Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	170506
Gene name	DEAH-box helicase 36
Gene symbol	DHX36
Synonyms (NCBI Gene)	DDX36G4R1MLEL1RHAU
Chromosome	3
Chromosome location	3q25.2
Summary	This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028475	hsa-miR-30a-5p	Proteomics	18668040
MIRT031417	hsa-miR-16-5p	Proteomics	18668040
MIRT609463	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT609462	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	21572407
MIRT609460	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	21572407
MIRT609458	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT690340	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT690339	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT690338	hsa-miR-548at-5p	HITS-CLIP	23313552
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT609458	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT688492	hsa-miR-5579-5p	HITS-CLIP	23313552
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT609462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT609460	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT609458	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT609463	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT609462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT609460	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT609458	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT478135	hsa-miR-302f	PAR-CLIP	23592263
MIRT478134	hsa-miR-3123	PAR-CLIP	23592263
MIRT478132	hsa-miR-3919	PAR-CLIP	23592263
MIRT478133	hsa-miR-7112-5p	PAR-CLIP	23592263
MIRT478131	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT478130	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT478129	hsa-miR-6089	PAR-CLIP	23592263
MIRT609463	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT609462	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	21572407
MIRT609460	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	21572407
MIRT609458	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT690340	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT690339	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT690338	hsa-miR-548at-5p	HITS-CLIP	23313552
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT609458	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT688492	hsa-miR-5579-5p	HITS-CLIP	23313552
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT609462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT609460	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT609458	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT609463	hsa-miR-5580-3p	HITS-CLIP	23824327
MIRT609462	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT609461	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT609460	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT609459	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT609458	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT478135	hsa-miR-302f	PAR-CLIP	23592263
MIRT478134	hsa-miR-3123	PAR-CLIP	23592263
MIRT478132	hsa-miR-3919	PAR-CLIP	23592263
MIRT478133	hsa-miR-7112-5p	PAR-CLIP	23592263
MIRT478131	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT478130	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT478129	hsa-miR-6089	PAR-CLIP	23592263
MIRT935586	hsa-miR-513c	CLIP-seq
MIRT935587	hsa-miR-514b-5p	CLIP-seq
MIRT935588	hsa-miR-1206	CLIP-seq
MIRT935589	hsa-miR-1264	CLIP-seq
MIRT935590	hsa-miR-1915	CLIP-seq
MIRT935591	hsa-miR-3149	CLIP-seq
MIRT935592	hsa-miR-323-5p	CLIP-seq
MIRT935593	hsa-miR-338-5p	CLIP-seq
MIRT935594	hsa-miR-3647-3p	CLIP-seq
MIRT935595	hsa-miR-410	CLIP-seq
MIRT935596	hsa-miR-4456	CLIP-seq
MIRT935597	hsa-miR-4468	CLIP-seq
MIRT935598	hsa-miR-4528	CLIP-seq
