Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1719
Gene name	Dihydrofolate reductase
Gene symbol	DHFR
Synonyms (NCBI Gene)	DHFR1DHFRP1DYR
Chromosome	5
Chromosome location	5q14.1
Summary	Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chro

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121913223	T>A	Pathogenic	Missense variant, coding sequence variant, intron variant, non coding transcript variant
rs387906619	G>A	Pathogenic	Non coding transcript variant, coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002018	hsa-miR-24-3p	real time qRT-PCRWestern blot	17686970
MIRT002018	hsa-miR-24-3p	real time qRT-PCRWestern blot	17686970
MIRT002018	hsa-miR-24-3p	Western blot	17686970
MIRT002018	hsa-miR-24-3p	Luciferase reporter assay	17686970
MIRT002018	hsa-miR-24-3p	Microarray	19748357
MIRT046435	hsa-miR-15b-5p	CLASH	23622248
MIRT044182	hsa-miR-99b-5p	CLASH	23622248
MIRT041132	hsa-miR-503-5p	CLASH	23622248
MIRT038796	hsa-miR-93-3p	CLASH	23622248
MIRT036640	hsa-miR-935	CLASH	23622248
MIRT026630	hsa-miR-192-5p	Luciferase reporter assayWestern blot	26506238
MIRT735249	hsa-miR-196a-3p	Luciferase reporter assayWestern blottingqRT-PCR	32509188
MIRT934710	hsa-miR-105	CLIP-seq
MIRT934711	hsa-miR-1185	CLIP-seq
MIRT934712	hsa-miR-1200	CLIP-seq
MIRT934713	hsa-miR-1207-3p	CLIP-seq
MIRT934714	hsa-miR-122	CLIP-seq
MIRT934715	hsa-miR-1228	CLIP-seq
MIRT934716	hsa-miR-1236	CLIP-seq
MIRT934717	hsa-miR-1238	CLIP-seq
MIRT934718	hsa-miR-1245	CLIP-seq
MIRT934719	hsa-miR-1245b-3p	CLIP-seq
MIRT934720	hsa-miR-1262	CLIP-seq
MIRT934721	hsa-miR-1270	CLIP-seq
MIRT934722	hsa-miR-1273e	CLIP-seq
MIRT934723	hsa-miR-1287	CLIP-seq
MIRT934724	hsa-miR-1298	CLIP-seq
MIRT934725	hsa-miR-1299	CLIP-seq
MIRT934726	hsa-miR-132	CLIP-seq
MIRT934727	hsa-miR-1468	CLIP-seq
MIRT934728	hsa-miR-1470	CLIP-seq
MIRT934729	hsa-miR-1913	CLIP-seq
MIRT934730	hsa-miR-193a-5p	CLIP-seq
MIRT934731	hsa-miR-205	CLIP-seq
MIRT934732	hsa-miR-212	CLIP-seq
MIRT934733	hsa-miR-2278	CLIP-seq
MIRT934734	hsa-miR-24	CLIP-seq
MIRT934735	hsa-miR-3074-5p	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT934737	hsa-miR-3124-3p	CLIP-seq
MIRT934738	hsa-miR-3126-3p	CLIP-seq
MIRT934739	hsa-miR-3128	CLIP-seq
MIRT934740	hsa-miR-3135b	CLIP-seq
MIRT934741	hsa-miR-3170	CLIP-seq
MIRT934742	hsa-miR-3182	CLIP-seq
MIRT934743	hsa-miR-3189-5p	CLIP-seq
MIRT934744	hsa-miR-3201	CLIP-seq
MIRT934745	hsa-miR-324-3p	CLIP-seq
MIRT934746	hsa-miR-331-3p	CLIP-seq
MIRT934747	hsa-miR-3605-5p	CLIP-seq
MIRT934748	hsa-miR-365	CLIP-seq
MIRT934749	hsa-miR-3652	CLIP-seq
MIRT934750	hsa-miR-3667-3p	CLIP-seq
MIRT934751	hsa-miR-3679-5p	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934754	hsa-miR-370	CLIP-seq
MIRT934755	hsa-miR-374a	CLIP-seq
MIRT934756	hsa-miR-374b	CLIP-seq
MIRT934757	hsa-miR-378	CLIP-seq
MIRT934758	hsa-miR-378b	CLIP-seq
MIRT934759	hsa-miR-378c	CLIP-seq
MIRT934760	hsa-miR-378d	CLIP-seq
MIRT934761	hsa-miR-378e	CLIP-seq
MIRT934762	hsa-miR-378f	CLIP-seq
MIRT934763	hsa-miR-378h	CLIP-seq
MIRT934764	hsa-miR-378i	CLIP-seq
MIRT934765	hsa-miR-3908	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT934768	hsa-miR-3942-5p	CLIP-seq
MIRT934769	hsa-miR-3976	CLIP-seq
MIRT934770	hsa-miR-422a	CLIP-seq
MIRT934771	hsa-miR-425	CLIP-seq
MIRT934772	hsa-miR-4259	CLIP-seq
MIRT934773	hsa-miR-4284	CLIP-seq
MIRT934774	hsa-miR-432	CLIP-seq
MIRT934775	hsa-miR-4324	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT934777	hsa-miR-4430	CLIP-seq
MIRT934778	hsa-miR-4434	CLIP-seq
MIRT934779	hsa-miR-4455	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT934781	hsa-miR-4516	CLIP-seq
MIRT934782	hsa-miR-451b	CLIP-seq
MIRT934783	hsa-miR-4528	CLIP-seq
MIRT934784	hsa-miR-4531	CLIP-seq
MIRT934785	hsa-miR-4652-3p	CLIP-seq
MIRT934786	hsa-miR-4663	CLIP-seq
MIRT934787	hsa-miR-4667-3p	CLIP-seq
MIRT934788	hsa-miR-4701-3p	CLIP-seq
MIRT934789	hsa-miR-4703-5p	CLIP-seq
MIRT934790	hsa-miR-4707-5p	CLIP-seq
MIRT934791	hsa-miR-4720-5p	CLIP-seq
