GPR183 (G protein-coupled receptor 183)

Gene

• Entrez ID: 1880
• Gene name: G protein-coupled receptor 183
• Gene symbol: GPR183
• Synonyms (NCBI Gene): EBI2, hEBI2
• Chromosome: 13
• Chromosome location: 13q32.3
• Summary: This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029809	hsa-miR-26b-5p	Microarray	19088304
MIRT709767	hsa-miR-1245b-3p	HITS-CLIP	19536157
MIRT709766	hsa-miR-4330	HITS-CLIP	19536157
MIRT709765	hsa-miR-1303	HITS-CLIP	19536157
MIRT709767	hsa-miR-1245b-3p	HITS-CLIP	19536157
MIRT709766	hsa-miR-4330	HITS-CLIP	19536157
MIRT709765	hsa-miR-1303	HITS-CLIP	19536157
MIRT1031155	hsa-miR-101	CLIP-seq
MIRT1031156	hsa-miR-144	CLIP-seq
MIRT1031157	hsa-miR-3143	CLIP-seq
MIRT1031158	hsa-miR-4477a	CLIP-seq
MIRT1031159	hsa-miR-495	CLIP-seq
MIRT1031160	hsa-miR-513a-3p	CLIP-seq
MIRT1031161	hsa-miR-548l	CLIP-seq
MIRT1031162	hsa-miR-548n	CLIP-seq
MIRT1031163	hsa-miR-561	CLIP-seq
MIRT1031164	hsa-miR-567	CLIP-seq
MIRT1031165	hsa-miR-582-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	ISS
GO:0002312	Process	B cell activation involved in immune response	IBA
GO:0002313	Process	Mature B cell differentiation involved in immune response	IEA
GO:0002313	Process	Mature B cell differentiation involved in immune response	ISS
GO:0002376	Process	Immune system process	IEA
GO:0002407	Process	Dendritic cell chemotaxis	IEA
GO:0002407	Process	Dendritic cell chemotaxis	ISS
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IDA	18628402, 22875855, 22930711
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	8383238
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA	18628402, 21673108, 22930711
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8383238
GO:0006955	Process	Immune response	TAS	8383238
GO:0006959	Process	Humoral immune response	IEA
GO:0006959	Process	Humoral immune response	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	18628402, 21673108, 22875855, 22930711
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	8383238
GO:0008142	Function	Oxysterol binding	IDA	21796212, 22875855, 22930711
GO:0008142	Function	Oxysterol binding	IEA
GO:0008142	Function	Oxysterol binding	IMP	24678947
GO:0010818	Process	T cell chemotaxis	IEA
GO:0010818	Process	T cell chemotaxis	ISS
GO:0016020	Component	Membrane	IEA
GO:0030316	Process	Osteoclast differentiation	IEA
GO:0030316	Process	Osteoclast differentiation	ISS
GO:0030595	Process	Leukocyte chemotaxis	IEA
GO:0030595	Process	Leukocyte chemotaxis	IMP	24678947
GO:0030890	Process	Positive regulation of B cell proliferation	IDA	21673108
GO:0030890	Process	Positive regulation of B cell proliferation	IEA
GO:0036145	Process	Dendritic cell homeostasis	IEA
GO:0036145	Process	Dendritic cell homeostasis	ISS
GO:0060326	Process	Cell chemotaxis	IEA
GO:0061470	Process	T follicular helper cell differentiation	IEA
GO:0061470	Process	T follicular helper cell differentiation	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	21673108, 25297897
GO:2000458	Process	Regulation of astrocyte chemotaxis	IDA	25297897

Other IDs

• MIM: 605741
• HGNC: 3128
• e!Ensembl: ENSG00000169508

Protein

• UniProt ID: P32249
• Protein name: G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)
• Protein function: G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (
• PDB: 7TUY, 7TUZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	48 → 308	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed:16540462, PubMed:8383238). Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogeni
• Sequence:

  MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR
  KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN
  FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT
  CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK
  KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
  CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG
  K

• Sequence length: 361

Pathways

Reactome:

Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BASAL CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IGA GLOMERULONEPHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA-LYMPHOMA, ADULT T-CELL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	CTD_human_DG	26437031		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	38046263	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	28125291		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	28125291, 34510493	Associate	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	28052250, 28147280, 29741800		★☆☆☆☆ Found in Text Mining only
Basal Cell Cancer	Basal Cell Neoplasm	GWASCAT_DG	31174203		★☆☆☆☆ Found in Text Mining only
Basal cell carcinoma	Carcinoma	GWASCAT_DG	31174203		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Basal Cell Neoplasm	Basal Cell Neoplasm	GWASCAT_DG	31174203		★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	28003273		★☆☆☆☆ Found in Text Mining only
Cleft Palate	Cleft palate	Pubtator	32241273	Associate	★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	29343433, 30742043		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	36746519	Associate	★☆☆☆☆ Found in Text Mining only
Demyelinating Diseases	Demyelinating Diseases	BEFREE	29246262		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	22403184	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	20827270, 22403184		★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	31113816		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	23541792	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	23541792		★☆☆☆☆ Found in Text Mining only
IGA Glomerulonephritis	Glomerulonephritis	CTD_human_DG	25133636		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASDB_DG	23128233		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASCAT_DG	23128233, 28067908		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	30742043		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29740492		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	35875859	Inhibit	★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28003273		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	28052250, 28147280, 29246262		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	28052250	Associate	★☆☆☆☆ Found in Text Mining only
Nasal Polyps	Nasal polyp	Pubtator	39253973	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23541792		★☆☆☆☆ Found in Text Mining only
Pancreatitis	Pancreatitis	Pubtator	22403184	Associate	★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	GWASCAT_DG	28537254		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pulmonary Emphysema	Pulmonary Emphysema	BEFREE	29674392		★☆☆☆☆ Found in Text Mining only
Pulmonary Eosinophilia	Pulmonary Eosinophilia	BEFREE	28125291		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	30742043		★★☆☆☆ Found in Text Mining + Unknown/Other Associations