Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	1810
Gene name	Down-regulator of transcription 1
Gene symbol	DR1
Synonyms (NCBI Gene)	NC2NC2-BETANC2BNCB2
Chromosome	1
Chromosome location	1p22.1
Summary	This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This pr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020005	hsa-miR-375	Microarray	20215506
MIRT020974	hsa-miR-155-5p	Proteomics	20584899
MIRT044688	hsa-miR-320a	CLASH	23622248
MIRT054518	hsa-miR-513a-5p	Luciferase reporter assayqRT-PCRWestern blot	24252134
MIRT054519	hsa-miR-513b-5p	Luciferase reporter assayqRT-PCRWestern blot	24252134
MIRT054520	hsa-miR-513c-5p	Luciferase reporter assayqRT-PCRWestern blot	24252134
MIRT668680	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT668679	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT668678	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT668677	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT668676	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT668675	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT668674	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT668673	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT668672	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT668671	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT668670	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT668669	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT293263	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT624085	hsa-miR-8080	HITS-CLIP	23824327
MIRT624084	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT624083	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT624082	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT624085	hsa-miR-8080	HITS-CLIP	23824327
MIRT624084	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT624083	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT624082	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT624081	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT624080	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT624079	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT483466	hsa-miR-4759	PAR-CLIP	20371350
MIRT483467	hsa-miR-3169	PAR-CLIP	20371350
MIRT483465	hsa-miR-8083	PAR-CLIP	20371350
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	20371350
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	20371350
MIRT483466	hsa-miR-4759	PAR-CLIP	20371350
MIRT483467	hsa-miR-3169	PAR-CLIP	20371350
MIRT483465	hsa-miR-8083	PAR-CLIP	20371350
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	20371350
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	20371350
MIRT293284	hsa-miR-137	PAR-CLIP	21572407
MIRT293290	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT293285	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT293286	hsa-miR-3120-3p	PAR-CLIP	21572407
MIRT388009	hsa-miR-499a-3p	PAR-CLIP	21572407
MIRT388010	hsa-miR-499b-3p	PAR-CLIP	21572407
MIRT558321	hsa-miR-4457	PAR-CLIP	21572407
MIRT558320	hsa-miR-125b-2-3p	PAR-CLIP	21572407
MIRT293289	hsa-miR-4635	PAR-CLIP	21572407
MIRT293287	hsa-miR-3185	PAR-CLIP	21572407
MIRT558319	hsa-miR-4709-3p	PAR-CLIP	21572407
MIRT293248	hsa-miR-548n	PAR-CLIP	21572407
MIRT548550	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT548549	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT293244	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT293256	hsa-miR-548ab	PAR-CLIP	21572407
MIRT293258	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT293259	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT293260	hsa-miR-548ak	PAR-CLIP	21572407