MIRT935599	hsa-miR-4705	CLIP-seq
MIRT935600	hsa-miR-4726-3p	CLIP-seq
MIRT935601	hsa-miR-4775	CLIP-seq
MIRT935586	hsa-miR-513c	CLIP-seq
MIRT935587	hsa-miR-514b-5p	CLIP-seq
MIRT935602	hsa-miR-556-5p	CLIP-seq
MIRT935603	hsa-miR-568	CLIP-seq
MIRT935604	hsa-miR-590-3p	CLIP-seq
MIRT935605	hsa-miR-876-3p	CLIP-seq
MIRT935606	hsa-miR-888	CLIP-seq
MIRT935589	hsa-miR-1264	CLIP-seq
MIRT1976952	hsa-miR-2052	CLIP-seq
MIRT1976953	hsa-miR-30a	CLIP-seq
MIRT1976954	hsa-miR-30b	CLIP-seq
MIRT1976955	hsa-miR-30c	CLIP-seq
MIRT1976956	hsa-miR-30d	CLIP-seq
MIRT1976957	hsa-miR-30e	CLIP-seq
MIRT1976958	hsa-miR-3117-5p	CLIP-seq
MIRT935591	hsa-miR-3149	CLIP-seq
MIRT1976959	hsa-miR-3170	CLIP-seq
MIRT935592	hsa-miR-323-5p	CLIP-seq
MIRT935593	hsa-miR-338-5p	CLIP-seq
MIRT935595	hsa-miR-410	CLIP-seq
MIRT1976960	hsa-miR-4260	CLIP-seq
MIRT935596	hsa-miR-4456	CLIP-seq
MIRT1976961	hsa-miR-4493	CLIP-seq
MIRT935598	hsa-miR-4528	CLIP-seq
MIRT935599	hsa-miR-4705	CLIP-seq
MIRT1976962	hsa-miR-4724-5p	CLIP-seq
MIRT935601	hsa-miR-4775	CLIP-seq
MIRT935586	hsa-miR-513c	CLIP-seq
MIRT935587	hsa-miR-514b-5p	CLIP-seq
MIRT935603	hsa-miR-568	CLIP-seq
MIRT935604	hsa-miR-590-3p	CLIP-seq
MIRT935605	hsa-miR-876-3p	CLIP-seq
MIRT935606	hsa-miR-888	CLIP-seq
MIRT2212301	hsa-miR-140-3p	CLIP-seq
MIRT2212302	hsa-miR-150	CLIP-seq
MIRT1976952	hsa-miR-2052	CLIP-seq
MIRT1976953	hsa-miR-30a	CLIP-seq
MIRT1976954	hsa-miR-30b	CLIP-seq
MIRT1976955	hsa-miR-30c	CLIP-seq
MIRT1976956	hsa-miR-30d	CLIP-seq
MIRT1976957	hsa-miR-30e	CLIP-seq
MIRT1976958	hsa-miR-3117-5p	CLIP-seq
MIRT935591	hsa-miR-3149	CLIP-seq
MIRT1976959	hsa-miR-3170	CLIP-seq
MIRT935592	hsa-miR-323-5p	CLIP-seq
MIRT935593	hsa-miR-338-5p	CLIP-seq
MIRT2212303	hsa-miR-383	CLIP-seq
MIRT2212304	hsa-miR-3941	CLIP-seq
MIRT2212305	hsa-miR-3945	CLIP-seq
MIRT935595	hsa-miR-410	CLIP-seq
MIRT2212306	hsa-miR-4253	CLIP-seq
MIRT1976960	hsa-miR-4260	CLIP-seq
MIRT935596	hsa-miR-4456	CLIP-seq
MIRT935597	hsa-miR-4468	CLIP-seq
MIRT2212307	hsa-miR-4481	CLIP-seq
MIRT935598	hsa-miR-4528	CLIP-seq
MIRT2212308	hsa-miR-4643	CLIP-seq
MIRT2212309	hsa-miR-466	CLIP-seq
MIRT2212310	hsa-miR-4672	CLIP-seq
MIRT935599	hsa-miR-4705	CLIP-seq
MIRT2212311	hsa-miR-4745-5p	CLIP-seq
MIRT2212312	hsa-miR-4772-5p	CLIP-seq
MIRT935601	hsa-miR-4775	CLIP-seq
MIRT2212313	hsa-miR-4789-3p	CLIP-seq
MIRT935586	hsa-miR-513c	CLIP-seq
MIRT2212314	hsa-miR-514	CLIP-seq
MIRT2212315	hsa-miR-514b-3p	CLIP-seq
MIRT935587	hsa-miR-514b-5p	CLIP-seq
MIRT935602	hsa-miR-556-5p	CLIP-seq
MIRT935603	hsa-miR-568	CLIP-seq
MIRT935605	hsa-miR-876-3p	CLIP-seq
MIRT935606	hsa-miR-888	CLIP-seq
MIRT2212316	hsa-miR-922	CLIP-seq
MIRT935588	hsa-miR-1206	CLIP-seq
MIRT2516020	hsa-miR-1271	CLIP-seq
MIRT2516021	hsa-miR-1272	CLIP-seq
MIRT2516022	hsa-miR-182	CLIP-seq
MIRT935590	hsa-miR-1915	CLIP-seq
MIRT1976952	hsa-miR-2052	CLIP-seq
MIRT1976953	hsa-miR-30a	CLIP-seq
MIRT1976954	hsa-miR-30b	CLIP-seq
MIRT1976955	hsa-miR-30c	CLIP-seq
MIRT1976956	hsa-miR-30d	CLIP-seq
MIRT1976957	hsa-miR-30e	CLIP-seq
MIRT1976958	hsa-miR-3117-5p	CLIP-seq
MIRT2516023	hsa-miR-3119	CLIP-seq
MIRT935591	hsa-miR-3149	CLIP-seq
MIRT1976959	hsa-miR-3170	CLIP-seq
MIRT2516024	hsa-miR-3185	CLIP-seq
MIRT935592	hsa-miR-323-5p	CLIP-seq
MIRT935593	hsa-miR-338-5p	CLIP-seq
MIRT935594	hsa-miR-3647-3p	CLIP-seq
MIRT2212304	hsa-miR-3941	CLIP-seq
MIRT2516025	hsa-miR-3942-3p	CLIP-seq
MIRT1976960	hsa-miR-4260	CLIP-seq
MIRT2516026	hsa-miR-4282	CLIP-seq
MIRT935596	hsa-miR-4456	CLIP-seq
MIRT935597	hsa-miR-4468	CLIP-seq
MIRT935598	hsa-miR-4528	CLIP-seq
MIRT2516027	hsa-miR-4642	CLIP-seq
MIRT2212308	hsa-miR-4643	CLIP-seq
MIRT2212309	hsa-miR-466	CLIP-seq
MIRT2212310	hsa-miR-4672	CLIP-seq
MIRT2516028	hsa-miR-4687-3p	CLIP-seq
MIRT935599	hsa-miR-4705	CLIP-seq
