Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	162989
Gene name	Death effector domain containing 2
Gene symbol	DEDD2
Synonyms (NCBI Gene)	FLAME-3FLAME3
Chromosome	19
Chromosome location	19q13.2
Summary	This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049538	hsa-miR-92a-3p	CLASH	23622248
MIRT049538	hsa-miR-92a-3p	CLASH	23622248
MIRT931767	hsa-miR-1273f	CLIP-seq
MIRT931768	hsa-miR-1324	CLIP-seq
MIRT931769	hsa-miR-148a	CLIP-seq
MIRT931770	hsa-miR-148b	CLIP-seq
MIRT931771	hsa-miR-152	CLIP-seq
MIRT931772	hsa-miR-1915	CLIP-seq
MIRT931773	hsa-miR-3166	CLIP-seq
MIRT931774	hsa-miR-4434	CLIP-seq
MIRT931775	hsa-miR-4504	CLIP-seq
MIRT931776	hsa-miR-4516	CLIP-seq
MIRT931777	hsa-miR-4645-3p	CLIP-seq
MIRT931778	hsa-miR-4690-3p	CLIP-seq
MIRT931779	hsa-miR-4726-3p	CLIP-seq
MIRT931780	hsa-miR-4768-3p	CLIP-seq
MIRT931781	hsa-miR-4771	CLIP-seq
MIRT931782	hsa-miR-542-3p	CLIP-seq
MIRT931783	hsa-miR-665	CLIP-seq
MIRT1975775	hsa-miR-130a	CLIP-seq
MIRT1975776	hsa-miR-130b	CLIP-seq
MIRT931768	hsa-miR-1324	CLIP-seq
MIRT1975777	hsa-miR-1909	CLIP-seq
MIRT1975778	hsa-miR-301a	CLIP-seq
MIRT1975779	hsa-miR-301b	CLIP-seq
MIRT931773	hsa-miR-3166	CLIP-seq
MIRT1975780	hsa-miR-3666	CLIP-seq
MIRT1975781	hsa-miR-378	CLIP-seq
MIRT1975782	hsa-miR-378b	CLIP-seq
MIRT1975783	hsa-miR-378c	CLIP-seq
MIRT1975784	hsa-miR-378d	CLIP-seq
MIRT1975785	hsa-miR-378e	CLIP-seq
MIRT1975786	hsa-miR-378f	CLIP-seq
MIRT1975787	hsa-miR-378h	CLIP-seq
MIRT1975788	hsa-miR-378i	CLIP-seq
MIRT1975789	hsa-miR-422a	CLIP-seq
MIRT1975790	hsa-miR-4295	CLIP-seq
MIRT931775	hsa-miR-4504	CLIP-seq
MIRT1975791	hsa-miR-454	CLIP-seq
MIRT1975792	hsa-miR-4638-3p	CLIP-seq
MIRT931777	hsa-miR-4645-3p	CLIP-seq
MIRT1975793	hsa-miR-4747-5p	CLIP-seq
MIRT931781	hsa-miR-4771	CLIP-seq
MIRT1975794	hsa-miR-519a	CLIP-seq
MIRT1975795	hsa-miR-519b-3p	CLIP-seq
MIRT1975796	hsa-miR-519c-3p	CLIP-seq
MIRT931782	hsa-miR-542-3p	CLIP-seq
MIRT1975797	hsa-miR-574-5p	CLIP-seq
MIRT1975798	hsa-miR-579	CLIP-seq
MIRT931768	hsa-miR-1324	CLIP-seq
MIRT931769	hsa-miR-148a	CLIP-seq
MIRT931770	hsa-miR-148b	CLIP-seq
MIRT931771	hsa-miR-152	CLIP-seq
MIRT1975777	hsa-miR-1909	CLIP-seq
MIRT931772	hsa-miR-1915	CLIP-seq
MIRT2211224	hsa-miR-214	CLIP-seq
MIRT2211225	hsa-miR-3156-5p	CLIP-seq
MIRT931773	hsa-miR-3166	CLIP-seq
MIRT2211226	hsa-miR-34a	CLIP-seq
MIRT2211227	hsa-miR-34c-5p	CLIP-seq
MIRT2211228	hsa-miR-3619-5p	CLIP-seq
MIRT2211229	hsa-miR-4291	CLIP-seq
MIRT2211230	hsa-miR-4302	CLIP-seq
MIRT2211231	hsa-miR-4436b-3p	CLIP-seq
MIRT2211232	hsa-miR-4474-3p	CLIP-seq
MIRT2211233	hsa-miR-449a	CLIP-seq
MIRT2211234	hsa-miR-449b	CLIP-seq
MIRT931775	hsa-miR-4504	CLIP-seq
MIRT931777	hsa-miR-4645-3p	CLIP-seq
MIRT2211235	hsa-miR-4685-5p	CLIP-seq
