Gene Gene information from NCBI Gene database.
Entrez ID 1845
Gene name Dual specificity phosphatase 3
Gene symbol DUSP3
Synonyms (NCBI Gene)
VHR
Chromosome 17
Chromosome location 17q21.31
Summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu
miRNA miRNA information provided by mirtarbase database.
745
miRTarBase ID miRNA Experiments Reference
MIRT020096 hsa-miR-361-5p Sequencing 20371350
MIRT021310 hsa-miR-125a-5p Sequencing 20371350
MIRT025606 hsa-miR-10a-5p Sequencing 20371350
MIRT039365 hsa-miR-421 CLASH 23622248
MIRT715189 hsa-miR-6872-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
56
GO ID Ontology Definition Evidence Reference
GO:0001772 Component Immunological synapse IDA 12447358
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IDA 11863439
GO:0004725 Function Protein tyrosine phosphatase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600183 3069 ENSG00000108861
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P51452
Protein name Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR)
Protein function Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:10224087, PubMed:11863439). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:102
PDB 1J4X , 1VHR , 3F81 , 8TK2 , 8TK3 , 8TK4 , 8TK5 , 8TK6 , 9DJ9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00782 DSPc 37 176 Dual specificity phosphatase, catalytic domain Domain
Sequence
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway   ERKs are inactivated
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, NON-SMALL-CELL LUNG CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 39954561 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 7829067
★☆☆☆☆
Found in Text Mining only
cervical cancer Cervical Cancer BEFREE 31797547
★☆☆☆☆
Found in Text Mining only
Cervix carcinoma Cervix carcinoma BEFREE 31797547
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 36171645 Associate
★☆☆☆☆
Found in Text Mining only
Dysplastic Nevus Dysplastic Nevus BEFREE 27377700
★☆☆☆☆
Found in Text Mining only
Laryngitis Laryngitis Pubtator 23071866 Associate
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Lung Neoplasms BEFREE 29020102
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of ovary Ovarian cancer BEFREE 7829067
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 19010898
★☆☆☆☆
Found in Text Mining only