GBP6 (guanylate binding protein family member 6)

Gene

• Entrez ID: 163351
• Gene name: Guanylate binding protein family member 6
• Gene symbol: GBP6
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p22.2
• Summary: Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT645870	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT645869	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT645868	hsa-miR-3155a	HITS-CLIP	23824327
MIRT645867	hsa-miR-3155b	HITS-CLIP	23824327
MIRT645866	hsa-miR-484	HITS-CLIP	23824327
MIRT645865	hsa-miR-1267	HITS-CLIP	23824327
MIRT645864	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT645863	hsa-miR-760	HITS-CLIP	23824327
MIRT645861	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT645862	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT645860	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT645859	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT625920	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625919	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625918	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625917	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625916	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625915	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625914	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625913	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT625912	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT625911	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT625910	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT625909	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT645870	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT645869	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT645868	hsa-miR-3155a	HITS-CLIP	23824327
MIRT645867	hsa-miR-3155b	HITS-CLIP	23824327
MIRT645866	hsa-miR-484	HITS-CLIP	23824327
MIRT645865	hsa-miR-1267	HITS-CLIP	23824327
MIRT645864	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT645863	hsa-miR-760	HITS-CLIP	23824327
MIRT645861	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT645862	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT645860	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT645859	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT625920	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT625919	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT625918	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT625917	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT625916	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT625915	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT625914	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT625913	hsa-miR-4714-5p	HITS-CLIP	23824327
