DUSP4 (dual specificity phosphatase 4)

Gene

• Entrez ID: 1846
• Gene name: Dual specificity phosphatase 4
• Gene symbol: DUSP4
• Synonyms (NCBI Gene): HVH2, MKP-2, MKP2, TYP
• Chromosome: 8
• Chromosome location: 8p12
• Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT437484	hsa-miR-185-5p	Luciferase reporter assay, qRT-PCR, Western blot	24014023
MIRT650480	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650478	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT650479	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT650477	hsa-miR-4287	HITS-CLIP	23824327
MIRT650476	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT650475	hsa-miR-4290	HITS-CLIP	23824327
MIRT650474	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT650473	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT650472	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT650471	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT650470	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT650469	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT650468	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT650467	hsa-miR-4705	HITS-CLIP	23824327
MIRT650466	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT650465	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT532325	hsa-miR-606	PAR-CLIP	22012620
MIRT532324	hsa-miR-3529-3p	PAR-CLIP	22012620
MIRT532323	hsa-miR-302b-5p	PAR-CLIP	22012620
MIRT532322	hsa-miR-302d-5p	PAR-CLIP	22012620
MIRT447935	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447933	hsa-miR-5584-5p	PAR-CLIP	22100165
MIRT447934	hsa-miR-3148	PAR-CLIP	22100165
MIRT447932	hsa-miR-1249-5p	PAR-CLIP	22100165
MIRT447931	hsa-miR-6797-5p	PAR-CLIP	22100165
MIRT447930	hsa-miR-4668-5p	PAR-CLIP	22100165
MIRT447935	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447933	hsa-miR-5584-5p	PAR-CLIP	22100165
MIRT447934	hsa-miR-3148	PAR-CLIP	22100165
MIRT447932	hsa-miR-1249-5p	PAR-CLIP	22100165
MIRT447931	hsa-miR-6797-5p	PAR-CLIP	22100165
MIRT447930	hsa-miR-4668-5p	PAR-CLIP	22100165
MIRT731390	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25877859
MIRT731390	hsa-miR-26a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25877859
MIRT650480	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650478	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT650479	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT650477	hsa-miR-4287	HITS-CLIP	23824327
MIRT650476	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT650475	hsa-miR-4290	HITS-CLIP	23824327
MIRT650474	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT650473	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT650472	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT650471	hsa-miR-3157-3p	HITS-CLIP	23824327
MIRT650470	hsa-miR-874-3p	HITS-CLIP	23824327
MIRT650469	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT650468	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT650467	hsa-miR-4705	HITS-CLIP	23824327
MIRT650466	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT650465	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT532325	hsa-miR-606	PAR-CLIP	22012620
MIRT532324	hsa-miR-3529-3p	PAR-CLIP	22012620
MIRT532323	hsa-miR-302b-5p	PAR-CLIP	22012620
MIRT532322	hsa-miR-302d-5p	PAR-CLIP	22012620
MIRT447935	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447933	hsa-miR-5584-5p	PAR-CLIP	22100165
MIRT447934	hsa-miR-3148	PAR-CLIP	22100165
MIRT447932	hsa-miR-1249-5p	PAR-CLIP	22100165
MIRT447931	hsa-miR-6797-5p	PAR-CLIP	22100165
MIRT447930	hsa-miR-4668-5p	PAR-CLIP	22100165
MIRT447935	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447933	hsa-miR-5584-5p	PAR-CLIP	22100165
MIRT447934	hsa-miR-3148	PAR-CLIP	22100165
MIRT447932	hsa-miR-1249-5p	PAR-CLIP	22100165
MIRT447931	hsa-miR-6797-5p	PAR-CLIP	22100165
MIRT447930	hsa-miR-4668-5p	PAR-CLIP	22100165
MIRT947967	hsa-let-7a	CLIP-seq
