Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	166824
Gene name	Ras association domain family member 6
Gene symbol	RASSF6
Synonyms (NCBI Gene)	-
Chromosome	4
Chromosome location	4q13.3
Summary	This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protei

149

Show/Hide all (149)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017788	hsa-miR-335-5p	Microarray	18185580
MIRT019339	hsa-miR-148b-3p	Microarray	17612493
MIRT021964	hsa-miR-128-3p	Microarray	17612493
MIRT025042	hsa-miR-181a-5p	Microarray	17612493
MIRT677224	hsa-miR-4528	HITS-CLIP	23824327
MIRT677223	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677222	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677221	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677220	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677219	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677218	hsa-miR-1976	HITS-CLIP	23824327
MIRT677217	hsa-miR-4720-5p	HITS-CLIP	23824327
MIRT677216	hsa-miR-4799-3p	HITS-CLIP	23824327
MIRT677215	hsa-miR-5588-5p	HITS-CLIP	23824327
MIRT677214	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677213	hsa-miR-1256	HITS-CLIP	23824327
MIRT551484	hsa-miR-8485	PAR-CLIP	21572407
MIRT551483	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT551482	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT551481	hsa-miR-603	PAR-CLIP	21572407
MIRT551480	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT551479	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT551478	hsa-miR-3941	PAR-CLIP	21572407
MIRT551477	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT551476	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT025042	hsa-miR-181a-5p	Luciferase reporter assayqRT-PCRWestern blot	28043911
MIRT025042	hsa-miR-181a-5p	Luciferase reporter assayqRT-PCRWestern blot	28043911
MIRT677224	hsa-miR-4528	HITS-CLIP	23824327
MIRT677223	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT677222	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT677221	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT677220	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT677219	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT677218	hsa-miR-1976	HITS-CLIP	23824327
MIRT677217	hsa-miR-4720-5p	HITS-CLIP	23824327
MIRT677216	hsa-miR-4799-3p	HITS-CLIP	23824327
MIRT677215	hsa-miR-5588-5p	HITS-CLIP	23824327
MIRT677214	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT677213	hsa-miR-1256	HITS-CLIP	23824327
MIRT551484	hsa-miR-8485	PAR-CLIP	21572407
MIRT551483	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT551482	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT551481	hsa-miR-603	PAR-CLIP	21572407
MIRT551480	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT551479	hsa-miR-5580-3p	PAR-CLIP	21572407
MIRT551478	hsa-miR-3941	PAR-CLIP	21572407
MIRT551477	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT551476	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT1292976	hsa-miR-1207-5p	CLIP-seq
MIRT1292977	hsa-miR-1307	CLIP-seq
MIRT1292978	hsa-miR-1827	CLIP-seq
MIRT1292979	hsa-miR-197	CLIP-seq
MIRT1292980	hsa-miR-2278	CLIP-seq
MIRT1292981	hsa-miR-3182	CLIP-seq
MIRT1292982	hsa-miR-3920	CLIP-seq
MIRT1292983	hsa-miR-3927	CLIP-seq
MIRT1292984	hsa-miR-4519	CLIP-seq
MIRT1292985	hsa-miR-4638-5p	CLIP-seq
MIRT1292986	hsa-miR-4716-5p	CLIP-seq
