DENND1B (DENN domain containing 1B)

Gene

• Entrez ID: 163486
• Gene name: DENN domain containing 1B
• Gene symbol: DENND1B
• Synonyms (NCBI Gene): C1ORF18, C1orf218, FAM31B
• Chromosome: 1
• Chromosome location: 1q31.3
• Summary: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT497954	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT497953	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT497952	hsa-miR-802	PAR-CLIP	22291592
MIRT497951	hsa-miR-532-5p	PAR-CLIP	22291592
MIRT497950	hsa-miR-4312	PAR-CLIP	22291592
MIRT497949	hsa-miR-155-5p	PAR-CLIP	22291592
MIRT497948	hsa-miR-6869-5p	PAR-CLIP	22291592
MIRT497954	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT497953	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT497952	hsa-miR-802	PAR-CLIP	22291592
MIRT497951	hsa-miR-532-5p	PAR-CLIP	22291592
MIRT497950	hsa-miR-4312	PAR-CLIP	22291592
MIRT497949	hsa-miR-155-5p	PAR-CLIP	22291592
MIRT497948	hsa-miR-6869-5p	PAR-CLIP	22291592
MIRT932190	hsa-miR-101	CLIP-seq
MIRT932191	hsa-miR-103a	CLIP-seq
MIRT932192	hsa-miR-107	CLIP-seq
MIRT932193	hsa-miR-1178	CLIP-seq
MIRT932194	hsa-miR-1184	CLIP-seq
MIRT932195	hsa-miR-1200	CLIP-seq
MIRT932196	hsa-miR-1205	CLIP-seq
MIRT932197	hsa-miR-1206	CLIP-seq
MIRT932198	hsa-miR-1244	CLIP-seq
MIRT932199	hsa-miR-1270	CLIP-seq
MIRT932200	hsa-miR-128	CLIP-seq
MIRT932201	hsa-miR-129-5p	CLIP-seq
MIRT932202	hsa-miR-1297	CLIP-seq
MIRT932203	hsa-miR-132	CLIP-seq
MIRT932204	hsa-miR-1323	CLIP-seq
MIRT932205	hsa-miR-137	CLIP-seq
MIRT932206	hsa-miR-141	CLIP-seq
MIRT932207	hsa-miR-142-5p	CLIP-seq
MIRT932208	hsa-miR-15a	CLIP-seq
MIRT932209	hsa-miR-15b	CLIP-seq
MIRT932210	hsa-miR-16	CLIP-seq
MIRT932211	hsa-miR-182	CLIP-seq
MIRT932212	hsa-miR-195	CLIP-seq
MIRT932213	hsa-miR-200a	CLIP-seq
MIRT932214	hsa-miR-205	CLIP-seq
MIRT932215	hsa-miR-2054	CLIP-seq
MIRT932216	hsa-miR-212	CLIP-seq
MIRT932217	hsa-miR-23a	CLIP-seq
MIRT932218	hsa-miR-23b	CLIP-seq
MIRT932219	hsa-miR-23c	CLIP-seq
MIRT932220	hsa-miR-26a	CLIP-seq
MIRT932221	hsa-miR-26b	CLIP-seq
MIRT932222	hsa-miR-298	CLIP-seq
MIRT932223	hsa-miR-29a	CLIP-seq
MIRT932224	hsa-miR-29b	CLIP-seq
MIRT932225	hsa-miR-29c	CLIP-seq
MIRT932226	hsa-miR-3065-3p	CLIP-seq
MIRT932227	hsa-miR-3074-5p	CLIP-seq
MIRT932228	hsa-miR-30a	CLIP-seq
MIRT932229	hsa-miR-30b	CLIP-seq
MIRT932230	hsa-miR-30c	CLIP-seq
MIRT932231	hsa-miR-30d	CLIP-seq
MIRT932232	hsa-miR-30e	CLIP-seq
MIRT932233	hsa-miR-3120-5p	CLIP-seq
MIRT932234	hsa-miR-3121-5p	CLIP-seq
MIRT932235	hsa-miR-3132	CLIP-seq
MIRT932236	hsa-miR-3140-3p	CLIP-seq
MIRT932237	hsa-miR-3140-5p	CLIP-seq
