Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	163702
Gene name	Interferon lambda receptor 1
Gene symbol	IFNLR1
Synonyms (NCBI Gene)	CRF2/12IFNLRIL-28R1IL28RALICR2
Chromosome	1
Chromosome location	1p36.11
Summary	The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, in

255

Show/Hide all (255)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024759	hsa-miR-215-5p	Microarray	19074876
MIRT026809	hsa-miR-192-5p	Microarray	19074876
MIRT710804	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT710803	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT710802	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT710801	hsa-miR-365a-3p	HITS-CLIP	19536157
MIRT710800	hsa-miR-365b-3p	HITS-CLIP	19536157
MIRT710799	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT710798	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT710797	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT710796	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT710795	hsa-miR-3666	HITS-CLIP	19536157
MIRT710794	hsa-miR-4295	HITS-CLIP	19536157
MIRT710793	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT710792	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710791	hsa-miR-1470	HITS-CLIP	19536157
MIRT710790	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT710789	hsa-miR-210-5p	HITS-CLIP	19536157
MIRT710788	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT710804	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT710803	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT710802	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT710801	hsa-miR-365a-3p	HITS-CLIP	19536157
MIRT710800	hsa-miR-365b-3p	HITS-CLIP	19536157
MIRT710799	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT710798	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT710797	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT710796	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT710795	hsa-miR-3666	HITS-CLIP	19536157
MIRT710794	hsa-miR-4295	HITS-CLIP	19536157
MIRT710793	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT710792	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710791	hsa-miR-1470	HITS-CLIP	19536157
MIRT710790	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT710789	hsa-miR-210-5p	HITS-CLIP	19536157
MIRT710788	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT702782	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT702781	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT702780	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT702779	hsa-miR-4676-5p	HITS-CLIP	23313552
MIRT702778	hsa-miR-575	HITS-CLIP	23313552
MIRT702777	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT702776	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT702775	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT702774	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT702773	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT702772	hsa-miR-3926	HITS-CLIP	23313552
MIRT702771	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT702770	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT702769	hsa-miR-548s	HITS-CLIP	23313552
MIRT489448	hsa-miR-4496	PAR-CLIP	23592263
MIRT489447	hsa-miR-665	PAR-CLIP	23592263
MIRT489446	hsa-miR-1236-3p	PAR-CLIP	23592263
MIRT489445	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT489444	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT489443	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT489442	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT489440	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT489441	hsa-miR-3182	PAR-CLIP	23592263
MIRT489439	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT489438	hsa-miR-6090	PAR-CLIP	23592263
MIRT489437	hsa-miR-4300	PAR-CLIP	23592263
MIRT489436	hsa-miR-5591-5p	PAR-CLIP	23592263
MIRT489435	hsa-miR-6726-5p	PAR-CLIP	23592263
MIRT489434	hsa-miR-920	PAR-CLIP	23592263
MIRT489433	hsa-miR-4314	PAR-CLIP	23592263
MIRT475355	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT475354	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT475353	hsa-miR-3154	PAR-CLIP	23592263
MIRT475352	hsa-miR-4499	PAR-CLIP	23592263
MIRT475351	hsa-miR-4463	PAR-CLIP	23592263
MIRT475350	hsa-miR-4476	PAR-CLIP	23592263
MIRT475349	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT475347	hsa-miR-2682-5p	PAR-CLIP	23592263
MIRT475348	hsa-miR-34b-5p	PAR-CLIP	23592263
MIRT475346	hsa-miR-449c-5p	PAR-CLIP	23592263
MIRT475344	hsa-miR-6755-5p	PAR-CLIP	23592263