MIRT947968	hsa-let-7b	CLIP-seq
MIRT947969	hsa-let-7c	CLIP-seq
MIRT947970	hsa-let-7d	CLIP-seq
MIRT947971	hsa-let-7e	CLIP-seq
MIRT947972	hsa-let-7f	CLIP-seq
MIRT947973	hsa-let-7g	CLIP-seq
MIRT947974	hsa-let-7i	CLIP-seq
MIRT947975	hsa-miR-1226	CLIP-seq
MIRT947976	hsa-miR-1286	CLIP-seq
MIRT947977	hsa-miR-1289	CLIP-seq
MIRT947978	hsa-miR-1293	CLIP-seq
MIRT947979	hsa-miR-137	CLIP-seq
MIRT947980	hsa-miR-139-5p	CLIP-seq
MIRT947981	hsa-miR-145	CLIP-seq
MIRT947982	hsa-miR-149	CLIP-seq
MIRT947983	hsa-miR-188-5p	CLIP-seq
MIRT947984	hsa-miR-202	CLIP-seq
MIRT947985	hsa-miR-204	CLIP-seq
MIRT947986	hsa-miR-211	CLIP-seq
MIRT947987	hsa-miR-2110	CLIP-seq
MIRT947988	hsa-miR-28-5p	CLIP-seq
MIRT947989	hsa-miR-3064-5p	CLIP-seq
MIRT947990	hsa-miR-3122	CLIP-seq
MIRT947991	hsa-miR-3127-5p	CLIP-seq
MIRT947992	hsa-miR-3139	CLIP-seq
MIRT947993	hsa-miR-3147	CLIP-seq
MIRT947994	hsa-miR-3169	CLIP-seq
MIRT947995	hsa-miR-3176	CLIP-seq
MIRT947996	hsa-miR-3180-5p	CLIP-seq
MIRT947997	hsa-miR-320a	CLIP-seq
MIRT947998	hsa-miR-320b	CLIP-seq
MIRT947999	hsa-miR-320c	CLIP-seq
MIRT948000	hsa-miR-320d	CLIP-seq
MIRT948001	hsa-miR-320e	CLIP-seq
MIRT948002	hsa-miR-342-5p	CLIP-seq
MIRT948003	hsa-miR-34c-3p	CLIP-seq
MIRT948004	hsa-miR-3609	CLIP-seq
MIRT948005	hsa-miR-361-3p	CLIP-seq
MIRT948006	hsa-miR-3652	CLIP-seq
MIRT948007	hsa-miR-3662	CLIP-seq
MIRT948008	hsa-miR-3668	CLIP-seq
MIRT948009	hsa-miR-3675-3p	CLIP-seq
MIRT948010	hsa-miR-3675-5p	CLIP-seq
MIRT948011	hsa-miR-3913-5p	CLIP-seq
MIRT948012	hsa-miR-3922-3p	CLIP-seq
MIRT948013	hsa-miR-3924	CLIP-seq
MIRT948014	hsa-miR-3941	CLIP-seq
MIRT948015	hsa-miR-4271	CLIP-seq
MIRT948016	hsa-miR-4283	CLIP-seq
MIRT948017	hsa-miR-4300	CLIP-seq
MIRT948018	hsa-miR-4316	CLIP-seq
MIRT948019	hsa-miR-4426	CLIP-seq
MIRT948020	hsa-miR-4428	CLIP-seq
MIRT948021	hsa-miR-4429	CLIP-seq
MIRT948022	hsa-miR-4430	CLIP-seq
MIRT948023	hsa-miR-4433	CLIP-seq
MIRT948024	hsa-miR-4438	CLIP-seq
MIRT948025	hsa-miR-4458	CLIP-seq
MIRT948026	hsa-miR-4483	CLIP-seq
MIRT948027	hsa-miR-4489	CLIP-seq
MIRT948028	hsa-miR-4500	CLIP-seq
MIRT948029	hsa-miR-4505	CLIP-seq
MIRT948030	hsa-miR-452	CLIP-seq
MIRT948031	hsa-miR-4532	CLIP-seq
MIRT948032	hsa-miR-4533	CLIP-seq
MIRT948033	hsa-miR-4633-3p	CLIP-seq
MIRT948034	hsa-miR-4638-5p	CLIP-seq
MIRT948035	hsa-miR-4639-3p	CLIP-seq
MIRT948036	hsa-miR-4647	CLIP-seq
MIRT948037	hsa-miR-4651	CLIP-seq
MIRT948038	hsa-miR-4659a-5p	CLIP-seq
MIRT948039	hsa-miR-4659b-5p	CLIP-seq
MIRT948040	hsa-miR-466	CLIP-seq
MIRT948041	hsa-miR-4661-3p	CLIP-seq
MIRT948042	hsa-miR-4662b	CLIP-seq
MIRT948043	hsa-miR-4663	CLIP-seq
MIRT948044	hsa-miR-4664-5p	CLIP-seq
MIRT948045	hsa-miR-4672	CLIP-seq
MIRT948046	hsa-miR-4676-3p	CLIP-seq
MIRT948047	hsa-miR-4676-5p	CLIP-seq
MIRT948048	hsa-miR-4699-3p	CLIP-seq
MIRT948049	hsa-miR-4700-3p	CLIP-seq
MIRT948050	hsa-miR-4714-5p	CLIP-seq
MIRT948051	hsa-miR-4720-3p	CLIP-seq
MIRT948052	hsa-miR-4725-3p	CLIP-seq
MIRT948053	hsa-miR-4728-3p	CLIP-seq
MIRT948054	hsa-miR-4731-3p	CLIP-seq
MIRT948055	hsa-miR-4731-5p	CLIP-seq
MIRT948056	hsa-miR-4733-3p	CLIP-seq
MIRT948057	hsa-miR-4738-3p	CLIP-seq
MIRT948058	hsa-miR-4747-5p	CLIP-seq
MIRT948059	hsa-miR-4757-5p	CLIP-seq
MIRT948060	hsa-miR-4766-3p	CLIP-seq
MIRT948061	hsa-miR-4766-5p	CLIP-seq
MIRT948062	hsa-miR-4776-3p	CLIP-seq
MIRT948063	hsa-miR-4789-3p	CLIP-seq
MIRT948064	hsa-miR-4794	CLIP-seq
MIRT948065	hsa-miR-4795-3p	CLIP-seq
MIRT948066	hsa-miR-4801	CLIP-seq
MIRT948067	hsa-miR-4804-3p	CLIP-seq
MIRT948068	hsa-miR-498	CLIP-seq
MIRT948069	hsa-miR-5095	CLIP-seq
MIRT948070	hsa-miR-510	CLIP-seq
MIRT948071	hsa-miR-513a-3p	CLIP-seq
MIRT948072	hsa-miR-522	CLIP-seq
MIRT948073	hsa-miR-539	CLIP-seq
MIRT948074	hsa-miR-548ah	CLIP-seq
MIRT948075	hsa-miR-548p	CLIP-seq
MIRT948076	hsa-miR-548t	CLIP-seq
MIRT948077	hsa-miR-570	CLIP-seq
MIRT948078	hsa-miR-575	CLIP-seq
MIRT948079	hsa-miR-579	CLIP-seq
MIRT948080	hsa-miR-603	CLIP-seq
MIRT948081	hsa-miR-608	CLIP-seq