MIRT625912	hsa-miR-146a-3p	HITS-CLIP	23824327
MIRT625911	hsa-miR-4766-5p	HITS-CLIP	23824327
MIRT625910	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT625909	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT1014090	hsa-miR-1197	CLIP-seq
MIRT1014091	hsa-miR-1246	CLIP-seq
MIRT1014092	hsa-miR-1285	CLIP-seq
MIRT1014093	hsa-miR-1304	CLIP-seq
MIRT1014094	hsa-miR-1305	CLIP-seq
MIRT1014095	hsa-miR-24	CLIP-seq
MIRT1014096	hsa-miR-2467-3p	CLIP-seq
MIRT1014097	hsa-miR-25	CLIP-seq
MIRT1014098	hsa-miR-30a	CLIP-seq
MIRT1014099	hsa-miR-30b	CLIP-seq
MIRT1014100	hsa-miR-30c	CLIP-seq
MIRT1014101	hsa-miR-30d	CLIP-seq
MIRT1014102	hsa-miR-30e	CLIP-seq
MIRT1014103	hsa-miR-3117-5p	CLIP-seq
MIRT1014104	hsa-miR-3122	CLIP-seq
MIRT1014105	hsa-miR-3123	CLIP-seq
MIRT1014106	hsa-miR-3145-5p	CLIP-seq
MIRT1014107	hsa-miR-3160-3p	CLIP-seq
MIRT1014108	hsa-miR-3161	CLIP-seq
MIRT1014109	hsa-miR-3165	CLIP-seq
MIRT1014110	hsa-miR-3187-5p	CLIP-seq
MIRT1014111	hsa-miR-32	CLIP-seq
MIRT1014112	hsa-miR-323-5p	CLIP-seq
MIRT1014113	hsa-miR-335	CLIP-seq
MIRT1014114	hsa-miR-3606	CLIP-seq
MIRT1014115	hsa-miR-3607-3p	CLIP-seq
MIRT1014116	hsa-miR-3616-3p	CLIP-seq
MIRT1014117	hsa-miR-3622b-5p	CLIP-seq
MIRT1014118	hsa-miR-363	CLIP-seq
MIRT1014119	hsa-miR-3646	CLIP-seq
MIRT1014120	hsa-miR-3656	CLIP-seq
MIRT1014121	hsa-miR-367	CLIP-seq
MIRT1014122	hsa-miR-3675-3p	CLIP-seq
MIRT1014123	hsa-miR-3689a-3p	CLIP-seq
MIRT1014124	hsa-miR-3689c	CLIP-seq
MIRT1014125	hsa-miR-3908	CLIP-seq
MIRT1014126	hsa-miR-3913-5p	CLIP-seq
MIRT1014127	hsa-miR-3925-5p	CLIP-seq
MIRT1014128	hsa-miR-3926	CLIP-seq
MIRT1014129	hsa-miR-3945	CLIP-seq
MIRT1014130	hsa-miR-3973	CLIP-seq
MIRT1014131	hsa-miR-4253	CLIP-seq
MIRT1014132	hsa-miR-4257	CLIP-seq
MIRT1014133	hsa-miR-4284	CLIP-seq
MIRT1014134	hsa-miR-4432	CLIP-seq
MIRT1014135	hsa-miR-4446-3p	CLIP-seq
MIRT1014136	hsa-miR-4455	CLIP-seq
MIRT1014137	hsa-miR-4487	CLIP-seq
MIRT1014138	hsa-miR-4492	CLIP-seq
MIRT1014139	hsa-miR-4498	CLIP-seq
MIRT1014140	hsa-miR-4505	CLIP-seq
MIRT1014141	hsa-miR-4522	CLIP-seq
MIRT1014142	hsa-miR-4659a-5p	CLIP-seq
MIRT1014143	hsa-miR-4659b-5p	CLIP-seq
MIRT1014144	hsa-miR-4662a-3p	CLIP-seq
MIRT1014145	hsa-miR-4684-5p	CLIP-seq
MIRT1014146	hsa-miR-4721	CLIP-seq
MIRT1014147	hsa-miR-4728-3p	CLIP-seq
MIRT1014148	hsa-miR-4728-5p	CLIP-seq
MIRT1014149	hsa-miR-4776-3p	CLIP-seq
MIRT1014150	hsa-miR-4786-5p	CLIP-seq
MIRT1014151	hsa-miR-4797-5p	CLIP-seq
MIRT1014152	hsa-miR-499-5p	CLIP-seq
MIRT1014153	hsa-miR-508-5p	CLIP-seq
MIRT1014154	hsa-miR-518d-5p	CLIP-seq