MIRT934792	hsa-miR-4724-3p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT934794	hsa-miR-4753-3p	CLIP-seq
MIRT934795	hsa-miR-4758-3p	CLIP-seq
MIRT934796	hsa-miR-4762-5p	CLIP-seq
MIRT934797	hsa-miR-4766-3p	CLIP-seq
MIRT934798	hsa-miR-4782-5p	CLIP-seq
MIRT934799	hsa-miR-4791	CLIP-seq
MIRT934800	hsa-miR-4795-3p	CLIP-seq
MIRT934801	hsa-miR-4799-3p	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT934803	hsa-miR-496	CLIP-seq
MIRT934804	hsa-miR-516b	CLIP-seq
MIRT934805	hsa-miR-544b	CLIP-seq
MIRT934806	hsa-miR-548c-3p	CLIP-seq
MIRT934807	hsa-miR-579	CLIP-seq
MIRT934808	hsa-miR-615-5p	CLIP-seq
MIRT934809	hsa-miR-620	CLIP-seq
MIRT934810	hsa-miR-629	CLIP-seq
MIRT934811	hsa-miR-646	CLIP-seq
MIRT934812	hsa-miR-656	CLIP-seq
MIRT934813	hsa-miR-658	CLIP-seq
MIRT934814	hsa-miR-944	CLIP-seq
MIRT934722	hsa-miR-1273e	CLIP-seq
MIRT934806	hsa-miR-548c-3p	CLIP-seq
MIRT1976721	hsa-miR-1183	CLIP-seq
MIRT934712	hsa-miR-1200	CLIP-seq
MIRT934713	hsa-miR-1207-3p	CLIP-seq
MIRT1976722	hsa-miR-1208	CLIP-seq
MIRT934714	hsa-miR-122	CLIP-seq
MIRT934718	hsa-miR-1245	CLIP-seq
MIRT1976723	hsa-miR-1268	CLIP-seq
MIRT1976724	hsa-miR-1268b	CLIP-seq
MIRT934721	hsa-miR-1270	CLIP-seq
MIRT1976725	hsa-miR-1273f	CLIP-seq
MIRT1976726	hsa-miR-150	CLIP-seq
MIRT1976727	hsa-miR-1827	CLIP-seq
MIRT934730	hsa-miR-193a-5p	CLIP-seq
MIRT1976728	hsa-miR-2116	CLIP-seq
MIRT934733	hsa-miR-2278	CLIP-seq
MIRT1976729	hsa-miR-2909	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT934740	hsa-miR-3135b	CLIP-seq
MIRT1976730	hsa-miR-3137	CLIP-seq
MIRT1976731	hsa-miR-3140-3p	CLIP-seq
MIRT1976732	hsa-miR-3144-5p	CLIP-seq
MIRT934741	hsa-miR-3170	CLIP-seq
MIRT1976733	hsa-miR-3177-5p	CLIP-seq
MIRT1976734	hsa-miR-3179	CLIP-seq
MIRT934742	hsa-miR-3182	CLIP-seq
MIRT1976735	hsa-miR-3191	CLIP-seq
MIRT934749	hsa-miR-3652	CLIP-seq
MIRT1976736	hsa-miR-3665	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934754	hsa-miR-370	CLIP-seq
MIRT934757	hsa-miR-378	CLIP-seq
MIRT934758	hsa-miR-378b	CLIP-seq
MIRT934759	hsa-miR-378c	CLIP-seq
MIRT934760	hsa-miR-378d	CLIP-seq
MIRT934761	hsa-miR-378e	CLIP-seq
MIRT934762	hsa-miR-378f	CLIP-seq
MIRT934763	hsa-miR-378h	CLIP-seq
MIRT934764	hsa-miR-378i	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT934769	hsa-miR-3976	CLIP-seq
MIRT934770	hsa-miR-422a	CLIP-seq
MIRT1976737	hsa-miR-4252	CLIP-seq
MIRT934772	hsa-miR-4259	CLIP-seq
MIRT1976738	hsa-miR-4273	CLIP-seq
MIRT1976739	hsa-miR-4274	CLIP-seq
MIRT1976740	hsa-miR-4278	CLIP-seq
MIRT1976741	hsa-miR-4300	CLIP-seq
MIRT934774	hsa-miR-432	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT934777	hsa-miR-4430	CLIP-seq
MIRT934778	hsa-miR-4434	CLIP-seq
MIRT1976742	hsa-miR-4436a	CLIP-seq
MIRT1976743	hsa-miR-4437	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT1976744	hsa-miR-4489	CLIP-seq
MIRT934781	hsa-miR-4516	CLIP-seq
MIRT934782	hsa-miR-451b	CLIP-seq
MIRT934783	hsa-miR-4528	CLIP-seq
MIRT934784	hsa-miR-4531	CLIP-seq
MIRT1976745	hsa-miR-4634	CLIP-seq
MIRT1976746	hsa-miR-4649-3p	CLIP-seq
MIRT1976747	hsa-miR-4652-5p	CLIP-seq
MIRT1976748	hsa-miR-4660	CLIP-seq
MIRT934786	hsa-miR-4663	CLIP-seq
MIRT1976749	hsa-miR-4667-5p	CLIP-seq
MIRT1976750	hsa-miR-4674	CLIP-seq
MIRT1976751	hsa-miR-4677-5p	CLIP-seq
MIRT1976752	hsa-miR-4680-5p	CLIP-seq
MIRT1976753	hsa-miR-4688	CLIP-seq
MIRT1976754	hsa-miR-4690-5p	CLIP-seq
MIRT1976755	hsa-miR-4700-3p	CLIP-seq
MIRT1976756	hsa-miR-4700-5p	CLIP-seq
MIRT1976757	hsa-miR-4704-3p	CLIP-seq
MIRT1976758	hsa-miR-4705	CLIP-seq
MIRT934790	hsa-miR-4707-5p	CLIP-seq
MIRT1976759	hsa-miR-4722-5p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT1976760	hsa-miR-4731-5p	CLIP-seq
MIRT1976761	hsa-miR-4738-3p	CLIP-seq
MIRT1976762	hsa-miR-4747-5p	CLIP-seq
MIRT1976763	hsa-miR-4763-5p	CLIP-seq
MIRT1976764	hsa-miR-4768-3p	CLIP-seq
MIRT934800	hsa-miR-4795-3p	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT1976765	hsa-miR-513c	CLIP-seq
MIRT1976766	hsa-miR-514b-5p	CLIP-seq