MIRT948082	hsa-miR-629	CLIP-seq
MIRT948083	hsa-miR-630	CLIP-seq
MIRT948084	hsa-miR-642b	CLIP-seq
MIRT948085	hsa-miR-664	CLIP-seq
MIRT948086	hsa-miR-708	CLIP-seq
MIRT948087	hsa-miR-874	CLIP-seq
MIRT948088	hsa-miR-920	CLIP-seq
MIRT948089	hsa-miR-939	CLIP-seq
MIRT948090	hsa-miR-942	CLIP-seq
MIRT948091	hsa-miR-98	CLIP-seq
MIRT947967	hsa-let-7a	CLIP-seq
MIRT947968	hsa-let-7b	CLIP-seq
MIRT947969	hsa-let-7c	CLIP-seq
MIRT947970	hsa-let-7d	CLIP-seq
MIRT947971	hsa-let-7e	CLIP-seq
MIRT947972	hsa-let-7f	CLIP-seq
MIRT947973	hsa-let-7g	CLIP-seq
MIRT947974	hsa-let-7i	CLIP-seq
MIRT948092	hsa-miR-1200	CLIP-seq
MIRT948093	hsa-miR-1228	CLIP-seq
MIRT948094	hsa-miR-1297	CLIP-seq
MIRT948095	hsa-miR-1302	CLIP-seq
MIRT948096	hsa-miR-133a	CLIP-seq
MIRT948097	hsa-miR-133b	CLIP-seq
MIRT948098	hsa-miR-135a	CLIP-seq
MIRT948099	hsa-miR-135b	CLIP-seq
MIRT947982	hsa-miR-149	CLIP-seq
MIRT947983	hsa-miR-188-5p	CLIP-seq
MIRT948100	hsa-miR-1915	CLIP-seq
MIRT948101	hsa-miR-200b	CLIP-seq
MIRT948102	hsa-miR-200c	CLIP-seq
MIRT947984	hsa-miR-202	CLIP-seq
MIRT947985	hsa-miR-204	CLIP-seq
MIRT947986	hsa-miR-211	CLIP-seq
MIRT948103	hsa-miR-26a	CLIP-seq
MIRT948104	hsa-miR-26b	CLIP-seq
MIRT948105	hsa-miR-2964a-3p	CLIP-seq
MIRT948106	hsa-miR-3065-5p	CLIP-seq
MIRT948107	hsa-miR-3119	CLIP-seq
MIRT947990	hsa-miR-3122	CLIP-seq
MIRT948108	hsa-miR-3140-3p	CLIP-seq
MIRT947993	hsa-miR-3147	CLIP-seq
MIRT948109	hsa-miR-3153	CLIP-seq
MIRT948110	hsa-miR-3157-5p	CLIP-seq
MIRT948111	hsa-miR-3192	CLIP-seq
MIRT948112	hsa-miR-3194-3p	CLIP-seq
MIRT948113	hsa-miR-3199	CLIP-seq
MIRT947997	hsa-miR-320a	CLIP-seq
MIRT947998	hsa-miR-320b	CLIP-seq
MIRT947999	hsa-miR-320c	CLIP-seq
MIRT948000	hsa-miR-320d	CLIP-seq
MIRT948001	hsa-miR-320e	CLIP-seq
MIRT948114	hsa-miR-329	CLIP-seq
MIRT948115	hsa-miR-339-5p	CLIP-seq
MIRT948003	hsa-miR-34c-3p	CLIP-seq
MIRT948005	hsa-miR-361-3p	CLIP-seq
MIRT948116	hsa-miR-3622a-3p	CLIP-seq
MIRT948117	hsa-miR-3622b-3p	CLIP-seq
MIRT948118	hsa-miR-362-3p	CLIP-seq
MIRT948119	hsa-miR-3646	CLIP-seq
MIRT948007	hsa-miR-3662	CLIP-seq
MIRT948008	hsa-miR-3668	CLIP-seq
MIRT948010	hsa-miR-3675-5p	CLIP-seq
MIRT948120	hsa-miR-3679-3p	CLIP-seq
MIRT948121	hsa-miR-3682-5p	CLIP-seq
MIRT948122	hsa-miR-3692	CLIP-seq
MIRT948011	hsa-miR-3913-5p	CLIP-seq
MIRT948013	hsa-miR-3924	CLIP-seq
MIRT948014	hsa-miR-3941	CLIP-seq
MIRT948123	hsa-miR-4268	CLIP-seq
MIRT948016	hsa-miR-4283	CLIP-seq
MIRT948124	hsa-miR-429	CLIP-seq
MIRT948125	hsa-miR-4298	CLIP-seq
MIRT948017	hsa-miR-4300	CLIP-seq
MIRT948126	hsa-miR-4314	CLIP-seq
MIRT948018	hsa-miR-4316	CLIP-seq
MIRT948127	hsa-miR-4324	CLIP-seq
MIRT948019	hsa-miR-4426	CLIP-seq
MIRT948021	hsa-miR-4429	CLIP-seq
MIRT948023	hsa-miR-4433	CLIP-seq
MIRT948025	hsa-miR-4458	CLIP-seq
MIRT948128	hsa-miR-4465	CLIP-seq
MIRT948129	hsa-miR-4487	CLIP-seq
MIRT948027	hsa-miR-4489	CLIP-seq
MIRT948028	hsa-miR-4500	CLIP-seq
MIRT948130	hsa-miR-4540	CLIP-seq
MIRT948131	hsa-miR-4636	CLIP-seq
MIRT948035	hsa-miR-4639-3p	CLIP-seq
MIRT948132	hsa-miR-4646-5p	CLIP-seq
MIRT948036	hsa-miR-4647	CLIP-seq
MIRT948133	hsa-miR-4648	CLIP-seq
MIRT948134	hsa-miR-4654	CLIP-seq
MIRT948040	hsa-miR-466	CLIP-seq
MIRT948042	hsa-miR-4662b	CLIP-seq
MIRT948043	hsa-miR-4663	CLIP-seq
MIRT948045	hsa-miR-4672	CLIP-seq
MIRT948047	hsa-miR-4676-5p	CLIP-seq
MIRT948135	hsa-miR-4682	CLIP-seq
MIRT948136	hsa-miR-4685-5p	CLIP-seq
MIRT948137	hsa-miR-4698	CLIP-seq
MIRT948048	hsa-miR-4699-3p	CLIP-seq
MIRT948138	hsa-miR-4699-5p	CLIP-seq
MIRT948139	hsa-miR-4704-3p	CLIP-seq
MIRT948050	hsa-miR-4714-5p	CLIP-seq
MIRT948051	hsa-miR-4720-3p	CLIP-seq
MIRT948053	hsa-miR-4728-3p	CLIP-seq
MIRT948054	hsa-miR-4731-3p	CLIP-seq
MIRT948055	hsa-miR-4731-5p	CLIP-seq
MIRT948061	hsa-miR-4766-5p	CLIP-seq
MIRT948140	hsa-miR-4769-5p	CLIP-seq
MIRT948065	hsa-miR-4795-3p	CLIP-seq
MIRT948066	hsa-miR-4801	CLIP-seq
MIRT948067	hsa-miR-4804-3p	CLIP-seq
MIRT948141	hsa-miR-490-3p	CLIP-seq