MIRT1014155	hsa-miR-519b-5p	CLIP-seq
MIRT1014156	hsa-miR-519c-5p	CLIP-seq
MIRT1014157	hsa-miR-520c-5p	CLIP-seq
MIRT1014158	hsa-miR-520g	CLIP-seq
MIRT1014159	hsa-miR-520h	CLIP-seq
MIRT1014160	hsa-miR-526a	CLIP-seq
MIRT1014161	hsa-miR-548c-3p	CLIP-seq
MIRT1014162	hsa-miR-548s	CLIP-seq
MIRT1014163	hsa-miR-558	CLIP-seq
MIRT1014164	hsa-miR-561	CLIP-seq
MIRT1014165	hsa-miR-579	CLIP-seq
MIRT1014166	hsa-miR-587	CLIP-seq
MIRT1014167	hsa-miR-595	CLIP-seq
MIRT1014168	hsa-miR-601	CLIP-seq
MIRT1014169	hsa-miR-607	CLIP-seq
MIRT1014170	hsa-miR-609	CLIP-seq
MIRT1014171	hsa-miR-612	CLIP-seq
MIRT1014172	hsa-miR-661	CLIP-seq
MIRT1014173	hsa-miR-762	CLIP-seq
MIRT1014174	hsa-miR-766	CLIP-seq
MIRT1014175	hsa-miR-767-5p	CLIP-seq
MIRT1014176	hsa-miR-876-3p	CLIP-seq
MIRT1014177	hsa-miR-92a	CLIP-seq
MIRT1014178	hsa-miR-92b	CLIP-seq
MIRT1014092	hsa-miR-1285	CLIP-seq
MIRT2000367	hsa-miR-150	CLIP-seq
MIRT2000368	hsa-miR-1827	CLIP-seq
MIRT1014095	hsa-miR-24	CLIP-seq
MIRT1014096	hsa-miR-2467-3p	CLIP-seq
MIRT1014098	hsa-miR-30a	CLIP-seq
MIRT1014099	hsa-miR-30b	CLIP-seq
MIRT1014100	hsa-miR-30c	CLIP-seq
MIRT1014101	hsa-miR-30d	CLIP-seq
MIRT1014102	hsa-miR-30e	CLIP-seq
MIRT1014106	hsa-miR-3145-5p	CLIP-seq
MIRT1014110	hsa-miR-3187-5p	CLIP-seq
MIRT1014113	hsa-miR-335	CLIP-seq
MIRT1014114	hsa-miR-3606	CLIP-seq
MIRT1014115	hsa-miR-3607-3p	CLIP-seq
MIRT1014122	hsa-miR-3675-3p	CLIP-seq
MIRT1014128	hsa-miR-3926	CLIP-seq
MIRT1014132	hsa-miR-4257	CLIP-seq
MIRT1014133	hsa-miR-4284	CLIP-seq
MIRT2000369	hsa-miR-4428	CLIP-seq
MIRT1014138	hsa-miR-4492	CLIP-seq
MIRT1014139	hsa-miR-4498	CLIP-seq
MIRT2000370	hsa-miR-4775	CLIP-seq
MIRT1014150	hsa-miR-4786-5p	CLIP-seq
MIRT1014153	hsa-miR-508-5p	CLIP-seq
MIRT2000371	hsa-miR-548an	CLIP-seq
MIRT1014162	hsa-miR-548s	CLIP-seq
MIRT1014171	hsa-miR-612	CLIP-seq
MIRT1014172	hsa-miR-661	CLIP-seq
MIRT1014173	hsa-miR-762	CLIP-seq
MIRT1014174	hsa-miR-766	CLIP-seq
MIRT1014175	hsa-miR-767-5p	CLIP-seq
MIRT2000372	hsa-miR-940	CLIP-seq
MIRT2233807	hsa-miR-122	CLIP-seq
MIRT2233808	hsa-miR-125a-3p	CLIP-seq
MIRT1014092	hsa-miR-1285	CLIP-seq
MIRT2233809	hsa-miR-1297	CLIP-seq
MIRT1014093	hsa-miR-1304	CLIP-seq
MIRT2233810	hsa-miR-1307	CLIP-seq
MIRT2233811	hsa-miR-130a	CLIP-seq
MIRT2233812	hsa-miR-130b	CLIP-seq
MIRT2233813	hsa-miR-146a	CLIP-seq
MIRT2233814	hsa-miR-146b-5p	CLIP-seq
MIRT2000367	hsa-miR-150	CLIP-seq
MIRT2000368	hsa-miR-1827	CLIP-seq
MIRT2233815	hsa-miR-183	CLIP-seq
MIRT2233816	hsa-miR-1915	CLIP-seq
MIRT2233817	hsa-miR-216b	CLIP-seq
MIRT1014095	hsa-miR-24	CLIP-seq
MIRT1014096	hsa-miR-2467-3p	CLIP-seq
MIRT1014097	hsa-miR-25	CLIP-seq
MIRT2233818	hsa-miR-26a	CLIP-seq
MIRT2233819	hsa-miR-26b	CLIP-seq