MIRT935600	hsa-miR-4726-3p	CLIP-seq
MIRT935601	hsa-miR-4775	CLIP-seq
MIRT2212313	hsa-miR-4789-3p	CLIP-seq
MIRT935586	hsa-miR-513c	CLIP-seq
MIRT935587	hsa-miR-514b-5p	CLIP-seq
MIRT935602	hsa-miR-556-5p	CLIP-seq
MIRT935603	hsa-miR-568	CLIP-seq
MIRT935604	hsa-miR-590-3p	CLIP-seq
MIRT935605	hsa-miR-876-3p	CLIP-seq
MIRT935606	hsa-miR-888	CLIP-seq
MIRT2516029	hsa-miR-892b	CLIP-seq
MIRT2516030	hsa-miR-96	CLIP-seq
MIRT935588	hsa-miR-1206	CLIP-seq
MIRT2516020	hsa-miR-1271	CLIP-seq
MIRT2516021	hsa-miR-1272	CLIP-seq
MIRT2516022	hsa-miR-182	CLIP-seq
MIRT935590	hsa-miR-1915	CLIP-seq
MIRT1976952	hsa-miR-2052	CLIP-seq
MIRT1976953	hsa-miR-30a	CLIP-seq
MIRT1976954	hsa-miR-30b	CLIP-seq
MIRT1976955	hsa-miR-30c	CLIP-seq
MIRT1976956	hsa-miR-30d	CLIP-seq
MIRT1976957	hsa-miR-30e	CLIP-seq
MIRT1976958	hsa-miR-3117-5p	CLIP-seq
MIRT2516023	hsa-miR-3119	CLIP-seq
MIRT935591	hsa-miR-3149	CLIP-seq
MIRT1976959	hsa-miR-3170	CLIP-seq
MIRT2516024	hsa-miR-3185	CLIP-seq
MIRT935592	hsa-miR-323-5p	CLIP-seq
MIRT935594	hsa-miR-3647-3p	CLIP-seq
MIRT2212304	hsa-miR-3941	CLIP-seq
MIRT2516025	hsa-miR-3942-3p	CLIP-seq
MIRT1976960	hsa-miR-4260	CLIP-seq
MIRT2516026	hsa-miR-4282	CLIP-seq
MIRT935596	hsa-miR-4456	CLIP-seq
MIRT935597	hsa-miR-4468	CLIP-seq
MIRT935598	hsa-miR-4528	CLIP-seq
MIRT2516027	hsa-miR-4642	CLIP-seq
MIRT2212308	hsa-miR-4643	CLIP-seq
MIRT2212309	hsa-miR-466	CLIP-seq
MIRT2212310	hsa-miR-4672	CLIP-seq
MIRT2516028	hsa-miR-4687-3p	CLIP-seq
MIRT935599	hsa-miR-4705	CLIP-seq
MIRT935600	hsa-miR-4726-3p	CLIP-seq
MIRT935601	hsa-miR-4775	CLIP-seq
MIRT2212313	hsa-miR-4789-3p	CLIP-seq
MIRT935586	hsa-miR-513c	CLIP-seq
MIRT935587	hsa-miR-514b-5p	CLIP-seq
MIRT935602	hsa-miR-556-5p	CLIP-seq
MIRT935603	hsa-miR-568	CLIP-seq
MIRT935604	hsa-miR-590-3p	CLIP-seq
MIRT935605	hsa-miR-876-3p	CLIP-seq
MIRT2516029	hsa-miR-892b	CLIP-seq
MIRT2516030	hsa-miR-96	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	16150737, 21846770
GO:0000781	Component	Chromosome, telomeric region	IDA	20472641, 21846770
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000976	Function	Transcription cis-regulatory region binding	ISS
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	21586581, 21993297
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0001503	Process	Ossification	IEA
GO:0001503	Process	Ossification	ISS
GO:0002151	Function	G-quadruplex RNA binding	IBA
GO:0002151	Function	G-quadruplex RNA binding	IDA	18842585, 20472641, 21149580, 21846770, 24151078, 24369427, 25579584, 26489465
GO:0002151	Function	G-quadruplex RNA binding	IMP	22238380, 27940037
GO:0002376	Process	Immune system process	IEA
GO:0002735	Process	Positive regulation of myeloid dendritic cell cytokine production	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003678	Function	DNA helicase activity	IBA
GO:0003678	Function	DNA helicase activity	IDA	16150737, 18842585, 25579584
GO:0003678	Function	DNA helicase activity	IEA
GO:0003697	Function	Single-stranded DNA binding	IDA	20696886
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	18854321
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IBA
GO:0003724	Function	RNA helicase activity	IDA	14731398, 18842585, 21846770
GO:0003724	Function	RNA helicase activity	IEA
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0003725	Function	Double-stranded RNA binding	IEA
GO:0003730	Function	MRNA 3'-UTR binding	IDA	24369427
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	14731398, 17932509, 18279852, 20696886, 21846770, 26030138, 26489465, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	ISS
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	14731398, 18279852, 18854321
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	14731398, 18279852, 18854321, 20696886