MIRT1976767	hsa-miR-518a-3p	CLIP-seq
MIRT1976768	hsa-miR-518b	CLIP-seq
MIRT1976769	hsa-miR-518c	CLIP-seq
MIRT1976770	hsa-miR-518d-3p	CLIP-seq
MIRT1976771	hsa-miR-518e	CLIP-seq
MIRT1976772	hsa-miR-518f	CLIP-seq
MIRT934805	hsa-miR-544b	CLIP-seq
MIRT934806	hsa-miR-548c-3p	CLIP-seq
MIRT934808	hsa-miR-615-5p	CLIP-seq
MIRT934809	hsa-miR-620	CLIP-seq
MIRT1976773	hsa-miR-622	CLIP-seq
MIRT934811	hsa-miR-646	CLIP-seq
MIRT934812	hsa-miR-656	CLIP-seq
MIRT1976774	hsa-miR-718	CLIP-seq
MIRT1976775	hsa-miR-764	CLIP-seq
MIRT1976776	hsa-miR-767-3p	CLIP-seq
MIRT1976777	hsa-miR-885-3p	CLIP-seq
MIRT1976778	hsa-miR-892a	CLIP-seq
MIRT1976779	hsa-miR-920	CLIP-seq
MIRT1976780	hsa-miR-940	CLIP-seq
MIRT1976781	hsa-miR-943	CLIP-seq
MIRT2212043	hsa-miR-1184	CLIP-seq
MIRT934712	hsa-miR-1200	CLIP-seq
MIRT934714	hsa-miR-122	CLIP-seq
MIRT934715	hsa-miR-1228	CLIP-seq
MIRT934720	hsa-miR-1262	CLIP-seq
MIRT934721	hsa-miR-1270	CLIP-seq
MIRT2212044	hsa-miR-1279	CLIP-seq
MIRT934724	hsa-miR-1298	CLIP-seq
MIRT934726	hsa-miR-132	CLIP-seq
MIRT934728	hsa-miR-1470	CLIP-seq
MIRT934729	hsa-miR-1913	CLIP-seq
MIRT934730	hsa-miR-193a-5p	CLIP-seq
MIRT934731	hsa-miR-205	CLIP-seq
MIRT934732	hsa-miR-212	CLIP-seq
MIRT2212045	hsa-miR-2355-5p	CLIP-seq
MIRT2212046	hsa-miR-302f	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT934740	hsa-miR-3135b	CLIP-seq
MIRT1976732	hsa-miR-3144-5p	CLIP-seq
MIRT2212047	hsa-miR-3146	CLIP-seq
MIRT934741	hsa-miR-3170	CLIP-seq
MIRT934742	hsa-miR-3182	CLIP-seq
MIRT934743	hsa-miR-3189-5p	CLIP-seq
MIRT1976735	hsa-miR-3191	CLIP-seq
MIRT2212048	hsa-miR-3192	CLIP-seq
MIRT2212049	hsa-miR-3199	CLIP-seq
MIRT934745	hsa-miR-324-3p	CLIP-seq
MIRT2212050	hsa-miR-324-5p	CLIP-seq
MIRT934746	hsa-miR-331-3p	CLIP-seq
MIRT2212051	hsa-miR-3545-3p	CLIP-seq
MIRT2212052	hsa-miR-3617	CLIP-seq
MIRT2212053	hsa-miR-3622b-5p	CLIP-seq
MIRT934749	hsa-miR-3652	CLIP-seq
MIRT934750	hsa-miR-3667-3p	CLIP-seq
MIRT2212054	hsa-miR-3677-3p	CLIP-seq
MIRT2212055	hsa-miR-3680	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934754	hsa-miR-370	CLIP-seq
MIRT934755	hsa-miR-374a	CLIP-seq
MIRT934756	hsa-miR-374b	CLIP-seq
MIRT934765	hsa-miR-3908	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT2212056	hsa-miR-3934	CLIP-seq
MIRT2212057	hsa-miR-3940-5p	CLIP-seq
MIRT934768	hsa-miR-3942-5p	CLIP-seq
MIRT934769	hsa-miR-3976	CLIP-seq
MIRT1976737	hsa-miR-4252	CLIP-seq
MIRT934772	hsa-miR-4259	CLIP-seq
MIRT2212058	hsa-miR-4275	CLIP-seq
MIRT2212059	hsa-miR-4293	CLIP-seq
MIRT2212060	hsa-miR-431	CLIP-seq
MIRT2212061	hsa-miR-4314	CLIP-seq
MIRT934774	hsa-miR-432	CLIP-seq
MIRT934775	hsa-miR-4324	CLIP-seq
MIRT2212062	hsa-miR-4328	CLIP-seq
MIRT2212063	hsa-miR-4417	CLIP-seq
MIRT2212064	hsa-miR-4418	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT934777	hsa-miR-4430	CLIP-seq
MIRT934778	hsa-miR-4434	CLIP-seq
MIRT1976743	hsa-miR-4437	CLIP-seq
MIRT2212065	hsa-miR-4438	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT2212066	hsa-miR-4507	CLIP-seq
MIRT934781	hsa-miR-4516	CLIP-seq
MIRT934784	hsa-miR-4531	CLIP-seq
MIRT2212067	hsa-miR-4636	CLIP-seq
MIRT2212068	hsa-miR-4640-5p	CLIP-seq
MIRT2212069	hsa-miR-4646-5p	CLIP-seq
MIRT934785	hsa-miR-4652-3p	CLIP-seq
MIRT1976747	hsa-miR-4652-5p	CLIP-seq
MIRT934786	hsa-miR-4663	CLIP-seq
MIRT934787	hsa-miR-4667-3p	CLIP-seq
MIRT1976750	hsa-miR-4674	CLIP-seq
MIRT1976752	hsa-miR-4680-5p	CLIP-seq
MIRT2212070	hsa-miR-4686	CLIP-seq
MIRT934788	hsa-miR-4701-3p	CLIP-seq
MIRT934789	hsa-miR-4703-5p	CLIP-seq
MIRT1976758	hsa-miR-4705	CLIP-seq
MIRT934790	hsa-miR-4707-5p	CLIP-seq
MIRT934792	hsa-miR-4724-3p	CLIP-seq
MIRT2212071	hsa-miR-4726-5p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT1976762	hsa-miR-4747-5p	CLIP-seq
MIRT934795	hsa-miR-4758-3p	CLIP-seq
MIRT2212072	hsa-miR-4764-3p	CLIP-seq
MIRT934797	hsa-miR-4766-3p	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT2212073	hsa-miR-509-3-5p	CLIP-seq
MIRT2212074	hsa-miR-5095	CLIP-seq
MIRT2212075	hsa-miR-509-5p	CLIP-seq