MIRT2211236	hsa-miR-4688	CLIP-seq
MIRT931778	hsa-miR-4690-3p	CLIP-seq
MIRT2211237	hsa-miR-4695-3p	CLIP-seq
MIRT931779	hsa-miR-4726-3p	CLIP-seq
MIRT931781	hsa-miR-4771	CLIP-seq
MIRT2211238	hsa-miR-4786-3p	CLIP-seq
MIRT2211239	hsa-miR-486-3p	CLIP-seq
MIRT931782	hsa-miR-542-3p	CLIP-seq
MIRT1975797	hsa-miR-574-5p	CLIP-seq
MIRT2211240	hsa-miR-761	CLIP-seq
MIRT2211241	hsa-miR-922	CLIP-seq
MIRT2515089	hsa-miR-1207-5p	CLIP-seq
MIRT2515090	hsa-miR-125a-3p	CLIP-seq
MIRT2515091	hsa-miR-127-5p	CLIP-seq
MIRT2515092	hsa-miR-1285	CLIP-seq
MIRT2515093	hsa-miR-1291	CLIP-seq
MIRT1975775	hsa-miR-130a	CLIP-seq
MIRT1975776	hsa-miR-130b	CLIP-seq
MIRT1975777	hsa-miR-1909	CLIP-seq
MIRT2211224	hsa-miR-214	CLIP-seq
MIRT1975778	hsa-miR-301a	CLIP-seq
MIRT1975779	hsa-miR-301b	CLIP-seq
MIRT2515094	hsa-miR-3064-5p	CLIP-seq
MIRT2515095	hsa-miR-3117-5p	CLIP-seq
MIRT2515096	hsa-miR-3150b-3p	CLIP-seq
MIRT2515097	hsa-miR-3187-5p	CLIP-seq
MIRT2515098	hsa-miR-320e	CLIP-seq
MIRT2515099	hsa-miR-3607-3p	CLIP-seq
MIRT2211228	hsa-miR-3619-5p	CLIP-seq
MIRT2515100	hsa-miR-3652	CLIP-seq
MIRT1975780	hsa-miR-3666	CLIP-seq
MIRT2515101	hsa-miR-3686	CLIP-seq
MIRT2515102	hsa-miR-3691-3p	CLIP-seq
MIRT1975781	hsa-miR-378	CLIP-seq
MIRT1975782	hsa-miR-378b	CLIP-seq
MIRT1975783	hsa-miR-378c	CLIP-seq
MIRT1975784	hsa-miR-378d	CLIP-seq
MIRT1975785	hsa-miR-378e	CLIP-seq
MIRT1975786	hsa-miR-378f	CLIP-seq
MIRT1975787	hsa-miR-378h	CLIP-seq
MIRT1975788	hsa-miR-378i	CLIP-seq
MIRT2515103	hsa-miR-3913-3p	CLIP-seq
MIRT2515104	hsa-miR-3918	CLIP-seq
MIRT1975789	hsa-miR-422a	CLIP-seq
MIRT2515105	hsa-miR-4271	CLIP-seq
MIRT1975790	hsa-miR-4295	CLIP-seq
MIRT2515106	hsa-miR-4430	CLIP-seq
MIRT2515107	hsa-miR-4505	CLIP-seq
MIRT2515108	hsa-miR-4520a-3p	CLIP-seq
MIRT1975791	hsa-miR-454	CLIP-seq
MIRT1975792	hsa-miR-4638-3p	CLIP-seq
MIRT2515109	hsa-miR-4689	CLIP-seq
MIRT2515110	hsa-miR-4710	CLIP-seq
MIRT2515111	hsa-miR-4725-3p	CLIP-seq
MIRT1975793	hsa-miR-4747-5p	CLIP-seq
MIRT2515112	hsa-miR-4763-3p	CLIP-seq
MIRT2515113	hsa-miR-4784	CLIP-seq
MIRT2515114	hsa-miR-489	CLIP-seq
MIRT2515115	hsa-miR-508-5p	CLIP-seq
MIRT1975794	hsa-miR-519a	CLIP-seq
MIRT1975795	hsa-miR-519b-3p	CLIP-seq
MIRT1975796	hsa-miR-519c-3p	CLIP-seq
MIRT2515116	hsa-miR-612	CLIP-seq
MIRT2515117	hsa-miR-625	CLIP-seq
MIRT2211240	hsa-miR-761	CLIP-seq
MIRT2515090	hsa-miR-125a-3p	CLIP-seq
MIRT1975775	hsa-miR-130a	CLIP-seq
MIRT1975776	hsa-miR-130b	CLIP-seq
MIRT1975777	hsa-miR-1909	CLIP-seq
MIRT2211224	hsa-miR-214	CLIP-seq
MIRT1975778	hsa-miR-301a	CLIP-seq
MIRT1975779	hsa-miR-301b	CLIP-seq
MIRT2515095	hsa-miR-3117-5p	CLIP-seq
MIRT2515096	hsa-miR-3150b-3p	CLIP-seq
MIRT2515099	hsa-miR-3607-3p	CLIP-seq
MIRT2211228	hsa-miR-3619-5p	CLIP-seq
MIRT1975780	hsa-miR-3666	CLIP-seq