MIRT293262	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT293264	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT293265	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT293266	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT293267	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT293268	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT293270	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT293243	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT293271	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT293245	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT293246	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT293249	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT293250	hsa-miR-548i	PAR-CLIP	21572407
MIRT293247	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT293255	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT293252	hsa-miR-548w	PAR-CLIP	21572407
MIRT293254	hsa-miR-548y	PAR-CLIP	21572407
MIRT293242	hsa-miR-559	PAR-CLIP	21572407
MIRT548548	hsa-miR-5571-5p	PAR-CLIP	21572407
MIRT548547	hsa-miR-4715-5p	PAR-CLIP	21572407
MIRT293253	hsa-miR-4259	PAR-CLIP	21572407
MIRT293261	hsa-miR-4495	PAR-CLIP	21572407
MIRT548546	hsa-miR-4529-5p	PAR-CLIP	21572407
MIRT548544	hsa-miR-3153	PAR-CLIP	21572407
MIRT548545	hsa-miR-6733-5p	PAR-CLIP	21572407
MIRT548543	hsa-miR-6739-5p	PAR-CLIP	21572407
MIRT293257	hsa-miR-4425	PAR-CLIP	21572407
MIRT548542	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT293241	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT483466	hsa-miR-4759	PAR-CLIP	21572407
MIRT483467	hsa-miR-3169	PAR-CLIP	21572407
MIRT483465	hsa-miR-8083	PAR-CLIP	21572407
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	21572407
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	21572407
MIRT494093	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT483466	hsa-miR-4759	PAR-CLIP	23592263
MIRT483467	hsa-miR-3169	PAR-CLIP	23592263
MIRT483465	hsa-miR-8083	PAR-CLIP	23592263
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	23592263
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	23592263
MIRT494093	hsa-miR-340-5p	PAR-CLIP	23592263
MIRT483466	hsa-miR-4759	PAR-CLIP	23592263
MIRT483467	hsa-miR-3169	PAR-CLIP	23592263
MIRT483465	hsa-miR-8083	PAR-CLIP	23592263
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	23592263
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	23592263
MIRT448879	hsa-miR-384	PAR-CLIP	22100165
MIRT448878	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT448877	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT448876	hsa-miR-5571-3p	PAR-CLIP	22100165
MIRT448875	hsa-miR-7975	PAR-CLIP	22100165
MIRT448873	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT448874	hsa-miR-573	PAR-CLIP	22100165
MIRT448879	hsa-miR-384	PAR-CLIP	22100165
MIRT448878	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT448877	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT448876	hsa-miR-5571-3p	PAR-CLIP	22100165
MIRT448875	hsa-miR-7975	PAR-CLIP	22100165
MIRT448873	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT448874	hsa-miR-573	PAR-CLIP	22100165
MIRT668680	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT668679	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT668678	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT668677	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT668676	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT668675	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT668674	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT668673	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT668672	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT668671	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT668670	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT668669	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT293263	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT624085	hsa-miR-8080	HITS-CLIP	23824327
MIRT624084	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT624083	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT624082	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT624085	hsa-miR-8080	HITS-CLIP	23824327
