcyase_NAD	191 → 352	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	Domain

• Sequence:

  MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
  AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
  KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
  NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
  ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
  HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
  SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
  CDGPFKPDHYRY

• Sequence length: 432

Pathways

KEGG:

Cysteine and methionine metabolism
One carbon pool by folate
Metabolic pathways

Reactome:

Methylation
Sulfur amino acid metabolism
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase	Pathogenic; Likely pathogenic	rs2515172714, rs757966746, rs2036548764, rs121918607, rs121918608, rs2515204321, rs2515176184, rs772729103, rs2515180222, rs773162208, rs369428934	RCV002829264 RCV005025372 RCV003335928 RCV000013818 RCV000013819 RCV003494579 RCV003494580 RCV003638512 RCV003639217 RCV000778630 RCV001813819	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Rhabdomyolysis	Likely pathogenic; Pathogenic	rs121918608	RCV000662292	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AHCY-related disorder	Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMINO ACID METABOLISM, INBORN ERRORS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEFICIENCY OF S-ADENOSYLHOMOCYSTEINE HYDROLASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DISORDER OF SULFUR-BEARING AMINO ACID METABOLISM	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEPATIC METHIONINE ADENOSYLTRANSFERASE DEFICIENCY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEPATOLENTICULAR DEGENERATION	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypermethioninemia	Uncertain significance; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOXIA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONALCOHOLIC STEATOHEPATITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
S-ADENOSYLHOMOCYSTEINE HYDROLASE DEFICIENCY	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute pancreatitis	Pancreatitis	BEFREE	31539805		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	CTD_human_DG	27602772		★☆☆☆☆ Found in Text Mining only
Amino Acid Metabolism, Inborn Errors	Disorder of amino acid metabolism	CTD_human_DG	15024124		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Amino Acid Metabolism, Inherited Disorders	Inherited Errors of Amino Acid Metabolism	CTD_human_DG	15024124		★☆☆☆☆ Found in Text Mining only
Antithrombin III Deficiency	Antithrombin Deficiency	HPO_DG			★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm Abdominal	Aortic aneurysm	Pubtator	20871623	Associate	★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm, Abdominal	Aortic Aneurysm	BEFREE	18635682		★☆☆☆☆ Found in Text Mining only
Aortic Dissection	Aortic dissection	Pubtator	20871623	Associate	★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	18591246		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	18591246		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	29155016, 31842999		★☆☆☆☆ Found in Text Mining only
Brain Ischemia	Brain ischemia	Pubtator	32020847	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	31340867		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	18084325, 36361596	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	26527160, 28459194, 31959915	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	33753854	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebellar Hypoplasia	Cerebellar Hypoplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	32020847, 33138824	Associate	★☆☆☆☆ Found in Text Mining only
Chondrosarcoma	Chondrosarcoma	BEFREE	31613064		★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	18635682		★☆☆☆☆ Found in Text Mining only
Clumsiness - motor delay	Motor delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	21220475		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	LHGDN	18713839		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31392094		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	23341073	Associate	★☆☆☆☆ Found in Text Mining only
Congenital disorder of glycosylation type 1A	Congenital disorder of glycosylation	BEFREE	22959829		★☆☆☆☆ Found in Text Mining only
Cystathionine beta-Synthase Deficiency Disease	Cystathionine Beta-Synthase Deficiency Disease	BEFREE	31131233		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	28744016		★☆☆☆☆ Found in Text Mining only
Developmental regression	Developmental regression	HPO_DG			★☆☆☆☆ Found in Text Mining only
Esotropia	Esotropia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty Liver	BEFREE	19201949		★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	29127188		★☆☆☆☆ Found in Text Mining only
Fibrinogen Deficiency	Fibrinogen Deficiency	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	19934320		★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glomerulonephritis	Glomerulonephritis	BEFREE	30696480		★☆☆☆☆ Found in Text Mining only
