Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	163259
Gene name	DENN domain containing 2C
Gene symbol	DENND2C
Synonyms (NCBI Gene)	dJ1156J9.1
Chromosome	1
Chromosome location	1p13.2

153

Show/Hide all (153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023271	hsa-miR-122-5p	Microarray	17612493
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT671559	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT672974	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT672973	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT672972	hsa-miR-603	HITS-CLIP	23824327
MIRT672971	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT672970	hsa-miR-3941	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT671559	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT635269	hsa-miR-5190	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT635266	hsa-miR-4276	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT635268	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT671559	hsa-miR-510-3p	HITS-CLIP	27418678
MIRT637069	hsa-miR-570-3p	HITS-CLIP	27418678
MIRT613155	hsa-miR-8485	HITS-CLIP	27418678
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT671559	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT672974	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT672973	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT672972	hsa-miR-603	HITS-CLIP	23824327
MIRT672971	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT672970	hsa-miR-3941	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT671559	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT637069	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT635269	hsa-miR-5190	HITS-CLIP	23824327
MIRT635268	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT635267	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT635266	hsa-miR-4276	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT613155	hsa-miR-8485	HITS-CLIP	23824327
MIRT613154	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT932343	hsa-miR-1224-3p	CLIP-seq
MIRT932344	hsa-miR-1260	CLIP-seq
MIRT932345	hsa-miR-1260b	CLIP-seq
MIRT932346	hsa-miR-1280	CLIP-seq
MIRT932347	hsa-miR-3674	CLIP-seq
MIRT932348	hsa-miR-371-5p	CLIP-seq
MIRT932349	hsa-miR-371b-5p	CLIP-seq
MIRT932350	hsa-miR-450b-3p	CLIP-seq
MIRT932351	hsa-miR-4713-3p	CLIP-seq
MIRT932352	hsa-miR-4726-3p	CLIP-seq
MIRT932353	hsa-miR-532-3p	CLIP-seq
MIRT932354	hsa-miR-638	CLIP-seq
MIRT932355	hsa-miR-769-3p	CLIP-seq
MIRT1976070	hsa-miR-27a	CLIP-seq
MIRT1976071	hsa-miR-27b	CLIP-seq
MIRT1976072	hsa-miR-513a-5p	CLIP-seq
MIRT1976073	hsa-miR-765	CLIP-seq
MIRT2211473	hsa-miR-1271	CLIP-seq
MIRT2211474	hsa-miR-182	CLIP-seq
MIRT1976070	hsa-miR-27a	CLIP-seq
MIRT1976071	hsa-miR-27b	CLIP-seq
MIRT2211475	hsa-miR-330-3p	CLIP-seq
MIRT1976072	hsa-miR-513a-5p	CLIP-seq
MIRT2211476	hsa-miR-9	CLIP-seq
MIRT2211477	hsa-miR-96	CLIP-seq
MIRT2679158	hsa-miR-3117-5p	CLIP-seq
MIRT2679159	hsa-miR-3138	CLIP-seq
MIRT2679160	hsa-miR-3165	CLIP-seq
MIRT2679161	hsa-miR-4717-3p	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005654	Component	Nucleoplasm	IDA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q68D51

Protein name

DENN domain-containing protein 2C

Protein function

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03456	uDENN	510 → 578	uDENN domain	Domain
PF02141	DENN	586 → 770	DENN (AEX-3) domain	Family
PF03455	dDENN	847 → 895	dDENN domain	Domain

Sequence

MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKK
NPIAERKSKNLDVTSRENVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCSR
VKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRV
LDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCEN
NSCAQSSLASSQEPEPKKYGGKIRGRSKRKSFEFEDIQHFRNRNSQTIREELGRNSGSAL
YYTQSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLPPKPQFL
HRKTMEVKNSQAYLRSKLTKDTTLPVTLTEWKLFRAGEVANTKRKNLPRLVLKIDDIFES
KRGKKKVKLHSYTGKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPSSKRNPHYQTLER
DLIELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKF
CFPDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCF
NLFSKILDEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPL
DSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTW
QHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDED
EILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVT
ERGERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYL
ETIPESEPSGMNRILRSLGSKMKFLQKK

Sequence length

928

Interactions

View interactions

	Reactome
			RAB GEFs exchange GTP for GDP on RABs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

DENND2C (DENN domain containing 2C)