MIRT624084	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT624083	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT624082	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT624081	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT624080	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT624079	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT483466	hsa-miR-4759	PAR-CLIP	20371350
MIRT483467	hsa-miR-3169	PAR-CLIP	20371350
MIRT483465	hsa-miR-8083	PAR-CLIP	20371350
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	20371350
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	20371350
MIRT483466	hsa-miR-4759	PAR-CLIP	20371350
MIRT483467	hsa-miR-3169	PAR-CLIP	20371350
MIRT483465	hsa-miR-8083	PAR-CLIP	20371350
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	20371350
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	20371350
MIRT293284	hsa-miR-137	PAR-CLIP	21572407
MIRT293290	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT293285	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT293286	hsa-miR-3120-3p	PAR-CLIP	21572407
MIRT388009	hsa-miR-499a-3p	PAR-CLIP	21572407
MIRT388010	hsa-miR-499b-3p	PAR-CLIP	21572407
MIRT558321	hsa-miR-4457	PAR-CLIP	21572407
MIRT558320	hsa-miR-125b-2-3p	PAR-CLIP	21572407
MIRT293289	hsa-miR-4635	PAR-CLIP	21572407
MIRT293287	hsa-miR-3185	PAR-CLIP	21572407
MIRT558319	hsa-miR-4709-3p	PAR-CLIP	21572407
MIRT293248	hsa-miR-548n	PAR-CLIP	21572407
MIRT548550	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT548549	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT293244	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT293256	hsa-miR-548ab	PAR-CLIP	21572407
MIRT293258	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT293259	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT293260	hsa-miR-548ak	PAR-CLIP	21572407
MIRT293262	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT293264	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT293265	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT293266	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT293267	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT293268	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT293270	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT293243	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT293271	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT293245	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT293246	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT293249	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT293250	hsa-miR-548i	PAR-CLIP	21572407
MIRT293247	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT293255	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT293252	hsa-miR-548w	PAR-CLIP	21572407
MIRT293254	hsa-miR-548y	PAR-CLIP	21572407
MIRT293242	hsa-miR-559	PAR-CLIP	21572407
MIRT548548	hsa-miR-5571-5p	PAR-CLIP	21572407
MIRT548547	hsa-miR-4715-5p	PAR-CLIP	21572407
MIRT293253	hsa-miR-4259	PAR-CLIP	21572407
MIRT293261	hsa-miR-4495	PAR-CLIP	21572407
MIRT548546	hsa-miR-4529-5p	PAR-CLIP	21572407
MIRT548544	hsa-miR-3153	PAR-CLIP	21572407
MIRT548545	hsa-miR-6733-5p	PAR-CLIP	21572407
MIRT548543	hsa-miR-6739-5p	PAR-CLIP	21572407
MIRT293257	hsa-miR-4425	PAR-CLIP	21572407
MIRT548542	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT293241	hsa-miR-450a-1-3p	PAR-CLIP	21572407
MIRT483466	hsa-miR-4759	PAR-CLIP	21572407
MIRT483467	hsa-miR-3169	PAR-CLIP	21572407
MIRT483465	hsa-miR-8083	PAR-CLIP	21572407
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	21572407
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	21572407
MIRT494093	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT483466	hsa-miR-4759	PAR-CLIP	23592263
MIRT483467	hsa-miR-3169	PAR-CLIP	23592263
MIRT483465	hsa-miR-8083	PAR-CLIP	23592263
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	23592263
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	23592263
MIRT494093	hsa-miR-340-5p	PAR-CLIP	23592263
MIRT483466	hsa-miR-4759	PAR-CLIP	23592263
MIRT483467	hsa-miR-3169	PAR-CLIP	23592263
MIRT483465	hsa-miR-8083	PAR-CLIP	23592263