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006359	Process	Regulation of transcription by RNA polymerase III	IMP	18279852
GO:0006417	Process	Regulation of translation	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0008094	Function	ATP-dependent activity, acting on DNA	IDA	21586581
GO:0009615	Process	Response to virus	IEA
GO:0010494	Component	Cytoplasmic stress granule	IDA	18854321
GO:0010494	Component	Cytoplasmic stress granule	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0016607	Component	Nuclear speck	IDA	18279852
GO:0016607	Component	Nuclear speck	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0017148	Process	Negative regulation of translation	IDA	24369427
GO:0030154	Process	Cell differentiation	IEA
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0031442	Process	Positive regulation of mRNA 3'-end processing	IMP	27940037
GO:0032206	Process	Positive regulation of telomere maintenance	IMP	22238380
GO:0032727	Process	Positive regulation of interferon-alpha production	IMP	20696886
GO:0034605	Process	Cellular response to heat	IDA	18854321
GO:0034644	Process	Cellular response to UV	IMP	27940037
GO:0035925	Function	MRNA 3'-UTR AU-rich region binding	IDA	14731398, 26489465
GO:0042826	Function	Histone deacetylase binding	IEA
GO:0042826	Function	Histone deacetylase binding	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	ISS
GO:0043204	Component	Perikaryon	IEA
GO:0043204	Component	Perikaryon	ISS
GO:0043330	Process	Response to exogenous dsRNA	IEA
GO:0043488	Process	Regulation of mRNA stability	IMP	18279852
GO:0045087	Process	Innate immune response	IEA
GO:0045727	Process	Positive regulation of translation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0045995	Process	Regulation of embryonic development	IEA
GO:0045995	Process	Regulation of embryonic development	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048027	Function	MRNA 5'-UTR binding	IDA	26489465
GO:0051607	Process	Defense response to virus	IEA
GO:0051880	Function	G-quadruplex DNA binding	IBA
GO:0051880	Function	G-quadruplex DNA binding	IDA	16150737, 18842585, 21586581, 21993297, 24151078
GO:0051880	Function	G-quadruplex DNA binding	IEA
GO:0051891	Process	Positive regulation of cardioblast differentiation	IEA
GO:0051891	Process	Positive regulation of cardioblast differentiation	ISS
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	IMP	21993297
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	IEA
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	ISS
GO:0061158	Process	3'-UTR-mediated mRNA destabilization	IMP	26489465
GO:0070034	Function	Telomerase RNA binding	IDA	21149580, 21846770, 22238380
GO:0070062	Component	Extracellular exosome	HDA	18570454
GO:0070883	Function	Pre-miRNA binding	IEA
GO:0070883	Function	Pre-miRNA binding	ISS
GO:0090669	Process	Telomerase RNA stabilization	IDA	22238380
GO:0140640	Function	Catalytic activity, acting on a nucleic acid	IDA	16150737, 18842585
GO:0140640	Function	Catalytic activity, acting on a nucleic acid	IEA
GO:1900153	Process	Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IMP	14731398
GO:1901534	Process	Positive regulation of hematopoietic progenitor cell differentiation	IEA
GO:1901534	Process	Positive regulation of hematopoietic progenitor cell differentiation	ISS
GO:1903843	Process	Cellular response to arsenite ion	IDA	18854321
GO:1904358	Process	Positive regulation of telomere maintenance via telomere lengthening	IMP	21149580
GO:1904582	Process	Positive regulation of intracellular mRNA localization	IEA
GO:1904582	Process	Positive regulation of intracellular mRNA localization	ISS
GO:2000767	Process	Positive regulation of cytoplasmic translation	IMP	26489465

