Gene Gene information from NCBI Gene database.
Entrez ID 166968
Gene name MIER family member 3
Gene symbol MIER3
Synonyms (NCBI Gene)
-
Chromosome 5
Chromosome location 5q11.2
miRNA miRNA information provided by mirtarbase database.
882
miRTarBase ID miRNA Experiments Reference
MIRT016054 hsa-miR-374b-5p Sequencing 20371350
MIRT016182 hsa-miR-590-3p Sequencing 20371350
MIRT019243 hsa-miR-331-3p Sequencing 20371350
MIRT021919 hsa-miR-128-3p Sequencing 20371350
MIRT023461 hsa-miR-30b-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0003714 Function Transcription corepressor activity IBA
GO:0004407 Function Histone deacetylase activity IDA 28046085
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IDA 28046085
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620100 26678 ENSG00000155545
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z3K6
Protein name Mesoderm induction early response protein 3 (Mi-er3)
Protein function Transcriptional repressor.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01448 ELM2 176 226 ELM2 domain Family
PF00249 Myb_DNA-binding 279 325 Myb-like DNA-binding domain Domain
Sequence
MAEASFGSSSPVGSLSSEDHDFDPTAEMLVHDYDDERTLEEEEMMDEGKNFSSEIEDLEK
EGTMPLEDLLAFYGYEPTIPAVANSSANSSPSELADELPDMTLDKEEIAKDLLSGDDEET
QSSADDLTPSVTSHETSDFFPRPLRSNTACDGDKESEVEDVETDSGNSPEDLRKEIMIGL
QYQAEIPPYLGEYDGNEKVYENEDQLLWCPDVVLESKVKEYLVETS
LRTGSEKIMDRISA
GTHTRDNEQALYELLKCNHNIKEAIERYCCNGKASQEGMTAWTEEECRSFEHALMLFGKD
FHLIQKNKVRTRTVAECVAFYYMWK
KSERYDYFAQQTRFGKKRYNHHPGVTDYMDRLVDE
TEALGGTVNASALTSNRPEPIPDQQLNILNSFTASDLTALTNSVATVCDPTDVNCLDDSF
PPLGNTPRGQVNHVPVVTEELLTLPSNGESDCFNLFETGFYHSELNPMNMCSEESERPAK
RLKMGIAVPESFMNEVSVNNLGVDFENHTHHITSAKMAVSVADFGSLSANETNGFISAHA
LHQHAALHSE
Sequence length 550
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
14
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHOROIDAL MELANOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 22993404
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Carcinoma Breast Carcinoma GWASCAT_DG 24493630, 29059683
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colorectal Carcinoma Colorectal Cancer BEFREE 28887525
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 22993404
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 22993404, 28887525
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 28887525
★☆☆☆☆
Found in Text Mining only