CDC20B (cell division cycle 20B)

Gene

• Entrez ID: 166979
• Gene name: Cell division cycle 20B
• Gene symbol: CDC20B
• Synonyms (NCBI Gene): G6VTS76519
• Chromosome: 5
• Chromosome location: 5q11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT876882	hsa-miR-3545-3p	CLIP-seq
MIRT876883	hsa-miR-369-3p	CLIP-seq
MIRT876884	hsa-miR-374a	CLIP-seq
MIRT876885	hsa-miR-374b	CLIP-seq
MIRT876886	hsa-miR-3915	CLIP-seq
MIRT876887	hsa-miR-3928	CLIP-seq
MIRT876888	hsa-miR-633	CLIP-seq
MIRT876889	hsa-miR-1200	CLIP-seq
MIRT876890	hsa-miR-371-5p	CLIP-seq
MIRT876891	hsa-miR-371b-5p	CLIP-seq
MIRT876892	hsa-miR-4311	CLIP-seq
MIRT876893	hsa-miR-4324	CLIP-seq
MIRT876894	hsa-miR-4471	CLIP-seq
MIRT876895	hsa-miR-544b	CLIP-seq
MIRT876896	hsa-miR-548p	CLIP-seq
MIRT1959869	hsa-miR-1257	CLIP-seq
MIRT1959870	hsa-miR-143	CLIP-seq
MIRT1959871	hsa-miR-4770	CLIP-seq
MIRT1959872	hsa-miR-889	CLIP-seq
MIRT1959869	hsa-miR-1257	CLIP-seq
MIRT2196860	hsa-miR-1305	CLIP-seq
MIRT1959870	hsa-miR-143	CLIP-seq
MIRT2196861	hsa-miR-412	CLIP-seq
MIRT2196862	hsa-miR-4662a-5p	CLIP-seq
MIRT1959871	hsa-miR-4770	CLIP-seq
MIRT1959872	hsa-miR-889	CLIP-seq
MIRT2500131	hsa-miR-124	CLIP-seq
MIRT2500132	hsa-miR-323b-3p	CLIP-seq
MIRT2500133	hsa-miR-3714	CLIP-seq
MIRT2500134	hsa-miR-3910	CLIP-seq
MIRT2500135	hsa-miR-506	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005680	Component	Anaphase-promoting complex	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0010997	Function	Anaphase-promoting complex binding	IBA
GO:0010997	Function	Anaphase-promoting complex binding	IEA
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	IBA
GO:0097027	Function	Ubiquitin-protein transferase activator activity	IEA
GO:0097742	Process	De novo centriole assembly	IDA	30405130
GO:0097742	Process	De novo centriole assembly	IEA
GO:0098536	Component	Deuterosome	IDA	30405130
GO:0098536	Component	Deuterosome	IEA
GO:1905786	Process	Positive regulation of anaphase-promoting complex-dependent catabolic process	IBA
GO:1990757	Function	Ubiquitin ligase activator activity	IBA

Other IDs

• MIM: 620335
• HGNC: 24222
• e!Ensembl: ENSG00000164287

Protein

• UniProt ID: Q86Y33
• Protein name: Cell division cycle protein 20 homolog B
• Protein function: Protein regulator of centriole-deuterosome disengagement and subsequently participates in the ciliogenesis in multiciliated cells (MCCs).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	346 → 382	WD domain, G-beta repeat	Repeat
  PF00400	WD40	479 → 517	WD domain, G-beta repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed in multiciliated cells (MCCs). {ECO:0000269|PubMed:30405130}.
• Sequence:

  MEWKLERTAPRRVRTEEEMLWESIMRVLSKDLKQKRSQDSANVLDSVNATYSDFKSNFAK
  RLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLTLGS
  RKEQLKTPSKGISETSNSALHFCKAPHAMDRDWKESVASKGQKCLKQLFVTQNVVQQANG
  KMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWS
  FQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLW
  DVVTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQHHVGTLRHKQAVCA
  LKWSPDGRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIG
  GGMKDGRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVS
  RSGGFFGHRGRVLHLSLSPDQTRVFSAAADGTASVWNCY

• Sequence length: 519

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atherosclerosis	Atherosclerosis	Pubtator	35212610	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	32041280	Associate	★☆☆☆☆ Found in Text Mining only
Hepatoblastoma	Hepatoblastoma	BEFREE	24912477		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29023247		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24912477, 29023247		★☆☆☆☆ Found in Text Mining only