MIRT948068	hsa-miR-498	CLIP-seq
MIRT948070	hsa-miR-510	CLIP-seq
MIRT948142	hsa-miR-511	CLIP-seq
MIRT948071	hsa-miR-513a-3p	CLIP-seq
MIRT948072	hsa-miR-522	CLIP-seq
MIRT948073	hsa-miR-539	CLIP-seq
MIRT948143	hsa-miR-541	CLIP-seq
MIRT948144	hsa-miR-544b	CLIP-seq
MIRT948145	hsa-miR-548aa	CLIP-seq
MIRT948146	hsa-miR-548ac	CLIP-seq
MIRT948147	hsa-miR-548ae	CLIP-seq
MIRT948148	hsa-miR-548aj	CLIP-seq
MIRT948149	hsa-miR-548am	CLIP-seq
MIRT948150	hsa-miR-548d-3p	CLIP-seq
MIRT948151	hsa-miR-548x	CLIP-seq
MIRT948152	hsa-miR-548z	CLIP-seq
MIRT948153	hsa-miR-554	CLIP-seq
MIRT948077	hsa-miR-570	CLIP-seq
MIRT948078	hsa-miR-575	CLIP-seq
MIRT948154	hsa-miR-593	CLIP-seq
MIRT948155	hsa-miR-622	CLIP-seq
MIRT948083	hsa-miR-630	CLIP-seq
MIRT948156	hsa-miR-654-5p	CLIP-seq
MIRT948157	hsa-miR-760	CLIP-seq
MIRT948087	hsa-miR-874	CLIP-seq
MIRT948158	hsa-miR-892a	CLIP-seq
MIRT948088	hsa-miR-920	CLIP-seq
MIRT948090	hsa-miR-942	CLIP-seq
MIRT948091	hsa-miR-98	CLIP-seq
MIRT1548078	hsa-miR-4421	CLIP-seq
MIRT1980888	hsa-miR-122	CLIP-seq
MIRT1980889	hsa-miR-1283	CLIP-seq
MIRT947977	hsa-miR-1289	CLIP-seq
MIRT948096	hsa-miR-133a	CLIP-seq
MIRT948097	hsa-miR-133b	CLIP-seq
MIRT948098	hsa-miR-135a	CLIP-seq
MIRT948099	hsa-miR-135b	CLIP-seq
MIRT947979	hsa-miR-137	CLIP-seq
MIRT1980890	hsa-miR-224	CLIP-seq
MIRT1980891	hsa-miR-2355-5p	CLIP-seq
MIRT947989	hsa-miR-3064-5p	CLIP-seq
MIRT948106	hsa-miR-3065-5p	CLIP-seq
MIRT948108	hsa-miR-3140-3p	CLIP-seq
MIRT947993	hsa-miR-3147	CLIP-seq
MIRT948111	hsa-miR-3192	CLIP-seq
MIRT1980892	hsa-miR-3198	CLIP-seq
MIRT947997	hsa-miR-320a	CLIP-seq
MIRT947998	hsa-miR-320b	CLIP-seq
MIRT947999	hsa-miR-320c	CLIP-seq
MIRT948000	hsa-miR-320d	CLIP-seq
MIRT948001	hsa-miR-320e	CLIP-seq
MIRT1980893	hsa-miR-3619-3p	CLIP-seq
MIRT1980894	hsa-miR-3653	CLIP-seq
MIRT1980895	hsa-miR-3658	CLIP-seq
MIRT1980896	hsa-miR-3659	CLIP-seq
MIRT948007	hsa-miR-3662	CLIP-seq
MIRT948008	hsa-miR-3668	CLIP-seq
MIRT948120	hsa-miR-3679-3p	CLIP-seq
MIRT1980897	hsa-miR-3688-5p	CLIP-seq
MIRT948122	hsa-miR-3692	CLIP-seq
MIRT1980898	hsa-miR-382	CLIP-seq
MIRT948013	hsa-miR-3924	CLIP-seq
MIRT1980899	hsa-miR-4255	CLIP-seq
MIRT1980900	hsa-miR-4292	CLIP-seq
MIRT1980901	hsa-miR-4308	CLIP-seq
MIRT1980902	hsa-miR-4309	CLIP-seq
MIRT948126	hsa-miR-4314	CLIP-seq
MIRT1548078	hsa-miR-4421	CLIP-seq
MIRT948019	hsa-miR-4426	CLIP-seq
MIRT948021	hsa-miR-4429	CLIP-seq
MIRT1980903	hsa-miR-4470	CLIP-seq
MIRT948032	hsa-miR-4533	CLIP-seq
MIRT948132	hsa-miR-4646-5p	CLIP-seq
MIRT948036	hsa-miR-4647	CLIP-seq
MIRT1980904	hsa-miR-4652-3p	CLIP-seq
MIRT948041	hsa-miR-4661-3p	CLIP-seq
MIRT948042	hsa-miR-4662b	CLIP-seq
MIRT948055	hsa-miR-4731-5p	CLIP-seq
MIRT948063	hsa-miR-4789-3p	CLIP-seq
MIRT948065	hsa-miR-4795-3p	CLIP-seq
MIRT948142	hsa-miR-511	CLIP-seq
MIRT1980905	hsa-miR-591	CLIP-seq
MIRT1980906	hsa-miR-604	CLIP-seq
MIRT1980907	hsa-miR-626	CLIP-seq
MIRT948082	hsa-miR-629	CLIP-seq
MIRT948083	hsa-miR-630	CLIP-seq
MIRT1980908	hsa-miR-642a	CLIP-seq
MIRT948084	hsa-miR-642b	CLIP-seq
MIRT1980909	hsa-miR-647	CLIP-seq
MIRT1980910	hsa-miR-670	CLIP-seq
MIRT948122	hsa-miR-3692	CLIP-seq
MIRT1980908	hsa-miR-642a	CLIP-seq
MIRT947967	hsa-let-7a	CLIP-seq
MIRT947968	hsa-let-7b	CLIP-seq
MIRT947969	hsa-let-7c	CLIP-seq
MIRT947970	hsa-let-7d	CLIP-seq
MIRT947971	hsa-let-7e	CLIP-seq
MIRT947972	hsa-let-7f	CLIP-seq
MIRT947973	hsa-let-7g	CLIP-seq
MIRT947974	hsa-let-7i	CLIP-seq
MIRT2215894	hsa-miR-105	CLIP-seq
MIRT2215895	hsa-miR-1184	CLIP-seq
MIRT2215896	hsa-miR-1205	CLIP-seq
MIRT2215897	hsa-miR-1206	CLIP-seq
MIRT2215898	hsa-miR-1207-3p	CLIP-seq
MIRT1980888	hsa-miR-122	CLIP-seq
MIRT2215899	hsa-miR-1225-3p	CLIP-seq
MIRT947975	hsa-miR-1226	CLIP-seq
MIRT948093	hsa-miR-1228	CLIP-seq
MIRT2215900	hsa-miR-1233	CLIP-seq
MIRT2215901	hsa-miR-1267	CLIP-seq
MIRT2215902	hsa-miR-1273f	CLIP-seq
MIRT1980889	hsa-miR-1283	CLIP-seq
MIRT947976	hsa-miR-1286	CLIP-seq
MIRT947977	hsa-miR-1289	CLIP-seq
