Gene Gene information from NCBI Gene database.
Entrez ID 1633
Gene name Deoxycytidine kinase
Gene symbol DCK
Synonyms (NCBI Gene)
-
Chromosome 4
Chromosome location 4q13.3
Summary Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxy
miRNA miRNA information provided by mirtarbase database.
438
miRTarBase ID miRNA Experiments Reference
MIRT019296 hsa-miR-148b-3p Microarray 17612493
MIRT021886 hsa-miR-128-3p Microarray 17612493
MIRT310571 hsa-miR-5692a PAR-CLIP 20371350
MIRT408158 hsa-miR-513b-3p PAR-CLIP 20371350
MIRT508452 hsa-miR-4712-3p PAR-CLIP 20371350
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SP1 Unknown 20544528
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004136 Function Deoxyadenosine kinase activity IDA 34768989
GO:0004136 Function Deoxyadenosine kinase activity IEA
GO:0004137 Function Deoxycytidine kinase activity IBA
GO:0004137 Function Deoxycytidine kinase activity IDA 12808445, 20637175, 34768989
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
125450 2704 ENSG00000156136
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P27707
Protein name Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113)
Protein function Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:1996353, PubMed:20614893, PubMed:20637175). Has broad substrate specificity, and does not display
PDB 1P5Z , 1P60 , 1P61 , 1P62 , 2A2Z , 2A30 , 2A7Q , 2NO0 , 2NO1 , 2NO6 , 2NO7 , 2NO9 , 2NOA , 2QRN , 2QRO , 2ZI3 , 2ZI4 , 2ZI5 , 2ZI6 , 2ZI7 , 2ZI9 , 2ZIA , 3HP1 , 3IPX , 3IPY , 3KFX , 3MJR , 3QEJ , 3QEN , 3QEO , 4JLJ , 4JLK , 4JLM , 4JLN , 4KCG , 4L5B , 4Q18 , 4Q19 , 4Q1A , 4Q1B , 4Q1C , 4Q1D , 4Q1E , 4Q1F , 5MQJ , 5MQL , 5MQT , 7ZI1 , 7ZI2 , 7ZI3 , 7ZI5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01712 dNK 24 258 Deoxynucleoside kinase Domain
Sequence
Sequence length 260
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Purine metabolism
Pyrimidine metabolism
Metabolic pathways
Nucleotide metabolism
  Pyrimidine salvage
Purine salvage
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 2473850, 28808226, 29473342
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 11896543, 27808171, 7514246
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 8640820
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 19828005
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 28808226, 29473342
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 26962792, 28196013
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 24294360 Associate
★☆☆☆☆
Found in Text Mining only
Ataxia Telangiectasia Ataxia Telangiectasia BEFREE 28808226
★☆☆☆☆
Found in Text Mining only
Autoimmune Chronic Hepatitis Autoimmune hepatitis BEFREE 29700125
★☆☆☆☆
Found in Text Mining only
B-CELL MALIGNANCY, LOW-GRADE Lymphocytic Leukemia BEFREE 15202025
★☆☆☆☆
Found in Text Mining only