MIRT1976767	hsa-miR-518a-3p	CLIP-seq
MIRT1976768	hsa-miR-518b	CLIP-seq
MIRT1976769	hsa-miR-518c	CLIP-seq
MIRT1976770	hsa-miR-518d-3p	CLIP-seq
MIRT1976771	hsa-miR-518e	CLIP-seq
MIRT1976772	hsa-miR-518f	CLIP-seq
MIRT934805	hsa-miR-544b	CLIP-seq
MIRT2212076	hsa-miR-550a	CLIP-seq
MIRT2212077	hsa-miR-552	CLIP-seq
MIRT2212078	hsa-miR-596	CLIP-seq
MIRT934808	hsa-miR-615-5p	CLIP-seq
MIRT934809	hsa-miR-620	CLIP-seq
MIRT1976773	hsa-miR-622	CLIP-seq
MIRT934810	hsa-miR-629	CLIP-seq
MIRT2212079	hsa-miR-641	CLIP-seq
MIRT934813	hsa-miR-658	CLIP-seq
MIRT2212080	hsa-miR-661	CLIP-seq
MIRT934727	hsa-miR-1468	CLIP-seq
MIRT934731	hsa-miR-205	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT2386879	hsa-miR-3620	CLIP-seq
MIRT934750	hsa-miR-3667-3p	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT2386880	hsa-miR-412	CLIP-seq
MIRT934792	hsa-miR-4724-3p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT2386881	hsa-miR-4780	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT934810	hsa-miR-629	CLIP-seq
MIRT934716	hsa-miR-1236	CLIP-seq
MIRT934717	hsa-miR-1238	CLIP-seq
MIRT2515809	hsa-miR-1244	CLIP-seq
MIRT2515810	hsa-miR-1254	CLIP-seq
MIRT2212044	hsa-miR-1279	CLIP-seq
MIRT2515811	hsa-miR-129-5p	CLIP-seq
MIRT2515812	hsa-miR-2113	CLIP-seq
MIRT1976729	hsa-miR-2909	CLIP-seq
MIRT2515813	hsa-miR-3064-5p	CLIP-seq
MIRT2515814	hsa-miR-3116	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT1976733	hsa-miR-3177-5p	CLIP-seq
MIRT2515815	hsa-miR-337-3p	CLIP-seq
MIRT934748	hsa-miR-365	CLIP-seq
MIRT934749	hsa-miR-3652	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT2386880	hsa-miR-412	CLIP-seq
MIRT1976737	hsa-miR-4252	CLIP-seq
MIRT1976739	hsa-miR-4274	CLIP-seq
MIRT1976740	hsa-miR-4278	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT934777	hsa-miR-4430	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT1976744	hsa-miR-4489	CLIP-seq
MIRT2515816	hsa-miR-4505	CLIP-seq
MIRT934783	hsa-miR-4528	CLIP-seq
MIRT2515817	hsa-miR-4646-3p	CLIP-seq
MIRT1976753	hsa-miR-4688	CLIP-seq
MIRT2515818	hsa-miR-4691-5p	CLIP-seq
MIRT1976757	hsa-miR-4704-3p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT2515819	hsa-miR-4735-5p	CLIP-seq
MIRT2515820	hsa-miR-4775	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT2212076	hsa-miR-550a	CLIP-seq
MIRT2515821	hsa-miR-590-3p	CLIP-seq
MIRT2515822	hsa-miR-599	CLIP-seq
MIRT2212080	hsa-miR-661	CLIP-seq
MIRT1976778	hsa-miR-892a	CLIP-seq
MIRT1976781	hsa-miR-943	CLIP-seq
MIRT2679254	hsa-miR-1	CLIP-seq
MIRT934717	hsa-miR-1238	CLIP-seq
MIRT2515809	hsa-miR-1244	CLIP-seq
MIRT2212044	hsa-miR-1279	CLIP-seq
MIRT2679255	hsa-miR-206	CLIP-seq
MIRT2515812	hsa-miR-2113	CLIP-seq
MIRT1976729	hsa-miR-2909	CLIP-seq
MIRT934736	hsa-miR-3122	CLIP-seq
MIRT1976733	hsa-miR-3177-5p	CLIP-seq
MIRT2679256	hsa-miR-3190	CLIP-seq
MIRT2679257	hsa-miR-3607-5p	CLIP-seq
MIRT934748	hsa-miR-365	CLIP-seq
MIRT2679258	hsa-miR-3673	CLIP-seq
MIRT934752	hsa-miR-3689a-3p	CLIP-seq
MIRT934753	hsa-miR-3689c	CLIP-seq
MIRT2679259	hsa-miR-3911	CLIP-seq
MIRT934766	hsa-miR-3913-5p	CLIP-seq
MIRT934767	hsa-miR-3929	CLIP-seq
MIRT2386880	hsa-miR-412	CLIP-seq
MIRT2679260	hsa-miR-4268	CLIP-seq
MIRT1976739	hsa-miR-4274	CLIP-seq
MIRT1976740	hsa-miR-4278	CLIP-seq
MIRT934776	hsa-miR-4419b	CLIP-seq
MIRT2679261	hsa-miR-4448	CLIP-seq
MIRT934779	hsa-miR-4455	CLIP-seq
MIRT934780	hsa-miR-4478	CLIP-seq
MIRT1976744	hsa-miR-4489	CLIP-seq
MIRT934783	hsa-miR-4528	CLIP-seq
MIRT2515817	hsa-miR-4646-3p	CLIP-seq
MIRT1976753	hsa-miR-4688	CLIP-seq
MIRT2515818	hsa-miR-4691-5p	CLIP-seq
MIRT1976757	hsa-miR-4704-3p	CLIP-seq
MIRT934793	hsa-miR-4728-5p	CLIP-seq
MIRT2515819	hsa-miR-4735-5p	CLIP-seq
MIRT2515820	hsa-miR-4775	CLIP-seq
MIRT934802	hsa-miR-485-5p	CLIP-seq
MIRT2679262	hsa-miR-556-3p	CLIP-seq
MIRT2515821	hsa-miR-590-3p	CLIP-seq
MIRT2515822	hsa-miR-599	CLIP-seq
MIRT2679263	hsa-miR-609	CLIP-seq
MIRT2679264	hsa-miR-613	CLIP-seq
MIRT1976778	hsa-miR-892a	CLIP-seq
MIRT1976781	hsa-miR-943	CLIP-seq