MIRT483464	hsa-miR-3607-3p	PAR-CLIP	23592263
MIRT483463	hsa-miR-3117-3p	PAR-CLIP	23592263
MIRT448879	hsa-miR-384	PAR-CLIP	22100165
MIRT448878	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT448877	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT448876	hsa-miR-5571-3p	PAR-CLIP	22100165
MIRT448875	hsa-miR-7975	PAR-CLIP	22100165
MIRT448873	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT448874	hsa-miR-573	PAR-CLIP	22100165
MIRT448879	hsa-miR-384	PAR-CLIP	22100165
MIRT448878	hsa-miR-4670-3p	PAR-CLIP	22100165
MIRT448877	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT448876	hsa-miR-5571-3p	PAR-CLIP	22100165
MIRT448875	hsa-miR-7975	PAR-CLIP	22100165
MIRT448873	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT448874	hsa-miR-573	PAR-CLIP	22100165
MIRT945147	hsa-miR-1208	CLIP-seq
MIRT945148	hsa-miR-122	CLIP-seq
MIRT945149	hsa-miR-1245b-3p	CLIP-seq
MIRT945150	hsa-miR-1285	CLIP-seq
MIRT945151	hsa-miR-141	CLIP-seq
MIRT945152	hsa-miR-194	CLIP-seq
MIRT945153	hsa-miR-200a	CLIP-seq
MIRT945154	hsa-miR-203	CLIP-seq
MIRT945155	hsa-miR-219-2-3p	CLIP-seq
MIRT945156	hsa-miR-224	CLIP-seq
MIRT945157	hsa-miR-2964a-3p	CLIP-seq
MIRT945158	hsa-miR-3065-3p	CLIP-seq
MIRT945159	hsa-miR-3161	CLIP-seq
MIRT945160	hsa-miR-3164	CLIP-seq
MIRT945161	hsa-miR-3187-5p	CLIP-seq
MIRT945162	hsa-miR-3198	CLIP-seq
MIRT945163	hsa-miR-323-3p	CLIP-seq
MIRT945164	hsa-miR-340	CLIP-seq
MIRT945165	hsa-miR-361-5p	CLIP-seq
MIRT945166	hsa-miR-3646	CLIP-seq
MIRT945167	hsa-miR-3647-5p	CLIP-seq
MIRT945168	hsa-miR-3662	CLIP-seq
MIRT945169	hsa-miR-3670	CLIP-seq
MIRT945170	hsa-miR-3681	CLIP-seq
MIRT945171	hsa-miR-3686	CLIP-seq
MIRT945172	hsa-miR-369-3p	CLIP-seq
MIRT945173	hsa-miR-371b-5p	CLIP-seq
MIRT945174	hsa-miR-374a	CLIP-seq
MIRT945175	hsa-miR-374b	CLIP-seq
MIRT945176	hsa-miR-374c	CLIP-seq
MIRT945177	hsa-miR-377	CLIP-seq
MIRT945178	hsa-miR-4309	CLIP-seq
MIRT945179	hsa-miR-4420	CLIP-seq
MIRT945180	hsa-miR-452	CLIP-seq
MIRT945181	hsa-miR-4539	CLIP-seq
MIRT945182	hsa-miR-4633-3p	CLIP-seq
MIRT945183	hsa-miR-4652-3p	CLIP-seq
MIRT945184	hsa-miR-4676-3p	CLIP-seq
MIRT945185	hsa-miR-4680-3p	CLIP-seq
MIRT945186	hsa-miR-4680-5p	CLIP-seq
MIRT945187	hsa-miR-4698	CLIP-seq
MIRT945188	hsa-miR-4711-5p	CLIP-seq
MIRT945189	hsa-miR-4728-3p	CLIP-seq
MIRT945190	hsa-miR-4742-3p	CLIP-seq
MIRT945191	hsa-miR-490-3p	CLIP-seq
MIRT945192	hsa-miR-499a-5p	CLIP-seq
MIRT945193	hsa-miR-513a-3p	CLIP-seq
MIRT945194	hsa-miR-548c-3p	CLIP-seq
MIRT945195	hsa-miR-612	CLIP-seq
MIRT945196	hsa-miR-617	CLIP-seq
MIRT945197	hsa-miR-645	CLIP-seq
MIRT945198	hsa-miR-649	CLIP-seq
MIRT945199	hsa-miR-655	CLIP-seq
MIRT1979797	hsa-miR-105	CLIP-seq
MIRT945147	hsa-miR-1208	CLIP-seq
MIRT1979798	hsa-miR-1269	CLIP-seq
MIRT1979799	hsa-miR-1269b	CLIP-seq
MIRT1979800	hsa-miR-1323	CLIP-seq
MIRT945151	hsa-miR-141	CLIP-seq
MIRT945152	hsa-miR-194	CLIP-seq
MIRT945153	hsa-miR-200a	CLIP-seq
MIRT1979801	hsa-miR-300	CLIP-seq
MIRT945158	hsa-miR-3065-3p	CLIP-seq
MIRT1979802	hsa-miR-3129-3p	CLIP-seq
MIRT1979803	hsa-miR-3158-3p	CLIP-seq
MIRT1979804	hsa-miR-337-3p	CLIP-seq
MIRT945166	hsa-miR-3646	CLIP-seq
MIRT945168	hsa-miR-3662	CLIP-seq
MIRT945169	hsa-miR-3670	CLIP-seq
MIRT1979805	hsa-miR-3690	CLIP-seq
MIRT1979806	hsa-miR-371-5p	CLIP-seq
MIRT945173	hsa-miR-371b-5p	CLIP-seq
MIRT945177	hsa-miR-377	CLIP-seq
MIRT1979807	hsa-miR-381	CLIP-seq
MIRT1979808	hsa-miR-383	CLIP-seq
MIRT1979809	hsa-miR-3913-3p	CLIP-seq
MIRT1979810	hsa-miR-409-3p	CLIP-seq
MIRT1979811	hsa-miR-421	CLIP-seq
MIRT1979812	hsa-miR-4254	CLIP-seq
MIRT1979813	hsa-miR-4320	CLIP-seq
MIRT1979814	hsa-miR-4446-3p	CLIP-seq
MIRT1979815	hsa-miR-4503	CLIP-seq
MIRT1979816	hsa-miR-4517	CLIP-seq
MIRT945180	hsa-miR-452	CLIP-seq
MIRT1979817	hsa-miR-4529-3p	CLIP-seq
MIRT1979818	hsa-miR-4656	CLIP-seq
MIRT1979819	hsa-miR-4666-3p	CLIP-seq
MIRT945184	hsa-miR-4676-3p	CLIP-seq
MIRT945186	hsa-miR-4680-5p	CLIP-seq
MIRT945187	hsa-miR-4698	CLIP-seq
MIRT1979820	hsa-miR-4717-5p	CLIP-seq
MIRT1979821	hsa-miR-4772-5p	CLIP-seq
MIRT1979822	hsa-miR-4781-3p	CLIP-seq
