DACT2 (dishevelled binding antagonist of beta catenin 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 168002
Gene name Dishevelled binding antagonist of beta catenin 2
Gene symbol DACT2
Synonyms (NCBI Gene)
C6orf116DAPPER2DPR2bA503C24.7
Chromosome 6
Chromosome location 6q27
miRNA miRNA information provided by mirtarbase database.
18
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (18)
miRTarBase ID miRNA Experiments Reference
MIRT022027 hsa-miR-128-3p Microarray 17612493
MIRT041542 hsa-miR-193b-3p CLASH 23622248
MIRT922674 hsa-miR-103a CLIP-seq
MIRT922675 hsa-miR-107 CLIP-seq
MIRT922676 hsa-miR-214 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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Transcription factor Regulation Reference
NKX2-5 Repression 19479054
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002244 Process Hematopoietic progenitor cell differentiation IEA
GO:0003382 Process Epithelial cell morphogenesis IEA
GO:0003382 Process Epithelial cell morphogenesis ISS
GO:0005080 Function Protein kinase C binding IEA
GO:0005080 Function Protein kinase C binding ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
608966 21231 ENSG00000164488
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5SW24
Protein name Dapper homolog 2 (Dapper antagonist of catenin 2)
Protein function Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of th
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15268 Dapper 20 → 774 Dapper Family
Sequence
Sequence length 774
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CORNEAL ASTIGMATISM — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (57)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asthma Asthma BEFREE 29456669
★★★★★
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma Pubtator 25521223 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 27708215, 28607412, 29435071, 29745077
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Diseases Breast disease Pubtator 34997107 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 27708215 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 29745077, 33492284, 34997107 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 25524937 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 27553089
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 23496880, 25375359 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 22806826, 25375359
★★★★★
★☆☆☆☆
Found in Text Mining only