MIRT932238	hsa-miR-3153	CLIP-seq
MIRT932239	hsa-miR-3158-5p	CLIP-seq
MIRT932240	hsa-miR-3182	CLIP-seq
MIRT932241	hsa-miR-3194-3p	CLIP-seq
MIRT932242	hsa-miR-3200-3p	CLIP-seq
MIRT932243	hsa-miR-324-5p	CLIP-seq
MIRT932244	hsa-miR-337-3p	CLIP-seq
MIRT932245	hsa-miR-340	CLIP-seq
MIRT932246	hsa-miR-3613-3p	CLIP-seq
MIRT932247	hsa-miR-362-5p	CLIP-seq
MIRT932248	hsa-miR-3647-3p	CLIP-seq
MIRT932249	hsa-miR-365	CLIP-seq
MIRT932250	hsa-miR-3668	CLIP-seq
MIRT932251	hsa-miR-3692	CLIP-seq
MIRT932252	hsa-miR-369-3p	CLIP-seq
MIRT932253	hsa-miR-371b-5p	CLIP-seq
MIRT932254	hsa-miR-374a	CLIP-seq
MIRT932255	hsa-miR-374b	CLIP-seq
MIRT932256	hsa-miR-375	CLIP-seq
MIRT932257	hsa-miR-383	CLIP-seq
MIRT932258	hsa-miR-3910	CLIP-seq
MIRT932259	hsa-miR-424	CLIP-seq
MIRT932260	hsa-miR-4260	CLIP-seq
MIRT932261	hsa-miR-4277	CLIP-seq
MIRT932262	hsa-miR-4291	CLIP-seq
MIRT932263	hsa-miR-4326	CLIP-seq
MIRT932264	hsa-miR-4420	CLIP-seq
MIRT932265	hsa-miR-4422	CLIP-seq
MIRT932266	hsa-miR-4426	CLIP-seq
MIRT932267	hsa-miR-4460	CLIP-seq
MIRT932268	hsa-miR-4464	CLIP-seq
MIRT932269	hsa-miR-4465	CLIP-seq
MIRT932270	hsa-miR-4480	CLIP-seq
MIRT932271	hsa-miR-4503	CLIP-seq
MIRT932272	hsa-miR-4524	CLIP-seq
MIRT932273	hsa-miR-4531	CLIP-seq
MIRT932274	hsa-miR-455-5p	CLIP-seq
MIRT932275	hsa-miR-4645-3p	CLIP-seq
MIRT932276	hsa-miR-4645-5p	CLIP-seq
MIRT932277	hsa-miR-4646-5p	CLIP-seq
MIRT932278	hsa-miR-4647	CLIP-seq
MIRT932279	hsa-miR-4659a-3p	CLIP-seq
MIRT932280	hsa-miR-4659b-3p	CLIP-seq
MIRT932281	hsa-miR-4662b	CLIP-seq
MIRT932282	hsa-miR-4668-3p	CLIP-seq
MIRT932283	hsa-miR-4668-5p	CLIP-seq
MIRT932284	hsa-miR-4673	CLIP-seq
MIRT932285	hsa-miR-4683	CLIP-seq
MIRT932286	hsa-miR-4686	CLIP-seq
MIRT932287	hsa-miR-4694-3p	CLIP-seq
MIRT932288	hsa-miR-4718	CLIP-seq
MIRT932289	hsa-miR-4719	CLIP-seq
MIRT932290	hsa-miR-4727-3p	CLIP-seq
MIRT932291	hsa-miR-4727-5p	CLIP-seq
MIRT932292	hsa-miR-4742-5p	CLIP-seq
MIRT932293	hsa-miR-4748	CLIP-seq
MIRT932294	hsa-miR-4760-3p	CLIP-seq
MIRT932295	hsa-miR-4772-5p	CLIP-seq
MIRT932296	hsa-miR-4776-3p	CLIP-seq
MIRT932297	hsa-miR-4789-5p	CLIP-seq
MIRT932298	hsa-miR-4795-3p	CLIP-seq
MIRT932299	hsa-miR-4799-5p	CLIP-seq
MIRT932300	hsa-miR-486-3p	CLIP-seq
MIRT932301	hsa-miR-497	CLIP-seq
MIRT932302	hsa-miR-500b	CLIP-seq
MIRT932303	hsa-miR-501-5p	CLIP-seq
MIRT932304	hsa-miR-503	CLIP-seq
MIRT932305	hsa-miR-513b	CLIP-seq
MIRT932306	hsa-miR-520a-5p	CLIP-seq
MIRT932307	hsa-miR-520f	CLIP-seq
MIRT932308	hsa-miR-525-5p	CLIP-seq
MIRT932309	hsa-miR-544	CLIP-seq
MIRT932310	hsa-miR-545	CLIP-seq
MIRT932311	hsa-miR-548a-5p	CLIP-seq
MIRT932312	hsa-miR-548aa	CLIP-seq
