Gene Gene information from NCBI Gene database.
Entrez ID 169714
Gene name Quiescin sulfhydryl oxidase 2
Gene symbol QSOX2
Synonyms (NCBI Gene)
QSCN6L1SOXN
Chromosome 9
Chromosome location 9q34.3
Summary QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, J
miRNA miRNA information provided by mirtarbase database.
1284
miRTarBase ID miRNA Experiments Reference
MIRT004986 hsa-miR-125b-5p Microarray 17891175
MIRT019576 hsa-miR-340-5p Sequencing 20371350
MIRT031819 hsa-miR-16-5p Proteomics 18668040
MIRT050770 hsa-miR-17-3p CLASH 23622248
MIRT049168 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IBA
GO:0003756 Function Protein disulfide isomerase activity IBA
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612860 30249 ENSG00000165661
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6ZRP7
Protein name Sulfhydryl oxidase 2 (EC 1.8.3.2) (Neuroblastoma-derived sulfhydryl oxidase) (Quiescin Q6-like protein 1)
Protein function Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role i
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00085 Thioredoxin 63 172 Thioredoxin Domain
PF18108 QSOX_Trx1 185 292 QSOX Trx-like domain Domain
PF18371 FAD_SOX 318 421 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Domain
PF04777 Evr1_Alr 430 531 Erv1 / Alr family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles. {ECO:0000269|PubMed:14633699}.
Sequence
Sequence length 698
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
GOUT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Atrial Fibrillation Atrial fibrillation Pubtator 37581400 Inhibit
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Atrial fibrillation Pubtator 37967346 Associate
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 36273131 Associate
★☆☆☆☆
Found in Text Mining only
Dermatitis Atopic Atopic dermatitis Pubtator 39341815 Associate
★☆☆☆☆
Found in Text Mining only
Gastrointestinal Diseases Gastrointestinal disease Pubtator 39341815 Associate
★☆☆☆☆
Found in Text Mining only
Growth Disorders Growth disorder Pubtator 39341815 Associate
★☆☆☆☆
Found in Text Mining only
Immune System Diseases Immune system disease Pubtator 39341815 Associate
★☆☆☆☆
Found in Text Mining only
Neuroblastoma Neuroblastoma BEFREE 14633699
★☆☆☆☆
Found in Text Mining only
Pancreatic Neoplasms Pancreatic neoplasm Pubtator 37338014 Associate
★☆☆☆☆
Found in Text Mining only
Prostatic Neoplasms Prostatic neoplasm Pubtator 36232996 Associate
★☆☆☆☆
Found in Text Mining only