MIRT947978	hsa-miR-1293	CLIP-seq
MIRT2215903	hsa-miR-1306	CLIP-seq
MIRT2215904	hsa-miR-1322	CLIP-seq
MIRT948098	hsa-miR-135a	CLIP-seq
MIRT948099	hsa-miR-135b	CLIP-seq
MIRT947979	hsa-miR-137	CLIP-seq
MIRT2215905	hsa-miR-143	CLIP-seq
MIRT2215906	hsa-miR-1470	CLIP-seq
MIRT947982	hsa-miR-149	CLIP-seq
MIRT2215907	hsa-miR-183	CLIP-seq
MIRT947983	hsa-miR-188-5p	CLIP-seq
MIRT2215908	hsa-miR-192	CLIP-seq
MIRT948101	hsa-miR-200b	CLIP-seq
MIRT948102	hsa-miR-200c	CLIP-seq
MIRT947984	hsa-miR-202	CLIP-seq
MIRT947985	hsa-miR-204	CLIP-seq
MIRT2215909	hsa-miR-205	CLIP-seq
MIRT2215910	hsa-miR-2054	CLIP-seq
MIRT947986	hsa-miR-211	CLIP-seq
MIRT947987	hsa-miR-2110	CLIP-seq
MIRT2215911	hsa-miR-215	CLIP-seq
MIRT1980891	hsa-miR-2355-5p	CLIP-seq
MIRT948105	hsa-miR-2964a-3p	CLIP-seq
MIRT947989	hsa-miR-3064-5p	CLIP-seq
MIRT948106	hsa-miR-3065-5p	CLIP-seq
MIRT948107	hsa-miR-3119	CLIP-seq
MIRT947990	hsa-miR-3122	CLIP-seq
MIRT2215912	hsa-miR-3130-3p	CLIP-seq
MIRT2215913	hsa-miR-3134	CLIP-seq
MIRT948108	hsa-miR-3140-3p	CLIP-seq
MIRT947993	hsa-miR-3147	CLIP-seq
MIRT948109	hsa-miR-3153	CLIP-seq
MIRT948110	hsa-miR-3157-5p	CLIP-seq
MIRT2215914	hsa-miR-3158-5p	CLIP-seq
MIRT947994	hsa-miR-3169	CLIP-seq
MIRT947995	hsa-miR-3176	CLIP-seq
MIRT947996	hsa-miR-3180-5p	CLIP-seq
MIRT2215915	hsa-miR-3187-3p	CLIP-seq
MIRT948111	hsa-miR-3192	CLIP-seq
MIRT948112	hsa-miR-3194-3p	CLIP-seq
MIRT1980892	hsa-miR-3198	CLIP-seq
MIRT948113	hsa-miR-3199	CLIP-seq
MIRT947997	hsa-miR-320a	CLIP-seq
MIRT947998	hsa-miR-320b	CLIP-seq
MIRT947999	hsa-miR-320c	CLIP-seq
MIRT948000	hsa-miR-320d	CLIP-seq
MIRT948001	hsa-miR-320e	CLIP-seq
MIRT948114	hsa-miR-329	CLIP-seq
MIRT2215916	hsa-miR-335	CLIP-seq
MIRT948002	hsa-miR-342-5p	CLIP-seq
MIRT948003	hsa-miR-34c-3p	CLIP-seq
MIRT2215917	hsa-miR-3591-5p	CLIP-seq
MIRT948004	hsa-miR-3609	CLIP-seq
MIRT1980893	hsa-miR-3619-3p	CLIP-seq
MIRT948116	hsa-miR-3622a-3p	CLIP-seq
MIRT948117	hsa-miR-3622b-3p	CLIP-seq
MIRT948118	hsa-miR-362-3p	CLIP-seq
MIRT948006	hsa-miR-3652	CLIP-seq
MIRT1980896	hsa-miR-3659	CLIP-seq
MIRT948007	hsa-miR-3662	CLIP-seq
MIRT2215918	hsa-miR-3663-3p	CLIP-seq
MIRT2215919	hsa-miR-3665	CLIP-seq
MIRT948008	hsa-miR-3668	CLIP-seq
MIRT948010	hsa-miR-3675-5p	CLIP-seq
MIRT2215920	hsa-miR-3680	CLIP-seq
MIRT948121	hsa-miR-3682-5p	CLIP-seq
MIRT1980897	hsa-miR-3688-5p	CLIP-seq
MIRT948122	hsa-miR-3692	CLIP-seq
MIRT1980898	hsa-miR-382	CLIP-seq
MIRT2215921	hsa-miR-3913-3p	CLIP-seq
MIRT948011	hsa-miR-3913-5p	CLIP-seq
MIRT948012	hsa-miR-3922-3p	CLIP-seq
MIRT2215922	hsa-miR-3926	CLIP-seq
MIRT948014	hsa-miR-3941	CLIP-seq
MIRT2215923	hsa-miR-409-5p	CLIP-seq
MIRT1980899	hsa-miR-4255	CLIP-seq
MIRT2215924	hsa-miR-4264	CLIP-seq
MIRT948015	hsa-miR-4271	CLIP-seq
MIRT2215925	hsa-miR-4280	CLIP-seq
MIRT948016	hsa-miR-4283	CLIP-seq
MIRT948124	hsa-miR-429	CLIP-seq
MIRT1980900	hsa-miR-4292	CLIP-seq
MIRT2215926	hsa-miR-4294	CLIP-seq
MIRT948017	hsa-miR-4300	CLIP-seq
MIRT1980901	hsa-miR-4308	CLIP-seq
MIRT1980902	hsa-miR-4309	CLIP-seq
MIRT2215927	hsa-miR-4312	CLIP-seq
MIRT948126	hsa-miR-4314	CLIP-seq
MIRT2215928	hsa-miR-4420	CLIP-seq
MIRT1548078	hsa-miR-4421	CLIP-seq
MIRT948019	hsa-miR-4426	CLIP-seq
MIRT948020	hsa-miR-4428	CLIP-seq
MIRT948021	hsa-miR-4429	CLIP-seq
MIRT948022	hsa-miR-4430	CLIP-seq
MIRT948023	hsa-miR-4433	CLIP-seq
MIRT2215929	hsa-miR-4435	CLIP-seq
MIRT948024	hsa-miR-4438	CLIP-seq
MIRT2215930	hsa-miR-4453	CLIP-seq
MIRT948025	hsa-miR-4458	CLIP-seq
MIRT2215931	hsa-miR-4469	CLIP-seq
MIRT2215932	hsa-miR-4475	CLIP-seq
MIRT948026	hsa-miR-4483	CLIP-seq
MIRT948027	hsa-miR-4489	CLIP-seq
MIRT948028	hsa-miR-4500	CLIP-seq
MIRT948029	hsa-miR-4505	CLIP-seq
MIRT2215933	hsa-miR-4517	CLIP-seq
MIRT948030	hsa-miR-452	CLIP-seq
MIRT948031	hsa-miR-4532	CLIP-seq
MIRT948032	hsa-miR-4533	CLIP-seq
MIRT2215934	hsa-miR-4538	CLIP-seq
MIRT948033	hsa-miR-4633-3p	CLIP-seq
MIRT948034	hsa-miR-4638-5p	CLIP-seq
MIRT948035	hsa-miR-4639-3p	CLIP-seq