MIRT932313	hsa-miR-548ab	CLIP-seq
MIRT932314	hsa-miR-548ac	CLIP-seq
MIRT932315	hsa-miR-548ae	CLIP-seq
MIRT932316	hsa-miR-548aj	CLIP-seq
MIRT932317	hsa-miR-548ak	CLIP-seq
MIRT932318	hsa-miR-548am	CLIP-seq
MIRT932319	hsa-miR-548an	CLIP-seq
MIRT932320	hsa-miR-548b-5p	CLIP-seq
MIRT932321	hsa-miR-548c-5p	CLIP-seq
MIRT932322	hsa-miR-548d-3p	CLIP-seq
MIRT932323	hsa-miR-548d-5p	CLIP-seq
MIRT932324	hsa-miR-548h	CLIP-seq
MIRT932325	hsa-miR-548i	CLIP-seq
MIRT932326	hsa-miR-548j	CLIP-seq
MIRT932327	hsa-miR-548k	CLIP-seq
MIRT932328	hsa-miR-548l	CLIP-seq
MIRT932329	hsa-miR-548n	CLIP-seq
MIRT932330	hsa-miR-548o	CLIP-seq
MIRT932331	hsa-miR-548v	CLIP-seq
MIRT932332	hsa-miR-548w	CLIP-seq
MIRT932333	hsa-miR-548x	CLIP-seq
MIRT932334	hsa-miR-548y	CLIP-seq
MIRT932335	hsa-miR-548z	CLIP-seq
MIRT932336	hsa-miR-553	CLIP-seq
MIRT932337	hsa-miR-559	CLIP-seq
MIRT932338	hsa-miR-579	CLIP-seq
MIRT932339	hsa-miR-620	CLIP-seq
MIRT932340	hsa-miR-622	CLIP-seq
MIRT932341	hsa-miR-646	CLIP-seq
MIRT932342	hsa-miR-938	CLIP-seq
MIRT932191	hsa-miR-103a	CLIP-seq
MIRT932192	hsa-miR-107	CLIP-seq
MIRT1976011	hsa-miR-1237	CLIP-seq
MIRT1976012	hsa-miR-1245b-3p	CLIP-seq
MIRT1976013	hsa-miR-1248	CLIP-seq
MIRT1976014	hsa-miR-1283	CLIP-seq
MIRT932201	hsa-miR-129-5p	CLIP-seq
MIRT1976015	hsa-miR-154	CLIP-seq
MIRT932208	hsa-miR-15a	CLIP-seq
MIRT932209	hsa-miR-15b	CLIP-seq
MIRT932210	hsa-miR-16	CLIP-seq
MIRT932212	hsa-miR-195	CLIP-seq
MIRT1976016	hsa-miR-2052	CLIP-seq
MIRT1976017	hsa-miR-219-1-3p	CLIP-seq
MIRT1976018	hsa-miR-31	CLIP-seq
MIRT932236	hsa-miR-3140-3p	CLIP-seq
MIRT1976019	hsa-miR-3155	CLIP-seq
MIRT1976020	hsa-miR-3155b	CLIP-seq
MIRT1976021	hsa-miR-3157-5p	CLIP-seq
MIRT1976022	hsa-miR-3161	CLIP-seq
MIRT1976023	hsa-miR-3173-3p	CLIP-seq
MIRT1976024	hsa-miR-320a	CLIP-seq
MIRT1976025	hsa-miR-320b	CLIP-seq
MIRT1976026	hsa-miR-320c	CLIP-seq
MIRT1976027	hsa-miR-320d	CLIP-seq
MIRT1976028	hsa-miR-323b-3p	CLIP-seq
MIRT1976029	hsa-miR-338-5p	CLIP-seq
MIRT1976030	hsa-miR-339-5p	CLIP-seq
MIRT932248	hsa-miR-3647-3p	CLIP-seq
MIRT1976031	hsa-miR-3685	CLIP-seq
MIRT932257	hsa-miR-383	CLIP-seq
MIRT1976032	hsa-miR-3907	CLIP-seq
MIRT1976033	hsa-miR-3923	CLIP-seq
MIRT932259	hsa-miR-424	CLIP-seq
MIRT1976034	hsa-miR-4263	CLIP-seq
MIRT1976035	hsa-miR-4282	CLIP-seq
MIRT1976036	hsa-miR-4307	CLIP-seq
MIRT1976037	hsa-miR-4330	CLIP-seq
MIRT1976038	hsa-miR-4428	CLIP-seq
MIRT1976039	hsa-miR-4429	CLIP-seq
MIRT1976040	hsa-miR-4452	CLIP-seq
MIRT932270	hsa-miR-4480	CLIP-seq
MIRT1976041	hsa-miR-4521	CLIP-seq
MIRT932272	hsa-miR-4524	CLIP-seq
MIRT1976042	hsa-miR-4659a-5p	CLIP-seq