Show/Hide all (3)

Transcription factor	Regulation	Reference
E2F1	Activation	14618416
RB1	Repression	9671466
TFDP1	Activation	14618416

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000900	Function	MRNA regulatory element binding translation repressor activity	IDA	8490020
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IDA	21876184
GO:0004146	Function	Dihydrofolate reductase activity	IBA
GO:0004146	Function	Dihydrofolate reductase activity	IDA	2303423, 12096917, 21876184, 23707606
GO:0004146	Function	Dihydrofolate reductase activity	IEA
GO:0004146	Function	Dihydrofolate reductase activity	ISS
GO:0004146	Function	Dihydrofolate reductase activity	NAS	6687716
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005542	Function	Folic acid binding	IDA	2303423
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006729	Process	Tetrahydrobiopterin biosynthetic process	IMP	23707606
GO:0006729	Process	Tetrahydrobiopterin biosynthetic process	ISS
GO:0006730	Process	One-carbon metabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0017148	Process	Negative regulation of translation	IDA	8490020
GO:0031103	Process	Axon regeneration	ISS
GO:0031427	Process	Response to methotrexate	IEA
GO:0046452	Process	Dihydrofolate metabolic process	IBA
GO:0046452	Process	Dihydrofolate metabolic process	IDA	2303423, 23707606
GO:0046653	Process	Tetrahydrofolate metabolic process	IDA	12096917, 21876184
GO:0046653	Process	Tetrahydrofolate metabolic process	IEA
GO:0046654	Process	Tetrahydrofolate biosynthetic process	IBA
GO:0046654	Process	Tetrahydrofolate biosynthetic process	IDA	2303423
GO:0046654	Process	Tetrahydrofolate biosynthetic process	IEA
GO:0046655	Process	Folic acid metabolic process	IBA
GO:0046655	Process	Folic acid metabolic process	ISS
GO:0050661	Function	NADP binding	IBA
GO:0050661	Function	NADP binding	IEA
GO:0070402	Function	NADPH binding	IDA	2303423
GO:1990825	Function	Sequence-specific mRNA binding	IDA	8490020
GO:2000121	Process	Regulation of removal of superoxide radicals	ISS