Hepatic Form of Wilson Disease	Hepatolenticular degeneration	CTD_human_DG	23519153		★☆☆☆☆ Found in Text Mining only
Hepatic methionine adenosyltransferase deficiency	Hepatic Methionine Adenosyltransferase Deficiency	CTD_human_DG	26974671		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatolenticular Degeneration	Hepatolenticular Degeneration	BEFREE	23519153, 30010856		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatolenticular Degeneration	Hepatolenticular Degeneration	CTD_human_DG	23519153		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hydrops Fetalis	Hydrops Fetalis	BEFREE	20852937		★☆☆☆☆ Found in Text Mining only
Hydrops Fetalis	Hydrops Fetalis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hyperhomocysteinemia	Hyperhomocysteinemia	BEFREE	28288933, 31131233		★☆☆☆☆ Found in Text Mining only
Hypermethioninemia due to deficiency of glycine N-methyltransferase	Glycine N-methyltransferase deficiency	CTD_human_DG	26974671		★☆☆☆☆ Found in Text Mining only
Hypoalbuminemia	Hypoalbuminemia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypofibrinogenemia	Hypofibrinogenemia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	HPO_DG			★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune system disease	Pubtator	312296	Associate	★☆☆☆☆ Found in Text Mining only
Immune thrombocytopenic purpura	Immune Thrombocytopenic Purpura	LHGDN	18683034		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	37951201	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	37951201	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	19638619		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29127188, 30228286		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	HPO_DG			★☆☆☆☆ Found in Text Mining only
Liver Diseases	Liver disease	Pubtator	26527160	Associate	★☆☆☆☆ Found in Text Mining only
Liver Failure	Liver failure	BEFREE	30121674		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	30696480		★☆☆☆☆ Found in Text Mining only
Lupus Nephritis	Lupus Nephritis	BEFREE	30696480		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31340867		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19934320, 30228286		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	21220475		★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	20634887		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy	Muscular dystrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	10213491, 27876123		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	25477524, 36361596	Associate	★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	CTD_human_DG	29127188		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	BEFREE	29127188		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonalcoholic Steatohepatitis	Non-alcoholic Fatty Liver Disease	CTD_human_DG	29127188		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	BEFREE	29155016		★☆☆☆☆ Found in Text Mining only
Respiratory Failure	Respiratory Failure	HPO_DG			★☆☆☆☆ Found in Text Mining only
S-adenosylhomocysteine hydrolase deficiency	S-Adenosylhomocysteine Hydrolase Deficiency	CLINGEN_DG	13641268, 15024124, 16736098, 20852937, 22959829, 26095522, 26527160, 27626380, 27848944, 30121674		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
S-adenosylhomocysteine hydrolase deficiency	S-Adenosylhomocysteine Hydrolase Deficiency	UNIPROT_DG	15024124, 16736098, 19177456, 20852937		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
S-adenosylhomocysteine hydrolase deficiency	S-Adenosylhomocysteine Hydrolase Deficiency	GENOMICS_ENGLAND_DG	15024124, 20852937		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
S-adenosylhomocysteine hydrolase deficiency	S-Adenosylhomocysteine Hydrolase Deficiency	ORPHANET_DG	16435181		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
S-adenosylhomocysteine hydrolase deficiency	S-Adenosylhomocysteine Hydrolase Deficiency	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
S-adenosylhomocysteine hydrolase deficiency	S-Adenosylhomocysteine Hydrolase Deficiency	CTD_human_DG	26974671		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
S-adenosylhomocysteine hydrolase deficiency	S-Adenosylhomocysteine Hydrolase Deficiency	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sensorimotor neuropathy	Sensorimotor neuropathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Severe combined immunodeficiency due to adenosine deaminase deficiency	Severe combined immunodeficiency	Pubtator	312296	Stimulate	★☆☆☆☆ Found in Text Mining only
Skin lesion	Skin Lesion	BEFREE	29155016		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	24430301		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	34709988	Associate	★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	BEFREE	19201949		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	35036435	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	32065779	Associate	★☆☆☆☆ Found in Text Mining only