MIRT1976043	hsa-miR-4659b-5p	CLIP-seq
MIRT932282	hsa-miR-4668-3p	CLIP-seq
MIRT1976044	hsa-miR-4691-3p	CLIP-seq
MIRT1976045	hsa-miR-4704-5p	CLIP-seq
MIRT1976046	hsa-miR-4738-3p	CLIP-seq
MIRT932292	hsa-miR-4742-5p	CLIP-seq
MIRT1976047	hsa-miR-4761-5p	CLIP-seq
MIRT932295	hsa-miR-4772-5p	CLIP-seq
MIRT1976048	hsa-miR-4775	CLIP-seq
MIRT932296	hsa-miR-4776-3p	CLIP-seq
MIRT1976049	hsa-miR-4777-3p	CLIP-seq
MIRT932298	hsa-miR-4795-3p	CLIP-seq
MIRT932299	hsa-miR-4799-5p	CLIP-seq
MIRT1976050	hsa-miR-484	CLIP-seq
MIRT932301	hsa-miR-497	CLIP-seq
MIRT932304	hsa-miR-503	CLIP-seq
MIRT1976051	hsa-miR-513a-5p	CLIP-seq
MIRT1976052	hsa-miR-539	CLIP-seq
MIRT932311	hsa-miR-548a-5p	CLIP-seq
MIRT932313	hsa-miR-548ab	CLIP-seq
MIRT932317	hsa-miR-548ak	CLIP-seq
MIRT932320	hsa-miR-548b-5p	CLIP-seq
MIRT932321	hsa-miR-548c-5p	CLIP-seq
MIRT932323	hsa-miR-548d-5p	CLIP-seq
MIRT1976053	hsa-miR-548g	CLIP-seq
MIRT932324	hsa-miR-548h	CLIP-seq
MIRT932325	hsa-miR-548i	CLIP-seq
MIRT932326	hsa-miR-548j	CLIP-seq
MIRT932328	hsa-miR-548l	CLIP-seq
MIRT932332	hsa-miR-548w	CLIP-seq
MIRT932334	hsa-miR-548y	CLIP-seq
MIRT932337	hsa-miR-559	CLIP-seq
MIRT1976054	hsa-miR-571	CLIP-seq
MIRT1976055	hsa-miR-576-5p	CLIP-seq
MIRT932341	hsa-miR-646	CLIP-seq
MIRT932191	hsa-miR-103a	CLIP-seq
MIRT2211415	hsa-miR-105	CLIP-seq
MIRT932192	hsa-miR-107	CLIP-seq
MIRT2211416	hsa-miR-1182	CLIP-seq
MIRT2211417	hsa-miR-1183	CLIP-seq
MIRT932197	hsa-miR-1206	CLIP-seq
MIRT932198	hsa-miR-1244	CLIP-seq
MIRT932200	hsa-miR-128	CLIP-seq
MIRT1976014	hsa-miR-1283	CLIP-seq
MIRT932201	hsa-miR-129-5p	CLIP-seq
MIRT932203	hsa-miR-132	CLIP-seq
MIRT2211418	hsa-miR-136	CLIP-seq
MIRT932206	hsa-miR-141	CLIP-seq
MIRT2211419	hsa-miR-143	CLIP-seq
MIRT2211420	hsa-miR-144	CLIP-seq
MIRT2211421	hsa-miR-147	CLIP-seq
MIRT932208	hsa-miR-15a	CLIP-seq
MIRT932209	hsa-miR-15b	CLIP-seq
MIRT932210	hsa-miR-16	CLIP-seq
MIRT932211	hsa-miR-182	CLIP-seq
MIRT2211422	hsa-miR-193a-5p	CLIP-seq
MIRT2211423	hsa-miR-194	CLIP-seq
MIRT932212	hsa-miR-195	CLIP-seq
MIRT932213	hsa-miR-200a	CLIP-seq
MIRT1976016	hsa-miR-2052	CLIP-seq
MIRT2211424	hsa-miR-2113	CLIP-seq
MIRT932216	hsa-miR-212	CLIP-seq
MIRT2211425	hsa-miR-216a	CLIP-seq
MIRT1976017	hsa-miR-219-1-3p	CLIP-seq
MIRT2211426	hsa-miR-2277-3p	CLIP-seq
MIRT2211427	hsa-miR-2682	CLIP-seq
MIRT932222	hsa-miR-298	CLIP-seq
MIRT932223	hsa-miR-29a	CLIP-seq
MIRT932224	hsa-miR-29b	CLIP-seq
MIRT932225	hsa-miR-29c	CLIP-seq
MIRT2211428	hsa-miR-3065-5p	CLIP-seq
MIRT1976018	hsa-miR-31	CLIP-seq
MIRT2211429	hsa-miR-3121-3p	CLIP-seq
MIRT2211430	hsa-miR-3127-5p	CLIP-seq
MIRT932236	hsa-miR-3140-3p	CLIP-seq