MIM	HGNC	e!Ensembl
126060	2861	ENSG00000228716

P00374

Protein name

Dihydrofolate reductase (EC 1.5.1.3)

Protein function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of

PDB

1BOZ , 1DHF , 1DLR , 1DLS , 1DRF , 1HFP , 1HFQ , 1HFR , 1KMS , 1KMV , 1MVS , 1MVT , 1OHJ , 1OHK , 1PD8 , 1PD9 , 1PDB , 1S3U , 1S3V , 1S3W , 1U71 , 1U72 , 1YHO , 2C2S , 2C2T , 2DHF , 2W3A , 2W3B , 2W3M , 3EIG , 3F8Y , 3F8Z , 3F91 , 3FS6 , 3GHC , 3GHV , 3GHW , 3GI2 , 3GYF , 3L3R , 3N0H , 3NTZ , 3NU0 , 3NXO , 3NXR , 3NXT , 3NXV , 3NXX , 3NXY , 3NZD , 3OAF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00186	DHFR_1	4 → 185	Dihydrofolate reductase	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain. {ECO:0000269|PubMed:21310276}.

Sequence

MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND

Sequence length

187

Interactions

View interactions

	KEGG		Reactome
	One carbon pool by folate Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Antifolate resistance Folate transport and metabolism		Metabolism of folate and pterines G1/S-Specific Transcription