MIRT1292987	hsa-miR-4762-3p	CLIP-seq
MIRT1292988	hsa-miR-4763-3p	CLIP-seq
MIRT1292989	hsa-miR-4781-3p	CLIP-seq
MIRT1292990	hsa-miR-502-5p	CLIP-seq
MIRT1292991	hsa-miR-5096	CLIP-seq
MIRT1292992	hsa-miR-566	CLIP-seq
MIRT1292993	hsa-miR-668	CLIP-seq
MIRT1292994	hsa-miR-940	CLIP-seq
MIRT1292976	hsa-miR-1207-5p	CLIP-seq
MIRT2086966	hsa-miR-1281	CLIP-seq
MIRT1292978	hsa-miR-1827	CLIP-seq
MIRT1292979	hsa-miR-197	CLIP-seq
MIRT2086967	hsa-miR-3187-3p	CLIP-seq
MIRT2086968	hsa-miR-3663-5p	CLIP-seq
MIRT2086969	hsa-miR-3908	CLIP-seq
MIRT2086970	hsa-miR-3942-5p	CLIP-seq
MIRT2086971	hsa-miR-411	CLIP-seq
MIRT2086972	hsa-miR-4279	CLIP-seq
MIRT2086973	hsa-miR-4303	CLIP-seq
MIRT2086974	hsa-miR-4427	CLIP-seq
MIRT2086975	hsa-miR-4435	CLIP-seq
MIRT2086976	hsa-miR-4532	CLIP-seq
MIRT2086977	hsa-miR-4680-3p	CLIP-seq
MIRT2086978	hsa-miR-4682	CLIP-seq
MIRT2086979	hsa-miR-4701-5p	CLIP-seq
MIRT2086980	hsa-miR-4703-5p	CLIP-seq
MIRT1292986	hsa-miR-4716-5p	CLIP-seq
MIRT2086981	hsa-miR-4755-3p	CLIP-seq
MIRT1292987	hsa-miR-4762-3p	CLIP-seq
MIRT1292988	hsa-miR-4763-3p	CLIP-seq
MIRT2086982	hsa-miR-4766-3p	CLIP-seq
MIRT1292989	hsa-miR-4781-3p	CLIP-seq
MIRT2086983	hsa-miR-498	CLIP-seq
MIRT1292991	hsa-miR-5096	CLIP-seq
MIRT2086984	hsa-miR-548s	CLIP-seq
MIRT2086985	hsa-miR-588	CLIP-seq
MIRT1292994	hsa-miR-940	CLIP-seq
MIRT2311904	hsa-miR-103b	CLIP-seq
MIRT1292976	hsa-miR-1207-5p	CLIP-seq
MIRT2086966	hsa-miR-1281	CLIP-seq
MIRT1292978	hsa-miR-1827	CLIP-seq
MIRT1292979	hsa-miR-197	CLIP-seq
MIRT2311905	hsa-miR-21	CLIP-seq
MIRT2086967	hsa-miR-3187-3p	CLIP-seq
MIRT2086968	hsa-miR-3663-5p	CLIP-seq
MIRT2086971	hsa-miR-411	CLIP-seq
MIRT2086972	hsa-miR-4279	CLIP-seq
MIRT2086973	hsa-miR-4303	CLIP-seq
MIRT2311906	hsa-miR-4432	CLIP-seq
MIRT2086975	hsa-miR-4435	CLIP-seq
MIRT2086976	hsa-miR-4532	CLIP-seq
MIRT2086978	hsa-miR-4682	CLIP-seq
MIRT2086979	hsa-miR-4701-5p	CLIP-seq
MIRT1292986	hsa-miR-4716-5p	CLIP-seq
MIRT2086981	hsa-miR-4755-3p	CLIP-seq
MIRT1292987	hsa-miR-4762-3p	CLIP-seq
MIRT1292988	hsa-miR-4763-3p	CLIP-seq
MIRT1292989	hsa-miR-4781-3p	CLIP-seq
MIRT2311907	hsa-miR-4795-3p	CLIP-seq
MIRT2311908	hsa-miR-487a	CLIP-seq
MIRT2086983	hsa-miR-498	CLIP-seq
MIRT2311909	hsa-miR-499-5p	CLIP-seq
MIRT1292990	hsa-miR-502-5p	CLIP-seq
MIRT1292991	hsa-miR-5096	CLIP-seq
MIRT2086984	hsa-miR-548s	CLIP-seq
MIRT2086985	hsa-miR-588	CLIP-seq
MIRT2311910	hsa-miR-590-5p	CLIP-seq
MIRT1292994	hsa-miR-940	CLIP-seq
MIRT2311911	hsa-miR-944	CLIP-seq
MIRT1292976	hsa-miR-1207-5p	CLIP-seq
MIRT1292978	hsa-miR-1827	CLIP-seq
MIRT1292979	hsa-miR-197	CLIP-seq
MIRT2086971	hsa-miR-411	CLIP-seq
MIRT1292986	hsa-miR-4716-5p	CLIP-seq
MIRT1292988	hsa-miR-4763-3p	CLIP-seq
MIRT1292989	hsa-miR-4781-3p	CLIP-seq
MIRT1292991	hsa-miR-5096	CLIP-seq
MIRT1292994	hsa-miR-940	CLIP-seq
MIRT2086966	hsa-miR-1281	CLIP-seq
MIRT2086972	hsa-miR-4279	CLIP-seq
MIRT2086976	hsa-miR-4532	CLIP-seq
MIRT2086983	hsa-miR-498	CLIP-seq
MIRT2086966	hsa-miR-1281	CLIP-seq
MIRT2086972	hsa-miR-4279	CLIP-seq
MIRT2086976	hsa-miR-4532	CLIP-seq
MIRT2086983	hsa-miR-498	CLIP-seq
MIRT2086966	hsa-miR-1281	CLIP-seq
MIRT2086972	hsa-miR-4279	CLIP-seq
MIRT2086976	hsa-miR-4532	CLIP-seq
MIRT2086983	hsa-miR-498	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20920251, 24366813, 33961781, 35271311
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA

MIM	HGNC	e!Ensembl
612620	20796	ENSG00000169435

Q6ZTQ3

Protein name

Ras association domain-containing protein 6

Protein function

Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). {ECO:0000250, ECO:0000269|PubM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00788	RA	218 → 306	Ras association (RalGDS/AF-6) domain	Domain
PF16517	Nore1-SARAH	318 → 357	Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gla

Sequence

MLWEETGAAPAPARASDLPYRISSDHLKKEEKMTMMAHQYPSWIFINEKTFITREQLNSL
LKTYNIFYENQKNLHILYGETEDGKLIVEGMLDIFWGVKRPIQLKIQDEKPFSSFTSMKS
SDVFSSKGMTRWGEFDDLYRISELDRTQIPMSEKRNSQEDYLSYHSNTLKPHAKDEPDSP
VLYRTMSEAALVRKRMKPLMMDRKERQKNRASINGHFYNHETSIFIPAFESETKVRVNSN
MRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQRRLKKTDIPLLQRLLQGPSEKNARIF
LMDKDAEEISSDVAQYINFHFSLLESILQRLNEEEKREIQRIVTKFNKEKAIILKCLQNK
LVIKTETTV

Sequence length

369

Interactions

View interactions

	KEGG
	Hippo signaling pathway Hippo signaling pathway - multiple species

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (45)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	31486880		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	27009808		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	28869817, 31486880		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	26074700		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	23148572	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	31807003		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	25482183	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29964010		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	31807003		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	26074700	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	31486880		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27009808, 28903410, 31273789		★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	24626183, 29864454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Giant Cell Arteritis	Giant Cell Arteritis	BEFREE	26456015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	31055025	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	19570220		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	22430796	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27983932		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29964010		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	21442347, 28043911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	31807003		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19570220, 21116130, 21442347, 27009808, 27983932		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	25482183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	25482183	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	35048636	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Melanoma	Pubtator	35048636	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	BEFREE	25482183		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	25028967		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	25028967	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19570220, 21442347, 22695170, 23363221, 24626183, 25028967, 27009808, 28869817, 29193479, 29864454, 29891515, 29931788, 29964010, 31812473		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	22695170		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	22695170	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29194827		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	29194827, 33416181	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	26074700		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis Chronic	Pancreatitis	Pubtator	26074700	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis, Chronic	Pancreatitis	BEFREE	26074700		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	28869817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	28869817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	29864454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	29891515		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	31812473		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	21442347, 28043911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	28043911	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	29964010		★★★★★ ★☆☆☆☆ Found in Text Mining only

RASSF6 (Ras association domain family member 6)