MIRT2211431	hsa-miR-3143	CLIP-seq
MIRT2211432	hsa-miR-3152-3p	CLIP-seq
MIRT932238	hsa-miR-3153	CLIP-seq
MIRT1976019	hsa-miR-3155	CLIP-seq
MIRT1976020	hsa-miR-3155b	CLIP-seq
MIRT1976022	hsa-miR-3161	CLIP-seq
MIRT2211433	hsa-miR-3170	CLIP-seq
MIRT1976023	hsa-miR-3173-3p	CLIP-seq
MIRT932242	hsa-miR-3200-3p	CLIP-seq
MIRT932245	hsa-miR-340	CLIP-seq
MIRT2211434	hsa-miR-3545-3p	CLIP-seq
MIRT932246	hsa-miR-3613-3p	CLIP-seq
MIRT2211435	hsa-miR-3613-5p	CLIP-seq
MIRT2211436	hsa-miR-3622a-5p	CLIP-seq
MIRT2211437	hsa-miR-3646	CLIP-seq
MIRT932249	hsa-miR-365	CLIP-seq
MIRT2211438	hsa-miR-3662	CLIP-seq
MIRT932250	hsa-miR-3668	CLIP-seq
MIRT2211439	hsa-miR-3671	CLIP-seq
MIRT1976031	hsa-miR-3685	CLIP-seq
MIRT2211440	hsa-miR-3688-3p	CLIP-seq
MIRT2211441	hsa-miR-371-5p	CLIP-seq
MIRT932253	hsa-miR-371b-5p	CLIP-seq
MIRT932257	hsa-miR-383	CLIP-seq
MIRT932258	hsa-miR-3910	CLIP-seq
MIRT2211442	hsa-miR-3935	CLIP-seq
MIRT2211443	hsa-miR-3941	CLIP-seq
MIRT932259	hsa-miR-424	CLIP-seq
MIRT2211444	hsa-miR-4273	CLIP-seq
MIRT932261	hsa-miR-4277	CLIP-seq
MIRT2211445	hsa-miR-4294	CLIP-seq
MIRT2211446	hsa-miR-4310	CLIP-seq
MIRT2211447	hsa-miR-4328	CLIP-seq
MIRT932265	hsa-miR-4422	CLIP-seq
MIRT2211448	hsa-miR-4423-3p	CLIP-seq
MIRT1976038	hsa-miR-4428	CLIP-seq
MIRT2211449	hsa-miR-4433	CLIP-seq
MIRT2211450	hsa-miR-4459	CLIP-seq
MIRT2211451	hsa-miR-449c	CLIP-seq
MIRT932271	hsa-miR-4503	CLIP-seq
MIRT1976041	hsa-miR-4521	CLIP-seq
MIRT932272	hsa-miR-4524	CLIP-seq
MIRT2211452	hsa-miR-4528	CLIP-seq
MIRT932274	hsa-miR-455-5p	CLIP-seq
MIRT2211453	hsa-miR-4643	CLIP-seq
MIRT932277	hsa-miR-4646-5p	CLIP-seq
MIRT2211454	hsa-miR-4652-3p	CLIP-seq
MIRT1976042	hsa-miR-4659a-5p	CLIP-seq
MIRT1976043	hsa-miR-4659b-5p	CLIP-seq
MIRT2211455	hsa-miR-466	CLIP-seq
MIRT932283	hsa-miR-4668-5p	CLIP-seq
MIRT2211456	hsa-miR-4672	CLIP-seq
MIRT932287	hsa-miR-4694-3p	CLIP-seq
MIRT2211457	hsa-miR-4698	CLIP-seq
MIRT932290	hsa-miR-4727-3p	CLIP-seq
MIRT932292	hsa-miR-4742-5p	CLIP-seq
MIRT2211458	hsa-miR-4768-3p	CLIP-seq
MIRT2211459	hsa-miR-4770	CLIP-seq
MIRT932295	hsa-miR-4772-5p	CLIP-seq
MIRT932296	hsa-miR-4776-3p	CLIP-seq
MIRT2211460	hsa-miR-4778-5p	CLIP-seq
MIRT2211461	hsa-miR-4781-3p	CLIP-seq
MIRT2211462	hsa-miR-4789-3p	CLIP-seq
MIRT932297	hsa-miR-4789-5p	CLIP-seq
MIRT932298	hsa-miR-4795-3p	CLIP-seq
MIRT932299	hsa-miR-4799-5p	CLIP-seq
MIRT1976050	hsa-miR-484	CLIP-seq
MIRT2211463	hsa-miR-496	CLIP-seq
MIRT932301	hsa-miR-497	CLIP-seq
MIRT932304	hsa-miR-503	CLIP-seq
MIRT1976051	hsa-miR-513a-5p	CLIP-seq
MIRT1976052	hsa-miR-539	CLIP-seq
MIRT2211464	hsa-miR-543	CLIP-seq