MIRT1979823	hsa-miR-4793-5p	CLIP-seq
MIRT1979824	hsa-miR-4803	CLIP-seq
MIRT1979825	hsa-miR-489	CLIP-seq
MIRT1979826	hsa-miR-496	CLIP-seq
MIRT945193	hsa-miR-513a-3p	CLIP-seq
MIRT1979827	hsa-miR-548a-3p	CLIP-seq
MIRT1979828	hsa-miR-548ag	CLIP-seq
MIRT1979829	hsa-miR-548ai	CLIP-seq
MIRT1979830	hsa-miR-548e	CLIP-seq
MIRT1979831	hsa-miR-548f	CLIP-seq
MIRT1979832	hsa-miR-548m	CLIP-seq
MIRT1979833	hsa-miR-548o	CLIP-seq
MIRT1979834	hsa-miR-548p	CLIP-seq
MIRT1979835	hsa-miR-579	CLIP-seq
MIRT945197	hsa-miR-645	CLIP-seq
MIRT1979797	hsa-miR-105	CLIP-seq
MIRT2215006	hsa-miR-1193	CLIP-seq
MIRT945147	hsa-miR-1208	CLIP-seq
MIRT945149	hsa-miR-1245b-3p	CLIP-seq
MIRT2215007	hsa-miR-1246	CLIP-seq
MIRT945150	hsa-miR-1285	CLIP-seq
MIRT945151	hsa-miR-141	CLIP-seq
MIRT945153	hsa-miR-200a	CLIP-seq
MIRT945154	hsa-miR-203	CLIP-seq
MIRT2215008	hsa-miR-2054	CLIP-seq
MIRT945156	hsa-miR-224	CLIP-seq
MIRT2215009	hsa-miR-3166	CLIP-seq
MIRT945161	hsa-miR-3187-5p	CLIP-seq
MIRT2215010	hsa-miR-320b	CLIP-seq
MIRT2215011	hsa-miR-320c	CLIP-seq
MIRT2215012	hsa-miR-320d	CLIP-seq
MIRT945163	hsa-miR-323-3p	CLIP-seq
MIRT1979804	hsa-miR-337-3p	CLIP-seq
MIRT945164	hsa-miR-340	CLIP-seq
MIRT2215013	hsa-miR-34c-3p	CLIP-seq
MIRT945165	hsa-miR-361-5p	CLIP-seq
MIRT945166	hsa-miR-3646	CLIP-seq
MIRT945167	hsa-miR-3647-5p	CLIP-seq
MIRT945168	hsa-miR-3662	CLIP-seq
MIRT2215014	hsa-miR-3667-3p	CLIP-seq
MIRT945169	hsa-miR-3670	CLIP-seq
MIRT945170	hsa-miR-3681	CLIP-seq
MIRT1979805	hsa-miR-3690	CLIP-seq
MIRT945172	hsa-miR-369-3p	CLIP-seq
MIRT945173	hsa-miR-371b-5p	CLIP-seq
MIRT945174	hsa-miR-374a	CLIP-seq
MIRT945175	hsa-miR-374b	CLIP-seq
MIRT945176	hsa-miR-374c	CLIP-seq
MIRT1979809	hsa-miR-3913-3p	CLIP-seq
MIRT2215015	hsa-miR-3925-5p	CLIP-seq
MIRT1979811	hsa-miR-421	CLIP-seq
MIRT2215016	hsa-miR-425	CLIP-seq
MIRT1979812	hsa-miR-4254	CLIP-seq
MIRT2215017	hsa-miR-4282	CLIP-seq
MIRT2215018	hsa-miR-431	CLIP-seq
MIRT1979813	hsa-miR-4320	CLIP-seq
MIRT2215019	hsa-miR-4325	CLIP-seq
MIRT2215020	hsa-miR-4328	CLIP-seq
MIRT2215021	hsa-miR-4429	CLIP-seq
MIRT945180	hsa-miR-452	CLIP-seq
MIRT945181	hsa-miR-4539	CLIP-seq
MIRT945182	hsa-miR-4633-3p	CLIP-seq
MIRT2215022	hsa-miR-4666-5p	CLIP-seq
MIRT945184	hsa-miR-4676-3p	CLIP-seq
MIRT945186	hsa-miR-4680-5p	CLIP-seq
MIRT945187	hsa-miR-4698	CLIP-seq
MIRT2215023	hsa-miR-4718	CLIP-seq
MIRT945189	hsa-miR-4728-3p	CLIP-seq
MIRT1979823	hsa-miR-4793-5p	CLIP-seq
MIRT1979825	hsa-miR-489	CLIP-seq
MIRT945192	hsa-miR-499a-5p	CLIP-seq
MIRT2215024	hsa-miR-5096	CLIP-seq
MIRT945193	hsa-miR-513a-3p	CLIP-seq
MIRT1979827	hsa-miR-548a-3p	CLIP-seq
MIRT945194	hsa-miR-548c-3p	CLIP-seq
MIRT1979830	hsa-miR-548e	CLIP-seq
MIRT1979831	hsa-miR-548f	CLIP-seq
MIRT1979835	hsa-miR-579	CLIP-seq
MIRT2215025	hsa-miR-589	CLIP-seq
MIRT945195	hsa-miR-612	CLIP-seq
MIRT945196	hsa-miR-617	CLIP-seq
MIRT2215026	hsa-miR-633	CLIP-seq
MIRT2215027	hsa-miR-639	CLIP-seq
MIRT945197	hsa-miR-645	CLIP-seq
MIRT945199	hsa-miR-655	CLIP-seq
MIRT2215028	hsa-miR-720	CLIP-seq
MIRT945158	hsa-miR-3065-3p	CLIP-seq
MIRT945177	hsa-miR-377	CLIP-seq
MIRT945147	hsa-miR-1208	CLIP-seq
MIRT2519472	hsa-miR-1909	CLIP-seq
MIRT2519473	hsa-miR-200b	CLIP-seq
MIRT2519474	hsa-miR-200c	CLIP-seq
MIRT2519475	hsa-miR-3148	CLIP-seq
MIRT945160	hsa-miR-3164	CLIP-seq
MIRT945176	hsa-miR-374c	CLIP-seq
MIRT2519476	hsa-miR-3944-5p	CLIP-seq
MIRT2519477	hsa-miR-429	CLIP-seq
MIRT945179	hsa-miR-4420	CLIP-seq
MIRT945180	hsa-miR-452	CLIP-seq
MIRT2519478	hsa-miR-4633-5p	CLIP-seq
MIRT945183	hsa-miR-4652-3p	CLIP-seq
MIRT945184	hsa-miR-4676-3p	CLIP-seq
MIRT945199	hsa-miR-655	CLIP-seq
MIRT945147	hsa-miR-1208	CLIP-seq
MIRT2519473	hsa-miR-200b	CLIP-seq
MIRT2519474	hsa-miR-200c	CLIP-seq
MIRT945176	hsa-miR-374c	CLIP-seq
MIRT2519477	hsa-miR-429	CLIP-seq
MIRT945179	hsa-miR-4420	CLIP-seq
MIRT945180	hsa-miR-452	CLIP-seq
MIRT945183	hsa-miR-4652-3p	CLIP-seq
MIRT945184	hsa-miR-4676-3p	CLIP-seq
MIRT945199	hsa-miR-655	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
BTAF1	Repression	20627952
NR2F1	Repression	22357705