MIRT475345	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT475343	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT475342	hsa-miR-4667-5p	PAR-CLIP	23592263
MIRT475341	hsa-miR-4700-5p	PAR-CLIP	23592263
MIRT475340	hsa-miR-8089	PAR-CLIP	23592263
MIRT475339	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT475338	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT475337	hsa-miR-1827	PAR-CLIP	23592263
MIRT475336	hsa-miR-6804-5p	PAR-CLIP	23592263
MIRT475335	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT475334	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT475333	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT475332	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT475331	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT475330	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT475329	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT475328	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT475326	hsa-miR-4458	PAR-CLIP	23592263
MIRT475327	hsa-miR-4500	PAR-CLIP	23592263
MIRT475325	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT475324	hsa-miR-4533	PAR-CLIP	23592263
MIRT475323	hsa-miR-3612	PAR-CLIP	23592263
MIRT475322	hsa-miR-650	PAR-CLIP	23592263
MIRT475321	hsa-miR-1255a	PAR-CLIP	23592263
MIRT475320	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT475319	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT475318	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT475317	hsa-miR-449a	PAR-CLIP	23592263
MIRT475316	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT475314	hsa-miR-5187-5p	PAR-CLIP	23592263
MIRT475315	hsa-miR-4450	PAR-CLIP	23592263
MIRT475313	hsa-miR-197-5p	PAR-CLIP	23592263
MIRT475312	hsa-miR-3132	PAR-CLIP	23592263
MIRT475311	hsa-miR-4650-3p	PAR-CLIP	23592263
MIRT475310	hsa-miR-3529-5p	PAR-CLIP	23592263
MIRT475309	hsa-miR-379-5p	PAR-CLIP	23592263
MIRT475308	hsa-miR-151a-3p	PAR-CLIP	23592263
MIRT475306	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT475307	hsa-miR-5186	PAR-CLIP	23592263
MIRT475305	hsa-miR-4537	PAR-CLIP	23592263
MIRT475304	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT475303	hsa-miR-6086	PAR-CLIP	23592263
MIRT475302	hsa-miR-508-3p	PAR-CLIP	23592263
MIRT475301	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT475300	hsa-miR-3689d	PAR-CLIP	23592263
MIRT475299	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT475298	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT475297	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT475296	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT475295	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT475305	hsa-miR-4537	PAR-CLIP	27292025
MIRT475302	hsa-miR-508-3p	PAR-CLIP	27292025
MIRT475307	hsa-miR-5186	PAR-CLIP	27292025
MIRT710804	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT710803	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT710802	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT710801	hsa-miR-365a-3p	HITS-CLIP	19536157
MIRT710800	hsa-miR-365b-3p	HITS-CLIP	19536157
MIRT710799	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT710798	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT710797	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT710796	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT710795	hsa-miR-3666	HITS-CLIP	19536157
MIRT710794	hsa-miR-4295	HITS-CLIP	19536157
MIRT710793	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT710792	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710791	hsa-miR-1470	HITS-CLIP	19536157
MIRT710790	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT710789	hsa-miR-210-5p	HITS-CLIP	19536157
MIRT710788	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT710804	hsa-miR-519a-3p	HITS-CLIP	19536157
MIRT710803	hsa-miR-519b-3p	HITS-CLIP	19536157
MIRT710802	hsa-miR-519c-3p	HITS-CLIP	19536157
MIRT710801	hsa-miR-365a-3p	HITS-CLIP	19536157
MIRT710800	hsa-miR-365b-3p	HITS-CLIP	19536157
MIRT710799	hsa-miR-130a-3p	HITS-CLIP	19536157
MIRT710798	hsa-miR-130b-3p	HITS-CLIP	19536157
MIRT710797	hsa-miR-301a-3p	HITS-CLIP	19536157
MIRT710796	hsa-miR-301b-3p	HITS-CLIP	19536157
MIRT710795	hsa-miR-3666	HITS-CLIP	19536157
MIRT710794	hsa-miR-4295	HITS-CLIP	19536157
MIRT710793	hsa-miR-454-3p	HITS-CLIP	19536157
MIRT710792	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT710791	hsa-miR-1470	HITS-CLIP	19536157
MIRT710790	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT710789	hsa-miR-210-5p	HITS-CLIP	19536157
MIRT710788	hsa-miR-106a-3p	HITS-CLIP	19536157