MIRT932311	hsa-miR-548a-5p	CLIP-seq
MIRT932313	hsa-miR-548ab	CLIP-seq
MIRT932314	hsa-miR-548ac	CLIP-seq
MIRT932315	hsa-miR-548ae	CLIP-seq
MIRT932316	hsa-miR-548aj	CLIP-seq
MIRT932317	hsa-miR-548ak	CLIP-seq
MIRT932318	hsa-miR-548am	CLIP-seq
MIRT932320	hsa-miR-548b-5p	CLIP-seq
MIRT932321	hsa-miR-548c-5p	CLIP-seq
MIRT932322	hsa-miR-548d-3p	CLIP-seq
MIRT932323	hsa-miR-548d-5p	CLIP-seq
MIRT932324	hsa-miR-548h	CLIP-seq
MIRT932325	hsa-miR-548i	CLIP-seq
MIRT932326	hsa-miR-548j	CLIP-seq
MIRT932327	hsa-miR-548k	CLIP-seq
MIRT932328	hsa-miR-548l	CLIP-seq
MIRT932329	hsa-miR-548n	CLIP-seq
MIRT932332	hsa-miR-548w	CLIP-seq
MIRT932333	hsa-miR-548x	CLIP-seq
MIRT932334	hsa-miR-548y	CLIP-seq
MIRT932335	hsa-miR-548z	CLIP-seq
MIRT932336	hsa-miR-553	CLIP-seq
MIRT932337	hsa-miR-559	CLIP-seq
MIRT1976054	hsa-miR-571	CLIP-seq
MIRT2211465	hsa-miR-586	CLIP-seq
MIRT2211466	hsa-miR-599	CLIP-seq
MIRT932341	hsa-miR-646	CLIP-seq
MIRT2211467	hsa-miR-885-5p	CLIP-seq
MIRT2211468	hsa-miR-934	CLIP-seq
MIRT932201	hsa-miR-129-5p	CLIP-seq
MIRT932206	hsa-miR-141	CLIP-seq
MIRT932213	hsa-miR-200a	CLIP-seq
MIRT932223	hsa-miR-29a	CLIP-seq
MIRT932224	hsa-miR-29b	CLIP-seq
MIRT932225	hsa-miR-29c	CLIP-seq
MIRT932271	hsa-miR-4503	CLIP-seq
MIRT932277	hsa-miR-4646-5p	CLIP-seq
MIRT932217	hsa-miR-23a	CLIP-seq
MIRT932218	hsa-miR-23b	CLIP-seq
MIRT932219	hsa-miR-23c	CLIP-seq
MIRT932228	hsa-miR-30a	CLIP-seq
MIRT932229	hsa-miR-30b	CLIP-seq
MIRT932230	hsa-miR-30c	CLIP-seq
MIRT932231	hsa-miR-30d	CLIP-seq
MIRT932232	hsa-miR-30e	CLIP-seq
MIRT2515198	hsa-miR-570	CLIP-seq
MIRT932338	hsa-miR-579	CLIP-seq
MIRT932222	hsa-miR-298	CLIP-seq
MIRT2211457	hsa-miR-4698	CLIP-seq
MIRT2679155	hsa-miR-548a-3p	CLIP-seq
MIRT2679156	hsa-miR-548e	CLIP-seq
MIRT2679157	hsa-miR-548f	CLIP-seq
MIRT1976053	hsa-miR-548g	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006897	Process	Endocytosis	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016607	Component	Nuclear speck	IBA
GO:0016607	Component	Nuclear speck	IDA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032456	Process	Endocytic recycling	IBA
GO:0032456	Process	Endocytic recycling	IEA
GO:0032456	Process	Endocytic recycling	ISS
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0050776	Process	Regulation of immune response	IEA
GO:0050776	Process	Regulation of immune response	ISS
GO:0050852	Process	T cell receptor signaling pathway	IBA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0050852	Process	T cell receptor signaling pathway	IMP	26774822
GO:1901981	Function	Phosphatidylinositol phosphate binding	IBA