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	8670811, 18838386
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	8670811, 16189514, 18692475, 18838386, 29997244, 31467278, 31515488, 32296183, 32814053, 33961781, 34819669, 37398436
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IMP	19936620
GO:0006355	Process	Regulation of DNA-templated transcription	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	22055187
GO:0006357	Process	Regulation of transcription by RNA polymerase II	ISS
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IBA
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IDA	8670811
GO:0017025	Function	TBP-class protein binding	IBA
GO:0017025	Function	TBP-class protein binding	IDA	18838386
GO:0017025	Function	TBP-class protein binding	IPI	8670811
GO:0017054	Component	Negative cofactor 2 complex	IBA
GO:0017054	Component	Negative cofactor 2 complex	IEA
GO:0045995	Process	Regulation of embryonic development	IEA
GO:0045995	Process	Regulation of embryonic development	ISO
GO:0045995	Process	Regulation of embryonic development	ISS
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	IBA
GO:0051302	Process	Regulation of cell division	IDA	20562830
GO:0051302	Process	Regulation of cell division	IEA
GO:0051302	Process	Regulation of cell division	ISS
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	19103755
GO:0051726	Process	Regulation of cell cycle	ISS
GO:0072686	Component	Mitotic spindle	NAS	20562830
GO:0090575	Component	RNA polymerase II transcription regulator complex	IDA	8670811
GO:0140223	Function	General transcription initiation factor activity	IEA
GO:0140672	Component	ATAC complex	IDA	18838386, 19936620
GO:0140672	Component	ATAC complex	IEA
GO:0140672	Component	ATAC complex	ISO