MIRT948132	hsa-miR-4646-5p	CLIP-seq
MIRT948036	hsa-miR-4647	CLIP-seq
MIRT948133	hsa-miR-4648	CLIP-seq
MIRT948037	hsa-miR-4651	CLIP-seq
MIRT1980904	hsa-miR-4652-3p	CLIP-seq
MIRT948134	hsa-miR-4654	CLIP-seq
MIRT948040	hsa-miR-466	CLIP-seq
MIRT948041	hsa-miR-4661-3p	CLIP-seq
MIRT948042	hsa-miR-4662b	CLIP-seq
MIRT948044	hsa-miR-4664-5p	CLIP-seq
MIRT2215935	hsa-miR-4667-3p	CLIP-seq
MIRT948045	hsa-miR-4672	CLIP-seq
MIRT948046	hsa-miR-4676-3p	CLIP-seq
MIRT948048	hsa-miR-4699-3p	CLIP-seq
MIRT948049	hsa-miR-4700-3p	CLIP-seq
MIRT2215936	hsa-miR-4701-5p	CLIP-seq
MIRT948139	hsa-miR-4704-3p	CLIP-seq
MIRT2215937	hsa-miR-4708-5p	CLIP-seq
MIRT948050	hsa-miR-4714-5p	CLIP-seq
MIRT948051	hsa-miR-4720-3p	CLIP-seq
MIRT948052	hsa-miR-4725-3p	CLIP-seq
MIRT948054	hsa-miR-4731-3p	CLIP-seq
MIRT948055	hsa-miR-4731-5p	CLIP-seq
MIRT948056	hsa-miR-4733-3p	CLIP-seq
MIRT2215938	hsa-miR-4733-5p	CLIP-seq
MIRT948057	hsa-miR-4738-3p	CLIP-seq
MIRT948059	hsa-miR-4757-5p	CLIP-seq
MIRT948061	hsa-miR-4766-5p	CLIP-seq
MIRT948140	hsa-miR-4769-5p	CLIP-seq
MIRT2215939	hsa-miR-4770	CLIP-seq
MIRT2215940	hsa-miR-4781-3p	CLIP-seq
MIRT948063	hsa-miR-4789-3p	CLIP-seq
MIRT948064	hsa-miR-4794	CLIP-seq
MIRT948065	hsa-miR-4795-3p	CLIP-seq
MIRT2215941	hsa-miR-4797-3p	CLIP-seq
MIRT2215942	hsa-miR-4799-5p	CLIP-seq
MIRT948066	hsa-miR-4801	CLIP-seq
MIRT2215943	hsa-miR-4803	CLIP-seq
MIRT948067	hsa-miR-4804-3p	CLIP-seq
MIRT2215944	hsa-miR-489	CLIP-seq
MIRT2215945	hsa-miR-490-5p	CLIP-seq
MIRT2215946	hsa-miR-495	CLIP-seq
MIRT948068	hsa-miR-498	CLIP-seq
MIRT948069	hsa-miR-5095	CLIP-seq
MIRT948070	hsa-miR-510	CLIP-seq
MIRT948142	hsa-miR-511	CLIP-seq
MIRT948071	hsa-miR-513a-3p	CLIP-seq
MIRT2215947	hsa-miR-513a-5p	CLIP-seq
MIRT2215948	hsa-miR-514	CLIP-seq
MIRT2215949	hsa-miR-514b-3p	CLIP-seq
MIRT948072	hsa-miR-522	CLIP-seq
MIRT2215950	hsa-miR-526b	CLIP-seq
MIRT948073	hsa-miR-539	CLIP-seq
MIRT948143	hsa-miR-541	CLIP-seq
MIRT2215951	hsa-miR-544	CLIP-seq
MIRT948145	hsa-miR-548aa	CLIP-seq
MIRT948074	hsa-miR-548ah	CLIP-seq
MIRT2215952	hsa-miR-548s	CLIP-seq
MIRT948076	hsa-miR-548t	CLIP-seq
MIRT948077	hsa-miR-570	CLIP-seq
MIRT2215953	hsa-miR-588	CLIP-seq
MIRT1980905	hsa-miR-591	CLIP-seq
MIRT1980906	hsa-miR-604	CLIP-seq
MIRT2215954	hsa-miR-605	CLIP-seq
MIRT948081	hsa-miR-608	CLIP-seq
MIRT948155	hsa-miR-622	CLIP-seq
MIRT1980908	hsa-miR-642a	CLIP-seq
MIRT948084	hsa-miR-642b	CLIP-seq
MIRT1980909	hsa-miR-647	CLIP-seq
MIRT2215955	hsa-miR-653	CLIP-seq
MIRT948156	hsa-miR-654-5p	CLIP-seq
MIRT2215956	hsa-miR-657	CLIP-seq
MIRT948085	hsa-miR-664	CLIP-seq
MIRT2215957	hsa-miR-665	CLIP-seq
MIRT1980910	hsa-miR-670	CLIP-seq
MIRT948087	hsa-miR-874	CLIP-seq
MIRT948088	hsa-miR-920	CLIP-seq
MIRT948089	hsa-miR-939	CLIP-seq
MIRT948090	hsa-miR-942	CLIP-seq
MIRT948091	hsa-miR-98	CLIP-seq
MIRT1980888	hsa-miR-122	CLIP-seq
MIRT947975	hsa-miR-1226	CLIP-seq
MIRT2215902	hsa-miR-1273f	CLIP-seq
MIRT1980889	hsa-miR-1283	CLIP-seq
MIRT947978	hsa-miR-1293	CLIP-seq
MIRT947979	hsa-miR-137	CLIP-seq
MIRT2215905	hsa-miR-143	CLIP-seq
MIRT2387155	hsa-miR-182	CLIP-seq
MIRT1980890	hsa-miR-224	CLIP-seq
MIRT947989	hsa-miR-3064-5p	CLIP-seq
MIRT948108	hsa-miR-3140-3p	CLIP-seq
MIRT948109	hsa-miR-3153	CLIP-seq
MIRT2387156	hsa-miR-3174	CLIP-seq
MIRT1980892	hsa-miR-3198	CLIP-seq
MIRT948001	hsa-miR-320e	CLIP-seq
MIRT948002	hsa-miR-342-5p	CLIP-seq
MIRT2387157	hsa-miR-3620	CLIP-seq
MIRT1980896	hsa-miR-3659	CLIP-seq
MIRT948122	hsa-miR-3692	CLIP-seq
MIRT1980898	hsa-miR-382	CLIP-seq
MIRT1980899	hsa-miR-4255	CLIP-seq
MIRT1980900	hsa-miR-4292	CLIP-seq
MIRT1980901	hsa-miR-4308	CLIP-seq
MIRT1980902	hsa-miR-4309	CLIP-seq
MIRT948026	hsa-miR-4483	CLIP-seq
MIRT948037	hsa-miR-4651	CLIP-seq
MIRT1980904	hsa-miR-4652-3p	CLIP-seq
MIRT948044	hsa-miR-4664-5p	CLIP-seq
MIRT948048	hsa-miR-4699-3p	CLIP-seq
MIRT2215937	hsa-miR-4708-5p	CLIP-seq
MIRT948054	hsa-miR-4731-3p	CLIP-seq
MIRT948055	hsa-miR-4731-5p	CLIP-seq