MIRT2515101	hsa-miR-3686	CLIP-seq
MIRT2515102	hsa-miR-3691-3p	CLIP-seq
MIRT1975781	hsa-miR-378	CLIP-seq
MIRT1975782	hsa-miR-378b	CLIP-seq
MIRT1975783	hsa-miR-378c	CLIP-seq
MIRT1975784	hsa-miR-378d	CLIP-seq
MIRT1975785	hsa-miR-378e	CLIP-seq
MIRT1975786	hsa-miR-378f	CLIP-seq
MIRT1975787	hsa-miR-378h	CLIP-seq
MIRT1975788	hsa-miR-378i	CLIP-seq
MIRT2515103	hsa-miR-3913-3p	CLIP-seq
MIRT1975789	hsa-miR-422a	CLIP-seq
MIRT2515105	hsa-miR-4271	CLIP-seq
MIRT1975790	hsa-miR-4295	CLIP-seq
MIRT2515108	hsa-miR-4520a-3p	CLIP-seq
MIRT1975791	hsa-miR-454	CLIP-seq
MIRT1975792	hsa-miR-4638-3p	CLIP-seq
MIRT2515109	hsa-miR-4689	CLIP-seq
MIRT2515110	hsa-miR-4710	CLIP-seq
MIRT2515111	hsa-miR-4725-3p	CLIP-seq
MIRT1975793	hsa-miR-4747-5p	CLIP-seq
MIRT2515113	hsa-miR-4784	CLIP-seq
MIRT2515114	hsa-miR-489	CLIP-seq
MIRT2515115	hsa-miR-508-5p	CLIP-seq
MIRT1975794	hsa-miR-519a	CLIP-seq
MIRT1975795	hsa-miR-519b-3p	CLIP-seq
MIRT1975796	hsa-miR-519c-3p	CLIP-seq
MIRT2515117	hsa-miR-625	CLIP-seq
MIRT2211240	hsa-miR-761	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11741985
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	11741985
GO:0005730	Component	Nucleolus	IEA
GO:0006396	Process	RNA processing	NAS	11741985
GO:0006915	Process	Apoptotic process	IEA
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IBA
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	IMP	11741985
GO:0016075	Process	RRNA catabolic process	NAS	11741985
GO:0019725	Process	Cellular homeostasis	NAS	11741985
GO:0030159	Function	Signaling receptor complex adaptor activity	NAS	11741985
GO:0030262	Process	Apoptotic nuclear changes	IDA	11741985
GO:0035556	Process	Intracellular signal transduction	NAS	11741985
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	NAS	11741985
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IMP	11741985

MIM	HGNC	e!Ensembl
617078	24450	ENSG00000160570

Q8WXF8

Protein name

DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3)

Protein function

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucle

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01335	DED	26 → 108	Death effector domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high

Sequence

MALSGSTPAPCWEEDECLDYYGMLSLHRMFEVVGGQLTECELELLAFLLDEAPGAAGGLA
RARSGLELLLELERRGQCDESNLRLLGQLLRVLARHDLLPHLARKRRRPVSPERYSYGTS
SSSKRTEGSCRRRRQSSSSANSQQGQWETGSPPTKRQRRSRGRPSGGARRRRRGAPAAPQ
QQSEPARPSSEGKVTCDIRLRVRAEYCEHGPALEQGVASRRPQALARQLDVFGQATAVLR
SRDLGSVVCDIKFSELSYLDAFWGDYLSGALLQALRGVFLTEALREAVGREAVRLLVSVD
EADYEAGRRRLLLMEEEGGRRPTEAS

Sequence length

326

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	37488513	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DEDD2 (death effector domain containing 2)