GO:2000553	Process	Positive regulation of T-helper 2 cell cytokine production	IEA
GO:2000553	Process	Positive regulation of T-helper 2 cell cytokine production	IMP	26774822

Other IDs

• MIM: 613292
• HGNC: 28404
• e!Ensembl: ENSG00000213047

Protein

• UniProt ID: Q6P3S1
• Protein name: DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B)
• Protein function: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP,
• PDB: 3TW8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03456	uDENN	29 → 88	uDENN domain	Domain
  PF02141	DENN	92 → 291	DENN (AEX-3) domain	Family
  PF03455	dDENN	355 → 405	dDENN domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive T-cells. {ECO:0000269|PubMed:20032
• Sequence:

  MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV
  SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK
  ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTG
  LPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMY
  WQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDL
  NNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESF
  VKHRSSVMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPRSYQ
  QWVHTVKKGGALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYGTCSS
  SVQYTPVYKLHNEKGGNSEKRKLAQARLKRPLKSLDGALYDDEDDDDIERASKLSSEDGE
  EASAYLYESDDSVETRVKTPYSGEMDLLGEILDTLSTHSSDQGKLAAAKSLDFFRSMDDI
  DYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSSSGLTDSL
  FILKEENSNKHLGADNVSDPTSGLDFQLTSPEVSQTDKGKTEKRETLSQISDDLLIPGLG
  RHSSTFVPWEKEGKEAKETSEDIGLLHEVVSLCHMTSDFQQSLNISDKNTNGNQT

• Sequence length: 775

Pathways

Reactome:

RAB GEFs exchange GTP for GDP on RABs

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BILIARY CIRRHOSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BILIARY LIVER CIRRHOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN DISEASE	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHNS DISEASE OF LARGE BOWEL	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EXOSTOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, BILIARY	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NARCOLEPSY-CATAPLEXY SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CHOLANGITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CIRRHOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Ankylosing spondylitis	Ankylosing Spondylitis	GWASCAT_DG	26974007		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	20032318, 21150878, 23517042, 28668455		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	20032318, 23517042	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	GWASDB_DG	21907864		★☆☆☆☆ Found in Text Mining only