MIRT948056	hsa-miR-4733-3p	CLIP-seq
MIRT948057	hsa-miR-4738-3p	CLIP-seq
MIRT2215939	hsa-miR-4770	CLIP-seq
MIRT948063	hsa-miR-4789-3p	CLIP-seq
MIRT948065	hsa-miR-4795-3p	CLIP-seq
MIRT948066	hsa-miR-4801	CLIP-seq
MIRT2387158	hsa-miR-513c	CLIP-seq
MIRT2387159	hsa-miR-514b-5p	CLIP-seq
MIRT1980906	hsa-miR-604	CLIP-seq
MIRT948081	hsa-miR-608	CLIP-seq
MIRT948082	hsa-miR-629	CLIP-seq
MIRT948084	hsa-miR-642b	CLIP-seq
MIRT1980909	hsa-miR-647	CLIP-seq
MIRT1980910	hsa-miR-670	CLIP-seq
MIRT948087	hsa-miR-874	CLIP-seq
MIRT2387160	hsa-miR-921	CLIP-seq
MIRT2215906	hsa-miR-1470	CLIP-seq
MIRT948110	hsa-miR-3157-5p	CLIP-seq
MIRT948113	hsa-miR-3199	CLIP-seq
MIRT2215930	hsa-miR-4453	CLIP-seq
MIRT2215931	hsa-miR-4469	CLIP-seq
MIRT948029	hsa-miR-4505	CLIP-seq
MIRT2448612	hsa-miR-4515	CLIP-seq
MIRT2215934	hsa-miR-4538	CLIP-seq
MIRT2215935	hsa-miR-4667-3p	CLIP-seq
MIRT2448613	hsa-miR-4691-3p	CLIP-seq
MIRT2448614	hsa-miR-4755-3p	CLIP-seq
MIRT1980908	hsa-miR-642a	CLIP-seq
MIRT948093	hsa-miR-1228	CLIP-seq
MIRT947979	hsa-miR-137	CLIP-seq
MIRT947989	hsa-miR-3064-5p	CLIP-seq
MIRT948114	hsa-miR-329	CLIP-seq
MIRT2520139	hsa-miR-3613-3p	CLIP-seq
MIRT948118	hsa-miR-362-3p	CLIP-seq
MIRT1980900	hsa-miR-4292	CLIP-seq
MIRT1980901	hsa-miR-4308	CLIP-seq
MIRT2520140	hsa-miR-4736	CLIP-seq
MIRT948063	hsa-miR-4789-3p	CLIP-seq
MIRT2520141	hsa-miR-491-3p	CLIP-seq
MIRT1980906	hsa-miR-604	CLIP-seq
MIRT948084	hsa-miR-642b	CLIP-seq
MIRT1980909	hsa-miR-647	CLIP-seq
MIRT2215956	hsa-miR-657	CLIP-seq
MIRT1980910	hsa-miR-670	CLIP-seq
MIRT948093	hsa-miR-1228	CLIP-seq
MIRT947976	hsa-miR-1286	CLIP-seq
MIRT947978	hsa-miR-1293	CLIP-seq
MIRT947979	hsa-miR-137	CLIP-seq
MIRT1980890	hsa-miR-224	CLIP-seq
MIRT947989	hsa-miR-3064-5p	CLIP-seq
MIRT2679587	hsa-miR-3125	CLIP-seq
MIRT2679588	hsa-miR-3133	CLIP-seq
MIRT948109	hsa-miR-3153	CLIP-seq
MIRT947994	hsa-miR-3169	CLIP-seq
MIRT948111	hsa-miR-3192	CLIP-seq
MIRT948115	hsa-miR-339-5p	CLIP-seq
MIRT948002	hsa-miR-342-5p	CLIP-seq
MIRT2679589	hsa-miR-34a	CLIP-seq
MIRT2679590	hsa-miR-34c-5p	CLIP-seq
MIRT2679591	hsa-miR-3545-3p	CLIP-seq
MIRT2520139	hsa-miR-3613-3p	CLIP-seq
MIRT2387157	hsa-miR-3620	CLIP-seq
MIRT948119	hsa-miR-3646	CLIP-seq
MIRT2679592	hsa-miR-3916	CLIP-seq
MIRT2679593	hsa-miR-3977	CLIP-seq
MIRT2679594	hsa-miR-412	CLIP-seq
MIRT2679595	hsa-miR-4256	CLIP-seq
MIRT1980900	hsa-miR-4292	CLIP-seq
MIRT1980901	hsa-miR-4308	CLIP-seq
MIRT948126	hsa-miR-4314	CLIP-seq
MIRT948018	hsa-miR-4316	CLIP-seq
MIRT948026	hsa-miR-4483	CLIP-seq
MIRT2679596	hsa-miR-449a	CLIP-seq
MIRT2679597	hsa-miR-449b	CLIP-seq
MIRT948030	hsa-miR-452	CLIP-seq
MIRT2679598	hsa-miR-4539	CLIP-seq
MIRT948132	hsa-miR-4646-5p	CLIP-seq
MIRT948037	hsa-miR-4651	CLIP-seq
MIRT948043	hsa-miR-4663	CLIP-seq
MIRT948044	hsa-miR-4664-5p	CLIP-seq
MIRT948046	hsa-miR-4676-3p	CLIP-seq
MIRT948047	hsa-miR-4676-5p	CLIP-seq
MIRT948138	hsa-miR-4699-5p	CLIP-seq
MIRT948053	hsa-miR-4728-3p	CLIP-seq
MIRT948055	hsa-miR-4731-5p	CLIP-seq
MIRT2520140	hsa-miR-4736	CLIP-seq
MIRT948060	hsa-miR-4766-3p	CLIP-seq
MIRT2679599	hsa-miR-4777-5p	CLIP-seq
MIRT948063	hsa-miR-4789-3p	CLIP-seq
MIRT2520141	hsa-miR-491-3p	CLIP-seq
MIRT2679600	hsa-miR-518d-5p	CLIP-seq
MIRT2679601	hsa-miR-519b-5p	CLIP-seq
MIRT2679602	hsa-miR-519c-5p	CLIP-seq
MIRT2679603	hsa-miR-520c-5p	CLIP-seq
MIRT2679604	hsa-miR-526a	CLIP-seq
MIRT948073	hsa-miR-539	CLIP-seq
MIRT948143	hsa-miR-541	CLIP-seq
MIRT948145	hsa-miR-548aa	CLIP-seq
MIRT948075	hsa-miR-548p	CLIP-seq
MIRT948077	hsa-miR-570	CLIP-seq
MIRT948078	hsa-miR-575	CLIP-seq
MIRT1980906	hsa-miR-604	CLIP-seq
MIRT948081	hsa-miR-608	CLIP-seq
MIRT948155	hsa-miR-622	CLIP-seq
MIRT948084	hsa-miR-642b	CLIP-seq
MIRT1980909	hsa-miR-647	CLIP-seq
MIRT948156	hsa-miR-654-5p	CLIP-seq
MIRT2215956	hsa-miR-657	CLIP-seq
MIRT1980910	hsa-miR-670	CLIP-seq
MIRT2679605	hsa-miR-877	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CREM	Repression	21325296