MIM	HGNC	e!Ensembl
612767	14410	ENSG00000174953

Q9H2U1

Protein name

ATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein)

Protein function

Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (PubMed:16150737, PubMed:18854321, PubMed:20472641, PubMed:21586581). Plays a role in many biological processes such as genomic integrity, gene expression regulatio

PDB

2N16 , 2N21 , 6Q6R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00270	DEAD	210 → 376	DEAD/DEAH box helicase	Domain
PF00271	Helicase_C	472 → 607	Helicase conserved C-terminal domain	Family
PF04408	HA2	670 → 759	Helicase associated domain (HA2)	Domain
PF07717	OB_NTP_bind	831 → 917	Oligonucleotide/oligosaccharide-binding (OB)-fold	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis. {ECO:0000269|PubMed:12198572, ECO:0000269|PubMed:14731398}.

Sequence

MSYDYHQNWGRDGGPRSSGGGYGGGPAGGHGGNRGSGGGGGGGGGGRGGRGRHPGHLKGR
EIGMWYAKKQGQKNKEAERQERAVVHMDERREEQIVQLLNSVQAKNDKESEAQISWFAPE
DHGYGTEVSTKNTPCSENKLDIQEKKLINQEKKMFRIRNRSYIDRDSEYLLQENEPDGTL
DQKLLEDLQKKKNDLRYIEMQHFREKLPSYGMQKELVNLIDNHQVTVISGETGCGKTTQV
TQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGSGNSTGYQIRLQSRL
PRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLMTVVKDLLNFRSDL
KVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDVIEKIRYVPEQKEHRSQFKR
GFMQGHVNRQEKEEKEAIYKERWPDYVRELRRRYSASTVDVIEMMEDDKVDLNLIVALIR
YIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFLIIPLHSLMPTVNQTQVFKRT
PPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRK
GRAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMD
PPSNEAVLLSIRHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLT
IAASLSFKDPFVIPLGKEKIADARRKELAKDTRSDHLTVVNAFEGWEEARRRGFRYEKDY
CWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPKDPESNINSDNEKIIKAVICAGLY
PKVAKIRLNLGKKRKMVKVYTKTDGLVAVHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLY
DCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIVFQSPARIAHLVKELRKELDILLQEK
IESPHPVDWNDTKSRDCAVLSAIIDLIKTQEKATPRNFPPRFQDGYYS

Sequence length

1008

Interactions

View interactions

	KEGG		Reactome
	RNA degradation		DEx/H-box helicases activate type I IFN and inflammatory cytokines production

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	33855846	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21993297	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	27797375		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glomerulonephritis Membranous	Membranous glomerulonephritis	Pubtator	40018947	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	27797375		★★★★★ ★☆☆☆☆ Found in Text Mining only

DHX36 (DEAH-box helicase 36)