MIRT2233820	hsa-miR-301a	CLIP-seq
MIRT2233821	hsa-miR-301b	CLIP-seq
MIRT1014098	hsa-miR-30a	CLIP-seq
MIRT1014099	hsa-miR-30b	CLIP-seq
MIRT1014100	hsa-miR-30c	CLIP-seq
MIRT1014101	hsa-miR-30d	CLIP-seq
MIRT1014102	hsa-miR-30e	CLIP-seq
MIRT2233822	hsa-miR-3121-3p	CLIP-seq
MIRT2233823	hsa-miR-3124-3p	CLIP-seq
MIRT2233824	hsa-miR-3135b	CLIP-seq
MIRT1014106	hsa-miR-3145-5p	CLIP-seq
MIRT2233825	hsa-miR-3150b-3p	CLIP-seq
MIRT1014107	hsa-miR-3160-3p	CLIP-seq
MIRT1014110	hsa-miR-3187-5p	CLIP-seq
MIRT1014111	hsa-miR-32	CLIP-seq
MIRT1014113	hsa-miR-335	CLIP-seq
MIRT1014114	hsa-miR-3606	CLIP-seq
MIRT1014115	hsa-miR-3607-3p	CLIP-seq
MIRT2233826	hsa-miR-3612	CLIP-seq
MIRT1014116	hsa-miR-3616-3p	CLIP-seq
MIRT1014117	hsa-miR-3622b-5p	CLIP-seq
MIRT1014118	hsa-miR-363	CLIP-seq
MIRT2233827	hsa-miR-3652	CLIP-seq
MIRT2233828	hsa-miR-3665	CLIP-seq
MIRT2233829	hsa-miR-3666	CLIP-seq
MIRT1014121	hsa-miR-367	CLIP-seq
MIRT1014128	hsa-miR-3926	CLIP-seq
MIRT1014129	hsa-miR-3945	CLIP-seq
MIRT1014131	hsa-miR-4253	CLIP-seq
MIRT1014132	hsa-miR-4257	CLIP-seq
MIRT1014133	hsa-miR-4284	CLIP-seq
MIRT2233830	hsa-miR-4290	CLIP-seq
MIRT2233831	hsa-miR-4295	CLIP-seq
MIRT2233832	hsa-miR-4430	CLIP-seq
MIRT1014135	hsa-miR-4446-3p	CLIP-seq
MIRT2233833	hsa-miR-4459	CLIP-seq
MIRT2233834	hsa-miR-4465	CLIP-seq
MIRT1014137	hsa-miR-4487	CLIP-seq
MIRT1014138	hsa-miR-4492	CLIP-seq
MIRT1014139	hsa-miR-4498	CLIP-seq
MIRT1014140	hsa-miR-4505	CLIP-seq
MIRT2233835	hsa-miR-454	CLIP-seq
MIRT2233836	hsa-miR-4635	CLIP-seq
MIRT2233837	hsa-miR-4638-5p	CLIP-seq
MIRT2233838	hsa-miR-4695-5p	CLIP-seq
MIRT1014146	hsa-miR-4721	CLIP-seq
MIRT2233839	hsa-miR-4726-3p	CLIP-seq
MIRT2233840	hsa-miR-4772-3p	CLIP-seq
MIRT2233841	hsa-miR-4784	CLIP-seq
MIRT1014150	hsa-miR-4786-5p	CLIP-seq
MIRT1014151	hsa-miR-4797-5p	CLIP-seq
MIRT1014153	hsa-miR-508-5p	CLIP-seq
MIRT1014162	hsa-miR-548s	CLIP-seq
MIRT1014163	hsa-miR-558	CLIP-seq
MIRT1014165	hsa-miR-579	CLIP-seq
MIRT1014171	hsa-miR-612	CLIP-seq
MIRT2233842	hsa-miR-650	CLIP-seq
MIRT1014172	hsa-miR-661	CLIP-seq
MIRT2233843	hsa-miR-665	CLIP-seq
MIRT1014173	hsa-miR-762	CLIP-seq
MIRT2233844	hsa-miR-765	CLIP-seq
MIRT1014174	hsa-miR-766	CLIP-seq
MIRT1014175	hsa-miR-767-5p	CLIP-seq
MIRT1014177	hsa-miR-92a	CLIP-seq
MIRT1014178	hsa-miR-92b	CLIP-seq
MIRT2233807	hsa-miR-122	CLIP-seq
MIRT2233811	hsa-miR-130a	CLIP-seq
MIRT2233812	hsa-miR-130b	CLIP-seq
MIRT2233815	hsa-miR-183	CLIP-seq
MIRT2233820	hsa-miR-301a	CLIP-seq
MIRT2233821	hsa-miR-301b	CLIP-seq
MIRT2233824	hsa-miR-3135b	CLIP-seq
MIRT2233827	hsa-miR-3652	CLIP-seq
MIRT2233829	hsa-miR-3666	CLIP-seq
MIRT2233831	hsa-miR-4295	CLIP-seq
MIRT2233832	hsa-miR-4430	CLIP-seq
