DOK1 (docking protein 1)

Gene

• Entrez ID: 1796
• Gene name: Docking protein 1
• Gene symbol: DOK1
• Synonyms (NCBI Gene): P62DOK, pp62
• Chromosome: 2
• Chromosome location: 2p13.1
• Summary: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcrip

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440784	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440784	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1979248	hsa-miR-1343	CLIP-seq
MIRT2518677	hsa-miR-1224-3p	CLIP-seq
MIRT2518678	hsa-miR-1227	CLIP-seq
MIRT2518679	hsa-miR-1260	CLIP-seq
MIRT2518680	hsa-miR-1260b	CLIP-seq
MIRT2518681	hsa-miR-1280	CLIP-seq
MIRT2518682	hsa-miR-138	CLIP-seq
MIRT2518683	hsa-miR-149	CLIP-seq
MIRT2518684	hsa-miR-3064-5p	CLIP-seq
MIRT2518685	hsa-miR-371-3p	CLIP-seq
MIRT2518686	hsa-miR-371b-3p	CLIP-seq
MIRT2518687	hsa-miR-377	CLIP-seq
MIRT2518688	hsa-miR-4281	CLIP-seq
MIRT2518689	hsa-miR-4662a-5p	CLIP-seq
MIRT2518690	hsa-miR-4715-3p	CLIP-seq
MIRT2518691	hsa-miR-4749-3p	CLIP-seq
MIRT2518692	hsa-miR-4778-3p	CLIP-seq
MIRT2518693	hsa-miR-4794	CLIP-seq
MIRT2518694	hsa-miR-515-3p	CLIP-seq
MIRT2518695	hsa-miR-519e	CLIP-seq
MIRT2518696	hsa-miR-532-3p	CLIP-seq
MIRT2518697	hsa-miR-640	CLIP-seq
MIRT2518677	hsa-miR-1224-3p	CLIP-seq
MIRT2518678	hsa-miR-1227	CLIP-seq
MIRT2518679	hsa-miR-1260	CLIP-seq
MIRT2518680	hsa-miR-1260b	CLIP-seq
MIRT2518681	hsa-miR-1280	CLIP-seq
MIRT2518682	hsa-miR-138	CLIP-seq
MIRT2518683	hsa-miR-149	CLIP-seq
MIRT2518684	hsa-miR-3064-5p	CLIP-seq
MIRT2518685	hsa-miR-371-3p	CLIP-seq
MIRT2518686	hsa-miR-371b-3p	CLIP-seq
MIRT2518687	hsa-miR-377	CLIP-seq
MIRT2518691	hsa-miR-4749-3p	CLIP-seq
MIRT2518692	hsa-miR-4778-3p	CLIP-seq
MIRT2518693	hsa-miR-4794	CLIP-seq
MIRT2518694	hsa-miR-515-3p	CLIP-seq
MIRT2518695	hsa-miR-519e	CLIP-seq
MIRT2518696	hsa-miR-532-3p	CLIP-seq
MIRT2518697	hsa-miR-640	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Unknown	23028047

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16273093, 22190034, 22252131, 23822091
GO:0005634	Component	Nucleus	IDA	23822091
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	9008160, 10799545
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10799545
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	TAS	9008160
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0038145	Process	Macrophage colony-stimulating factor signaling pathway	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

Other IDs

• MIM: 602919
• HGNC: 2990
• e!Ensembl: ENSG00000115325

Protein

• UniProt ID: Q99704
• Protein name: Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
• Protein function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates int
• PDB: 2V76
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	4 → 119	PH domain	Domain
  PF02174	IRS	151 → 254	PTB domain (IRS-1 type)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269|PubMed:12595900}.
• Sequence:

  MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRL
  DCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFP
  KGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEA
  ERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGND
  IFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPL
  DSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDP
  IYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPL
  LAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGS
  T

• Sequence length: 481

Pathways

Reactome:

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RET signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BELL'S PALSY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOPIA 28, AUTOSOMAL RECESSIVE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anodontia	Anodontia	Pubtator	28844109	Associate	★☆☆☆☆ Found in Text Mining only
B-CELL MALIGNANCY, LOW-GRADE	Lymphocytic Leukemia	BEFREE	14730347		★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	BEFREE	16338067, 21796618		★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	LHGDN	16338067		★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt lymphoma	Pubtator	21796618	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	21536658, 21796618, 21856257, 24809689	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	27078152	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	21856257	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	21856257		★☆☆☆☆ Found in Text Mining only
Carotid Artery Thrombosis	Carotid Artery Thrombosis	BEFREE	26790499		★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	14730347, 15541476		★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	9056668		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	9056668		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27428427		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	27428427, 28844109, 34941983	Associate	★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	BEFREE	10724351		★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	21856257		★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	21796618		★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	21796618	Inhibit	★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	23028047	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	16823827, 21796618, 21856257, 27428427, 29150948		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	16823827, 20697350, 21856257, 27428427	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	29150948		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	21146512, 27078152		★☆☆☆☆ Found in Text Mining only
Liver Diseases	Liver disease	Pubtator	27078152	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	CTD_human_DG	20139980		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung Neoplasms	Lung neoplasms	Pubtator	21796618	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoproliferative Disorders	Lymphoproliferative syndrome	Pubtator	10852966	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	21796618		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23822091		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	CTD_human_DG	20139980		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	CTD_human_DG	21856257		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	21831520, 31646096		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16338067, 21796618, 21856257, 24809689, 30348947, 31638742		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	9056668		★☆☆☆☆ Found in Text Mining only
Mouth Diseases	Mouth disease	Pubtator	34941983	Inhibit	★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	11489947		★☆☆☆☆ Found in Text Mining only
Myeloproliferative disease	Myeloproliferative disorder	BEFREE	11489947		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16338067, 21146512, 21796618, 21856257, 23640045, 24523872, 24809689, 27078152, 27428427, 28844109, 31646096		★☆☆☆☆ Found in Text Mining only
Osteopenia	Osteopenia	BEFREE	29548825		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	CTD_human_DG	21856257		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	21831520, 31646096		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	24773628		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	24773628	Associate	★☆☆☆☆ Found in Text Mining only
Tyrosine Kinase 2 Deficiency	Tyrosine kinase 2 deficiency	Pubtator	21536658	Associate	★☆☆☆☆ Found in Text Mining only
X-Linked Lymphoproliferative Disorder	Lymphoproliferative Syndrome, X-Linked	BEFREE	10852966		★☆☆☆☆ Found in Text Mining only