Gene Gene information from NCBI Gene database.
Entrez ID 165631
Gene name Poly(ADP-ribose) polymerase family member 15
Gene symbol PARP15
Synonyms (NCBI Gene)
ARTD7BAL3pART7
Chromosome 3
Chromosome location 3q21.1
Summary PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]
miRNA miRNA information provided by mirtarbase database.
321
miRTarBase ID miRNA Experiments Reference
MIRT018935 hsa-miR-335-5p Microarray 18185580
MIRT498782 hsa-miR-3662 HITS-CLIP 23313552
MIRT498783 hsa-miR-8084 HITS-CLIP 23313552
MIRT690399 hsa-miR-7153-3p HITS-CLIP 23313552
MIRT690398 hsa-miR-4789-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 16061477
GO:0003714 Function Transcription corepressor activity IBA
GO:0003714 Function Transcription corepressor activity IMP 16061477
GO:0003950 Function NAD+ poly-ADP-ribosyltransferase activity IBA
GO:0003950 Function NAD+ poly-ADP-ribosyltransferase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612066 26876 ENSG00000173200
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q460N3
Protein name Protein mono-ADP-ribosyltransferase PARP15 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) (Poly [ADP-ribose] polymerase 15) (PARP-15)
Protein function Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049). Acts as a negative regulator of transcription (PubMed:16061477). {ECO:0000269|PubMed:16061477, ECO:0000269|Pu
PDB 3BLJ , 3GEY , 3V2B , 4F0E , 6EK3 , 6RY4 , 7F41 , 7F42 , 7F43 , 7OQQ , 7OSP , 7OSS , 7OSX , 7OTF , 7OTH , 7OUW , 7OUX , 7PW3 , 7PWA , 7PWC , 7PWK , 7PWL , 7PWM , 7PWP , 7PWQ , 7PWR , 7PWS , 7PWU , 7PWW , 7PX6 , 7PX7 , 7R3O , 7R4A , 7R5D , 7Z1V , 7Z1W , 7Z1Y , 7Z2O , 7Z2Q , 7Z41
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01661 Macro 107 223 Macro domain Domain
PF01661 Macro 322 424 Macro domain Domain
PF00644 PARP 503 678 Poly(ADP-ribose) polymerase catalytic domain Family
Sequence
MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLPAGNRGARKASRRSSSR
SMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIWADVIVNSVPMNLQLGGGP
LSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSW
QIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAVFAKLI
LSEVFEYSSSTRPITSP
LQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARIPMAGDTQGVVGTVSKPCFTAYEMK
IGAITFQVATGDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHR
DFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAGKNPITV
ADNI
IDAIVDFSSQHSTPSLKTVKVVIFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTC
NLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVK
KRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSA
KDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLF
VVFFDNQAYPEYLITFTA
Sequence length 678
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PERIODONTITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Head and Neck Neoplasms Head and neck neoplasm Pubtator 24786473 Associate
★☆☆☆☆
Found in Text Mining only
Leukemia, Myelocytic, Acute Leukemia BEFREE 27610459
★☆☆☆☆
Found in Text Mining only
Major Depressive Disorder Mental Depression BEFREE 26192912
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant Neoplasms Malignant Neoplasm BEFREE 24135866, 27610459
★☆☆☆☆
Found in Text Mining only
Pituitary Neoplasms Pituitary neoplasm Pubtator 36161330 Associate
★☆☆☆☆
Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck Squamous cell carcinoma Pubtator 28814981, 39748722 Associate
★☆☆☆☆
Found in Text Mining only
Unipolar Depression Mental Depression BEFREE 26192912
★☆☆☆☆
Found in Text Mining only