MIRT702782	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT702781	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT702780	hsa-miR-6858-3p	HITS-CLIP	23313552
MIRT702779	hsa-miR-4676-5p	HITS-CLIP	23313552
MIRT702778	hsa-miR-575	HITS-CLIP	23313552
MIRT702777	hsa-miR-3613-3p	HITS-CLIP	23313552
MIRT702776	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT702775	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT702774	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT702773	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT702772	hsa-miR-3926	HITS-CLIP	23313552
MIRT702771	hsa-miR-4662a-5p	HITS-CLIP	23313552
MIRT702770	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT702769	hsa-miR-548s	HITS-CLIP	23313552
MIRT489448	hsa-miR-4496	PAR-CLIP	23592263
MIRT489447	hsa-miR-665	PAR-CLIP	23592263
MIRT489446	hsa-miR-1236-3p	PAR-CLIP	23592263
MIRT489445	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT489444	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT489443	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT489442	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT489440	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT489441	hsa-miR-3182	PAR-CLIP	23592263
MIRT489439	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT489438	hsa-miR-6090	PAR-CLIP	23592263
MIRT489437	hsa-miR-4300	PAR-CLIP	23592263
MIRT489436	hsa-miR-5591-5p	PAR-CLIP	23592263
MIRT489435	hsa-miR-6726-5p	PAR-CLIP	23592263
MIRT489434	hsa-miR-920	PAR-CLIP	23592263
MIRT489433	hsa-miR-4314	PAR-CLIP	23592263
MIRT475355	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT475354	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT475353	hsa-miR-3154	PAR-CLIP	23592263
MIRT475352	hsa-miR-4499	PAR-CLIP	23592263
MIRT475351	hsa-miR-4463	PAR-CLIP	23592263
MIRT475350	hsa-miR-4476	PAR-CLIP	23592263
MIRT475349	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT475347	hsa-miR-2682-5p	PAR-CLIP	23592263
MIRT475348	hsa-miR-34b-5p	PAR-CLIP	23592263
MIRT475346	hsa-miR-449c-5p	PAR-CLIP	23592263
MIRT475344	hsa-miR-6755-5p	PAR-CLIP	23592263
MIRT475345	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT475343	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT475342	hsa-miR-4667-5p	PAR-CLIP	23592263
MIRT475341	hsa-miR-4700-5p	PAR-CLIP	23592263
MIRT475340	hsa-miR-8089	PAR-CLIP	23592263
MIRT475339	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT475338	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT475337	hsa-miR-1827	PAR-CLIP	23592263
MIRT475336	hsa-miR-6804-5p	PAR-CLIP	23592263
MIRT475335	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT475334	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT475333	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT475332	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT475331	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT475330	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT475329	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT475328	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT475326	hsa-miR-4458	PAR-CLIP	23592263
MIRT475327	hsa-miR-4500	PAR-CLIP	23592263
MIRT475325	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT475324	hsa-miR-4533	PAR-CLIP	23592263
MIRT475323	hsa-miR-3612	PAR-CLIP	23592263
MIRT475322	hsa-miR-650	PAR-CLIP	23592263
MIRT475321	hsa-miR-1255a	PAR-CLIP	23592263
MIRT475320	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT475319	hsa-miR-34a-5p	PAR-CLIP	23592263
MIRT475318	hsa-miR-34c-5p	PAR-CLIP	23592263
MIRT475317	hsa-miR-449a	PAR-CLIP	23592263
MIRT475316	hsa-miR-449b-5p	PAR-CLIP	23592263
MIRT475314	hsa-miR-5187-5p	PAR-CLIP	23592263
MIRT475315	hsa-miR-4450	PAR-CLIP	23592263
MIRT475313	hsa-miR-197-5p	PAR-CLIP	23592263
MIRT475312	hsa-miR-3132	PAR-CLIP	23592263
MIRT475311	hsa-miR-4650-3p	PAR-CLIP	23592263
MIRT475310	hsa-miR-3529-5p	PAR-CLIP	23592263
MIRT475309	hsa-miR-379-5p	PAR-CLIP	23592263
MIRT475308	hsa-miR-151a-3p	PAR-CLIP	23592263
MIRT475306	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT475307	hsa-miR-5186	PAR-CLIP	23592263
MIRT475305	hsa-miR-4537	PAR-CLIP	23592263
MIRT475304	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT475303	hsa-miR-6086	PAR-CLIP	23592263
MIRT475302	hsa-miR-508-3p	PAR-CLIP	23592263
MIRT475301	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT475300	hsa-miR-3689d	PAR-CLIP	23592263
MIRT475299	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT475298	hsa-miR-6880-5p	PAR-CLIP	23592263
MIRT475297	hsa-miR-7847-3p	PAR-CLIP	23592263
MIRT475296	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT475295	hsa-miR-6516-5p	PAR-CLIP	23592263

