Gene Gene information from NCBI Gene database.
Entrez ID 1847
Gene name Dual specificity phosphatase 5
Gene symbol DUSP5
Synonyms (NCBI Gene)
DUSPHVH3
Chromosome 10
Chromosome location 10q25.2
Summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively re
miRNA miRNA information provided by mirtarbase database.
560
miRTarBase ID miRNA Experiments Reference
MIRT006483 hsa-miR-181a-5p Luciferase reporter assayWestern blot 17382377
MIRT006483 hsa-miR-181a-5p Luciferase reporter assayWestern blot 17382377
MIRT006483 hsa-miR-181a-5p Luciferase reporter assayWestern blot 17382377
MIRT006483 hsa-miR-181a-5p Luciferase reporter assayWestern blot 17382377
MIRT006483 hsa-miR-181a-5p Luciferase reporter assayWestern blot 17382377
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0001706 Process Endoderm formation IBA
GO:0004721 Function Phosphoprotein phosphatase activity IBA
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603069 3071 ENSG00000138166
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q16690
Protein name Dual specificity protein phosphatase 5 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH3)
Protein function Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.
PDB 2G6Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00581 Rhodanese 8 135 Rhodanese-like domain Domain
PF00782 DSPc 186 316 Dual specificity phosphatase, catalytic domain Domain
Sequence
Sequence length 384
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway
Efferocytosis
  RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HYPERTENSION CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acquired Hypogammaglobulinemia Common Variable Immunodeficiency BEFREE 1569182
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 30529164
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 30529164
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 14556661
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 30952040
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 20554528, 29910679, 31357550 Associate
★☆☆☆☆
Found in Text Mining only
Bronchopulmonary Dysplasia Bronchopulmonary Dysplasia BEFREE 31330530
★☆☆☆☆
Found in Text Mining only
Bronchopulmonary Dysplasia Bronchopulmonary dysplasia Pubtator 31330530 Associate
★☆☆☆☆
Found in Text Mining only
Burkitt Lymphoma Burkitt`s Lymphoma BEFREE 2497076, 2786910
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 23402999 Associate
★☆☆☆☆
Found in Text Mining only