MIRT1014138	hsa-miR-4492	CLIP-seq
MIRT1014139	hsa-miR-4498	CLIP-seq
MIRT2233835	hsa-miR-454	CLIP-seq
MIRT1014173	hsa-miR-762	CLIP-seq
MIRT1014112	hsa-miR-323-5p	CLIP-seq
MIRT1014122	hsa-miR-3675-3p	CLIP-seq
MIRT1014136	hsa-miR-4455	CLIP-seq
MIRT1014145	hsa-miR-4684-5p	CLIP-seq
MIRT1014161	hsa-miR-548c-3p	CLIP-seq
MIRT1014170	hsa-miR-609	CLIP-seq
MIRT1014176	hsa-miR-876-3p	CLIP-seq
MIRT1014092	hsa-miR-1285	CLIP-seq
MIRT1014094	hsa-miR-1305	CLIP-seq
MIRT1014098	hsa-miR-30a	CLIP-seq
MIRT1014099	hsa-miR-30b	CLIP-seq
MIRT1014100	hsa-miR-30c	CLIP-seq
MIRT1014101	hsa-miR-30d	CLIP-seq
MIRT1014102	hsa-miR-30e	CLIP-seq
MIRT1014104	hsa-miR-3122	CLIP-seq
MIRT1014106	hsa-miR-3145-5p	CLIP-seq
MIRT2537769	hsa-miR-3177-5p	CLIP-seq
MIRT1014110	hsa-miR-3187-5p	CLIP-seq
MIRT1014112	hsa-miR-323-5p	CLIP-seq
MIRT1014115	hsa-miR-3607-3p	CLIP-seq
MIRT2537770	hsa-miR-3609	CLIP-seq
MIRT1014122	hsa-miR-3675-3p	CLIP-seq
MIRT2537771	hsa-miR-3685	CLIP-seq
MIRT1014123	hsa-miR-3689a-3p	CLIP-seq
MIRT1014124	hsa-miR-3689c	CLIP-seq
MIRT2537772	hsa-miR-384	CLIP-seq
MIRT1014126	hsa-miR-3913-5p	CLIP-seq
MIRT2537773	hsa-miR-3919	CLIP-seq
MIRT1014134	hsa-miR-4432	CLIP-seq
MIRT2537774	hsa-miR-4452	CLIP-seq
MIRT1014136	hsa-miR-4455	CLIP-seq
MIRT1014145	hsa-miR-4684-5p	CLIP-seq
MIRT2537775	hsa-miR-4698	CLIP-seq
MIRT1014148	hsa-miR-4728-5p	CLIP-seq
MIRT2537776	hsa-miR-4756-3p	CLIP-seq
MIRT1014151	hsa-miR-4797-5p	CLIP-seq
MIRT1014152	hsa-miR-499-5p	CLIP-seq
MIRT1014153	hsa-miR-508-5p	CLIP-seq
MIRT2537777	hsa-miR-548ah	CLIP-seq
MIRT1014161	hsa-miR-548c-3p	CLIP-seq
MIRT2537778	hsa-miR-548n	CLIP-seq
MIRT2537779	hsa-miR-548t	CLIP-seq
MIRT1014169	hsa-miR-607	CLIP-seq
MIRT1014170	hsa-miR-609	CLIP-seq
MIRT1014171	hsa-miR-612	CLIP-seq
MIRT1014172	hsa-miR-661	CLIP-seq
MIRT1014174	hsa-miR-766	CLIP-seq
MIRT1014175	hsa-miR-767-5p	CLIP-seq
MIRT1014176	hsa-miR-876-3p	CLIP-seq
MIRT1014092	hsa-miR-1285	CLIP-seq
MIRT1014098	hsa-miR-30a	CLIP-seq
MIRT1014099	hsa-miR-30b	CLIP-seq
MIRT1014100	hsa-miR-30c	CLIP-seq
MIRT1014101	hsa-miR-30d	CLIP-seq
MIRT1014102	hsa-miR-30e	CLIP-seq
MIRT1014104	hsa-miR-3122	CLIP-seq
MIRT1014106	hsa-miR-3145-5p	CLIP-seq
MIRT2537769	hsa-miR-3177-5p	CLIP-seq
MIRT1014110	hsa-miR-3187-5p	CLIP-seq
MIRT1014112	hsa-miR-323-5p	CLIP-seq
MIRT1014115	hsa-miR-3607-3p	CLIP-seq
MIRT1014122	hsa-miR-3675-3p	CLIP-seq
MIRT1014123	hsa-miR-3689a-3p	CLIP-seq
MIRT1014124	hsa-miR-3689c	CLIP-seq
MIRT1014126	hsa-miR-3913-5p	CLIP-seq
MIRT2537773	hsa-miR-3919	CLIP-seq
MIRT1014134	hsa-miR-4432	CLIP-seq
MIRT2537774	hsa-miR-4452	CLIP-seq
MIRT1014136	hsa-miR-4455	CLIP-seq
MIRT1014145	hsa-miR-4684-5p	CLIP-seq
MIRT1014148	hsa-miR-4728-5p	CLIP-seq
MIRT2537776	hsa-miR-4756-3p	CLIP-seq