Biliary cirrhosis	Biliary cirrhosis	CTD_human_DG	21399635		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Biliary Cirrhosis, Primary, 1	Biliary cirrhosis	CTD_human_DG	21399635		★☆☆☆☆ Found in Text Mining only
Childhood asthma	Asthma	BEFREE	20032318, 26774822		★☆☆☆☆ Found in Text Mining only
Cholangitis, Sclerosing	Cholangitis	GWASCAT_DG	26974007		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASCAT_DG	21102463, 26192919, 26974007, 28067908		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Crohn Disease	Crohn Disease	CTD_human_DG	21102463		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Crohn Disease	Crohn Disease	GWASDB_DG	21102463		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Crohn`s disease of large bowel	Crohn`s Disease Of Large Bowel	CTD_human_DG	21102463		★☆☆☆☆ Found in Text Mining only
Crohn`s disease of the ileum	Crohn`s Disease Of The Ileum	CTD_human_DG	21102463		★☆☆☆☆ Found in Text Mining only
Dementia Vascular	Vascular dementia	Pubtator	39909351	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	24455749	Associate	★☆☆☆☆ Found in Text Mining only
IIeocolitis	Ileocolitis	CTD_human_DG	21102463		★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	26774822		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASDB_DG	23128233		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	GWASCAT_DG	23128233, 26192919, 28067908		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	27479909, 29662059, 30718901		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Narcolepsy	Narcolepsy	Pubtator	37188663	Associate	★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	24455749	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	25945796	Associate	★☆☆☆☆ Found in Text Mining only
Primary biliary cirrhosis	Biliary Cirrhosis	CTD_human_DG	21399635		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Primary biliary cirrhosis	Biliary Cirrhosis	GWASDB_DG	21399635, 22961000		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Primary biliary cirrhosis	Biliary Cirrhosis	GWASCAT_DG	22961000, 26394269		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	GWASCAT_DG	26974007		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Regional enteritis	Crohn Disease	CTD_human_DG	21102463		★☆☆☆☆ Found in Text Mining only
Secondary Biliary Cholangitis	Biliary Cholangitis	CTD_human_DG	21399635		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	GWASCAT_DG	26192919, 26974007		★★☆☆☆ Found in Text Mining + Unknown/Other Associations