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Constitutional megaloblastic anemia with severe neurologic disease	Pathogenic	rs387906619, rs121913223	RCV000022524 RCV000022525	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANEMIA, MEGALOBLASTIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTHRITIS, RHEUMATOID	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DHFR-related disorder	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL ADENOMATOUS POLYPOSIS 4	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FOLIC ACID DEFICIENCY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFERTILITY, FEMALE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MEGALOBLASTIC ANEMIA DUE TO DIHYDROFOLATE REDUCTASE DEFICIENCY	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MEGALOBLASTIC ANEMIA DUE TO FOLATE DEFICIENCY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NERVOUS SYSTEM DISEASES	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NERVOUS SYSTEM DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOSARCOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCYTOPENIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (167)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute leukemia	Leukemia	BEFREE	14666692		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	11380466, 12972803, 17148505, 20072153, 22954684, 22994778, 26335211, 28719513, 29805575, 30684021, 31262877, 7605998, 9226157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute myelomonocytic leukemia	Myelomonocytic Leukemia	BEFREE	1560671		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	23709418		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenomatous Polyps	Adenomatous Polyposis	BEFREE	26875486		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adrenoleukodystrophy	Adrenoleukodystrophy	Pubtator	19353223	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	20072153, 28719513, 29805575, 30684021, 7605998, 9226157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Medulloblastoma	Medulloblastoma	BEFREE	25739012, 26506238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	21310276, 37519165	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	8860837		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	BEFREE	11504402		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	Pubtator	21310276	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia Megaloblastic	Megaloblastic anemia	Pubtator	21310276, 21310277	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia, Megaloblastic	Anemia	CTD_human_DG	21310276, 21310277		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Megaloblastic	Anemia	BEFREE	21310277		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia, Megaloblastic	Anemia	HPO_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Aortic Aneurysm Abdominal	Aortic aneurysm	Pubtator	34176283	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm, Abdominal	Aortic Aneurysm	BEFREE	27912196, 30954686		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	22450926, 23897011, 30758239	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	30544400		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	2824082, 7809366		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	17597297		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autistic Disorder	Autism	LHGDN	17597297		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autistic Disorder	Autism	CTD_human_DG	17597297		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autoimmune Diseases	Autoimmune disease	Pubtator	23197646	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	27993660		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	30655756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bone Diseases	Bone disease	Pubtator	18005268	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	33545223	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast adenocarcinoma	Breast Adenocarcinoma	BEFREE	28188287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	17413111, 19446547, 20942657, 23053953, 28188287, 30018733, 3022136, 3724746, 3978632		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	21501481, 28188287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	17413111, 1834700, 22954684, 28188287, 7174686	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma of bladder	Bladder carcinoma	BEFREE	30655756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	7529065		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	31964986	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebellar Diseases	Cerebellar diseases	Pubtator	32157568	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebellar Hypoplasia	Cerebellar Hypoplasia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral atrophy	Cerebral Atrophy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	32319147	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	18096764, 19861437, 20072153, 28719513, 29210328, 29805575, 30684021, 31786878, 7605998, 9172800, 9226157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Medulloblastoma	Medulloblastoma	BEFREE	25739012, 26506238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Choriocarcinoma	Choriocarcinoma	BEFREE	21495249, 3409169		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cleft Lip	Cleft lip	Pubtator	26221921	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cleft Lip with or without Cleft Palate	Cleft Lip With Or Without Cleft Palate	BEFREE	24361572, 26221921, 30318092		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cleft Palate	Cleft palate	Pubtator	26221921	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cockayne Syndrome	Cockayne Syndrome	BEFREE	12509286		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cockayne Syndrome	Cockayne syndrome	Pubtator	21214942, 23733932	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cockayne Syndrome, Type II	Cockayne Syndrome	BEFREE	21214942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	34788822	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognitive Dysfunction	Cognition disorder	Pubtator	34788822	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	21438757, 21752725, 27187663, 2914962, 8449831		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	2914962, 8449831	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	12664136, 18607850, 24333356, 26633373, 26676887		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	CTD_human_DG	15814641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	CTD_human_DG	15814641		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	20020129, 20615890, 25537274, 26108676, 26633373, 26676887, 26875486, 29925788, 34521988	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	20615890	Inhibit	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Conotruncal defect	Conotruncal defect	BEFREE	22495907		★★★★★ ★☆☆☆☆ Found in Text Mining only
Constitutional megaloblastic anemia with severe neurologic disease	Constitutional Megaloblastic Anemia With Severe Neurologic Disease	Orphanet			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Coronary heart disease	Coronary Heart Disease	BEFREE	23701284		★★★★★ ★☆☆☆☆ Found in Text Mining only
Deficiency of dihydrofolate reductase	Deficiency Of Dihydrofolate Reductase	BEFREE	21310277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Deficiency of dihydrofolate reductase	Deficiency Of Dihydrofolate Reductase	GENOMICS_ENGLAND_DG	27604308, 27830117		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder	Major depressive disorder	Pubtator	21310276	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	34682638	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	34682638	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	21120433, 23421317		★★★★★ ★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	23421317	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi Anemia	BEFREE	2544311		★★★★★ ★☆☆☆☆ Found in Text Mining only
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	Anemia	BEFREE	8504485		★★★★★ ★☆☆☆☆ Found in Text Mining only
Folate Malabsorption Hereditary	Hereditary folate malabsorption	Pubtator	34502300	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Folic Acid Deficiency	Folic Acid Deficiency	CTD_human_DG	21310277		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Folic Acid Deficiency	Folic Acid Deficiency	BEFREE	30240347		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Generalized glycogen storage disease of infants	Glycogen Storage Disease	BEFREE	11027569		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	33545223	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Glycogen storage disease type II	Glycogen Storage Disease	BEFREE	11027569		★★★★★ ★☆☆☆☆ Found in Text Mining only
