PARP15 (poly(ADP-ribose) polymerase family member 15)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 165631 |
| Gene name | Poly(ADP-ribose) polymerase family member 15 |
| Gene symbol | PARP15 |
| Synonyms (NCBI Gene) |
ARTD7BAL3pART7
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| Chromosome | 3 |
| Chromosome location | 3q21.1 |
| Summary | PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008] |
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miRNA
miRNA information provided by mirtarbase database.
321
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q460N3 | ||||||||||||||||||||
| Protein name | Protein mono-ADP-ribosyltransferase PARP15 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) (Poly [ADP-ribose] polymerase 15) (PARP-15) | ||||||||||||||||||||
| Protein function | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049). Acts as a negative regulator of transcription (PubMed:16061477). {ECO:0000269|PubMed:16061477, ECO:0000269|Pu | ||||||||||||||||||||
| PDB | 3BLJ , 3GEY , 3V2B , 4F0E , 6EK3 , 6RY4 , 7F41 , 7F42 , 7F43 , 7OQQ , 7OSP , 7OSS , 7OSX , 7OTF , 7OTH , 7OUW , 7OUX , 7PW3 , 7PWA , 7PWC , 7PWK , 7PWL , 7PWM , 7PWP , 7PWQ , 7PWR , 7PWS , 7PWU , 7PWW , 7PX6 , 7PX7 , 7R3O , 7R4A , 7R5D , 7Z1V , 7Z1W , 7Z1Y , 7Z2O , 7Z2Q , 7Z41 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 678 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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