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001706	Process	Endoderm formation	IBA
GO:0004721	Function	Phosphoprotein phosphatase activity	IBA
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	7535768
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	TAS
GO:0005515	Function	Protein binding	IPI	16038800, 25241761, 27880917, 31980649, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	7535768
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0007165	Process	Signal transduction	IBA
GO:0008330	Function	Protein tyrosine/threonine phosphatase activity	IDA	7535768
GO:0016311	Process	Dephosphorylation	IDA	24531476
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	24531476
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA
GO:0033549	Function	MAP kinase phosphatase activity	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	IBA
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IMP	7535768
GO:1990439	Function	MAP kinase serine/threonine phosphatase activity	IDA	7535768

Other IDs

• MIM: 602747
• HGNC: 3070
• e!Ensembl: ENSG00000120875

Protein

• UniProt ID: Q13115
• Protein name: Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)
• Protein function: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
• PDB: 3EZZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00581	Rhodanese	37 → 153	Rhodanese-like domain	Domain
  PF00782	DSPc	203 → 333	Dual specificity phosphatase, catalytic domain	Domain

• Sequence:

  MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY
  ILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLRE
  DSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLD
  LGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHY
  QYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKR
  VRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATP
  TSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC

• Sequence length: 394

Pathways

KEGG:

MAPK signaling pathway
Efferocytosis

Reactome:

RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ARTHRITIS, JUVENILE	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORTICOBASAL DEGENERATION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSIVE DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL DEPRESSION	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	19525976, 30475228		★☆☆☆☆ Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	BEFREE	25847947		★☆☆☆☆ Found in Text Mining only
Anaplastic astrocytoma	Anaplastic Astrocytoma	BEFREE	20124482		★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	20177145		★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	30678657	Associate	★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	25847947, 27957827		★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	32890776	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	23127286, 24658355, 25201346, 25281216, 25629224, 29100381, 30443298		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23127286, 24658355, 25201346, 25629224, 26859151, 28400477, 36234680	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25281216	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	15184884, 26941286		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	20345479	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	29425759	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	19525976, 19836351, 28500316, 30475228		★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	33819739	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	25733583	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	22427941	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	23048029, 29668927		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	35774798	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	22965873, 23749251, 26148620, 27590223, 29150975		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	23350875, 26148620, 29150975, 33495832, 33662786	Associate	★☆☆☆☆ Found in Text Mining only
Craniosynostosis	Craniosynostosis	BEFREE	30657646		★☆☆☆☆ Found in Text Mining only
Delirium	Delirium	Pubtator	30678657	Associate	★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	PSYGENET_DG	11331420, 15496935		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes	Diabetes	BEFREE	30862678		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	30862678		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	30862678		★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	25847947		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	32890776	Inhibit	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	20124482		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	20124482, 31480854		★☆☆☆☆ Found in Text Mining only
Hepatitis Alcoholic	Alcoholic hepatitis	Pubtator	29425759	Associate	★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	26859151	Associate	★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	28874504	Associate	★☆☆☆☆ Found in Text Mining only
IMMUNODEFICIENCY 13	Immunodeficiency	BEFREE	25733583		★☆☆☆☆ Found in Text Mining only
Intraepithelial Neoplasia	Intraepithelial Neoplasia	BEFREE	26941286		★☆☆☆☆ Found in Text Mining only
Juvenile arthritis	Arthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Juvenile psoriatic arthritis	Juvenile arthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Juvenile-Onset Still Disease	Still Disease	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31258782		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	19525976, 28500316	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus	Lupus Erythematosus	BEFREE	31653682		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	31653682	Stimulate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Discoid	Lupus Erythematosus	BEFREE	31653682		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	31653682		★☆☆☆☆ Found in Text Mining only
Lupus Vulgaris	Lupus Vulgaris	BEFREE	31653682		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22683778, 23127286, 24658355, 25201346, 25281216, 25629224, 27393618, 29100381, 30443298		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	19525976, 19836351, 28500316, 30475228		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	27957827, 29212207, 29509059		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	24222120		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	14767517, 23966295, 28874504		★☆☆☆☆ Found in Text Mining only
Marinesco-Sjogren syndrome	Marinesco-Sjogren Syndrome	BEFREE	22965873		★☆☆☆☆ Found in Text Mining only
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS	Megalencephalic Leukoencephalopathy With Subcortical Cysts	BEFREE	29133249		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	26084293, 31839677, 32767816, 35189148, 35580987	Associate	★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	31839677		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	PSYGENET_DG	11331420, 15496935		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial infarction	Pubtator	30678657	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16087957, 19525976, 22965873, 23749251, 23875912, 23966295, 26224146, 27957827, 28791489, 28867346, 31801953		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28554129		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	16087957		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	36362153	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	BEFREE	26941286		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	39639217	Associate	★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Negative	Seronegative polyarthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Positive	Polyarthritis, Rheumatoid Factor Positive	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Renal fibrosis	Renal fibrosis	BEFREE	30322849, 30760641		★☆☆☆☆ Found in Text Mining only
Secondary malignant neoplasm of colon and/or rectum	Colorectal Neoplasms	BEFREE	25520391		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	25027955		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	27957827, 29212207, 29509059		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	27957827, 29509059, 33402458	Associate	★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	30678657	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	33760201	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	24222120		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	24222120		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	25201346, 25281216, 27604655	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	25281216, 27393618, 27604655		★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	36576731	Associate	★☆☆☆☆ Found in Text Mining only