Graft vs Host Disease	Graft-versus-host disease	Pubtator	25425682	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	22954684		★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	22954684, 23276522, 33369477	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Diseases	Hematologic disease	Pubtator	21310277	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic neoplasm	Pubtator	20059476	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Hereditary breast and ovarian cancer syndrome	Pubtator	7529065	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary spherocytosis	Hereditary Spherocytosis	BEFREE	31076457		★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	31216018		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperphenylalaninemia, Non-Phenylketonuric	Hyperphenylalaninemia	BEFREE	21310276		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	32319147, 33382484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	30571557, 30954686		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inborn Errors of Metabolism	Inborn Errors Of Metabolism	CTD_human_DG	21310276, 21310277		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial Aneurysm	BEFREE	18799873		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kaposi Sarcoma	Kaposi Sarcoma	BEFREE	10683342		★★★★★ ★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Laryngeal neoplasm	Pubtator	23838799	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	10898545, 2492521, 3856428, 6583326, 7850779, 8099375, 8449831		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	6572370, 8449831	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Promyelocytic leukemia	Pubtator	3856428	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	22037714		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	BEFREE	26335211, 30684021		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Neoplasms	Liver neoplasm	Pubtator	21128869	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	28943344		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	22954684		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	17413111, 19446547, 20942657, 23053953, 28188287, 30018733, 3022136, 3724746, 3978632		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	21501481, 28188287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	7529065		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	25759212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	30655756		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10683342, 10898545, 19959110, 23053953, 23726796, 2698661, 27187663, 27914300, 27993660, 28693150, 29321536, 29453377, 30346152, 30500537, 30754680, 30909399, 30938661, 31706887, 9766655 View all (4 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	21438757, 21752725, 27187663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	21501481, 28188287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	21501481, 28188287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	21501481, 28188287		★★★★★ ★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	25739012, 26506238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency	Megaloblastic anemia	ORPHANET_DG	21310276, 21310277		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency	Megaloblastic anemia	UNIPROT_DG	21310276, 21310277		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency	Megaloblastic anemia	GENOMICS_ENGLAND_DG	21310276, 21310277, 27604308, 27830117		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency	Megaloblastic anemia	BEFREE	21310277, 30954686		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency	Megaloblastic anemia	Pubtator	21310277	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency	Megaloblastic anemia	CLINVAR_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency	Megaloblastic anemia	CTD_human_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
melanoma	Melanoma	BEFREE	17611626, 20564235, 23792190		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	17611626	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	20485525	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Miscarriage	Miscarriage	CTD_human_DG	18539642		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	28259901		★★★★★ ★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy, Duchenne	Duchenne Muscular Dystrophy	BEFREE	1719396		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	23053953, 23726796		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10100715, 10898545, 11891321, 12664136, 1596583, 16942440, 20485525, 21036757, 21367480, 2141497, 21752725, 23726796, 28177228, 28188287, 29280388 View all (5 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	CTD_human_DG	21064136, 21310277		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
nervous system disorder	Nervous System Disorder	BEFREE	21310277		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neural Tube Defects	Neural Tube Defect	BEFREE	17486595, 24361572, 30120883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	BEFREE	30684021		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	20737570, 21036757, 21367480, 23709418, 25145669, 31446981		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nystagmus Pathologic	Nystagmus	Pubtator	32157568	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Orofacial Cleft 1	Orofacial cleft	Pubtator	26221921	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	LHGDN	12788094, 14679136		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteosarcoma	Osteosarcoma	BEFREE	14582536, 14679136, 18385200, 19159907, 25739012, 25778468, 28693150		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteosarcoma	Osteosarcoma	Pubtator	14679136, 18385200, 19159907, 25739012	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteosarcoma	Osteosarcoma	CTD_human_DG	19159907		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ovarian neoplasm	Ovarian neoplasm	BEFREE	7529065		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancytopenia	Pancytopenia	CTD_human_DG	21310276		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancytopenia	Pancytopenia	Pubtator	21310276	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancytopenia	Pancytopenia	HPO_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Papillary craniopharyngioma	Papillary Craniopharyngioma	BEFREE	12018659		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	21310276	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	9226157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	12972803, 22954684, 22994778, 26335211, 28719513, 29805575, 31262877, 7605998, 9226157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	9226157		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary central nervous system lymphoma	Central Nervous System Lymphoma	BEFREE	20237949		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	30346152		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	14679136, 22648968, 8852336		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	Pubtator	17510060	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	Pubtator	22648968	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	12684695, 18034620, 22324981, 27627584, 27636122, 30544400, 30583708, 30758239		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rheumatoid Arthritis	Rheumatoid arthritis	CTD_human_DG	23897011		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Sarcoma	BEFREE	6298606		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	2755489		★★★★★ ★☆☆☆☆ Found in Text Mining only
Severe Combined Immunodeficiency	Severe combined immunodeficiency disease	BEFREE	7809366		★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Diseases	Skin disease	Pubtator	25759212	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin lesion	Skin Lesion	BEFREE	25759212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Spina Bifida	Spina Bifida	BEFREE	14735580, 17336564, 17486595, 19683694		★★★★★ ★☆☆☆☆ Found in Text Mining only
Spina Bifida	Spina Bifida	LHGDN	17336564		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	33382484	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Subfertility, Female	Subfertility	CTD_human_DG	17519396		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombocytopenia	Thrombocytopenia	Pubtator	22994778	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
UV-Sensitive Syndrome	UV-Sensitive Syndrome	BEFREE	12509286		★★★★★ ★☆☆☆☆ Found in Text Mining only
Xeroderma Pigmentosum Complementation Group C	Xeroderma pigmentosum	Pubtator	1649389	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C	Xeroderma Pigmentosum	BEFREE	1649389		★★★★★ ★☆☆☆☆ Found in Text Mining only
Xeroderma pigmentosum, group A	Xeroderma Pigmentosum	BEFREE	8504485, 9753735		★★★★★ ★☆☆☆☆ Found in Text Mining only

DHFR (dihydrofolate reductase)