Show/Hide all (1)

Transcription factor	Regulation	Reference
STAT1	Unknown	20372826

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002385	Process	Mucosal immune response	IEA
GO:0002385	Process	Mucosal immune response	ISS
GO:0004896	Function	Cytokine receptor activity	IBA
GO:0004896	Function	Cytokine receptor activity	NAS	12483210
GO:0005515	Function	Protein binding	IPI	12469119, 12483210, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0008285	Process	Negative regulation of cell population proliferation	NAS	12469119
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	12483210
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0032002	Component	Interleukin-28 receptor complex	IDA	12469119
GO:0034342	Process	Response to type III interferon	ISS
GO:0038196	Process	Type III interferon-mediated signaling pathway	NAS	30936491
GO:0050691	Process	Regulation of defense response to virus by host	IDA	12469119
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	ISS
GO:0098586	Process	Cellular response to virus	NAS	30936491
GO:1901857	Process	Positive regulation of cellular respiration	IMP	25930096

MIM	HGNC	e!Ensembl
607404	18584	ENSG00000185436

Q8IU57

Protein name

Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (L

Protein function

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimula

PDB

3OG4 , 3OG6 , 5IXD , 5IXI , 5L04 , 5T5W , 9BPU , 9BPV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01108	Tissue_fac	8 → 111	Tissue factor	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}.

Sequence

MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQ
SSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYL
FEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQ
PVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLL
VIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTR
GVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHS
EAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDG
HQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSP
EEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR

Sequence length

520

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway		Other interleukin signaling Interleukin-20 family signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IFNLR1-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY SKIN DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS VULGARIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (32)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Allergic rhinitis (disorder)	Allergic rhinitis	BEFREE	16819289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	23078630	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	24286242	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	23252691		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	22386267		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bronchiolitis	Bronchiolitis	BEFREE	29549834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	20372826		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	27433031		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	36421848	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Eosinophilia	Eosinophilia	BEFREE	29549834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	28342759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	28777004	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	21707611, 24070858		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	20372826		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	20372826		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	31799654		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20372826		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	20103601	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	22386267		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	27433031	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	31799654		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	31799654	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pseudohyperkalemia Cardiff	Pseudohyperkalemia Cardiff	BEFREE	24752298		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	CTD_human_DG	20953190		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	BEFREE	23897274, 24070858, 30632069		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis vulgaris	Psoriasis vulgaris	BEFREE	23252691		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pustulosis of Palms and Soles	Palmoplantar Pustules	CTD_human_DG	20953190		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	24286242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhinitis	Rhinitis	LHGDN	16819289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Sjogren syndrome	Pubtator	27613139	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vitiligo	Vitiligo	BEFREE	22333690		★★★★★ ★☆☆☆☆ Found in Text Mining only
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)	Vitiligo-associated SYSTEMIC LUPUS ERYTHEMATOSUS	BEFREE	22333690		★★★★★ ★☆☆☆☆ Found in Text Mining only

IFNLR1 (interferon lambda receptor 1)