MIM	HGNC	e!Ensembl
601482	3017	ENSG00000117505

Q01658

Protein name

Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)

Protein function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the

PDB

1JFI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00808	CBFD_NFYB_HMF	11 → 75	Histone-like transcription factor (CBF/NF-Y) and archaeal histone	Domain

Sequence

MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNK
SEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLR
QQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI

Sequence length

176

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (29)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adrenal Hyperplasia Congenital	Congenital adrenal hyperplasia	Pubtator	2226916	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	11407687, 1466602, 1496989, 17346433, 17491100, 19014626, 1974413, 2042983, 2481309, 2732676, 6428222, 6606398, 7688934, 8154934, 8496681, 8571964 View all (1 more)	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	1371662	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	25135188	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	26222778	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital adrenal hyperplasia due to 21 hydroxylase deficiency	Congenital adrenal hyperplasia	Pubtator	15004406, 18187875, 2443540, 3013005, 6789674	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	10689124, 8349790	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	20966625, 8700877	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	20966625, 24034553, 2979618, 6334991, 8900244	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epidermolysis Bullosa Dystrophica	Dystrophic epidermolysis bullosa	Pubtator	11274208, 7593178	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Graft vs Host Disease	Graft-versus-host disease	Pubtator	11472342	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Granulomatosis with Polyangiitis	Granulomatosis with polyangiitis	Pubtator	1550412	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis Autoimmune	Autoimmune hepatitis	Pubtator	21301006	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	12477712	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
IgA Deficiency	Selective immunoglobulin a deficiency	Pubtator	19052350	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	10689124	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	36512357	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19188696		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	LHGDN	18538002		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	18538002	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	1447210	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pituitary Neoplasms	Pituitary neoplasm	Pubtator	19293270	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	15084912, 9510154		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	10327913		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sleep Disorders Circadian Rhythm	Sleep disorder	Pubtator	11186112	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	6814009		★★★★★ ★☆☆☆☆ Found in Text Mining only
Trifunctional Protein Deficiency With Myopathy And Neuropathy	Trifunctional protein deficiency	Pubtator	15004406, 3013005	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	25135188	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DR1 (down-regulator of transcription 1)