MIRT1014151	hsa-miR-4797-5p	CLIP-seq
MIRT1014152	hsa-miR-499-5p	CLIP-seq
MIRT1014153	hsa-miR-508-5p	CLIP-seq
MIRT1014161	hsa-miR-548c-3p	CLIP-seq
MIRT1014170	hsa-miR-609	CLIP-seq
MIRT1014171	hsa-miR-612	CLIP-seq
MIRT1014172	hsa-miR-661	CLIP-seq
MIRT1014174	hsa-miR-766	CLIP-seq
MIRT1014175	hsa-miR-767-5p	CLIP-seq
MIRT1014176	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0006955	Process	Immune response	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042742	Process	Defense response to bacterium	ISS
GO:0042832	Process	Defense response to protozoan	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0050830	Process	Defense response to Gram-positive bacterium	IBA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0071346	Process	Cellular response to type II interferon	IBA
GO:0071346	Process	Cellular response to type II interferon	ISS

Other IDs

• MIM: 612467
• HGNC: 25395
• e!Ensembl: ENSG00000183347

Protein

• UniProt ID: Q6ZN66
• Protein name: Guanylate-binding protein 6 (EC 3.6.5.-) (GTP-binding protein 6) (GBP-6) (Guanine nucleotide-binding protein 6)
• Protein function: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens, such as bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the pr
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02263	GBP	18 → 281	Guanylate-binding protein, N-terminal domain	Domain
  PF02841	GBP_C	283 → 579	Guanylate-binding protein, C-terminal domain	Domain

• Sequence:

  MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAG
  QNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAV
  LLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTV
  RDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPT
  NDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYV
  EAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACE
  REAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMES
  ISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKA
  LTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREH
  LLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNL
  ADELTAILSAPAKLIGHGVKGVSSLFKKHKLPF

• Sequence length: 633

Pathways

Reactome:

Interferon gamma signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31707626		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	31707626		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	19861202, 32269280	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lip	Carcinoma of Lip	BEFREE	31707626		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	31707626		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31959204	Associate	★☆☆☆☆ Found in Text Mining only