Gene Gene information from NCBI Gene database.
Entrez ID 1803
Gene name Dipeptidyl peptidase 4
Gene symbol DPP4
Synonyms (NCBI Gene)
ADABPADCP2CD26DPPIVTP103
Chromosome 2
Chromosome location 2q24.2
Summary The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline
miRNA miRNA information provided by mirtarbase database.
190
miRTarBase ID miRNA Experiments Reference
MIRT755410 hsa-let-7b-5p qRT-PCR 36073344
MIRT944211 hsa-miR-1273g CLIP-seq
MIRT944212 hsa-miR-1305 CLIP-seq
MIRT944213 hsa-miR-4294 CLIP-seq
MIRT944214 hsa-miR-924 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
61
GO ID Ontology Definition Evidence Reference
GO:0001618 Function Virus receptor activity IDA 23486063
GO:0001662 Process Behavioral fear response IEA
GO:0001666 Process Response to hypoxia IDA 16670267
GO:0002020 Function Protease binding IPI 16651416
GO:0004177 Function Aminopeptidase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
102720 3009 ENSG00000197635
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P27487
Protein name Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl
Protein function Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10900005, PubMed:10951221, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell c
PDB 1J2E , 1N1M , 1NU6 , 1NU8 , 1PFQ , 1R9M , 1R9N , 1RWQ , 1TK3 , 1TKR , 1U8E , 1W1I , 1WCY , 1X70 , 2AJL , 2BGN , 2BGR , 2BUB , 2FJP , 2G5P , 2G5T , 2G63 , 2HHA , 2I03 , 2I78 , 2IIT , 2IIV , 2JID , 2OAG , 2OGZ , 2OLE , 2ONC , 2OPH , 2OQI , 2OQV , 2P8S , 2QJR , 2QKY , 2QOE , 2QT9 , 2QTB , 2RGU , 2RIP , 3BJM , 3C43 , 3C45 , 3CCB , 3CCC , 3D4L , 3EIO , 3F8S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00930 DPPIV_N 108 479 Dipeptidyl peptidase IV (DPP IV) N-terminal region Family
PF00326 Peptidase_S9 559 765 Prolyl oligopeptidase family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at prote
Sequence
Sequence length 766
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Virion - Hepatitis viruses
Protein digestion and absorption
  Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
16
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acquired Hypogammaglobulinemia Common Variable Immunodeficiency BEFREE 23654079
★☆☆☆☆
Found in Text Mining only
Acromegaly Acromegaly BEFREE 30332686
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome BEFREE 28847797, 29301579, 31115964
★☆☆☆☆
Found in Text Mining only
Acute leukemia Leukemia BEFREE 19469710
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 19469710, 29772458
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 27630212, 29310393, 29335646, 29618573, 29850606, 30310100, 31436848, 31750601, 31827684
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 12634639, 12675245
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 21284881
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 30698677
★☆☆☆☆
Found in Text Mining only
Adenosine deaminase deficiency Adenosine Deaminase Deficiency BEFREE 11067872, 6933468
★☆☆☆☆
Found in Text Mining only